D:Lifespan

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pChart

Disease Term
Synonyms None
Documents 594
Hot Single Events 200
Hot Interactions 43

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lifespan. They are ordered first by their relevance to Lifespan and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0 100.00
2 INT329677 CDKN2A Regulation of CBX7 1 0.31 2.23 0 98.28
3 INT238264 pma Negative_regulation of Gene_expression of Cr1l 1 0.02 0.26 0.16 98.20
4 INT238222 pma Positive_regulation of Prkcg Negative_regulation of Gene_expression of Cr1l 1 0.01 0.26 0.16 98.20
5 INT238262 Prkcg Negative_regulation of Gene_expression of Cr1l 1 0.12 0.26 0.16 98.20
6 INT239181 Gene_expression of Gh Negative_regulation of Sod1 1 0.24 0.33 0 97.44
7 INT238263 pma Positive_regulation of Gene_expression of Cd59 1 0.02 0.57 0.26 97.24
8 INT188802 Il1 Negative_regulation of Gene_expression of Col7a1 1 0.00 0.71 0.26 97.16
9 INT239182 Gene_expression of Gh Negative_regulation of Cat 1 0.17 0.33 0 97.08
10 INT238261 pma Positive_regulation of Prkcg 1 0.01 0.33 0.34 96.08
11 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21 93.68
12 INT309509 Negative_regulation of Binding of Xrcc6 and Htt 1 0.31 0.41 0 93.68
13 INT342625 Binding of IFN1@ and Vps54 1 0.03 1.18 0.3 93.28
14 INT334044 Cdt1 Regulation of Gene_expression of ALPP 1 0.04 0.72 0.12 93.24
15 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58 92.12
16 INT187673 GNRH1 Regulation of Localization of PLOD1 1 0.06 0.09 0 91.48
17 INT95125 Binding of KCNA6 and SGCG 1 0.40 2.73 0.18 91.12
18 INT188804 S100a8 Positive_regulation of Gene_expression of Tnfsf11 1 0.00 0.7 0.31 90.08
19 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57 89.84
20 INT239185 Binding of Clk1 and Shc1 1 0.04 2.42 0 89.60
21 INT220677 Binding of Mfi2 and Gtf3a 1 0.00 0.77 0.04 89.60
22 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57 89.32
23 INT301241 Mir29a Positive_regulation of Runx1 1 0.00 2.85 0 88.84
24 INT234164 Binding of Sod1 and Dynll1 1 0.06 1.27 0 88.24
25 INT297733 Cbr1 Regulation of Gene_expression of Bcl2 1 0.05 0.94 0.07 87.20
26 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0 85.96
27 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0 85.72
28 INT189301 Atp6v1e1 Positive_regulation of Positive_regulation of Htr2a 1 0.01 1.13 0.11 85.20
29 INT305281 Obsty1 Regulation of Localization of Gopc 1 0.02 1.49 0 83.48
30 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71 83.28
31 INT297736 Cbr1 Positive_regulation of Ucp3 1 0.11 1.29 0.07 82.64
32 INT297735 Cbr1 Positive_regulation of Sod2 1 0.11 1.28 0.07 82.64
33 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06 82.40
34 INT189298 Atp6v1e1 Positive_regulation of Positive_regulation of Htr1a 1 0.00 1.15 0.11 81.52
35 INT324305 Binding of CST3 and UMOD 1 0.05 3.22 0 81.48
36 INT324313 Binding of STC1 and UMOD 1 0.29 3.22 0 81.48
37 INT324312 Binding of GATM and UMOD 1 0.02 1.62 0 81.48
38 INT324306 Binding of GATM and STC1 1 0.02 1.61 0 81.48
39 INT324311 Binding of UMOD and SHROOM3 1 0.29 1.62 0 81.48
40 INT324310 Binding of STC1 and SHROOM3 1 0.24 1.61 0 81.48
41 INT324309 Binding of CST3 and GATM 1 0.00 1.6 0 81.48
42 INT324308 Binding of CST3 and SHROOM3 1 0.04 1.6 0 81.48
43 INT296324 NFE2L2 Regulation of GSTK1 1 0.01 0.91 0.14 80.88
44 INT342622 Binding of MMP14 and Mmp2 1 0.39 1.15 0.37 80.00
45 INT342606 Binding of MMP14 and VEGFA 1 0.08 1.16 0.37 80.00
46 INT342623 Binding of VEGFA and Col18a1 1 0.02 1.15 0.37 79.04
47 INT342617 Binding of Col18a1 and Mmp2 1 0.11 1.15 0.37 79.04
48 INT302493 Binding of AGRP and IMPACT 1 0.25 0.53 0 78.88
49 INT101813 KEAP1 Negative_regulation of NFE2L2 3 0.47 1.63 0.28 75.36
50 INT101810 Binding of NFE2L2 and KEAP1 7 0.53 4.12 0.29 73.04
51 INT239186 H2 Negative_regulation of Aco1 1 0.00 1.96 0.05 71.56
52 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0 69.44
53 INT329679 CBX7 Regulation of CDKN2A 1 0.31 4.18 0 69.44
54 INT294290 PROK1 Positive_regulation of Gene_expression of IL11 1 0.59 0.46 0.23 68.92
55 INT294302 PROK1 Positive_regulation of Localization of IL11 1 0.40 0.36 0.08 68.92
56 INT239188 Proc Positive_regulation of Akt1 3 0.01 1.72 0 68.52
57 INT238260 Positive_regulation of pma Negative_regulation of Transcription of C3 1 0.02 0.12 0.23 64.16
58 INT334043 Cdt1 Positive_regulation of Gene_expression of ALPP 1 0.08 0.39 0.05 63.92
59 INT235596 HNF4A Regulation of Gene_expression of TPI1 1 0.00 0.25 0 63.76
60 INT297738 Cbr1 Positive_regulation of Ifih1 1 0.01 1.83 0.39 63.56
61 INT294300 PROK1 Positive_regulation of Positive_regulation of IL11 1 0.40 0.15 0 61.28
62 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0 60.32
63 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05 58.28
64 INT174561 Binding of Cd28 and Ncl 1 0.00 0.62 0.07 57.48
65 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21 57.36
66 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1 55.88
67 INT329568 GOPC Positive_regulation of Phosphorylation of MAPK1 1 0.04 0.79 0 55.12
68 INT324347 Binding of UMOD and Scr 1 0.20 2.23 0 54.04
69 INT220682 tf Positive_regulation of Positive_regulation of F10 1 0.04 0.67 0.19 54.00
70 INT220673 Binding of tf and Gtf3a Positive_regulation of F10 1 0.00 0.67 0.19 54.00
71 INT220675 Binding of tf and Gtf3a 1 0.02 0.67 0.19 54.00
72 INT250531 Ghrh Regulation of Gh 1 0.22 0 0.41 50.00
73 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24 50.00
74 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2 50.00
75 INT250533 Ghrh Regulation of Localization of Gh 1 0.13 0 0.15 50.00
76 INT250535 Ghrh Regulation of Gene_expression of Gh 1 0.31 0 0.15 50.00
77 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06 50.00
78 INT297737 Cbr1 Positive_regulation of Bax 1 0.06 0.53 0.03 50.00
79 INT297739 Binding of Cbr1 and Ucp3 1 0.06 0.5 0 50.00
80 INT297740 Cbr1 Negative_regulation of Positive_regulation of PROC 1 0.00 0.42 0 50.00
81 INT297741 Cbr1 Negative_regulation of PROC 1 0.00 0.4 0 50.00
82 INT297734 Cbr1 Regulation of Positive_regulation of Ifih1 1 0.00 0.42 0 50.00
83 INT294306 Positive_regulation of PROK1 Positive_regulation of Transcription of IL11 1 0.40 0.08 0 49.56
84 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34 48.64
85 INT220679 Binding of F3 and Gtf3a 1 0.00 0.98 0.15 48.64
86 INT179699 LPCAT3 Regulation of LHX2 1 0.00 0.31 0 48.48
87 INT83425 Binding of CD40LG and IGHG3 11 0.21 4.56 2.09 47.80
88 INT324340 Binding of SLC12A1 and Scr 1 0.00 1.42 0 46.52
89 INT267927 asa Negative_regulation of Gene_expression of Tbxa2r 1 0.00 0.78 0.12 45.52
90 INT220676 tf Positive_regulation of Gene_expression of Ik 1 0.00 0.66 0.21 37.92
91 INT323486 Ghrl Regulation of Localization of Ins1 1 0.21 2.07 0.07 37.24
92 INT305274 Obsty1 Regulation of Gene_expression of Prkag1 1 0.01 0.94 0.08 37.12
93 INT295573 Igf1 Positive_regulation of Gene_expression of Mstn 1 0.19 0 0 37.12
94 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05 37.04
95 INT294296 Binding of IL11 and PROK1 1 0.32 0.07 0 36.60
96 INT305257 Obsty1 Regulation of Gene_expression of Mapk1 1 0.03 2.05 0.08 36.40
97 INT220678 Positive_regulation of Binding of tf and Par2 1 0.16 0.71 0.2 34.92
98 INT295576 Binding of Dmd and Mstn 1 0.23 1.1 0 34.64
99 INT220683 Binding of tf and PAR1 1 0.06 0.7 0.2 34.32
100 INT220674 Binding of tf and Par2 1 0.13 0.71 0.2 34.32
101 INT207845 Binding of INS and Hypism 3 0.04 2.88 0.22 33.00
102 INT301244 Rb1 Regulation of Hbp1 1 0.03 0.75 0 32.76
103 INT301246 Binding of HMGB1 and Hbp1 1 0.03 0.74 0 32.76
104 INT301245 Binding of FUT1 and Runx1 1 0.00 0.66 0 30.80
105 INT283199 Binding of DMD and PTPRC 1 0.01 0.82 0 30.72
106 INT288349 TNF Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.1 0.18 30.48
107 INT288351 Mcpt1 Positive_regulation of Gene_expression of TNF 1 0.02 1.1 0.18 30.48
108 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 0.01 0.16 0.73 28.80
109 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32 28.64
110 INT270043 Binding of Ldlr and Hdl1 1 0.01 2.3 0.43 28.00
111 INT270206 Hdl1 Positive_regulation of Gene_expression of IL2 1 0.01 0.35 0.03 26.64
112 INT268279 Positive_regulation of Binding of Aggf1 and Alms1 1 0.02 0.15 0.18 22.48
113 INT268280 Binding of Aggf1 and Alms1 1 0.01 0.15 0.18 22.48
114 INT301784 Binding of Dmd and Sntb1 1 0.05 0.36 0.16 21.32
115 INT301783 Binding of Dtna and Sntb1 1 0.01 0.05 0.12 21.32
116 INT301788 Binding of Dmd and Dtna 1 0.09 0.05 0.12 21.32
117 INT301789 Binding of Sntb1 and Utrn 1 0.03 0.05 0.12 21.32
118 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08 18.04
119 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0 18.04
120 INT301238 Gene_expression of Mir29a Positive_regulation of Runx1 1 0.00 1.39 0 16.32
121 INT239184 Msr1 Negative_regulation of Msra 1 0.21 0.13 0 15.20
122 INT305271 Binding of Lep and Obsty1 1 0.06 4.86 0 13.84
123 INT337352 Binding of ARNT and HIF1A 1 0.14 0.61 0 11.68
124 INT265501 Binding of SGCB and SGCD 1 0.00 1.41 0 11.44
125 INT294309 PROK1 Regulation of Gene_expression of IL11 1 0.53 0.25 0.15 10.68
126 INT257937 Binding of CSF2 and INVS 1 0.04 1.1 0.14 8.12
127 INT311557 Binding of ROS1 and Ptpn2 1 0.02 2.32 0.46 6.16
128 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
129 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
130 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
131 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
132 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
133 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 5.00
134 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 5.00
135 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
136 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
137 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 5.00
138 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41 5.00
139 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 5.00
140 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
141 INT261410 Slc7a2 Positive_regulation of Ltp 1 0.06 0.08 1.21 5.00
142 INT280949 Binding of Fst and Inhbe 3 0.01 2.51 1.15 5.00
143 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11 5.00
144 INT235709 Binding of NA and SSR1 1 0.07 0.72 1.08 5.00
145 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 5.00
146 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03 5.00
147 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
148 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95 5.00
149 INT188803 Il1 Positive_regulation of Gene_expression of Crp 1 0.03 2.95 0.94 5.00
150 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88 5.00
151 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8 5.00
152 INT261413 Positive_regulation of GRIN1 Positive_regulation of Positive_regulation of Creb1 1 0.00 0.81 0.77 5.00
153 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75 5.00
154 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74 5.00
155 INT218933 Cyp3a23/3a1 Regulation of Alpi 1 0.00 1.07 0.73 5.00
156 INT170992 Binding of FN1 and MMRN1 3 0.01 2.13 0.73 5.00
157 INT260551 Igh-Dex Negative_regulation of Il6 1 0.09 0.37 0.72 5.00
158 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7 5.00
159 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7 5.00
160 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69 5.00
161 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67 5.00
162 INT242635 Binding of Bdnf and Ntrk3 3 0.25 0.98 0.64 5.00
163 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63 5.00
164 INT183387 Il6 Positive_regulation of Gene_expression of Il10 2 0.19 1.8 0.63 5.00
165 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 5.00
166 INT299792 Positive_regulation of Binding of CD80 and CTLA4 1 0.17 1.63 0.63 5.00
167 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61 5.00
168 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58 5.00
169 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58 5.00
170 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55 5.00
171 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55 5.00
172 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54 5.00
173 INT270044 Il10 Positive_regulation of Positive_regulation of Hmox1 1 0.20 1.59 0.53 5.00
174 INT271902 Binding of KCNK1 and Jun 1 0.12 0.08 0.53 5.00
175 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52 5.00
176 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 5.00
177 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49 5.00
178 INT172207 Binding of Drd4 and ADHD1 2 0.03 1.56 0.48 5.00
179 INT158400 Binding of CD80 and CD86 3 0.36 0.76 0.48 5.00
180 INT288350 IFNA1 Positive_regulation of Localization of Il6 1 0.01 1.49 0.46 5.00
181 INT218932 Cyp3a23/3a1 Regulation of Gene_expression of Alpi 1 0.00 0.53 0.46 5.00
182 INT317427 IFN1@ Positive_regulation of ISYNA1 1 0.12 0.49 0.45 5.00
183 INT323484 Ghsr Positive_regulation of Localization of Ins1 1 0.27 0.87 0.43 5.00
184 INT303857 DDR1 Positive_regulation of IL8 1 0.05 1.5 0.42 5.00
185 INT303858 DDR1 Positive_regulation of CXCR2 1 0.11 1.5 0.42 5.00
186 INT186373 Il6 Positive_regulation of Gene_expression of Il17a 2 0.14 1.52 0.42 5.00
187 INT186385 Binding of TNF and Tnfrsf1b 4 0.30 3.24 0.42 5.00
188 INT346130 Il17a Positive_regulation of Gene_expression of TNFSF11 1 0.08 0.61 0.41 5.00
189 INT299789 IL4 Negative_regulation of Gene_expression of RAE1 1 0.00 0.84 0.41 5.00
190 INT342181 Binding of Igfals and Ros1 1 0.01 0.76 0.41 5.00
191 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41 5.00
192 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41 5.00
193 INT319313 Socs4 Positive_regulation of Mapk14 1 0.02 0.68 0.41 5.00
194 INT323491 Olfr781 Positive_regulation of Localization of Ins1 1 0.01 0.87 0.4 5.00
195 INT299786 IL4 Negative_regulation of Gene_expression of CD5 1 0.07 0.82 0.4 5.00
196 INT189300 Atp6v1e1 Regulation of Gene_expression of Prl 1 0.03 0.29 0.39 5.00
197 INT350241 Binding of Pgp and Slc8a2 1 0.02 0.79 0.39 5.00
198 INT172125 Binding of Tnfrsf11b and Tnfrsf11a 2 0.17 2.12 0.39 5.00
199 INT354820 Creb1 Negative_regulation of Transcription of Cpox 1 0.03 0.59 0.38 5.00
200 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lifespan. They are ordered first by their pain relevance and then by number of times they were reported in Lifespan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 100.00
2 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 100.00
3 INT266170 Negative_regulation of Transcription of POLG 1 0.36 1.43 0 100.00
4 INT136681 Gene_expression of Shc1 13 0.77 9.67 2.52 100.00
5 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13 100.00
6 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1 100.00
7 INT101189 Transcription of Gtf3a 49 0.17 24.39 7.93 100.00
8 INT136678 Positive_regulation of Gene_expression of Shc1 4 0.50 2.93 1.42 100.00
9 INT136680 Negative_regulation of Gene_expression of Shc1 4 0.43 3.36 1.57 100.00
10 INT288080 Regulation of Gene_expression of Racgap1 3 0.04 3.42 0.41 100.00
11 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 100.00
12 INT95048 Negative_regulation of ADHD1 61 0.51 56.01 5.62 100.00
13 INT341925 Positive_regulation of Localization of SLC5A5 1 0.03 0.17 0 100.00
14 INT341926 Positive_regulation of Localization of MEA1 1 0.11 0.17 0 100.00
15 INT249746 Positive_regulation of Gene_expression of Sirt3 1 0.15 1.47 0 99.98
16 INT243876 Gene_expression of GPHN 8 0.75 2.63 1.49 99.96
17 INT246623 Regulation of Ccl22 1 0.01 2.65 0.06 99.96
18 INT266894 Positive_regulation of Positive_regulation of Sod2 5 0.41 3.26 0.67 99.96
19 INT266162 Transcription of POLG 2 0.68 0.76 0 99.92
20 INT326784 Localization of MEA1 2 0.39 0.32 0 99.92
21 INT246618 Regulation of Sirt2 2 0.12 1.66 0.09 99.90
22 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1 99.90
23 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 99.84
24 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 99.84
25 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 99.84
26 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65 99.84
27 INT213475 Negative_regulation of Positive_regulation of Lep 2 0.40 1.79 0.07 99.84
28 INT341927 Localization of SLC5A5 1 0.04 0.17 0 99.84
29 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 99.80
30 INT95877 Gene_expression of St13 24 0.49 11.18 3.95 99.80
31 INT272219 Negative_regulation of Rabgef1 1 0.09 0.6 0.04 99.76
32 INT156350 Positive_regulation of FOXO1 2 0.49 1.53 0.13 99.66
33 INT78297 Gene_expression of CD59 31 0.72 24.11 3.18 99.64
34 INT29777 Negative_regulation of CD59 16 0.42 14.88 1.56 99.64
35 INT134338 Gene_expression of CD55 23 0.65 13.01 1.38 99.64
36 INT134341 Negative_regulation of CD55 12 0.58 10.06 0.95 99.64
37 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 99.60
38 INT114739 Positive_regulation of Negative_regulation of Prkaca 2 0.41 2.03 0 99.60
39 INT41988 Positive_regulation of NFS1 2 0.02 1.28 0.4 99.60
40 INT920 Localization of PLOD1 223 0.81 42.25 78.7 99.60
41 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 99.60
42 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87 99.60
43 INT13501 Binding of Drd2 65 0.48 23.76 35.6 99.60
44 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19 99.60
45 INT296251 Gene_expression of Slc8a3 2 0.19 1.04 0.65 99.60
46 INT249747 Gene_expression of Sirt3 1 0.17 2.48 0 99.58
47 INT250515 Regulation of Gene_expression of Ucp2 3 0.39 1.88 0.22 99.56
48 INT10443 Regulation of Gene_expression of CNR1 10 0.50 3.96 3.06 99.52
49 INT243873 Regulation of Gene_expression of GPHN 2 0.60 0.62 0.36 99.52
50 INT39358 Regulation of PDXP 3 0.23 2.7 0.63 99.52
51 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 99.48
52 INT10442 Negative_regulation of CNR1 47 0.59 20.88 20.2 99.48
53 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38 99.46
54 INT318271 Gene_expression of SLC32A1 7 0.44 2.74 3.28 99.44
55 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53 99.44
56 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 99.44
57 INT105784 Binding of Nrg1 7 0.37 1.29 1.52 99.44
58 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 99.40
59 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 99.38
60 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 99.38
61 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 99.38
62 INT227265 Negative_regulation of Gene_expression of Ucp2 4 0.57 3.5 0.25 99.38
63 INT104290 Gene_expression of Ucp2 21 0.78 12.81 2.34 99.38
64 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 99.36
65 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 99.32
66 INT49454 Negative_regulation of Gene_expression of Gtf3a 13 0.08 9.99 2.43 99.32
67 INT106020 Transcription of EPO 8 0.71 9.34 0.6 99.32
68 INT273491 Negative_regulation of Transcription of EPO 1 0.58 4.29 0.2 99.32
69 INT21132 Gene_expression of GABRB3 36 0.33 11.32 17.61 99.28
70 INT105974 Positive_regulation of PRKAB1 43 0.67 23.47 4.16 99.28
71 INT157121 Gene_expression of GAD2 15 0.67 7.21 5.91 99.28
72 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59 99.28
73 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3 99.28
74 INT318279 Negative_regulation of SLC32A1 1 0.31 0.15 0.38 99.28
75 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 99.24
76 INT200191 Gene_expression of Xpa 1 0.64 10.1 0 99.24
77 INT200196 Negative_regulation of Gene_expression of Xpa 1 0.41 1.64 0 99.24
78 INT143208 Negative_regulation of TPI1 30 0.59 7.54 1.08 99.22
79 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 99.14
80 INT106286 Gene_expression of UCP2 15 0.77 7.24 2.78 99.12
81 INT207842 Gene_expression of KL 3 0.34 2.88 0 99.12
82 INT207843 Positive_regulation of Gene_expression of KL 2 0.26 1.1 0 99.12
83 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 99.08
84 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 99.08
85 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07 99.08
86 INT250519 Negative_regulation of Igf1r 5 0.42 2.7 0.09 99.04
87 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 99.00
88 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67 99.00
89 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 99.00
90 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 98.96
91 INT216459 Positive_regulation of Hao2 1 0.53 0.99 0 98.96
92 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 98.92
93 INT79723 Positive_regulation of Sod2 34 0.70 24.61 3.92 98.88
94 INT77148 Gene_expression of Kcna1 20 0.73 4.08 4.46 98.82
95 INT86486 Negative_regulation of Gene_expression of Kcna1 4 0.55 1.74 1.21 98.82
96 INT28861 Binding of Gh 61 0.46 25.61 6.38 98.80
97 INT322218 Binding of SCGB1D4 2 0.05 1.88 0 98.80
98 INT212458 Binding of Mtor 8 0.04 6.77 0.03 98.80
99 INT1530 Regulation of Gh 382 0.61 115.96 112.47 98.76
100 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 98.76
101 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 98.72
102 INT28210 Negative_regulation of Localization of Tbxa2r 6 0.49 2.09 1.58 98.68
103 INT61429 Gene_expression of Adcy5 6 0.60 1.49 1.27 98.60
104 INT196762 Negative_regulation of Adcy5 5 0.39 1.49 0.8 98.60
105 INT155988 Regulation of Localization of ABAT 5 0.24 2.19 6.59 98.56
106 INT19488 Localization of ABAT 56 0.69 21.51 50.56 98.56
107 INT309502 Positive_regulation of Xrcc6 1 0.38 1.58 0 98.56
108 INT67350 Binding of Ghr 9 0.43 1.83 0.28 98.52
109 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 98.50
110 INT199768 Gene_expression of Fmo3 3 0.50 3.11 0.17 98.48
111 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 98.48
112 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 98.48
113 INT123551 Regulation of Mmp2 17 0.57 11.6 6 98.38
114 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 98.38
115 INT252 Localization of GH1 529 0.80 227.4 122.05 98.38
116 INT200201 Binding of Xpa 1 0.36 2.34 0 98.36
117 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.32
118 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 98.32
119 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13 98.32
120 INT103020 Gene_expression of SGCA 22 0.56 14.29 2.75 98.28
121 INT34777 Localization of IGF1 82 0.80 42.68 8.62 98.24
122 INT1793 Localization of CGA 379 0.81 67.38 114.69 98.24
123 INT131152 Gene_expression of Cr1l 17 0.75 10.83 4.88 98.20
124 INT131153 Negative_regulation of Gene_expression of Cr1l 2 0.41 0.83 0.52 98.20
125 INT118711 Positive_regulation of Binding of Om 1 0.05 1.12 0.13 98.16
126 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 98.04
127 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 98.04
128 INT121481 Localization of St13 4 0.54 1.7 1.3 98.04
129 INT244937 Positive_regulation of Localization of St13 1 0.18 0.29 0 98.04
130 INT129106 Negative_regulation of Mstn 102 0.57 30.57 0.49 98.00
131 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 97.96
132 INT168046 Positive_regulation of Gene_expression of PRKAB1 5 0.38 4.31 0.08 97.96
133 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96 97.92
134 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57 97.88
135 INT118710 Negative_regulation of Binding of Om 1 0.05 1.12 0.13 97.88
136 INT83623 Gene_expression of Cd59 7 0.76 7.35 4.7 97.84
137 INT238252 Negative_regulation of Gene_expression of Cd59 1 0.24 0.26 0.13 97.84
138 INT168043 Gene_expression of PRKAB1 14 0.62 7.01 0.23 97.76
139 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 97.76
140 INT73935 Gene_expression of Slc8a2 2 0.65 5.24 5.99 97.72
141 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 97.64
142 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 97.64
143 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 97.60
144 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 97.60
145 INT73067 Binding of Om 8 0.08 2.35 2.56 97.56
146 INT249748 Localization of Sirt3 1 0.16 0.6 0 97.52
147 INT42707 Gene_expression of Tbce 24 0.65 12.92 7.93 97.52
148 INT318272 Negative_regulation of GPHN 1 0.29 0.1 0.37 97.52
149 INT84700 Positive_regulation of HSP90B2P 34 0.67 30.22 4.07 97.50
150 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83 97.44
151 INT142344 Transcription of Igf1 22 0.69 7.55 6.77 97.34
152 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 97.32
153 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 97.28
154 INT138639 Gene_expression of Hcn4 32 0.75 13.85 11.25 97.28
155 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 97.26
156 INT126505 Positive_regulation of Ntf3 26 0.70 9.17 4.92 97.26
157 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87 97.24
158 INT239161 Positive_regulation of Negative_regulation of Pik3r1 1 0.30 0.77 0 97.24
159 INT239157 Positive_regulation of Negative_regulation of Mtor 2 0.11 0.89 0 97.24
160 INT46470 Positive_regulation of Regulation of Ins1 8 0.46 4.51 1.01 97.14
161 INT79034 Negative_regulation of GPI 7 0.58 3.94 0.66 97.12
162 INT207836 Negative_regulation of GAD2 2 0.37 0.19 0.45 97.12
163 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 97.08
164 INT1114 Localization of Ins1 748 0.80 192.95 165.48 97.04
165 INT214005 Gene_expression of Ank2 1 0.78 29.4 1.88 97.04
166 INT6481 Binding of TNF 624 0.48 510.2 214.82 96.96
167 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 96.90
168 INT181818 Gene_expression of Ppargc1a 50 0.78 24.33 2.71 96.88
169 INT181823 Positive_regulation of Gene_expression of Ppargc1a 20 0.67 6.45 1.33 96.88
170 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 96.88
171 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 96.84
172 INT123253 Localization of Chrna4 4 0.44 1.31 1.99 96.76
173 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 96.72
174 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 96.64
175 INT301724 Gene_expression of Pomt2 1 0.24 0.4 0 96.60
176 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41 96.56
177 INT250510 Gene_expression of Arsi 1 0.12 0.8 0 96.40
178 INT198512 Binding of HK1 2 0.28 0.66 0 96.40
179 INT83622 Positive_regulation of Gene_expression of Cd59 4 0.49 3.77 2.35 96.40
180 INT310892 Positive_regulation of Gene_expression of 53T 1 0.32 6.77 0.89 96.40
181 INT235510 Binding of Il17a 14 0.34 10.67 3.99 96.32
182 INT181650 Gene_expression of Glud1 23 0.77 13.66 5.05 96.28
183 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 96.20
184 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 96.20
185 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 96.20
186 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 96.20
187 INT319263 Localization of Ube3a 2 0.73 1.09 0.04 96.20
188 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 96.12
189 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 96.12
190 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 96.12
191 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 96.08
192 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 96.08
193 INT1893 Localization of Gh 1041 0.79 340.23 256.58 96.04
194 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 96.04
195 INT108690 Gene_expression of Hcn1 19 0.76 7.2 8 96.04
196 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 96.00
197 INT203311 Positive_regulation of Gene_expression of Igfals 5 0.16 6.87 0.8 96.00
198 INT200132 Regulation of Ercc2 2 0.36 4.56 0.05 96.00
199 INT200135 Regulation of Ercc3 2 0.34 3.47 0.05 96.00
200 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 95.96
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