D:Lissencephaly

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Disease Term
Synonyms Agyria, Agyrias, Lissencephalia, Lissencephalias, Lissencephalies, Pachygyria, PACHYGYRIAS
Documents 12
Hot Single Events 9
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lissencephaly. They are ordered first by their relevance to Lissencephaly and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT302373 Binding of Arx and Tuba1a 1 0.30 1.26 0 98.64
2 INT302364 Binding of Arx and Reln 1 0.32 1.25 0 98.64
3 INT302370 Binding of Arx and Dcx 1 0.35 1.25 0 98.64
4 INT302368 Binding of Arx and Pafah1b1 1 0.27 1.25 0 98.64
5 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15 68.32
6 INT234800 RAB27A Positive_regulation of INS 1 0.02 1.26 0 54.12
7 INT234793 RAB27A Positive_regulation of Localization of INS 1 0.03 1.26 0 54.12
8 INT234831 Binding of SPTLC1 and Abo 1 0.00 1.61 0.23 19.12
9 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07 19.12
10 INT234791 Binding of AVP and AVPR2 1 0.14 0.55 0 19.12
11 INT234796 Binding of AQP2 and AVP 1 0.15 1.1 0 19.12
12 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03 5.00
13 INT302369 Binding of Arx and Dlx1 1 0.34 0 0.43 5.00
14 INT302371 Dlx1 Regulation of Gene_expression of Arx 1 0.28 0 0.35 5.00
15 INT344923 Binding of CEBPZ and GOPC 1 0.06 0.24 0.33 5.00
16 INT302367 Dlx2 Regulation of Gene_expression of Arx 1 0.59 0.23 0.22 5.00
17 INT302372 Arx Negative_regulation of Gene_expression of Calb2 1 0.13 0.05 0.18 5.00
18 INT176257 Positive_regulation of p53-ps Positive_regulation of Gene_expression of Fas 1 0.04 0.32 0.06 5.00
19 INT303500 Regulation of Ebf2 Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 0.13 0.16 0.05 5.00
20 INT176283 Fasl Positive_regulation of Fas 1 0.21 0.3 0.03 5.00
21 INT176254 Fasl Positive_regulation of Fas Negative_regulation of Gene_expression of PCNA 1 0.02 0.3 0.03 5.00
22 INT176286 Fasl Positive_regulation of Gene_expression of Pcna 1 0.02 0.81 0.03 5.00
23 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03 5.00
24 INT176253 Fasl Positive_regulation of Fas Positive_regulation of Gene_expression of PCNA 1 0.02 0.3 0.03 5.00
25 INT176259 p53-ps Positive_regulation of Transcription of Fas 1 0.04 0.35 0 5.00
26 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0 5.00
27 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0 5.00
28 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0 5.00
29 INT176291 Fasl Regulation of Gene_expression of Pcna 1 0.01 0.31 0 5.00
30 INT176284 Binding of E2f1 and p53-ps 1 0.02 0.28 0 5.00
31 INT234790 B4GALNT1 Positive_regulation of AGFG1 1 0.00 0.08 0 5.00
32 INT257547 HBEGF Positive_regulation of Phosphorylation of CDCP1 1 0.00 0.36 0 5.00
33 INT176258 p53-ps Regulation of Fas 1 0.03 0.06 0 5.00
34 INT176290 Fasl Positive_regulation of Pcna 1 0.02 0.44 0 5.00
35 INT234803 AVP Regulation of AQP2 1 0.11 1.3 0 5.00
36 INT176282 Binding of Pcna and p53-ps 1 0.00 0.69 0 5.00
37 INT176285 Fasl Regulation of Gene_expression of Cdc2b 1 0.03 0.34 0 5.00
38 INT234794 Binding of GDI1 and AGFG1 1 0.01 0 0 5.00
39 INT234797 AVP Regulation of GOPC 1 0.01 0.65 0 5.00
40 INT176256 p53-ps Positive_regulation of Localization of Fas 1 0.04 0.35 0 5.00
41 INT176287 Cdk2 Positive_regulation of Phosphorylation of Esr1 1 0.05 0.67 0 5.00
42 INT234795 Negative_regulation of CHM Negative_regulation of RAB27A 1 0.01 0.8 0 5.00
43 INT176293 Fasl Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.42 0 5.00
44 INT210285 Ccrs1 Regulation of RAI1 1 0.00 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lissencephaly. They are ordered first by their pain relevance and then by number of times they were reported in Lissencephaly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT99270 Negative_regulation of Gene_expression of Pvalb 5 0.08 5.74 3.15 98.48
2 INT15777 Gene_expression of Pvalb 66 0.78 25.97 26.13 98.48
3 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 96.92
4 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78 96.92
5 INT176248 Binding of Pafah1b1 1 0.07 0.45 0 95.16
6 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 84.60
7 INT51444 Regulation of PMP22 2 0.44 1.39 0.07 82.04
8 INT210277 Regulation of RAI1 3 0.37 1.49 0 82.04
9 INT302343 Negative_regulation of Arx 1 0.51 0.76 0.4 80.72
10 INT302338 Gene_expression of Arx 1 0.77 2.8 4.93 76.96
11 INT302345 Positive_regulation of Gene_expression of Arx 1 0.69 1.06 1.4 76.96
12 INT14572 Binding of INS 205 0.48 175.43 13.38 76.20
13 INT233259 Binding of LBX1 2 0.01 0.63 0.04 73.00
14 INT302375 Regulation of Binding of LBX1 1 0.01 0.45 0 73.00
15 INT60388 Gene_expression of Helt 90 0.07 19.18 41.72 71.24
16 INT210272 Binding of Ccrs1 1 0.01 1.13 0 70.76
17 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 66.84
18 INT17962 Regulation of Car2 124 0.41 33.98 22.71 63.60
19 INT267796 Gene_expression of Capns1 2 0.61 0.77 0 62.16
20 INT302359 Gene_expression of Ebf3 1 0.63 0.11 0.14 59.84
21 INT297726 Gene_expression of Cbr1 27 0.20 7.68 1.64 57.28
22 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 55.04
23 INT302339 Regulation of Arx 1 0.45 1.23 0.66 54.80
24 INT234828 Gene_expression of RAB3A 2 0.30 2.05 0.37 53.52
25 INT812 Localization of INS 1026 0.81 515.6 145.31 53.16
26 INT98686 Gene_expression of Calb2 28 0.51 12.07 2.84 51.76
27 INT142719 Binding of Col1a1 7 0.34 5.83 1.47 50.60
28 INT324304 Regulation of Capn9 1 0.45 1 0.04 50.44
29 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 49.68
30 INT170321 Binding of Mmp13 3 0.36 2.54 1.09 48.88
31 INT47780 Gene_expression of CREM 17 0.74 5.37 2.13 46.64
32 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 46.08
33 INT302342 Localization of Arx 1 0.80 0.94 0.83 46.08
34 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 45.96
35 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 44.92
36 INT228295 Negative_regulation of Transcription of INS 2 0.43 1.1 0.07 43.64
37 INT183046 Transcription of INS 25 0.70 11.14 1.13 42.92
38 INT123643 Gene_expression of Reln 19 0.75 1.85 1.13 42.24
39 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47 41.64
40 INT53212 Negative_regulation of RAB27A 4 0.57 2.46 0.26 40.64
41 INT234824 Negative_regulation of SYTL4 1 0.07 0.95 0 40.64
42 INT302354 Gene_expression of Xic 1 0.02 0.08 0.08 39.92
43 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 37.92
44 INT21794 Positive_regulation of Gene_expression of Npy 20 0.70 8.44 9.3 37.92
45 INT302358 Positive_regulation of Gene_expression of Calb2 1 0.12 0.11 0.27 37.92
46 INT248207 Positive_regulation of Calb2 3 0.20 0.49 0.46 37.20
47 INT302362 Positive_regulation of Positive_regulation of Calb2 1 0.11 0.12 0.3 37.20
48 INT21646 Positive_regulation of Npy 40 0.70 31.31 13.57 34.64
49 INT122472 Positive_regulation of Positive_regulation of Npy 6 0.51 2.66 0.83 34.64
50 INT143482 Negative_regulation of Gene_expression of Fas 20 0.41 8.3 0.79 32.80
51 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 31.20
52 INT69744 Gene_expression of CDT1 3 0.65 1.6 0.75 31.20
53 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 30.80
54 INT234810 Regulation of RAB5A 3 0.38 1.64 0.16 30.80
55 INT125573 Gene_expression of CS 26 0.41 8 0.98 25.00
56 INT324299 Gene_expression of Capn8 1 0.67 2.09 0.34 25.00
57 INT324300 Gene_expression of Capn9 1 0.66 1.78 0.28 25.00
58 INT302341 Positive_regulation of Arx 1 0.44 0.4 0.11 24.96
59 INT22901 Negative_regulation of Gene_expression of Esr1 30 0.42 20.92 6.29 20.68
60 INT52347 Negative_regulation of CHM 17 0.58 13.03 0.59 20.40
61 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36 20.24
62 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 19.92
63 INT234812 Binding of AVPR2 1 0.17 0.55 0 19.12
64 INT75629 Gene_expression of Mtap2 41 0.66 8.19 4.51 9.20
65 INT176269 Phosphorylation of p53-ps 1 0.12 4.3 0.31 5.60
66 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 5.32
67 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48 5.32
68 INT15450 Positive_regulation of Gene_expression of Cpe 11 0.34 4.53 4.34 5.32
69 INT113137 Positive_regulation of Ppp1r1b 14 0.65 0.89 4.21 5.32
70 INT196774 Positive_regulation of Gene_expression of Ppp1r1b 4 0.31 0.29 0.56 5.32
71 INT302346 Positive_regulation of Gene_expression of Ebf1 1 0.41 0 0.18 5.32
72 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
73 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
74 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67 5.00
75 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
76 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 5.00
77 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
78 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
79 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
80 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
81 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
82 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
83 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
84 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
85 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
86 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 5.00
87 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
88 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
89 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
90 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
91 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
92 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
93 INT13716 Positive_regulation of TH 33 0.68 19.11 16 5.00
94 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
95 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
96 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
97 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
98 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
99 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
100 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
101 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
102 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 5.00
103 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97 5.00
104 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 5.00
105 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53 5.00
106 INT34544 Gene_expression of L1cam 43 0.77 5.3 8.89 5.00
107 INT108336 Phosphorylation of EPHB2 41 0.80 22.25 8.21 5.00
108 INT234813 Gene_expression of RAB5A 58 0.66 3.67 6.48 5.00
109 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 5.00
110 INT185252 Gene_expression of Dlx2 7 0.71 8.8 6.24 5.00
111 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
112 INT147263 Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 51 0.53 15.32 5.86 5.00
113 INT113516 Negative_regulation of Fas 16 0.51 8.37 5.32 5.00
114 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 5.00
115 INT113517 Binding of Fas 16 0.37 15.86 4.62 5.00
116 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 5.00
117 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
118 INT152552 Gene_expression of Muc5ac 24 0.73 19.44 4 5.00
119 INT123752 Regulation of Bax 19 0.60 16.45 4 5.00
120 INT196736 Gene_expression of Ppp1r1b 24 0.55 2.01 3.99 5.00
121 INT121171 Negative_regulation of Gene_expression of Ngfr 6 0.58 3.46 3.89 5.00
122 INT78203 Gene_expression of PMP22 12 0.63 7.49 3.58 5.00
123 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 5.00
124 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33 5.00
125 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07 5.00
126 INT234825 Positive_regulation of Gene_expression of RAB5A 16 0.59 1.15 2.71 5.00
127 INT121683 Gene_expression of Hc 23 0.75 7.15 2.7 5.00
128 INT134375 Gene_expression of Cflar 14 0.58 8.4 2.66 5.00
129 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61 5.00
130 INT73592 Positive_regulation of p53-ps 19 0.10 7.85 2.56 5.00
131 INT68792 Gene_expression of p53-ps 14 0.75 6.81 2.47 5.00
132 INT87287 Phosphorylation of CDCP1 20 0.04 5.62 2.43 5.00
133 INT142741 Gene_expression of Atp6v1e1 28 0.31 9.41 2.34 5.00
134 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3 5.00
135 INT88017 Regulation of Fas 12 0.62 8.27 2.29 5.00
136 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21 5.00
137 INT96762 Gene_expression of RAI1 9 0.56 5.77 2.17 5.00
138 INT112868 Gene_expression of Pcna 21 0.75 8.6 2.15 5.00
139 INT302340 Positive_regulation of Gene_expression of Dlx2 2 0.64 3.43 2.15 5.00
140 INT77621 Regulation of Gene_expression of Fas 10 0.56 7.62 2.08 5.00
141 INT73591 Positive_regulation of Positive_regulation of p53-ps 4 0.07 2.74 2.08 5.00
142 INT72040 Binding of L1cam 14 0.48 3.57 1.97 5.00
143 INT201232 Binding of CEBPZ 7 0.31 1.73 1.7 5.00
144 INT234827 Positive_regulation of RAB5A 3 0.59 0.54 1.69 5.00
145 INT73589 Positive_regulation of Gene_expression of p53-ps 4 0.49 3.51 1.66 5.00
146 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63 5.00
147 INT86247 Gene_expression of Bcl2l10 14 0.34 12.21 1.61 5.00
148 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44 5.00
149 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39 5.00
150 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
151 INT96643 Positive_regulation of Gene_expression of Gad2 3 0.49 0.15 1.18 5.00
152 INT81945 Negative_regulation of Binding of Esr1 3 0.32 0.55 1.06 5.00
153 INT155042 Gene_expression of SHFM1 25 0.65 4.57 0.94 5.00
154 INT21660 Regulation of CHM 14 0.61 8.51 0.93 5.00
155 INT326601 Gene_expression of SLC18A2 2 0.42 1.31 0.92 5.00
156 INT201261 Regulation of AGFG1 4 0.09 2.72 0.9 5.00
157 INT210276 Positive_regulation of Gene_expression of PMP22 3 0.46 1.58 0.88 5.00
158 INT94546 Transcription of Fas 13 0.56 6.99 0.88 5.00
159 INT51704 Phosphorylation of AVP 2 0.79 0.33 0.86 5.00
160 INT176261 Gene_expression of DDAH2 4 0.65 1.97 0.82 5.00
161 INT294805 Gene_expression of Dlx1 4 0.70 0.45 0.81 5.00
162 INT201233 Localization of CEBPZ 4 0.62 0.82 0.77 5.00
163 INT234820 Localization of AGFG1 3 0.14 0.86 0.74 5.00
164 INT167178 Gene_expression of Cdc2b 4 0.78 2.4 0.66 5.00
165 INT94548 Localization of Fas 9 0.77 5.15 0.65 5.00
166 INT114879 Gene_expression of Cdk2 5 0.55 2.33 0.6 5.00
167 INT173748 Phosphorylation of Esr1 11 0.77 5.7 0.55 5.00
168 INT176271 Negative_regulation of Positive_regulation of p53-ps 2 0.06 1.15 0.54 5.00
169 INT176242 Binding of Bax 10 0.42 10.18 0.52 5.00
170 INT173744 Positive_regulation of Positive_regulation of Esr1 10 0.43 7.05 0.52 5.00
171 INT176264 Binding of PCNA 21 0.21 9.08 0.51 5.00
172 INT168225 Gene_expression of ge 3 0.12 0.09 0.5 5.00
173 INT57163 Gene_expression of AGFG1 11 0.75 2.45 0.48 5.00
174 INT114672 Negative_regulation of p53-ps 3 0.09 0.51 0.48 5.00
175 INT302344 Localization of ge 1 0.04 0 0.47 5.00
176 INT302337 Positive_regulation of Gene_expression of ge 1 0.03 0 0.46 5.00
177 INT64965 Binding of AGFG1 8 0.10 3.53 0.45 5.00
178 INT344929 Localization of AOC2 1 0.31 0.2 0.45 5.00
179 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43 5.00
180 INT302335 Gene_expression of Ebf1 1 0.55 0 0.41 5.00
181 INT302352 Positive_regulation of Binding of Dlx1 1 0.45 0 0.4 5.00
182 INT302357 Binding of Dlx1 1 0.33 0 0.39 5.00
183 INT158764 Binding of SPINK5 7 0.35 8.84 0.37 5.00
184 INT302351 Regulation of Gene_expression of Arx 1 0.45 0 0.35 5.00
185 INT139391 Regulation of PCNA 10 0.60 3.12 0.33 5.00
186 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31 5.00
187 INT302349 Regulation of Negative_regulation of Arx 1 0.39 0.27 0.31 5.00
188 INT294806 Gene_expression of Dlx5 6 0.71 2.07 0.3 5.00
189 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29 5.00
190 INT169996 Positive_regulation of Negative_regulation of Fas 2 0.25 1.69 0.28 5.00
191 INT176260 Binding of CASP8 5 0.36 2.73 0.27 5.00
192 INT302350 Negative_regulation of Gene_expression of Arx 1 0.58 0.26 0.26 5.00
193 INT234817 Gene_expression of GDI1 4 0.17 2.99 0.25 5.00
194 INT303498 Gene_expression of Ebf2 1 0.77 0.29 0.22 5.00
195 INT244750 Gene_expression of Dbx1 2 0.46 0 0.21 5.00
196 INT178603 Gene_expression of NUCKS1 4 0.23 0.37 0.2 5.00
197 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19 5.00
198 INT176266 Negative_regulation of Negative_regulation of Fas 2 0.22 0.33 0.17 5.00
199 INT176241 Negative_regulation of Gene_expression of Atp6v1e1 5 0.17 2.16 0.17 5.00
200 INT257557 Negative_regulation of MAP3K11 3 0.30 2.38 0.16 5.00
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