D:Limbic Encephalitis

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pChart

Disease Term
Synonyms Encephalitides Paraneoplastic Limbic, Encephalitis Limbic, ENCEPHALITIS PARANEOPLASTIC LIMBIC, Limbic Encephalitis Paraneoplastic, Paraneoplastic Limbic Encephalitis
Documents 32
Hot Single Events 34
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Limbic Encephalitis. They are ordered first by their relevance to Limbic Encephalitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT244116 ELAVL3 Negative_regulation of MUC1 1 0.09 3.41 0.15 100.00
2 INT329116 Binding of LGI1 and CNTNAP2 1 0.38 1.3 0.44 91.60
3 INT329121 Binding of LGI1 and ADAM22 1 0.14 0.5 0.06 79.08
4 INT329119 Binding of CNTN2 and CNTNAP2 1 0.08 2.41 0.73 75.00
5 INT329120 Binding of KCNA1 and CNTNAP2 1 0.09 1.23 0.75 70.84
6 INT329122 Binding of KCNA1 and LGI1 1 0.08 0.29 0.43 50.00
7 INT329118 Binding of KCNA1 and CNTN2 1 0.02 0 0.14 50.00
8 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
9 INT259184 Binding of Gria2 and Gria1 2 0.26 0.28 0.54 5.00
10 INT346745 Binding of Cacng2 and Grip2 1 0.01 0 0.25 5.00
11 INT346765 Binding of RBM10 and Grip2 1 0.00 0 0.25 5.00
12 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21 5.00
13 INT346748 Binding of Shisa9 and Grip2 1 0.00 0 0.17 5.00
14 INT346766 Negative_regulation of Binding of RBM10 and Grip2 1 0.00 0 0.17 5.00
15 INT265256 Binding of Gria2 and Cdh2 2 0.02 0.17 0.07 5.00
16 INT346752 Binding of Dlg1 and Gria1 1 0.02 0 0.06 5.00
17 INT346754 Binding of Dlg4 and Gria2 1 0.02 0 0.06 5.00
18 INT313273 Binding of GRIN1 and MAP2 1 0.16 0.79 0.04 5.00
19 INT346742 Binding of Cacng2 and Dlg4 1 0.03 0 0 5.00
20 INT346753 Binding of Grip2 and Nptx1 1 0.00 0.1 0 5.00
21 INT313271 Binding of GRIN1 and GRIN2B 1 0.24 0.06 0 5.00
22 INT346756 Binding of Cdh2 and Grip2 1 0.00 0.1 0 5.00
23 INT346746 Binding of Cacng2 and Gria2 1 0.21 0.18 0 5.00
24 INT346755 Atf6 Positive_regulation of Hsp90b1 1 0.00 0 0 5.00
25 INT313272 Binding of DLG4 and GRIN1 1 0.09 0.06 0 5.00
26 INT346747 Binding of Dlg4 and Shisa9 1 0.01 0 0 5.00
27 INT346743 Atf6 Positive_regulation of Hspa5 1 0.00 0 0 5.00
28 INT346744 Binding of Dlg4 and Tinagl1 1 0.03 0 0 5.00
29 INT346764 Binding of RBM10 and Gria2 1 0.01 0.18 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Limbic Encephalitis. They are ordered first by their pain relevance and then by number of times they were reported in Limbic Encephalitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT244117 Binding of ELAVL3 1 0.15 5.2 0.42 100.00
2 INT244118 Negative_regulation of ELAVL3 1 0.17 3.77 0.19 100.00
3 INT244121 Negative_regulation of Transcription of ELAVL3 1 0.17 2.05 0.32 100.00
4 INT244119 Transcription of ELAVL3 1 0.28 1.94 0.32 100.00
5 INT144266 Gene_expression of ELAVL3 4 0.65 1.98 0.12 100.00
6 INT329149 Localization of LGI1 1 0.73 4.95 1.79 99.64
7 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 99.56
8 INT43707 Positive_regulation of CCBE1 11 0.07 8.22 4.86 99.56
9 INT156320 Regulation of LGI1 2 0.38 1.18 0.45 99.24
10 INT34790 Localization of KCNA1 4 0.43 11.34 3.99 99.18
11 INT9473 Binding of MUC1 66 0.48 46.77 2.36 99.04
12 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 99.00
13 INT207867 Gene_expression of H2-Ob 1 0.01 5.46 0.18 98.40
14 INT132613 Gene_expression of LGI1 2 0.71 5.9 4.15 98.34
15 INT329148 Gene_expression of CNTNAP2 17 0.76 6 2.95 98.18
16 INT132335 Gene_expression of KCNA1 36 0.77 18.31 13.36 97.24
17 INT329151 Positive_regulation of Gene_expression of KCNA1 1 0.11 1.18 0.24 97.24
18 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 96.24
19 INT190833 Regulation of KCNA1 8 0.53 6.61 4.66 95.00
20 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 94.64
21 INT329150 Regulation of Gene_expression of LGI1 1 0.41 0.87 0.11 94.08
22 INT329160 Regulation of Gene_expression of CNTNAP2 1 0.44 0.87 0.11 94.08
23 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 93.52
24 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 92.32
25 INT143551 Binding of KCNA1 13 0.46 8.81 2.81 92.12
26 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 91.96
27 INT329144 Binding of LGI1 1 0.38 5.79 1.59 91.60
28 INT329143 Binding of CNTNAP2 1 0.47 5.04 1.32 91.60
29 INT329140 Localization of CNTNAP2 1 0.73 3.56 1.31 87.52
30 INT132334 Negative_regulation of Gene_expression of KCNA1 4 0.43 1.52 1.14 86.52
31 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 83.96
32 INT329161 Negative_regulation of CNTNAP2 1 0.42 0.73 0.51 82.80
33 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 82.04
34 INT25464 Binding of SAA1 11 0.42 6.89 3.72 81.28
35 INT329159 Positive_regulation of LGI1 1 0.46 1.07 0.29 79.16
36 INT329152 Positive_regulation of CNTNAP2 1 0.49 0.54 0.15 79.16
37 INT329154 Binding of ADAM22 1 0.11 0.96 0.12 78.88
38 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 77.08
39 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 75.00
40 INT69395 Gene_expression of CNTN2 28 0.68 13.29 4.37 75.00
41 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 71.20
42 INT178591 Binding of CNTN2 4 0.23 1.56 0.44 69.08
43 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21 67.40
44 INT94127 Positive_regulation of Il18 14 0.69 14 7.47 64.84
45 INT244120 Negative_regulation of FCGR1B 1 0.03 1.27 0 62.88
46 INT72294 Binding of CA3 3 0.32 0.54 0.55 61.96
47 INT105021 Binding of GOPC 187 0.40 60.39 20.38 50.00
48 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 50.00
49 INT50535 Gene_expression of CA3 25 0.51 9.25 2.89 50.00
50 INT132612 Negative_regulation of LGI1 2 0.39 0.79 1.07 50.00
51 INT132333 Negative_regulation of KCNA1 8 0.47 0.87 0.71 50.00
52 INT178590 Regulation of CNTN2 7 0.24 2.91 0.68 50.00
53 INT329156 Regulation of CNTNAP2 1 0.19 2.35 0.48 50.00
54 INT329158 Positive_regulation of Gene_expression of CNTNAP2 1 0.49 1.3 0.26 50.00
55 INT329147 Positive_regulation of Gene_expression of LGI1 1 0.42 0 0 50.00
56 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 38.52
57 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 25.00
58 INT28647 Binding of CTD 13 0.31 14.2 1.5 17.52
59 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
60 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
61 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
62 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
63 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37 5.00
64 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
65 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
66 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
67 INT49110 Regulation of Grip2 46 0.61 13.57 30.87 5.00
68 INT7664 Negative_regulation of Grip2 68 0.49 10.11 29.93 5.00
69 INT56525 Gene_expression of Gria2 74 0.75 23.15 28.6 5.00
70 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
71 INT56524 Gene_expression of Grip2 67 0.74 14.77 26.23 5.00
72 INT48832 Positive_regulation of Grip2 48 0.69 12.13 25.99 5.00
73 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
74 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 5.00
75 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
76 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
77 INT48690 Localization of Grip2 33 0.61 6.13 16.81 5.00
78 INT49263 Binding of Grip2 31 0.41 9.86 16.38 5.00
79 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
80 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 5.00
81 INT114510 Positive_regulation of Gria2 36 0.57 14.91 14.85 5.00
82 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
83 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
84 INT49538 Binding of Gria1 22 0.47 2.66 13.35 5.00
85 INT2038 Localization of Esr1 104 0.79 40.12 13.27 5.00
86 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 5.00
87 INT57069 Regulation of Gria2 28 0.44 10.11 11.06 5.00
88 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 5.00
89 INT6065 Localization of GRIN1 15 0.74 3.15 9.81 5.00
90 INT78766 Negative_regulation of Gria2 20 0.52 6.27 8.12 5.00
91 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 5.00
92 INT75932 Binding of Csf2 45 0.37 33.2 8.01 5.00
93 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19 5.00
94 INT25 Positive_regulation of LAMC2 19 0.67 8.64 7.06 5.00
95 INT88786 Binding of Dlg4 11 0.46 2.73 6.58 5.00
96 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 5.00
97 INT57068 Regulation of Gene_expression of Gria2 12 0.36 3.76 5.44 5.00
98 INT85946 Localization of Gria2 10 0.61 1.23 5.09 5.00
99 INT26042 Binding of Gria2 20 0.40 4.88 5.04 5.00
100 INT5561 Negative_regulation of GRIN2D 10 0.50 2.46 4.88 5.00
101 INT114511 Positive_regulation of Gene_expression of Gria2 14 0.41 3.9 4.71 5.00
102 INT70356 Gene_expression of GRIN2D 10 0.74 2.11 4.7 5.00
103 INT19449 Binding of FANCB 22 0.47 7.4 4.27 5.00
104 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 5.00
105 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 5.00
106 INT65049 Positive_regulation of Gene_expression of Grip2 7 0.60 1.72 2.71 5.00
107 INT66002 Binding of LAMC2 9 0.47 4.5 2.54 5.00
108 INT82587 Positive_regulation of Gene_expression of GRIN1 8 0.67 3.66 2.18 5.00
109 INT117197 Gene_expression of Zmat3 19 0.05 8.3 2.05 5.00
110 INT173512 Positive_regulation of Gene_expression of Alms1 12 0.44 8.66 1.95 5.00
111 INT97062 Binding of PML 10 0.41 11.63 1.65 5.00
112 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58 5.00
113 INT56526 Gene_expression of Gria4 4 0.75 0.15 1.54 5.00
114 INT147873 Negative_regulation of Gene_expression of GRIN1 8 0.58 2.3 1.46 5.00
115 INT11984 Gene_expression of IGHA1 9 0.54 6.12 1.35 5.00
116 INT128752 Negative_regulation of Localization of Esr1 11 0.43 4.8 1.23 5.00
117 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21 5.00
118 INT67156 Binding of ITGA4 6 0.14 2.63 1.03 5.00
119 INT235929 Regulation of Positive_regulation of Alms1 2 0.02 2.84 1.02 5.00
120 INT114524 Binding of GRIN2B 3 0.36 0.44 0.74 5.00
121 INT239494 Regulation of Localization of Esr1 4 0.19 1.15 0.72 5.00
122 INT272575 Binding of Cacng2 3 0.36 0.54 0.58 5.00
123 INT243864 Gene_expression of DLG4 5 0.34 0.22 0.54 5.00
124 INT120665 Binding of TACC2 4 0.07 4.33 0.46 5.00
125 INT154748 Positive_regulation of Gene_expression of Hspa5 11 0.44 7.66 0.44 5.00
126 INT144582 Gene_expression of Shisa9 3 0.22 0.22 0.36 5.00
127 INT192845 Negative_regulation of Positive_regulation of Esr1 2 0.35 1.15 0.31 5.00
128 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28 5.00
129 INT243208 Negative_regulation of Protein_catabolism of Alms1 2 0.06 2.21 0.26 5.00
130 INT172021 Localization of Hspa5 2 0.18 0.93 0.2 5.00
131 INT170513 Gene_expression of Cacng2 3 0.65 0.06 0.18 5.00
132 INT346726 Binding of Shisa9 1 0.14 0 0.17 5.00
133 INT244270 Localization of GOLPH3 2 0.68 0.29 0.17 5.00
134 INT346761 Regulation of Localization of Grip2 1 0.01 0 0.1 5.00
135 INT207866 Binding of H2-Ob 1 0.01 1.04 0.09 5.00
136 INT251367 Binding of Cdh2 3 0.38 0.19 0.09 5.00
137 INT156437 Binding of DLG4 2 0.35 0.29 0.07 5.00
138 INT346730 Positive_regulation of Cacng2 1 0.49 0 0.06 5.00
139 INT346741 Positive_regulation of RBM10 1 0.01 0 0.06 5.00
140 INT256975 Binding of Dlg1 7 0.36 0 0.06 5.00
141 INT346740 Binding of RBM10 1 0.02 0 0.06 5.00
142 INT265497 Positive_regulation of TTN 2 0.04 0 0.03 5.00
143 INT346727 Regulation of Cacng2 1 0.26 0 0.03 5.00
144 INT346738 Regulation of RBM10 1 0.01 0 0.03 5.00
145 INT346729 Localization of Tinagl1 1 0.73 0 0 5.00
146 INT346732 Gene_expression of Tinagl1 1 0.65 0 0 5.00
147 INT346763 Positive_regulation of Gosr1 1 0.00 0 0 5.00
148 INT346731 Localization of Shisa9 1 0.21 0 0 5.00
149 INT346728 Localization of Cacng2 1 0.73 0 0 5.00
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