D:Lipidosis

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Disease Term
Synonyms Acid Cholesteryl Ester Hydrolase Deficiency, Amaurotic Familial Idiocies, AMAUROTIC FAMILIAL IDIOCY, Arsa Dificiency, Arylsulfatase A Dificiency Syndrome, B Sitosterolaemia, B SITOSTEROLEMIA, Cerebral Sclerosis Diffuse Metachromatic Form Cerebroside Sulphatase Dificiency Disease, Cerebrotendinous Xanthomatosis, Cholesteryl Ester Disease, Fabry S Disease
Documents 64
Hot Single Events 58
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lipidosis. They are ordered first by their relevance to Lipidosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT347806 Binding of MOCS1 and SMAP2 1 0.00 0.48 0.12 62.24
2 INT185468 Fabp6 Regulation of Abcg5 1 0.00 0.44 0 50.00
3 INT240941 Binding of Akt1 and Ins1 1 0.06 0.75 0.11 46.56
4 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 15.36
5 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 15.36
6 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
7 INT183387 Il6 Positive_regulation of Gene_expression of Il10 2 0.19 1.8 0.63 5.00
8 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37 5.00
9 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35 5.00
10 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34 5.00
11 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34 5.00
12 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34 5.00
13 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34 5.00
14 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34 5.00
15 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34 5.00
16 INT342457 CSF1 Negative_regulation of Gene_expression of CCR4 1 0.00 0.93 0.31 5.00
17 INT237641 Binding of Cntnap1 and Nfasc 2 0.36 0.1 0.29 5.00
18 INT342458 CSF1 Positive_regulation of Gene_expression of CCL2 1 0.17 0.84 0.27 5.00
19 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25 5.00
20 INT347807 GLA Positive_regulation of Positive_regulation of A4GALT 1 0.05 1.57 0.13 5.00
21 INT254488 Dtx1 Regulation of Sorbs1 1 0.01 0 0.12 5.00
22 INT254490 Dtx1 Regulation of Gopc 1 0.04 0 0.12 5.00
23 INT342459 CXCR3 Positive_regulation of CRTC1 1 0.00 0.59 0.11 5.00
24 INT254492 Dtx1 Regulation of Cldn11 1 0.03 0 0.09 5.00
25 INT254491 Positive_regulation of Binding of Cntnap1 and Nfasc 1 0.02 0.1 0.08 5.00
26 INT240946 G6pc Positive_regulation of Regulation of Hgd 1 0.22 0.21 0.03 5.00
27 INT240943 G6pc Regulation of Regulation of Hgd 1 0.12 0.21 0.03 5.00
28 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
29 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00
30 INT240942 Ins1 Regulation of Transcription of Pck1 1 0.08 0.73 0 5.00
31 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 5.00
32 INT240944 Akt1 Positive_regulation of Phosphorylation of Foxo1 1 0.22 0.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lipidosis. They are ordered first by their pain relevance and then by number of times they were reported in Lipidosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT62843 Negative_regulation of Binding of HEXA 1 0.41 0.82 0.09 99.92
2 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 99.90
3 INT55529 Negative_regulation of Gba 13 0.59 7.91 2.1 99.78
4 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 99.34
5 INT62844 Binding of HEXA 2 0.36 1.45 0.23 99.20
6 INT183370 Negative_regulation of Galc 1 0.42 6.11 2.59 98.90
7 INT121013 Positive_regulation of CYB5A 1 0.00 0.67 0.19 98.12
8 INT121015 Positive_regulation of Positive_regulation of CYB5A 1 0.00 0.67 0.19 98.12
9 INT273143 Negative_regulation of Tat 1 0.01 2.3 0 97.52
10 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 97.52
11 INT79941 Negative_regulation of Npc1 9 0.59 3.97 0.82 96.80
12 INT137221 Gene_expression of Sh2d1b2 6 0.47 1.99 0.6 95.12
13 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 95.04
14 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 94.80
15 INT121010 Negative_regulation of Gene_expression of Por 1 0.58 2.84 0.19 94.80
16 INT121012 Gene_expression of Por 14 0.77 3.71 0.72 94.28
17 INT121009 Positive_regulation of Gene_expression of Por 1 0.41 0.65 0.19 94.28
18 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 93.72
19 INT97859 Localization of Npc1 12 0.75 6.66 0.35 93.48
20 INT77928 Binding of Pla2g4a 3 0.10 2.5 0.84 92.68
21 INT38039 Positive_regulation of LIPA 2 0.37 1.36 0.22 92.64
22 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 92.08
23 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 90.60
24 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 90.56
25 INT87332 Gene_expression of Cyb5d2 8 0.65 2.85 0.15 90.28
26 INT240923 Regulation of Hnf1a 1 0.19 0.48 0 90.16
27 INT240915 Regulation of Foxo1 2 0.39 1.31 0 90.16
28 INT27534 Negative_regulation of Gba 10 0.57 6.23 0.38 90.08
29 INT63317 Positive_regulation of Negative_regulation of CYP27A1 2 0.45 1.41 0.37 89.84
30 INT63318 Regulation of Negative_regulation of CYP27A1 1 0.44 0.9 0.18 89.84
31 INT73434 Negative_regulation of Nppa 8 0.35 3.86 4.31 89.84
32 INT94302 Gene_expression of Myelin 3 0.11 4.05 1.77 89.36
33 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 88.88
34 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 88.88
35 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 88.56
36 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 87.68
37 INT121008 Localization of Por 1 0.75 1.29 0.19 87.04
38 INT3214 Localization of Ins1 527 0.80 196.9 79.26 86.88
39 INT20233 Negative_regulation of SMPD1 8 0.51 4.19 1.4 86.16
40 INT20272 Negative_regulation of Por 12 0.58 3.09 1.8 85.16
41 INT3970 Positive_regulation of Sord 9 0.70 4.29 3.93 84.52
42 INT39667 Positive_regulation of Positive_regulation of Sord 2 0.18 1.99 0.27 84.52
43 INT76925 Negative_regulation of G6pc 6 0.57 2.9 1.25 84.52
44 INT183375 Binding of Nppa 14 0.38 8.95 0.51 84.52
45 INT9144 Localization of MSC 18 0.56 10.17 3.69 84.40
46 INT69169 Gene_expression of Cds1 3 0.54 3.07 10.65 84.32
47 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 82.72
48 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 82.72
49 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 82.72
50 INT233974 Negative_regulation of Negative_regulation of Il1 2 0.30 1.47 1.07 82.72
51 INT61252 Negative_regulation of Gene_expression of Itgam 38 0.54 16.48 5.01 82.16
52 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 82.08
53 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36 82.08
54 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 81.76
55 INT102734 Gene_expression of Atp6v0a2 18 0.50 6.28 2.76 81.64
56 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68 81.04
57 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72 81.00
58 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10 81.00
59 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 79.92
60 INT229276 Negative_regulation of Pck1 4 0.54 4.56 0.51 78.96
61 INT171117 Binding of Itgam 35 0.36 14.87 2.76 78.32
62 INT199650 Negative_regulation of Phyh 1 0.42 2.2 0.04 77.64
63 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 75.92
64 INT37405 Positive_regulation of Cst7 7 0.49 3.32 2.99 75.00
65 INT277878 Binding of Ids 4 0.34 0.8 0.24 72.44
66 INT254480 Localization of Cldn19 1 0.35 0.81 0.4 72.28
67 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34 70.84
68 INT8792 Gene_expression of GBA 20 0.78 14.73 1.98 70.84
69 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 67.96
70 INT194794 Binding of TTPA 7 0.08 2.56 0.57 67.60
71 INT199661 Negative_regulation of TTPA 2 0.04 1.84 0 67.60
72 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 67.08
73 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 67.08
74 INT76155 Binding of Gvhd1 2 0.31 1.65 0.1 66.48
75 INT121011 Binding of Por 1 0.37 0.33 0 63.84
76 INT296661 Positive_regulation of Cds1 1 0.40 1.33 4.45 63.68
77 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 62.44
78 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 61.28
79 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 61.28
80 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 60.88
81 INT347808 Binding of SMAP2 1 0.00 0.47 0.12 60.88
82 INT94301 Negative_regulation of Gene_expression of myelin 2 0.07 1.33 0.25 60.40
83 INT240940 Positive_regulation of Gene_expression of UBXN11 1 0.49 0.55 0 59.88
84 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 59.88
85 INT254471 Gene_expression of Cldn11 1 0.49 0.8 0.96 58.40
86 INT254477 Negative_regulation of Gene_expression of Cldn11 1 0.31 0.46 0.15 58.40
87 INT198787 Localization of Cyb5d2 3 0.73 0.56 0.03 57.68
88 INT130300 Gene_expression of Abcc3 14 0.70 5.34 4.96 57.04
89 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 56.16
90 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 56.16
91 INT74631 Gene_expression of UBXN11 19 0.75 6.11 0.57 55.64
92 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 55.48
93 INT121014 Regulation of CYB5A 1 0.00 0.3 0 55.44
94 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08 55.20
95 INT62579 Negative_regulation of Gene_expression of Cyp2e1 8 0.59 2.95 5.48 55.20
96 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12 54.32
97 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78 54.32
98 INT97861 Negative_regulation of Gene_expression of CTSA 3 0.13 1.11 0.09 50.72
99 INT97860 Gene_expression of CTSA 8 0.43 2.22 0.54 50.28
100 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 50.00
101 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 50.00
102 INT174844 Binding of Fig4 81 0.41 18.03 12.87 50.00
103 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 50.00
104 INT1224 Gene_expression of Fabp6 34 0.64 23.69 9.08 50.00
105 INT1540 Positive_regulation of SAFB 9 0.43 1.97 2.56 50.00
106 INT27135 Gene_expression of SAFB 9 0.68 0.96 0.79 50.00
107 INT185467 Gene_expression of Abcg5 2 0.64 0.86 0.15 50.00
108 INT185466 Regulation of Gene_expression of Abcg5 1 0.43 0 0.13 50.00
109 INT185463 Positive_regulation of Abcg5 1 0.48 0 0.13 50.00
110 INT185469 Regulation of Binding of ABCG8 1 0.18 0.2 0.07 50.00
111 INT185470 Regulation of ABCG8 1 0.18 0.2 0.07 50.00
112 INT185471 Binding of ABCG8 1 0.15 0.2 0.07 50.00
113 INT185473 Regulation of Localization of ABCG8 1 0.21 0.22 0 50.00
114 INT185472 Localization of ABCG8 1 0.35 0.22 0 50.00
115 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 49.04
116 INT1843 Positive_regulation of Hrasls 16 0.69 2.16 5.08 47.44
117 INT345357 Protein_catabolism of Ids 1 0.57 0.2 0.09 46.56
118 INT240931 Regulation of Binding of Ad 1 0.08 0.18 0 44.12
119 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 43.76
120 INT229564 Binding of Ad 8 0.36 10.31 0.2 43.56
121 INT84638 Regulation of Smpd1 3 0.37 2.36 0.22 42.88
122 INT345361 Positive_regulation of Positive_regulation of Ids 1 0.44 0.41 0.06 40.08
123 INT345359 Positive_regulation of Ids 1 0.50 0.27 0.24 39.60
124 INT199330 Regulation of Pck1 3 0.57 3.12 0 37.68
125 INT240917 Regulation of Cpt1a 1 0.11 0.26 0 37.68
126 INT320845 Regulation of Localization of Npc1 1 0.39 0.71 0 37.36
127 INT199341 Localization of Pck1 2 0.65 1.29 0 36.96
128 INT6849 Localization of IL1B 229 0.81 112.56 69.63 36.24
129 INT176183 Gene_expression of Abcg5 1 0.77 5.01 1.08 34.72
130 INT96767 Negative_regulation of Cpt1a 9 0.48 2.2 0.39 34.56
131 INT240937 Negative_regulation of Transcription of Pck1 3 0.39 0.32 0.08 34.56
132 INT240938 Negative_regulation of Transcription of Cpt1a 2 0.24 0.39 0 34.56
133 INT176190 Gene_expression of Abcg8 1 0.78 10.4 3.19 34.48
134 INT240922 Transcription of Cpt1a 2 0.36 0.51 0 34.24
135 INT240924 Transcription of Pck1 7 0.66 3.6 0.37 33.80
136 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 33.52
137 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75 33.52
138 INT240919 Positive_regulation of Mlycd 1 0.09 0.23 0 31.80
139 INT240927 Positive_regulation of Negative_regulation of Cpt1a 1 0.20 0.23 0 31.80
140 INT36915 Gene_expression of Neo1 39 0.36 7.28 1.31 28.88
141 INT199647 Regulation of Phyh 1 0.27 2.71 0 27.52
142 INT296659 Regulation of Cds1 1 0.41 0.54 1.08 26.92
143 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 25.92
144 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 22.44
145 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43 21.12
146 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 20.80
147 INT240920 Positive_regulation of Phosphorylation of Ins1 12 0.42 10.71 0.52 20.80
148 INT15172 Positive_regulation of Itgam 45 0.67 23.54 10.3 20.40
149 INT59321 Transcription of Il1 13 0.50 9.73 2.68 19.00
150 INT152888 Transcription of Itgam 4 0.44 1.29 0.25 19.00
151 INT10006 Regulation of Mtr 9 0.23 3.56 5.42 17.60
152 INT282213 Negative_regulation of Regulation of Mtr 1 0.01 0.82 0.27 17.60
153 INT147810 Positive_regulation of TP53TG3 3 0.03 3.13 0.34 15.52
154 INT70958 Binding of NOS3 19 0.37 11.84 3.29 13.48
155 INT62896 Binding of NOSTRIN 4 0.30 2.86 1.3 13.48
156 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 11.16
157 INT138438 Gene_expression of Smpd1 7 0.67 2.67 0.21 11.04
158 INT320839 Regulation of Gene_expression of Smpd1 1 0.37 0.61 0 11.04
159 INT176203 Positive_regulation of Gene_expression of Abcg5 1 0.69 0.34 0.03 8.40
160 INT176199 Positive_regulation of Gene_expression of Abcg8 1 0.50 0.34 0.03 8.40
161 INT71946 Negative_regulation of Ass1 7 0.41 1.9 2.68 7.76
162 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 6.96
163 INT77602 Binding of VCAM1 8 0.41 8.66 2.86 6.04
164 INT183792 Gene_expression of MAFK 2 0.41 2.23 0.46 5.36
165 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
166 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
167 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
168 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
169 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
170 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
171 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
172 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
173 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
174 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
175 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
176 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
177 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
178 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
179 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
180 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
181 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
182 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
183 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
184 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
185 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
186 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
187 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 5.00
188 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
189 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
190 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
191 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 5.00
192 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
193 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
194 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
195 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
196 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
197 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
198 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
199 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 5.00
200 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
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