D:Limited Scleroderma

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Disease Term
Synonyms None
Documents 10
Hot Single Events 5
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Limited Scleroderma. They are ordered first by their relevance to Limited Scleroderma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
2 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
3 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
4 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
5 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
6 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 5.00
7 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
8 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 5.00
9 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 5.00
10 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 5.00
11 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35 5.00
12 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34 5.00
13 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33 5.00
14 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33 5.00
15 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33 5.00
16 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33 5.00
17 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31 5.00
18 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Limited Scleroderma. They are ordered first by their pain relevance and then by number of times they were reported in Limited Scleroderma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 87.28
2 INT285484 Negative_regulation of Col10a1 2 0.14 1.32 0.13 87.28
3 INT285491 Negative_regulation of Col12a1 1 0.15 1.08 0.1 87.28
4 INT285502 Negative_regulation of Col8a1 1 0.14 1.08 0.1 87.28
5 INT285505 Negative_regulation of Col5a2 1 0.14 1.08 0.1 87.28
6 INT181414 Gene_expression of Ccl19 12 0.74 9.8 4.11 74.64
7 INT285485 Negative_regulation of Gene_expression of Ccl19 1 0.07 1.15 0.1 74.64
8 INT285481 Positive_regulation of Gene_expression of Ccl19 1 0.08 1.15 0.1 74.64
9 INT75158 Gene_expression of Fgf5 5 0.28 2.12 3.58 74.60
10 INT141565 Gene_expression of Cdt1 7 0.19 2.61 0.39 74.60
11 INT285497 Gene_expression of Traip 1 0.08 1.03 0.11 74.60
12 INT285504 Gene_expression of Cdc7 2 0.44 1.31 0.1 74.60
13 INT51803 Negative_regulation of Pde7a 14 0.59 14.98 4.85 74.24
14 INT181032 Gene_expression of Fgf7 8 0.61 5.96 1.41 73.68
15 INT285494 Positive_regulation of Gene_expression of Fgf7 2 0.40 1.48 0.13 73.68
16 INT285509 Negative_regulation of Gene_expression of Fgf7 1 0.14 1.14 0.1 73.68
17 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93 72.64
18 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51 72.64
19 INT92681 Positive_regulation of Ctgf 13 0.69 9.78 3.47 72.64
20 INT113604 Negative_regulation of Gene_expression of Ctgf 19 0.58 9.37 3.43 72.64
21 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84 71.36
22 INT73590 Positive_regulation of Positive_regulation of Casp1 2 0.19 1.94 1.28 71.36
23 INT353117 Negative_regulation of Positive_regulation of Casp1 1 0.06 1.25 0 71.36
24 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57 70.00
25 INT150948 Positive_regulation of Gene_expression of Fgfr1 3 0.15 3.19 0.32 70.00
26 INT285474 Negative_regulation of Gene_expression of Fgfr1 2 0.40 2.15 0.24 70.00
27 INT93144 Gene_expression of CCR1 18 0.75 14.69 6.84 69.44
28 INT171023 Negative_regulation of Gene_expression of CCR1 2 0.37 1.53 0.36 69.44
29 INT285555 Positive_regulation of Gene_expression of CCR1 1 0.16 1.11 0.1 69.44
30 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 64.32
31 INT136388 Gene_expression of Cxcl5 13 0.75 21.45 2.98 64.32
32 INT285501 Gene_expression of Smad1 6 0.42 3.09 0.41 64.32
33 INT204720 Gene_expression of CD53 3 0.09 1.38 0.1 63.76
34 INT266354 Gene_expression of S100A7 9 0.58 7.35 0.75 62.96
35 INT182474 Gene_expression of Cdh5 17 0.57 14.58 1.23 62.32
36 INT85964 Gene_expression of Pecam1 109 0.78 69.73 15.21 61.28
37 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 60.80
38 INT285473 Gene_expression of Nid2 1 0.24 2.3 0.19 60.24
39 INT285507 Gene_expression of Col5a2 1 0.18 1.12 0.09 57.04
40 INT178483 Gene_expression of Col18a1 12 0.75 11.87 1.03 25.72
41 INT157772 Gene_expression of ASF1B 3 0.07 2.78 0.49 22.40
42 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 19.64
43 INT232067 Gene_expression of RNPC3 6 0.65 0.95 0.2 19.04
44 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 18.80
45 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 18.60
46 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 18.24
47 INT46485 Positive_regulation of Pdgfc 3 0.18 2.74 0.92 14.96
48 INT285472 Positive_regulation of Fgfrl1 2 0.28 1.39 0.3 14.96
49 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 14.12
50 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 10.48
51 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
52 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
53 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
54 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
55 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
56 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
57 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
58 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
59 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
60 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
61 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
62 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
63 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
64 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
65 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
66 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
67 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
68 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
69 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
70 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
71 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
72 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
73 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 5.00
74 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
75 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
76 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
77 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
78 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
79 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
80 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 5.00
81 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
82 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
83 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
84 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
85 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
86 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
87 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
88 INT166203 Positive_regulation of Cia1 62 0.43 75.94 31.37 5.00
89 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82 5.00
90 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
91 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
92 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 5.00
93 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
94 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 5.00
95 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
96 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
97 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
98 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
99 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
100 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
101 INT57257 Gene_expression of IL7 69 0.62 50.24 20.36 5.00
102 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
103 INT104395 Gene_expression of Cxcl9 83 0.76 73.1 19.79 5.00
104 INT182031 Gene_expression of Cia1 38 0.24 46.37 19.64 5.00
105 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
106 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
107 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
108 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
109 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
110 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 5.00
111 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 5.00
112 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 5.00
113 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
114 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
115 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
116 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
117 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
118 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
119 INT176453 Negative_regulation of Cia1 23 0.14 28.27 12.33 5.00
120 INT87239 Localization of Il12a 51 0.75 31.95 12.05 5.00
121 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68 5.00
122 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 5.00
123 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
124 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
125 INT140224 Localization of Ccl2 32 0.72 26.91 9.39 5.00
126 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 5.00
127 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 5.00
128 INT18025 Binding of Pah 32 0.45 30.72 7.93 5.00
129 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 5.00
130 INT131359 Positive_regulation of Gene_expression of Cd4 40 0.58 22.43 7.53 5.00
131 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47 5.00
132 INT151823 Binding of Tnfrsf1b 19 0.42 17.92 7.31 5.00
133 INT53491 Negative_regulation of Jun 28 0.57 14.2 6.9 5.00
134 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 5.00
135 INT186623 Negative_regulation of Mag 13 0.42 12.22 6.48 5.00
136 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 5.00
137 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 5.00
138 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29 5.00
139 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 5.00
140 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11 5.00
141 INT115947 Regulation of Il17a 17 0.37 14.26 5.97 5.00
142 INT53196 Binding of Cd4 44 0.47 27.28 5.85 5.00
143 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 5.00
144 INT237051 Gene_expression of Cxcl11 24 0.64 25.74 5.77 5.00
145 INT170056 Binding of Cxcl10 11 0.45 12.72 5.32 5.00
146 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17 5.00
147 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 5.00
148 INT124976 Positive_regulation of Tnfrsf1b 15 0.67 14.92 5.15 5.00
149 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07 5.00
150 INT161220 Binding of Ccl2 17 0.46 17.63 4.94 5.00
151 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83 5.00
152 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 5.00
153 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 5.00
154 INT91333 Gene_expression of CXCL11 11 0.65 10.96 4.1 5.00
155 INT99778 Localization of Cxcl10 12 0.75 14.24 3.91 5.00
156 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
157 INT285489 Positive_regulation of Gene_expression of Il22 9 0.32 10.97 3.63 5.00
158 INT135408 Transcription of Il17a 8 0.64 10.7 3.39 5.00
159 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 5.00
160 INT97599 Gene_expression of Il20 4 0.23 5.11 2.98 5.00
161 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98 5.00
162 INT126966 Positive_regulation of IL1R1 8 0.67 6.93 2.84 5.00
163 INT241437 Negative_regulation of OMG 3 0.42 3.21 2.48 5.00
164 INT174481 Positive_regulation of Gene_expression of IL7 9 0.56 6.19 2.46 5.00
165 INT170053 Binding of Cxcl9 5 0.46 6.34 2.43 5.00
166 INT177455 Binding of Cia1 4 0.11 6.76 2.24 5.00
167 INT163912 Binding of Il11ra1 5 0.33 5.06 2.22 5.00
168 INT153406 Gene_expression of Cxcl16 18 0.72 6.16 2.16 5.00
169 INT201652 Positive_regulation of Tnfsf10 26 0.68 26.79 2.14 5.00
170 INT57258 Regulation of Gene_expression of IL7 9 0.36 4.28 2.12 5.00
171 INT258780 Regulation of Il23a 6 0.13 4.77 1.96 5.00
172 INT181720 Regulation of IL15 9 0.20 3.65 1.79 5.00
173 INT132939 Positive_regulation of Taok2 3 0.07 1.15 1.63 5.00
174 INT285510 Regulation of Localization of Hand1 6 0.14 6.13 1.61 5.00
175 INT181963 Regulation of IL7 7 0.49 3.56 1.61 5.00
176 INT219781 Gene_expression of IL17F 6 0.65 3.32 1.59 5.00
177 INT231917 Gene_expression of Cebpb 10 0.25 4.45 1.56 5.00
178 INT240527 Gene_expression of Il27 4 0.26 5.05 1.56 5.00
179 INT135024 Regulation of Cd14 6 0.57 4.9 1.52 5.00
180 INT220585 Gene_expression of Il1r2 17 0.72 17.42 1.51 5.00
181 INT285482 Negative_regulation of Il22 3 0.30 3.02 1.37 5.00
182 INT237772 Localization of Il23a 5 0.42 4.16 1.34 5.00
183 INT181961 Gene_expression of IL7R 10 0.75 3.9 1.29 5.00
184 INT285470 Regulation of Il22 4 0.11 4.18 1.21 5.00
185 INT187835 Gene_expression of Tradd 5 0.53 3.3 1.2 5.00
186 INT178262 Transcription of Stat1 4 0.59 4.73 1.12 5.00
187 INT89967 Negative_regulation of Gene_expression of Fas 19 0.58 19.28 1.1 5.00
188 INT260802 Transcription of Tnfsf10 5 0.67 6.75 1.1 5.00
189 INT90546 Gene_expression of Siglec1 7 0.24 4.98 1.09 5.00
190 INT87192 Positive_regulation of Gene_expression of Tnfrsf1b 7 0.35 3.66 1.04 5.00
191 INT285490 Localization of Cxcl11 2 0.43 5.29 1.03 5.00
192 INT91334 Localization of CXCL11 3 0.73 1.97 1 5.00
193 INT231793 Negative_regulation of Il27ra 4 0.08 3.04 0.98 5.00
194 INT114379 Negative_regulation of Gene_expression of CFLAR 7 0.57 7.31 0.97 5.00
195 INT62031 Gene_expression of Cd19 27 0.65 10.39 0.93 5.00
196 INT140080 Positive_regulation of S100P 6 0.66 3.15 0.91 5.00
197 INT116197 Positive_regulation of Gene_expression of CFLAR 6 0.67 7.11 0.9 5.00
198 INT161682 Positive_regulation of Cdc42 8 0.53 4.55 0.9 5.00
199 INT204825 Negative_regulation of Plp1 3 0.33 2.96 0.87 5.00
200 INT97597 Positive_regulation of Gene_expression of Il20 2 0.21 1.4 0.86 5.00
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