D:Low Tension Glaucoma

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Disease Term
Synonyms Glaucoma Low Tension, Glaucoma Normal Tension, Glaucomas Low Tension, Glaucomas Normal Tension, LOW TENSION GLAUCOMAS, Normal Tension Glaucoma, Normal Tension Glaucomas, Tension Glaucoma Low, Tension Glaucoma Normal, Tension Glaucomas Low, Tension Glaucomas Normal
Documents 38
Hot Single Events 58
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Low Tension Glaucoma. They are ordered first by their relevance to Low Tension Glaucoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT302507 Binding of GLC1F and OPA1 1 0.01 3.76 0 100.00
2 INT302511 Binding of OPA1 and Nos3 1 0.02 1.57 0.1 100.00
3 INT274095 Binding of EDNRA and OPA1 1 0.12 0.65 0.04 100.00
4 INT299232 Onc1 Regulation of Gene_expression of Aqp4 1 0.01 0.43 0 96.48
5 INT247851 Negative_regulation of Aqp4 Negative_regulation of Positive_regulation of Narfl 1 0.09 1.78 0.15 87.52
6 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 76.48
7 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97 76.48
8 INT274096 Binding of EDN1 and EDNRA Positive_regulation of Positive_regulation of EDN1 1 0.22 0.78 0 76.48
9 INT247843 Narfl Regulation of Aqp4 1 0.04 1.07 0.04 67.92
10 INT247855 Positive_regulation of Narfl Regulation of Aqp4 1 0.04 2.93 0.04 67.92
11 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2 65.64
12 INT111080 Binding of CA1 and CA2 2 0.02 1.62 0.73 59.36
13 INT299234 Onc1 Negative_regulation of Thy1 1 0.02 0.16 0 37.36
14 INT299233 Onc1 Regulation of Gene_expression of Aqp9 1 0.01 0.19 0 16.24
15 INT247856 Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 1 0.03 10.00
16 INT247853 Positive_regulation of Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 0.54 0 10.00
17 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43 5.00
18 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22 5.00
19 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22 5.00
20 INT289997 CNTF Negative_regulation of Binding of CNTF and Casp3 1 0.05 0.99 0.22 5.00
21 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22 5.00
22 INT274285 AGT Positive_regulation of Gene_expression of VEGFA 1 0.01 0.98 0.03 5.00
23 INT274288 AGT Positive_regulation of Gene_expression of Vegfa 1 0.07 0.98 0.03 5.00
24 INT274284 AGT Positive_regulation of Binding of VEGFA 1 0.01 0.99 0.03 5.00
25 INT247847 Narfl Positive_regulation of Positive_regulation of Casp3 1 0.02 0.79 0 5.00
26 INT247846 Positive_regulation of Narfl Positive_regulation of Positive_regulation of Ube4a 1 0.00 0.82 0 5.00
27 INT247848 Narfl Negative_regulation of Uchl1 1 0.03 0.74 0 5.00
28 INT247857 Narfl Positive_regulation of Gene_expression of Gfap 1 0.07 0.81 0 5.00
29 INT247888 Narfl Positive_regulation of CASP3 1 0.00 0.77 0 5.00
30 INT247850 Positive_regulation of Narfl Regulation of Ube4a 1 0.00 1.86 0 5.00
31 INT247849 Edn1 Regulation of Gene_expression of Aqp4 1 0.12 1.05 0 5.00
32 INT247852 Narfl Positive_regulation of Localization of Aqp4 1 0.08 0.81 0 5.00
33 INT247889 Positive_regulation of Narfl Positive_regulation of CASP3 1 0.00 0.84 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Low Tension Glaucoma. They are ordered first by their pain relevance and then by number of times they were reported in Low Tension Glaucoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 100.00
2 INT5913 Binding of OPA1 12 0.41 9.33 2.92 100.00
3 INT34870 Positive_regulation of OPA1 18 0.59 10.66 5 100.00
4 INT3605 Negative_regulation of OPA1 14 0.38 10.88 2.84 100.00
5 INT34976 Positive_regulation of Gene_expression of OPA1 4 0.43 4.21 0.4 100.00
6 INT24883 Regulation of OPA1 14 0.45 9.73 3.44 100.00
7 INT33854 Localization of OPA1 19 0.65 10.55 5.04 100.00
8 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 99.84
9 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 99.84
10 INT302509 Gene_expression of GLC1F 1 0.21 1.2 0 99.80
11 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 99.66
12 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 99.56
13 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 99.48
14 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 99.48
15 INT114472 Regulation of Izumo1 13 0.48 7.95 3.2 99.28
16 INT37764 Positive_regulation of Izumo1 21 0.61 8.75 5.79 99.20
17 INT308240 Gene_expression of Prm3 1 0.06 3.69 0.09 99.02
18 INT302502 Regulation of Agap3 1 0.28 0.73 0 98.84
19 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 98.48
20 INT308238 Binding of Prm3 2 0.05 1.3 0.2 97.92
21 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 97.44
22 INT247868 Positive_regulation of Narfl 1 0.11 37.11 0.68 96.64
23 INT225966 Regulation of Gene_expression of Aqp4 18 0.62 20.39 2.3 96.48
24 INT302503 Binding of Agap3 1 0.19 0.8 0 96.32
25 INT165821 Positive_regulation of Aqp4 27 0.70 24.37 3.22 96.28
26 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 95.80
27 INT264283 Negative_regulation of Regulation of Izumo1 1 0.01 0.73 0.13 95.28
28 INT181642 Negative_regulation of Narf 2 0.01 28.07 4.01 95.12
29 INT274271 Negative_regulation of Negative_regulation of NARFL 1 0.06 5.13 0.22 94.76
30 INT274273 Regulation of Gene_expression of NARFL 3 0.10 4.39 0.2 94.76
31 INT272272 Positive_regulation of Gene_expression of NARFL 17 0.40 18.85 0.31 94.12
32 INT136304 Negative_regulation of Aqp4 54 0.59 48.42 7.4 92.64
33 INT225965 Localization of Aqp4 26 0.81 18.85 3.75 92.64
34 INT247870 Negative_regulation of Localization of Aqp4 3 0.43 2 0.24 92.64
35 INT272415 Negative_regulation of Gene_expression of NARFL 14 0.34 17.62 0.73 92.04
36 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49 92.00
37 INT54978 Binding of EDNRA 36 0.41 14.97 7.86 91.96
38 INT139512 Positive_regulation of Localization of EDNRB 3 0.37 0.69 0.26 91.68
39 INT139514 Localization of EDNRB 7 0.73 4.63 1.52 91.68
40 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 91.60
41 INT139515 Positive_regulation of EDNRB 15 0.67 10.35 0.93 90.44
42 INT178130 Binding of EDNRB 12 0.36 6.18 1.84 88.76
43 INT308239 Negative_regulation of Gene_expression of Prm3 1 0.04 1.12 0 87.96
44 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 86.92
45 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 86.88
46 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 86.88
47 INT49555 Positive_regulation of Positive_regulation of Gfap 18 0.69 11.51 10.29 86.88
48 INT178127 Positive_regulation of Gene_expression of EDNRB 7 0.51 5.24 0.78 86.48
49 INT302501 Positive_regulation of Agap3 1 0.42 0.73 0 86.24
50 INT169748 Positive_regulation of Gene_expression of Aqp4 38 0.69 34.29 3.79 86.16
51 INT235951 Positive_regulation of Positive_regulation of Aqp4 4 0.57 5.13 0.75 86.16
52 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75 85.32
53 INT247871 Negative_regulation of Thy1 8 0.54 7.23 0.03 85.12
54 INT299196 Transcription of Thy1 1 0.66 1.98 0 85.12
55 INT3183 Negative_regulation of MRXS5 15 0.41 6.56 3.45 84.60
56 INT247867 Positive_regulation of Positive_regulation of Narfl 1 0.11 5.16 0.05 83.44
57 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 83.04
58 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 82.64
59 INT3581 Negative_regulation of Edv 5 0.38 1.88 0.61 75.84
60 INT9191 Localization of EDN1 94 0.81 57.01 14.78 74.68
61 INT146983 Regulation of Kcnj1 2 0.08 1.34 0.86 74.56
62 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 72.96
63 INT274272 Transcription of MRXS5 1 0.57 1.75 0.09 72.20
64 INT274270 Negative_regulation of Transcription of MRXS5 1 0.35 1.76 0.09 72.20
65 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14 70.16
66 INT82885 Gene_expression of Mip 7 0.65 7.89 2.76 70.16
67 INT179213 Gene_expression of Aqp3 10 0.63 5.13 0.77 70.16
68 INT299215 Gene_expression of Kcnj1 1 0.08 1.94 0.09 66.68
69 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 66.56
70 INT274098 Regulation of EDNRB 1 0.33 2.41 0.18 66.56
71 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 62.16
72 INT289984 Regulation of Narf 1 0.01 0.78 0 61.68
73 INT144918 Gene_expression of Thy1 5 0.62 4.39 0.06 61.28
74 INT299228 Regulation of Gene_expression of Thy1 1 0.22 1.47 0.03 61.28
75 INT299217 Positive_regulation of Gene_expression of Thy1 1 0.40 0.39 0 61.28
76 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79 59.36
77 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 59.12
78 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77 59.12
79 INT247863 Positive_regulation of Negative_regulation of Aqp4 3 0.45 2.63 0.25 58.80
80 INT182516 Negative_regulation of Negative_regulation of ACE 9 0.42 6.84 0.99 58.24
81 INT164480 Negative_regulation of Gene_expression of Aqp4 14 0.58 10.84 1.52 58.12
82 INT271442 Positive_regulation of Thy1 10 0.40 6.64 3.05 56.72
83 INT247885 Regulation of Thy1 8 0.33 5.25 1.44 56.72
84 INT55662 Negative_regulation of Negative_regulation of KNG1 4 0.36 3.45 0.57 55.88
85 INT64310 Negative_regulation of GRIN2A 7 0.42 2.16 3.49 55.60
86 INT2074 Negative_regulation of CA1 6 0.58 4.44 1.68 55.60
87 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 55.40
88 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 54.88
89 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 54.40
90 INT299198 Regulation of Gene_expression of Kcnj1 1 0.06 0.65 0.04 54.28
91 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92 53.24
92 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 50.00
93 INT25834 Positive_regulation of Dbp 59 0.68 24.34 9.32 50.00
94 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 50.00
95 INT29231 Regulation of Dbp 44 0.53 10.08 4.47 50.00
96 INT32688 Positive_regulation of Gene_expression of Shbg 14 0.45 7.01 1.6 50.00
97 INT194546 Positive_regulation of Gene_expression of Dbp 9 0.28 2.93 0.36 50.00
98 INT299200 Negative_regulation of Kcnj1 1 0.06 0.99 0.13 49.52
99 INT299190 Positive_regulation of Onc1 1 0.02 0.12 0.04 43.28
100 INT299212 Positive_regulation of Positive_regulation of Kcnj1 1 0.05 0.12 0.04 43.12
101 INT299191 Positive_regulation of Kcnj1 1 0.07 0.12 0.04 42.52
102 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 42.36
103 INT299209 Regulation of Transcription of Kcnj1 1 0.03 0.17 0.03 32.96
104 INT299220 Transcription of Kcnj1 1 0.07 0.7 0.12 32.52
105 INT272274 Localization of NARFL 24 0.60 27.55 1.18 31.28
106 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 30.96
107 INT198124 Regulation of Aqp9 6 0.61 3.62 0.1 30.28
108 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76 29.96
109 INT227781 Positive_regulation of GON4L 4 0.13 7.56 0.54 29.20
110 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 28.64
111 INT335958 Negative_regulation of Binding of Ubl4 1 0.27 2.08 1.34 28.52
112 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 28.32
113 INT5490 Binding of CA2 52 0.36 9.73 5.53 28.32
114 INT264594 Negative_regulation of Binding of CA2 4 0.20 1.1 0.52 28.32
115 INT167520 Binding of Ubl4 2 0.29 3.93 2.66 28.20
116 INT247860 Regulation of Uchl1 1 0.14 1.46 0 26.96
117 INT335957 Localization of Ubl4 1 0.51 0.87 0.43 25.80
118 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68 24.64
119 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 20.80
120 INT89288 Positive_regulation of Negative_regulation of NOS1 5 0.40 4.84 0.96 20.80
121 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 20.48
122 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 20.16
123 INT167519 Gene_expression of Ubl4 7 0.43 5.28 3.2 18.64
124 INT248346 Binding of PLXNA2 4 0.29 1.38 0.46 16.68
125 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 16.56
126 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 16.56
127 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84 15.80
128 INT198121 Gene_expression of Aqp9 19 0.77 5.67 0.12 15.56
129 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22 13.44
130 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 7.84
131 INT110069 Regulation of Negative_regulation of ras 3 0.26 4.38 0.3 7.04
132 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
133 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
134 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
135 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
136 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
137 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
138 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
139 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
140 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
141 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 5.00
142 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
143 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
144 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07 5.00
145 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 5.00
146 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
147 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
148 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
149 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
150 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
151 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 5.00
152 INT1116 Regulation of Ren 103 0.62 27.66 33.26 5.00
153 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
154 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
155 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
156 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
157 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
158 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
159 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
160 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
161 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7 5.00
162 INT6866 Regulation of Gfap 51 0.61 19.6 23.56 5.00
163 INT29704 Regulation of Casp3 51 0.56 22.13 22.79 5.00
164 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
165 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
166 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
167 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
168 INT5137 Binding of PCa 45 0.47 16.91 18.47 5.00
169 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69 5.00
170 INT6850 Gene_expression of SPANXB1 34 0.46 15.91 16.38 5.00
171 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
172 INT6853 Positive_regulation of SPANXB1 17 0.40 14.05 16.14 5.00
173 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
174 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
175 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14 5.00
176 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
177 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 5.00
178 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77 5.00
179 INT3962 Regulation of AGT 50 0.62 20.96 13.01 5.00
180 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66 5.00
181 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 5.00
182 INT398 Localization of AGT 45 0.78 16.97 11.54 5.00
183 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 5.00
184 INT8065 Binding of AGT 54 0.48 20.54 10.85 5.00
185 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51 5.00
186 INT99505 Gene_expression of Bcl2l1 42 0.77 33.12 10.15 5.00
187 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28 5.00
188 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 5.00
189 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
190 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08 5.00
191 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
192 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 5.00
193 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65 5.00
194 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
195 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 5.00
196 INT42038 Localization of ACE 26 0.80 8.88 7.06 5.00
197 INT6758 Positive_regulation of Synm 12 0.43 2.57 6.83 5.00
198 INT89131 Negative_regulation of NOS2 20 0.58 9.68 6.56 5.00
199 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
200 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 5.00
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