D:Lyme Neuroborreliosis

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pChart

Disease Term
Synonyms Borrelia Burgdorferi Neuroborreliosis, Central Nervous System Lyme Disease, Encephalopathies Lyme Disease, Encephalopathy Lyme Disease, LYME BORRELIOSIS NERVOUS SYSTEM, LYME DISEASE CENTRAL NERVOUS SYSTEM, LYME DISEASE ENCEPHALOPATHIES, LYME DISEASE ENCEPHALOPATHY, LYME DISEASE MONONEURITIS MULTIPLEX, Lyme Disease Nervous System, Lyme Meningoencephalitis
Documents 46
Hot Single Events 51
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lyme Neuroborreliosis. They are ordered first by their relevance to Lyme Neuroborreliosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51 5.00
2 INT185279 Binding of CCND1 and CDK4 4 0.13 2.05 0.08 5.00
3 INT285909 AKT1 Regulation of Phosphorylation of Bad 1 0.01 0.4 0 5.00
4 INT285908 AKT1 Regulation of Pten 1 0.01 0.53 0 5.00
5 INT285878 Negative_regulation of Binding of CCND1 and CDK4 1 0.00 0.44 0 5.00
6 INT285910 Pten Regulation of AKT1 1 0.00 0.53 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lyme Neuroborreliosis. They are ordered first by their pain relevance and then by number of times they were reported in Lyme Neuroborreliosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94 99.92
2 INT89544 Phosphorylation of NEFL 2 0.79 1.05 0.86 99.92
3 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2 99.86
4 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 99.86
5 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37 99.84
6 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 99.84
7 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 99.72
8 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 99.72
9 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 99.68
10 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.66
11 INT89543 Gene_expression of NEFL 18 0.75 10.6 2.67 99.04
12 INT19511 Localization of Il6 212 0.81 118.17 67.67 98.52
13 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 98.40
14 INT236842 Positive_regulation of Gene_expression of CXCL13 6 0.32 3.91 2.55 98.16
15 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96 98.16
16 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 97.80
17 INT14301 Binding of CSF2 82 0.48 67.95 8.98 96.88
18 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 96.88
19 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 96.60
20 INT51474 Binding of Il6 55 0.48 44.99 20.52 96.48
21 INT10706 Regulation of Il6 150 0.62 93.23 62.34 96.20
22 INT182215 Regulation of CXCR5 4 0.27 4.49 2.18 95.92
23 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 94.64
24 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 94.64
25 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 94.56
26 INT58003 Localization of APP 32 0.80 13.75 4.2 92.72
27 INT14690 Localization of CSF2 124 0.80 85.17 27.26 91.84
28 INT70538 Regulation of Localization of CSF2 4 0.54 3.08 1.9 91.84
29 INT48393 Positive_regulation of Localization of CSF2 14 0.60 8.92 6.1 91.84
30 INT80237 Regulation of Copg2as2 1 0.00 0.64 0 90.88
31 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 90.68
32 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83 89.88
33 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 89.88
34 INT285900 Positive_regulation of Localization of MIP 1 0.49 1.09 0.17 89.88
35 INT285899 Positive_regulation of Localization of CCL3 1 0.12 1.08 0.17 89.88
36 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 89.24
37 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 89.24
38 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01 89.24
39 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14 89.24
40 INT65698 Localization of CCL2 118 0.81 77.54 32.69 88.64
41 INT12339 Localization of IL8 437 0.81 251.87 117.39 88.64
42 INT12082 Localization of IL6 365 0.81 241.78 105.78 88.64
43 INT91336 Localization of MIP 5 0.78 2.97 1.79 88.64
44 INT65699 Localization of CCL3 7 0.78 2.56 1.25 88.64
45 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 87.36
46 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 86.76
47 INT142958 Positive_regulation of Protein_catabolism of APP 3 0.55 2.04 0.1 84.04
48 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06 83.64
49 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 83.28
50 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41 81.76
51 INT41569 Regulation of APP 32 0.62 17.15 9.4 81.04
52 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 68.76
53 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 68.76
54 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 68.76
55 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 68.76
56 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35 68.76
57 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 68.08
58 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 68.08
59 INT19621 Positive_regulation of CD86 23 0.69 14 2.58 68.08
60 INT93912 Positive_regulation of CD80 11 0.56 7.01 1.88 68.08
61 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 60.40
62 INT133029 Regulation of TLR2 18 0.56 11.31 2.62 59.52
63 INT164189 Gene_expression of TREM1 82 0.62 60.77 5.85 52.84
64 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
65 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
66 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
67 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
68 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
69 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
70 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
71 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
72 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
73 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
74 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
75 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
76 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
77 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
78 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
79 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09 5.00
80 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
81 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65 5.00
82 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54 5.00
83 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46 5.00
84 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22 5.00
85 INT91337 Gene_expression of CCL4 29 0.75 16.23 8.64 5.00
86 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 5.00
87 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82 5.00
88 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86 5.00
89 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
90 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
91 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15 5.00
92 INT91327 Positive_regulation of CCL4 12 0.67 8.55 4.1 5.00
93 INT51654 Regulation of Bad 21 0.40 12.18 4.06 5.00
94 INT71681 Positive_regulation of Gene_expression of CCL3 8 0.54 8.21 2.41 5.00
95 INT120090 Positive_regulation of Gene_expression of CCL4 5 0.49 3.94 2.32 5.00
96 INT97748 Positive_regulation of BCL2L1 12 0.67 9.83 2.26 5.00
97 INT172874 Phosphorylation of Bad 31 0.80 27.46 2.07 5.00
98 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53 5.00
99 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42 5.00
100 INT190014 Regulation of Pten 8 0.62 6.03 1.2 5.00
101 INT185396 Gene_expression of PVRL1 17 0.34 15.18 1.18 5.00
102 INT98134 Binding of BAX 17 0.39 11.45 0.93 5.00
103 INT224156 Negative_regulation of Gene_expression of TREM1 7 0.32 4.93 0.9 5.00
104 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81 5.00
105 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79 5.00
106 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75 5.00
107 INT221040 Negative_regulation of Gene_expression of CCL3 2 0.20 1.19 0.53 5.00
108 INT285898 Negative_regulation of Gene_expression of CCL4 1 0.10 0.96 0.41 5.00
109 INT279985 Transcription of BCL2L1 5 0.69 3.76 0.34 5.00
110 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31 5.00
111 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29 5.00
112 INT200666 Transcription of AKT1 8 0.66 4.23 0.2 5.00
113 INT141488 Negative_regulation of GSK3B 3 0.24 1.59 0.16 5.00
114 INT285902 Positive_regulation of Transcription of AKT1 1 0.06 0.6 0.13 5.00
115 INT285904 Positive_regulation of Transcription of BCL2L1 1 0.05 0.95 0.13 5.00
116 INT185284 Binding of CDK4 7 0.25 4.79 0.07 5.00
117 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0 5.00
118 INT169427 Transcription of CDK2 2 0.09 0.42 0 5.00
119 INT285882 Gene_expression of Noxa1 1 0.01 0.5 0 5.00
120 INT285881 Positive_regulation of Noxa1 1 0.02 0.31 0 5.00
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