D:Lower Urinary Tract Symptoms

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Disease Term
Synonyms LUTS
Documents 299
Hot Single Events 79
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lower Urinary Tract Symptoms. They are ordered first by their relevance to Lower Urinary Tract Symptoms and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT278077 Binding of BPHL and AURKC 1 0.16 4.29 0.69 98.48
2 INT126791 RASL12 Positive_regulation of ADRA1D 1 0.24 2.62 0.22 94.08
3 INT126795 RASL12 Positive_regulation of Hal 1 0.01 2.62 0.22 94.08
4 INT349050 Binding of EPCAM and ZNF845 1 0.02 1.54 0 89.64
5 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17 69.92
6 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21 61.80
7 INT270330 Binding of HYAL1 and TIMP1 1 0.00 0.2 0.04 33.36
8 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
9 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74 5.00
10 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74 5.00
11 INT262809 Il10 Positive_regulation of Regulation of Slc11a1 1 0.17 1.12 0.27 5.00
12 INT262810 Slc11a1 Positive_regulation of Gene_expression of Il10 1 0.20 0.97 0.27 5.00
13 INT339897 Binding of Bnc1 and Shc4 1 0.05 0.69 0.07 5.00
14 INT329429 Binding of Col7a1 and Hmgcr 1 0.01 0.28 0.06 5.00
15 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03 5.00
16 INT349051 Binding of EPCAM and SCFV 1 0.03 1.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lower Urinary Tract Symptoms. They are ordered first by their pain relevance and then by number of times they were reported in Lower Urinary Tract Symptoms. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT24149 Gene_expression of BPHL 58 0.59 93.54 2.91 100.00
2 INT103942 Binding of BPHL 11 0.30 14.26 0.53 100.00
3 INT236865 Positive_regulation of AURKC 3 0.57 18.45 0.54 100.00
4 INT269743 Positive_regulation of Binding of BPHL 1 0.19 2.94 0.13 100.00
5 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 100.00
6 INT236872 Regulation of BPHL 6 0.16 6.52 1.14 99.96
7 INT118610 Localization of BPHL 6 0.57 6.88 0.33 99.88
8 INT126794 Binding of SRD5A1 2 0.36 3.26 0.22 99.66
9 INT335 Binding of Adra1a 16 0.36 6.16 6 99.66
10 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 99.58
11 INT287456 Binding of BCL2L10 9 0.42 4.66 0.19 99.40
12 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 99.40
13 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 99.30
14 INT108554 Gene_expression of BCL2L10 6 0.58 3.18 1.25 99.16
15 INT236867 Gene_expression of AURKC 6 0.55 31.96 1.86 99.08
16 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 98.94
17 INT18680 Positive_regulation of Gene_expression of Sst 4 0.45 1.94 1.41 98.94
18 INT153349 Binding of Bcl2l10 1 0.07 1.38 0.15 98.88
19 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 98.52
20 INT236876 Negative_regulation of Localization of SRD5A1 1 0.41 0.81 0.06 98.48
21 INT236875 Localization of SRD5A1 2 0.73 0.8 0.11 98.48
22 INT98445 Negative_regulation of BPHL 7 0.32 7.24 1.08 98.32
23 INT236868 Negative_regulation of AURKC 3 0.48 12.2 1.46 98.20
24 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 97.72
25 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 97.68
26 INT293632 Positive_regulation of Gene_expression of BCL2L10 1 0.44 0.62 0 97.64
27 INT19177 Negative_regulation of GRHPR 19 0.53 12.65 2.71 97.64
28 INT237382 Localization of VUR 11 0.72 14.58 0.11 97.56
29 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 97.32
30 INT293633 Localization of BCL2L10 1 0.65 1.02 0 96.48
31 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 96.40
32 INT21572 Gene_expression of Pebp1 9 0.71 2.52 3.3 95.44
33 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65 95.12
34 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 95.04
35 INT155827 Gene_expression of Dre 2 0.50 1.46 0.05 94.88
36 INT287448 Gene_expression of Tagln 6 0.65 3.73 0.16 94.72
37 INT287444 Regulation of Gene_expression of Tagln 1 0.17 0.44 0 94.72
38 INT14888 Gene_expression of PSS 9 0.66 6.9 1.65 94.48
39 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 94.08
40 INT102992 Regulation of Negative_regulation of SRD5A1 4 0.60 3.59 0.29 93.28
41 INT7523 Regulation of ADRA1D 42 0.45 11.63 14.52 93.28
42 INT223278 Positive_regulation of Binding of TERT 2 0.44 1.35 0 93.24
43 INT236877 Negative_regulation of Gene_expression of BPHL 12 0.32 16.43 0.56 93.08
44 INT6521 Negative_regulation of Gene_expression of ADRA1D 4 0.57 3.19 2.14 92.64
45 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 92.64
46 INT38625 Gene_expression of ELL 8 0.58 12.53 1 92.44
47 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 92.28
48 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 92.16
49 INT125029 Binding of PARN 1 0.36 0.18 0 91.80
50 INT287442 Gene_expression of Optn 1 0.47 2.64 0.22 91.60
51 INT168262 Positive_regulation of Gene_expression of BPHL 10 0.24 10.72 0.83 91.24
52 INT191343 Gene_expression of IDO1 23 0.55 11.3 4.81 90.96
53 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 90.80
54 INT147607 Binding of TERT 16 0.48 12.36 1.31 90.80
55 INT86247 Gene_expression of Bcl2l10 14 0.34 12.21 1.61 88.48
56 INT236864 Regulation of Gene_expression of BPHL 4 0.19 3.87 0.09 87.76
57 INT160568 Positive_regulation of PADI4 7 0.45 10.5 0.41 87.60
58 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 86.16
59 INT26833 Negative_regulation of P2rx1 9 0.41 1.5 2.89 85.36
60 INT229632 Binding of PADI4 21 0.48 37.45 0.34 84.72
61 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69 84.08
62 INT118270 Regulation of P2RY2 16 0.45 7.02 3.45 83.88
63 INT125028 Binding of NBL1 1 0.36 0.34 0 83.52
64 INT236874 Regulation of AURKC 3 0.37 2.83 0.09 83.36
65 INT78320 Gene_expression of EPCAM 57 0.75 50.34 7.53 83.32
66 INT256048 Negative_regulation of Gene_expression of EPCAM 7 0.41 4.37 0.57 83.32
67 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 83.20
68 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 83.12
69 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 83.12
70 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 82.68
71 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 82.60
72 INT236878 Regulation of Gene_expression of AURKC 3 0.15 2.33 0.09 82.52
73 INT38672 Binding of KRT20 69 0.39 48.01 6.31 82.44
74 INT110210 Negative_regulation of CSRP1 12 0.59 8.96 2.81 82.36
75 INT198405 Binding of CDX2 1 0.32 1.01 0 82.08
76 INT128882 Negative_regulation of Lgals1 2 0.42 0.96 0.41 81.68
77 INT236871 Binding of AURKC 2 0.39 8.53 0.83 81.36
78 INT151097 Positive_regulation of BCL2L10 3 0.44 1.43 0 80.68
79 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 80.08
80 INT236869 Negative_regulation of Negative_regulation of SRD5A1 2 0.41 2.68 0 79.96
81 INT284122 Gene_expression of ZNF845 6 0.07 6.67 0.27 79.36
82 INT226453 Positive_regulation of Gene_expression of IL15 9 0.24 12.66 2.38 77.44
83 INT167608 Regulation of Rock2 2 0.33 2.47 0.59 77.36
84 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 76.88
85 INT236870 Positive_regulation of Gene_expression of AURKC 3 0.41 10.18 0.35 76.56
86 INT143991 Gene_expression of Prdx2 5 0.61 1.54 0.22 76.28
87 INT102036 Positive_regulation of Dre 12 0.59 4.41 2.4 76.16
88 INT269741 Positive_regulation of Localization of PDE5A 1 0.04 0.65 0 75.68
89 INT194546 Positive_regulation of Gene_expression of Dbp 9 0.28 2.93 0.36 75.52
90 INT22066 Gene_expression of Phax 40 0.78 22.51 25.91 75.00
91 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 74.96
92 INT114840 Gene_expression of Lgals1 9 0.76 3.94 1.94 74.88
93 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 74.52
94 INT76621 Positive_regulation of Cnr2 32 0.69 17.77 26.57 74.00
95 INT240748 Positive_regulation of Gene_expression of VUR 2 0.41 6.74 0.32 73.36
96 INT152060 Gene_expression of VUR 75 0.67 83.83 2.34 73.36
97 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 73.36
98 INT244255 Negative_regulation of Gene_expression of VUR 5 0.35 3.32 0.32 72.96
99 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 71.76
100 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 71.76
101 INT168446 Gene_expression of Prep 25 0.64 15.17 5.94 71.68
102 INT227524 Positive_regulation of Gene_expression of Prep 13 0.48 7.69 3.28 71.68
103 INT242944 Negative_regulation of Localization of PDE5A 3 0.35 3.18 0.59 71.28
104 INT242945 Localization of PDE5A 9 0.75 4.57 1.28 71.28
105 INT275891 Negative_regulation of Localization of BPHL 1 0.19 0.98 0.05 70.56
106 INT214 Localization of AVP 370 0.81 208.51 91.09 70.40
107 INT269744 Negative_regulation of Binding of PDE5A 2 0.43 0.74 0 69.84
108 INT200441 Negative_regulation of Gene_expression of AES 1 0.36 1.56 0 69.68
109 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 69.60
110 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 69.52
111 INT14764 Negative_regulation of Localization of Nppa 28 0.59 11.29 12.82 69.52
112 INT6852 Localization of TNF 883 0.81 705.95 270.84 69.32
113 INT6849 Localization of IL1B 229 0.81 112.56 69.63 69.32
114 INT654 Localization of REN 250 0.81 75.12 47.86 69.20
115 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 68.08
116 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 67.60
117 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 66.72
118 INT5617 Localization of Nppa 266 0.81 83.51 83.89 66.64
119 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45 66.64
120 INT270331 Negative_regulation of CLNK 1 0.05 0.7 0.03 65.92
121 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 65.92
122 INT265085 Binding of OR5BS1P 1 0.04 0.77 0.05 64.76
123 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 61.32
124 INT33781 Binding of Pebp1 11 0.44 1.76 6.61 60.72
125 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 58.96
126 INT159956 Phosphorylation of Rock2 3 0.79 1.57 0.2 58.28
127 INT301343 Negative_regulation of Positive_regulation of ELL 1 0.08 1.64 0.17 57.44
128 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 57.16
129 INT48364 Localization of Dre 2 0.34 1.65 0.09 56.00
130 INT159936 Positive_regulation of Shc4 8 0.50 3.43 0.04 55.44
131 INT146107 Positive_regulation of Lrp1 4 0.37 1.91 0.34 54.64
132 INT138689 Positive_regulation of Rrbp1 8 0.46 2.61 0.34 54.24
133 INT126627 Gene_expression of Rock2 9 0.60 3.33 0.32 54.24
134 INT22269 Gene_expression of IGKV1-5 32 0.50 1.71 1.95 53.28
135 INT238096 Positive_regulation of ELL 4 0.09 2.68 0.16 52.32
136 INT25834 Positive_regulation of Dbp 59 0.68 24.34 9.32 49.96
137 INT17880 Positive_regulation of TPR 3 0.40 0.84 0.51 49.96
138 INT241491 Positive_regulation of Regulation of Dbp 1 0.05 0.13 0.07 49.96
139 INT29231 Regulation of Dbp 44 0.53 10.08 4.47 49.64
140 INT38388 Regulation of TPR 3 0.23 0.75 0.19 49.64
141 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 47.84
142 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 47.84
143 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 46.32
144 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 46.20
145 INT306177 Regulation of Gene_expression of Rock2 1 0.26 0.84 0 44.04
146 INT212562 Positive_regulation of Adrm1 16 0.10 5.08 0.62 43.84
147 INT278078 Regulation of Positive_regulation of AURKC 1 0.37 2.03 0 43.36
148 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 41.12
149 INT234095 Gene_expression of Rrbp1 7 0.27 2.42 0.82 39.76
150 INT339896 Negative_regulation of Gene_expression of Rrbp1 1 0.02 0.97 0 39.76
151 INT339895 Positive_regulation of Gene_expression of Rrbp1 1 0.02 0.96 0 39.76
152 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4 39.32
153 INT339892 Positive_regulation of Bnc1 1 0.17 3.82 0.15 39.28
154 INT339894 Negative_regulation of Positive_regulation of Bnc1 1 0.11 0.96 0 39.28
155 INT44972 Negative_regulation of Gfra1 16 0.58 10.17 0.93 38.72
156 INT17817 Binding of VUR 41 0.48 46.85 0.95 36.44
157 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2 27.88
158 INT236873 Positive_regulation of Localization of AURKC 1 0.17 1.43 0 27.60
159 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 26.72
160 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 26.72
161 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 25.68
162 INT178987 Positive_regulation of Positive_regulation of TIMP1 5 0.20 2.81 0.83 25.68
163 INT236866 Localization of AURKC 2 0.61 2.22 0 24.84
164 INT274377 Localization of TERT 3 0.70 0.78 0 24.32
165 INT183933 Binding of CD68 8 0.31 8.74 1.06 23.36
166 INT21682 Binding of CD34 18 0.47 13.19 1.47 22.64
167 INT228148 Localization of Sepp1 2 0.39 0.89 0.03 22.32
168 INT261279 Localization of GNAQ 1 0.05 1.1 0 22.32
169 INT59784 Binding of DES 22 0.47 19.48 2.27 22.16
170 INT38379 Positive_regulation of VUR 15 0.58 15 0.71 21.92
171 INT9482 Positive_regulation of Gene_expression of Jun 60 0.69 9.95 18.61 21.60
172 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24 21.60
173 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61 21.60
174 INT131931 Binding of KRT7 13 0.36 19.24 0.5 21.52
175 INT349053 Binding of ZNF845 1 0.04 0.22 0 20.96
176 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54 20.92
177 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 20.92
178 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14 18.80
179 INT47764 Binding of Jun 106 0.48 22.62 31.39 18.52
180 INT116265 Binding of Myc 9 0.36 4.28 1.36 18.52
181 INT137690 Negative_regulation of Gene_expression of Ncam1 3 0.50 3.37 2.18 16.44
182 INT18672 Gene_expression of Ncam1 54 0.78 36.64 18.79 15.72
183 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 15.44
184 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82 15.20
185 INT102071 Negative_regulation of Gene_expression of Myc 8 0.57 3.5 0.22 15.20
186 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 14.88
187 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53 14.16
188 INT221108 Negative_regulation of Slc11a1 5 0.33 3.76 0.69 11.08
189 INT50308 Binding of Cnr1 61 0.48 14.41 33.52 10.28
190 INT85144 Binding of Cnr2 14 0.47 6.41 9.49 10.28
191 INT117313 Negative_regulation of VUR 11 0.42 12.14 0.39 10.24
192 INT244254 Negative_regulation of Positive_regulation of VUR 1 0.35 0.75 0 10.24
193 INT264641 Binding of AES 25 0.42 18.56 6.98 7.52
194 INT265083 Regulation of OR5BS1P 1 0.02 1.05 0.13 5.80
195 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.64
196 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.64
197 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 5.64
198 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 5.60
199 INT278079 Positive_regulation of Positive_regulation of PVR 1 0.17 2.24 0.49 5.36
200 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
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