D:Lung Cancer

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Disease Term
Synonyms Alveolar Soft Part Sarcoma, Alveolar Soft Part Sarcomata, CANCER LUNG, Cancer Of Lung, CANCER OF THE LUNG, CANCER PULMONARY, Cancers Lung, Cancers Pulmonary, Lung Cancer Susceptibility, Lung Cancers, Lung Carcinoma
Documents 4000
Hot Single Events 200
Hot Interactions 183

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lung Cancer. They are ordered first by their relevance to Lung Cancer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21 100.00
2 INT116466 Vegfa Positive_regulation of Amfr 1 0.07 1.41 0.21 100.00
3 INT116469 VEGFA Positive_regulation of Amfr 1 0.01 1.39 0.21 100.00
4 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21 100.00
5 INT324057 Fn1 Positive_regulation of Gene_expression of Mmp9 1 0.04 1.55 0 100.00
6 INT286769 Tusc2 Regulation of Foxm1 1 0.02 1.55 0.15 100.00
7 INT341632 Binding of EGFR and FOXM1 1 0.02 0.56 0 100.00
8 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24 100.00
9 INT290675 SPP1 Positive_regulation of Gene_expression of VEGFA 1 0.16 2.37 0 100.00
10 INT245119 Negative_regulation of RBM45 Negative_regulation of CDKN2B 1 0.01 1.43 0.08 99.92
11 INT319173 TXN Positive_regulation of Gene_expression of SOD2 1 0.23 0.1 0.18 99.84
12 INT243281 Binding of IGKV2D-38 and AIRN 1 0.20 0.1 0 99.76
13 INT150787 ZNF398 Positive_regulation of Gene_expression of SPARC 1 0.13 1.02 1.05 99.60
14 INT233855 Binding of Ppara and Mapk7 1 0.09 0.9 0.05 99.52
15 INT196348 PTGER2 Negative_regulation of Negative_regulation of MMP2 1 0.01 0.29 0.43 99.52
16 INT106809 ZNF398 Positive_regulation of Transcription of RECK 1 0.02 0.5 1.01 99.40
17 INT159188 Binding of IL6 and VEGFA 1 0.21 0.58 0.08 99.36
18 INT315066 AKT1 Negative_regulation of PAR4 1 0.39 1.8 0.03 99.20
19 INT106810 ZNF398 Positive_regulation of RECK 1 0.02 0.5 1.01 99.16
20 INT197576 Loh1 Positive_regulation of NFE2L2 1 0.49 1.1 0 99.16
21 INT70444 Binding of SGCG and TMED4 1 0.17 0.61 0 99.12
22 INT99602 ZNF398 Negative_regulation of MMP2 1 0.14 0.85 0.63 99.12
23 INT99599 ZNF398 Negative_regulation of NR4A2 1 0.05 0.41 0.3 99.12
24 INT99601 ZNF398 Negative_regulation of Transcription of MMP2 1 0.10 0.41 0.3 99.12
25 INT99600 ZNF398 Negative_regulation of Transcription of NR4A2 1 0.10 0.41 0.3 99.12
26 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18 99.04
27 INT235304 Binding of Aldh1a1 and Cpa1 1 0.12 0.86 0 99.04
28 INT235305 Binding of Aldh3a1 and Cpa1 1 0.12 0.86 0 99.04
29 INT251776 Negative_regulation of TXK Negative_regulation of ERBB4 1 0.04 1.07 0.06 98.88
30 INT326164 Binding of S100A2 and Scrib 1 0.01 1.16 0 98.78
31 INT245118 RBM45 Negative_regulation of CDKN2B 1 0.01 1.41 0.08 98.72
32 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 98.68
33 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18 98.68
34 INT293055 Binding of ANXA5 and PRSS1 1 0.00 0.59 0 98.66
35 INT274469 IL12A Positive_regulation of Gene_expression of IL6 1 0.04 1.39 0.06 98.62
36 INT315068 Binding of AKT1 and PAR4 1 0.34 4.41 0 98.52
37 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06 98.28
38 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54 98.04
39 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54 98.04
40 INT240271 Binding of GDNF and RET 1 0.09 1.04 0 97.64
41 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05 97.48
42 INT302179 PTGER2 Positive_regulation of Phosphorylation of IFI27 1 0.05 0.75 0 97.36
43 INT302126 PTGER2 Positive_regulation of SRC 1 0.11 1.08 0.03 97.28
44 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13 97.16
45 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13 97.16
46 INT263100 Binding of EFS and COPD 1 0.14 4.14 0.07 96.96
47 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 96.72
48 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 96.72
49 INT334323 IL8 Positive_regulation of EGFR 1 0.50 1.29 0 96.52
50 INT334319 IL8 Positive_regulation of MAPK1 1 0.25 1.29 0 96.52
51 INT341631 EGFR Positive_regulation of TXK 1 0.05 0.42 0 96.48
52 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77 96.38
53 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 96.36
54 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 96.08
55 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 96.08
56 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 96.08
57 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77 95.76
58 INT298193 AKT1 Regulation of IST1 1 0.00 0.3 0 95.76
59 INT298190 AKT1 Regulation of MPHOSPH6 1 0.00 0.3 0 95.76
60 INT260070 Binding of PHF2 and SPTLC1 1 0.17 1.93 0.1 95.64
61 INT189956 TP53 Positive_regulation of Gene_expression of Pttg1 1 0.06 1.21 0 95.40
62 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76 95.28
63 INT286770 Skil Negative_regulation of Egr1 1 0.08 0.75 0 95.28
64 INT286766 Tusc2 Positive_regulation of Gene_expression of Il15 1 0.28 1.73 0 95.12
65 INT251777 Negative_regulation of TXK Positive_regulation of PDGFA 1 0.04 1 0.08 94.96
66 INT251773 TXK Positive_regulation of PDGFA 1 0.04 1 0.08 94.96
67 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05 94.96
68 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05 94.96
69 INT164263 TGM7 Negative_regulation of CCND3 1 0.04 1.08 0.54 94.92
70 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53 94.92
71 INT164264 TGM7 Negative_regulation of CCNB1 1 0.07 1.08 0.53 94.92
72 INT164262 TGM7 Negative_regulation of E2F1 1 0.16 1.08 0.53 94.92
73 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54 94.92
74 INT232594 CDH1 Regulation of HEPACAM 1 0.01 1.02 0 94.12
75 INT286771 Ros1 Regulation of Gene_expression of Tusc2 1 0.01 0.66 0 94.08
76 INT150793 ZNF398 Negative_regulation of Gene_expression of DNMT1 1 0.07 0.46 0.48 93.68
77 INT227670 EGF Positive_regulation of Gene_expression of ISYNA1 1 0.01 2.92 0 93.64
78 INT197552 GSTK1 Positive_regulation of NQO1 1 0.09 1.06 0 93.52
79 INT345307 CXCL12 Positive_regulation of Gene_expression of MMP15 1 0.00 2.5 0.05 93.36
80 INT337536 Binding of Klrk1 and COPD 1 0.03 3.09 0.09 93.28
81 INT302142 PTGER3 Positive_regulation of SRC 1 0.09 1.07 0 93.24
82 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07 93.04
83 INT150784 ZNF398 Positive_regulation of Localization of THBS3 1 0.07 1.02 1.07 93.04
84 INT150782 ZNF398 Positive_regulation of THBS3 Negative_regulation of SPARC 1 0.05 0.51 0.54 93.04
85 INT150795 ZNF398 Positive_regulation of Localization of TIMP2 1 0.06 0.51 0.53 93.04
86 INT150790 ZNF398 Positive_regulation of Localization of MMP2 1 0.04 0.51 0.53 93.04
87 INT150797 ZNF398 Positive_regulation of THBS3 1 0.07 0.5 0.52 93.04
88 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52 93.04
89 INT150783 ZNF398 Positive_regulation of THBS1 Negative_regulation of TIMP2 1 0.04 0.5 0.52 93.04
90 INT150799 ZNF398 Positive_regulation of TIMP2 1 0.09 0.49 0.51 93.04
91 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09 92.92
92 INT318189 MUC5AC Regulation of Gene_expression of VEGFA 1 0.21 1.17 0.22 92.64
93 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45 92.16
94 INT244116 ELAVL3 Negative_regulation of MUC1 1 0.09 3.41 0.15 91.92
95 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 91.76
96 INT336926 Mir341 Regulation of Tlr4 1 0.02 1.57 0.41 91.68
97 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16 91.40
98 INT306822 Binding of E2F2 and GOPC 1 0.05 0.53 0.35 91.36
99 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28 91.32
100 INT298396 CEBPB Regulation of MIR155 1 0.01 1.06 0 91.28
101 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05 91.04
102 INT286767 Binding of Abl1 and Tusc2 1 0.54 1.04 0.03 91.04
103 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52 90.96
104 INT150798 THBS3 Negative_regulation of TIMP2 1 0.18 0.49 0.52 90.96
105 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0 90.88
106 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54 90.80
107 INT266402 Binding of S100P and Ager 1 0.00 2.25 0.35 90.56
108 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52 90.32
109 INT150792 THBS3 Negative_regulation of MMP2 1 0.11 0.49 0.51 90.32
110 INT211883 Binding of RET and CDCP1 1 0.00 2.12 0 90.32
111 INT302174 Positive_regulation of SRC Positive_regulation of Phosphorylation of STAT3 1 0.11 1.01 0 90.12
112 INT286772 Binding of Irf7 and Tusc2 1 0.20 0.17 0 89.96
113 INT315061 PAR4 Positive_regulation of Gene_expression of TNF 1 0.10 1.95 0 89.52
114 INT238406 Binding of ELANE and PPARA 1 0.07 0.43 0 89.52
115 INT266403 Negative_regulation of Binding of S100P and Ager 1 0.00 0.74 0.13 89.36
116 INT198006 ERI3 Negative_regulation of MCL1 1 0.01 1.63 0 89.32
117 INT292459 Phosphorylation of BAD Negative_regulation of Binding of BCL2L1 1 0.02 0.82 0 89.16
118 INT271852 Ngf Positive_regulation of Gene_expression of tf 1 0.34 1.36 0.21 89.08
119 INT271853 Ngf Positive_regulation of Gene_expression of Egr1 1 0.53 1.36 0.21 89.08
120 INT211882 Binding of KIT and CDCP1 1 0.00 2.1 0 89.04
121 INT302171 PTGER4 Positive_regulation of RASGRP1 1 0.01 1.03 0.03 89.00
122 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39 88.88
123 INT175399 Binding of TP53 and SACM1L 1 0.00 2.37 0 88.68
124 INT327341 VEGFA Regulation of Elavl1 1 0.08 1.27 0 88.52
125 INT327335 VEGFA Regulation of Binding of Elavl1 1 0.08 1.27 0 88.52
126 INT292447 Negative_regulation of Binding of BAD and BCL2L1 1 0.02 0.81 0 88.52
127 INT292458 Negative_regulation of Binding of BAD and BCL2 1 0.01 0.81 0 88.52
128 INT292454 Binding of BAD and BCL2 2 0.03 1.73 0 88.16
129 INT185856 Binding of BAD and BCL2L1 4 0.39 2.73 0 88.16
130 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17 87.96
131 INT252893 PTTG1 Positive_regulation of Gene_expression of TAF9 1 0.21 0.9 0 87.96
132 INT144030 STAT3 Regulation of CCND1 2 0.09 1.05 0 87.72
133 INT302154 STAT3 Regulation of Transcription of CCND1 1 0.04 0.99 0 87.72
134 INT261626 Binding of CHRNA5 and MAOA 1 0.22 1.6 0.17 87.52
135 INT324909 Negative_regulation of TP53 Positive_regulation of Negative_regulation of BAX 1 0.36 1.33 0 86.72
136 INT197545 KEAP1 Regulation of NFE2L2 3 0.49 0.8 0 86.68
137 INT302153 PTGER2 Positive_regulation of Localization of AREG 1 0.06 1.1 0.03 86.68
138 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9 86.56
139 INT73462 PTPLA Regulation of Gene_expression of SART1 1 0.00 0.79 0.82 86.48
140 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0 86.16
141 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06 85.44
142 INT150800 THBS3 Negative_regulation of SPARC 1 0.23 0.51 0.53 85.44
143 INT316250 Negative_regulation of DBT Negative_regulation of Gene_expression of TRPM8 1 0.11 1.06 0 85.36
144 INT108841 RXRG Positive_regulation of GDF15 1 0.41 0.58 0.24 85.32
145 INT244472 CS Negative_regulation of Binding of XBP1 1 0.19 1.07 0 85.20
146 INT353108 Binding of VEGFA and Pgf 1 0.02 2.17 0 84.84
147 INT353107 Binding of VEGFA and Vegfb 1 0.02 1.08 0 84.84
148 INT101813 KEAP1 Negative_regulation of NFE2L2 3 0.47 1.63 0.28 84.56
149 INT75769 Egf Positive_regulation of Cpox 1 0.26 0.76 0.31 84.20
150 INT303651 Binding of SSTR2 and SSTR5 1 0.24 0.23 0.45 84.16
151 INT339699 LDLR Positive_regulation of SREBF2 1 0.08 1.08 0 84.08
152 INT339694 LDLR Positive_regulation of Gene_expression of SREBF2 1 0.08 1.08 0 84.08
153 INT201379 RARS Regulation of Gene_expression of CPOX 1 0.04 0.23 0.03 84.08
154 INT175400 RASGRP1 Positive_regulation of MAP3K5 1 0.00 1.2 0 84.08
155 INT339693 HMGCR Positive_regulation of SREBF2 1 0.05 0.54 0 84.08
156 INT339709 HMGCR Positive_regulation of Gene_expression of SREBF2 1 0.05 0.54 0 84.08
157 INT264733 Hes1 Regulation of Mir199b 1 0.05 0.43 0 84.04
158 INT109539 Lox Negative_regulation of VEGFA 1 0.40 0.68 0.25 83.92
159 INT205480 Egfr Positive_regulation of Stat3 5 0.58 4.11 0.03 83.76
160 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 83.52
161 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 83.12
162 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07 83.04
163 INT268673 Binding of NCOR2 and BCOR 1 0.01 2.54 0.07 83.04
164 INT268675 Binding of NCOR2 and SIN3A 1 0.27 2.54 0.07 83.04
165 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07 83.04
166 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 82.88
167 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 82.88
168 INT302291 Positive_regulation of EGFR Positive_regulation of Myc 1 0.18 1.3 0.04 82.48
169 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34 82.24
170 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33 82.24
171 INT324908 TP53 Regulation of Gene_expression of BAX 1 0.47 1.33 0 82.16
172 INT189546 Binding of CD9 and FN1 1 0.01 0.6 0 81.60
173 INT268676 Binding of HDAC1 and BCOR 1 0.01 1.31 0.04 81.52
174 INT99603 ZNF398 Regulation of Transcription of MMP2 1 0.15 0.44 0.33 81.48
175 INT227700 MET Positive_regulation of Stat3 1 0.04 0.8 0.03 81.36
176 INT279965 STAT3 Regulation of Transcription of BCL2L1 1 0.10 2.31 0.19 81.20
177 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 81.08
178 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 81.08
179 INT101810 Binding of NFE2L2 and KEAP1 7 0.53 4.12 0.29 81.04
180 INT252900 PTTG1 Regulation of Gene_expression of TAF9 1 0.20 0.84 0 80.68
181 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0 80.48
182 INT188204 Negative_regulation of IL6 Positive_regulation of STAT3 1 0.28 0.54 0.34 80.48
183 INT298195 Negative_regulation of EGFR Regulation of IFI27 1 0.08 0.58 0 80.40
184 INT306830 E2F2 Regulation of C1orf61 1 0.02 0.48 0.36 79.84
185 INT298191 EGFR Regulation of IFI27 1 0.05 1.14 0 79.56
186 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0 79.56
187 INT266661 AKT1 Regulation of BAD 2 0.10 1.86 0.03 79.36
188 INT292444 BAD Positive_regulation of Phosphorylation of PTK2 1 0.13 0.9 0 79.16
189 INT109538 Lox Negative_regulation of Transcription of VEGFA 1 0.30 0.69 0.26 78.96
190 INT106808 RECK Negative_regulation of MMP2 1 0.40 0.5 0.83 78.88
191 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82 78.60
192 INT225556 Binding of Ncoa6 and Cytip 1 0.12 1.7 0.04 78.56
193 INT225569 Binding of Ncoa6 and Ep300 1 0.18 0.63 0.04 78.56
194 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 78.40
195 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96 77.96
196 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95 77.96
197 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94 77.96
198 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33 77.88
199 INT312372 Binding of MME and TCHP 1 0.06 1.56 0 77.32
200 INT217149 MIR20A Regulation of Gene_expression of E2F1 1 0.19 0.86 0 76.72

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lung Cancer. They are ordered first by their pain relevance and then by number of times they were reported in Lung Cancer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT286757 Gene_expression of Tusc2 1 0.77 44.57 1.56 100.00
2 INT83735 Gene_expression of Foxm1 41 0.77 22.9 5.07 100.00
3 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 100.00
4 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 100.00
5 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 100.00
6 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 100.00
7 INT286754 Negative_regulation of Gene_expression of Tusc2 1 0.58 8.91 0.44 100.00
8 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82 100.00
9 INT113203 Regulation of Foxm1 8 0.34 7.5 2.36 100.00
10 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13 100.00
11 INT50337 Negative_regulation of Foxm1 24 0.43 11.12 6.48 100.00
12 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 100.00
13 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 100.00
14 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 100.00
15 INT219961 Negative_regulation of SPAG9 1 0.14 3.29 0.08 100.00
16 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 100.00
17 INT201239 Gene_expression of FOXM1 9 0.51 4.07 0.19 100.00
18 INT125627 Gene_expression of TTF1 11 0.78 12.68 0.78 100.00
19 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 100.00
20 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 100.00
21 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 100.00
22 INT219958 Gene_expression of SPAG9 4 0.38 2.53 0 100.00
23 INT129492 Gene_expression of Hpse 11 0.75 6.56 1.59 100.00
24 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 100.00
25 INT203749 Binding of FOXM1 10 0.31 6.1 0.64 100.00
26 INT244511 Regulation of EIF2S2 1 0.37 4.46 0 100.00
27 INT234206 Localization of HSP90AA1 4 0.68 2.89 0.06 100.00
28 INT277186 Localization of HSPA8 1 0.30 1.27 0.04 100.00
29 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 100.00
30 INT32431 Gene_expression of HTC2 17 0.75 9.72 1.93 100.00
31 INT206006 Negative_regulation of Gene_expression of Foxm1 4 0.43 2.63 0.56 100.00
32 INT219963 Positive_regulation of SPAG9 2 0.15 2.38 0.03 100.00
33 INT153327 Gene_expression of Aspscr1 5 0.57 3.28 0.91 100.00
34 INT189944 Negative_regulation of Gene_expression of Pttg1 4 0.42 4.53 0 100.00
35 INT50335 Positive_regulation of Foxm1 20 0.69 5.11 2.81 100.00
36 INT249785 Positive_regulation of Gene_expression of Foxm1 13 0.69 4.71 0.36 100.00
37 INT219962 Localization of SPAG9 1 0.18 0.95 0.03 100.00
38 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 100.00
39 INT221827 Negative_regulation of BPIFA1 1 0.01 1.56 0 100.00
40 INT56085 Binding of PNO1 1 0.10 0.77 0.06 100.00
41 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 100.00
42 INT113432 Regulation of Gene_expression of UCHL1 1 0.24 0.6 0.06 100.00
43 INT178962 Gene_expression of Oca2 15 0.19 5.15 0.38 100.00
44 INT252954 Positive_regulation of Gene_expression of Oca2 2 0.03 2.21 0 100.00
45 INT221832 Negative_regulation of Negative_regulation of BPIFA1 1 0.01 1.07 0 100.00
46 INT144266 Gene_expression of ELAVL3 4 0.65 1.98 0.12 100.00
47 INT274757 Negative_regulation of Positive_regulation of ASPSCR1 1 0.26 1.15 0 100.00
48 INT274759 Negative_regulation of ASPSCR1 1 0.26 1.1 0 100.00
49 INT274760 Negative_regulation of Gene_expression of ASPSCR1 1 0.26 1.1 0 100.00
50 INT249769 Localization of Foxm1 6 0.74 1.13 0 100.00
51 INT96141 Gene_expression of ASPSCR1 9 0.68 11.46 1.29 100.00
52 INT274758 Positive_regulation of Gene_expression of ASPSCR1 1 0.30 1.13 0 100.00
53 INT219964 Regulation of SPAG9 1 0.11 1.04 0.13 100.00
54 INT192519 Positive_regulation of ASPSCR1 2 0.30 2.17 0 100.00
55 INT175994 Negative_regulation of HEPACAM 3 0.18 2.02 0.28 100.00
56 INT240711 Gene_expression of Srsf1 3 0.67 1.99 0.03 100.00
57 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 100.00
58 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 100.00
59 INT1901 Binding of Mefv 24 0.48 32.26 4.5 100.00
60 INT67670 Regulation of SCLC1 3 0.21 1.6 0.59 100.00
61 INT214241 Positive_regulation of Magea3 1 0.02 0.72 0 100.00
62 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.98
63 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.98
64 INT39877 Positive_regulation of EPX 13 0.69 6.01 1.21 99.98
65 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 99.98
66 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 99.98
67 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 99.98
68 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57 99.98
69 INT189948 Gene_expression of Pttg1 106 0.76 104.68 1.41 99.96
70 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 99.96
71 INT61292 Positive_regulation of Gene_expression of Fn1 16 0.35 10.25 0.76 99.96
72 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 99.96
73 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 99.96
74 INT66227 Gene_expression of COX18 41 0.50 26.91 6.26 99.96
75 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 99.96
76 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 99.96
77 INT244562 Gene_expression of EIF2S2 1 0.46 23.74 0 99.92
78 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 99.92
79 INT64176 Transcription of CPOX 35 0.41 15.1 5.5 99.92
80 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 99.92
81 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 99.92
82 INT244118 Negative_regulation of ELAVL3 1 0.17 3.77 0.19 99.92
83 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12 99.92
84 INT205021 Positive_regulation of Gene_expression of Egfr 3 0.64 4.15 0.05 99.92
85 INT245122 Negative_regulation of Gene_expression of RBM45 1 0.42 1.43 0.08 99.92
86 INT245120 Negative_regulation of RBM45 1 0.42 1.42 0.08 99.92
87 INT172479 Positive_regulation of NFE2L2 74 0.70 35.22 0.79 99.90
88 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 99.90
89 INT3364 Binding of SGCG 87 0.47 31.93 17.24 99.90
90 INT82168 Positive_regulation of S100b 20 0.68 9.72 3.08 99.90
91 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 99.88
92 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.88
93 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 99.88
94 INT112363 Regulation of Gene_expression of HIF1A 6 0.60 2.28 0.61 99.88
95 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 99.86
96 INT286745 Positive_regulation of Gene_expression of Tusc2 1 0.69 5.74 0.07 99.86
97 INT217166 Gene_expression of MIR17HG 7 0.58 7.09 0.29 99.86
98 INT217180 Positive_regulation of Gene_expression of MIR17HG 5 0.42 4.75 0.11 99.86
99 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 99.86
100 INT172808 Positive_regulation of Positive_regulation of ROS1 35 0.40 31.39 2.27 99.86
101 INT286761 Negative_regulation of Tusc2 1 0.58 21.23 1.36 99.84
102 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 99.84
103 INT286746 Regulation of Gene_expression of Tusc2 1 0.61 11.42 0.38 99.84
104 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49 99.84
105 INT101820 Negative_regulation of KEAP1 20 0.58 18.79 0.19 99.84
106 INT125871 Gene_expression of XIAP 5 0.65 11.46 1.46 99.84
107 INT125100 Positive_regulation of IL24 4 0.65 7.15 1.57 99.84
108 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39 99.84
109 INT260150 Gene_expression of MIR34C 1 0.19 10.17 0 99.84
110 INT277185 Gene_expression of BIRC7 1 0.07 4.7 0.12 99.84
111 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 99.84
112 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 99.84
113 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 99.84
114 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 99.84
115 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 99.84
116 INT206198 Negative_regulation of ESRRG 1 0.18 6.21 0 99.84
117 INT189949 Regulation of Gene_expression of Pttg1 1 0.60 6.84 0 99.84
118 INT197562 Positive_regulation of KEAP1 16 0.63 6.78 0.08 99.84
119 INT286758 Localization of Tusc2 1 0.80 1.73 0 99.84
120 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 99.84
121 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 99.84
122 INT189447 Positive_regulation of Gene_expression of MSLN 3 0.22 1.65 0 99.84
123 INT169172 Positive_regulation of XIAP 3 0.49 2.54 0.12 99.84
124 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37 99.84
125 INT52199 Regulation of Gene_expression of IFNA2 2 0.06 1.69 0.07 99.84
126 INT52198 Regulation of Gene_expression of Il28b 1 0.10 1.25 0 99.84
127 INT45668 Gene_expression of Il28b 3 0.15 2.66 0.16 99.84
128 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 99.84
129 INT286743 Negative_regulation of Loh1 2 0.02 1.19 0.07 99.84
130 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 99.84
131 INT189445 Positive_regulation of MSLN 20 0.37 3.5 0.3 99.84
132 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15 99.84
133 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17 99.84
134 INT99453 Gene_expression of SOD2 25 0.77 13.28 3.6 99.84
135 INT190454 Regulation of NANOG 2 0.30 1.29 0.17 99.84
136 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62 99.84
137 INT88008 Positive_regulation of Gene_expression of GDNF 14 0.70 8.9 3.61 99.84
138 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 99.84
139 INT189945 Localization of Pttg1 3 0.73 3.02 0.16 99.84
140 INT300362 Positive_regulation of MIR203 1 0.15 1.37 0 99.84
141 INT300379 Positive_regulation of MIR205 1 0.11 1.36 0 99.84
142 INT189579 Gene_expression of TM4SF1 1 0.27 1.94 0.03 99.84
143 INT300372 Positive_regulation of Gene_expression of MIR32 1 0.13 1.27 0 99.84
144 INT300341 Gene_expression of MIR32 1 0.16 1.27 0 99.84
145 INT152681 Gene_expression of PDPN 29 0.65 23.06 0.18 99.82
146 INT286747 Positive_regulation of Negative_regulation of Tusc2 1 0.50 2.34 0.16 99.80
147 INT286763 Regulation of Negative_regulation of Tusc2 1 0.27 1.44 0.16 99.80
148 INT258057 Gene_expression of MARCKSL1 1 0.08 3.7 0 99.80
149 INT61418 Positive_regulation of ITGAL 24 0.14 12.86 2.3 99.80
150 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 99.78
151 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61 99.78
152 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 99.78
153 INT181756 Positive_regulation of Erbb2 6 0.46 4.12 0.28 99.78
154 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 99.76
155 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 99.76
156 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 99.76
157 INT90674 Negative_regulation of LOX 56 0.57 38.01 8.58 99.76
158 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 99.76
159 INT189947 Regulation of Pttg1 4 0.49 7.18 0 99.76
160 INT244117 Binding of ELAVL3 1 0.15 5.2 0.42 99.76
161 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 99.76
162 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 99.76
163 INT184748 Phosphorylation of Gem 2 0.32 1.75 0.2 99.76
164 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 99.76
165 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01 99.76
166 INT174987 Binding of AIRN 12 0.32 6.79 1.21 99.76
167 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 99.74
168 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 99.74
169 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 99.72
170 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.72
171 INT62387 Gene_expression of PTX4 1 0.07 0.49 0.48 99.72
172 INT21631 Positive_regulation of Gene_expression of Adh1 4 0.70 12.56 0.39 99.70
173 INT116463 Negative_regulation of Gene_expression of Birc5 40 0.59 33.99 2.74 99.70
174 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 99.70
175 INT160121 Localization of PDPN 1 0.73 1.07 0.16 99.70
176 INT628 Negative_regulation of GAST 10 0.58 4.44 2.08 99.70
177 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 99.70
178 INT260152 Gene_expression of MIR34B 1 0.16 11.2 0 99.68
179 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 99.68
180 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 99.68
181 INT9210 Regulation of IL6 166 0.62 125.61 49.95 99.68
182 INT2243 Localization of GAST 67 0.81 34.54 16.19 99.68
183 INT260154 Negative_regulation of Gene_expression of MIR34B 1 0.09 1.04 0 99.68
184 INT189954 Negative_regulation of Positive_regulation of TCEAL1 2 0.07 2.03 0.04 99.68
185 INT38541 Binding of NEO1 1 0.33 0.68 0.33 99.68
186 INT10835 Regulation of IL8 79 0.49 53.04 24.14 99.68
187 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68 99.68
188 INT251797 Positive_regulation of ERBB4 3 0.33 3.14 0.06 99.68
189 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39 99.66
190 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 99.66
191 INT192807 Gene_expression of SSRP1 14 0.49 19.28 1.15 99.64
192 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 99.64
193 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26 99.64
194 INT12823 Positive_regulation of FAIM3 9 0.64 3.23 4.76 99.64
195 INT185352 Regulation of Gene_expression of Egfr 5 0.62 2.33 0.16 99.64
196 INT293487 Regulation of Gene_expression of Erbb2 4 0.61 3.4 1.06 99.64
197 INT171361 Regulation of Egfr 16 0.62 8.36 0.81 99.64
198 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34 99.64
199 INT178191 Regulation of Erbb2 7 0.36 4.11 0.24 99.64
200 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 99.62
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