D:Lymphatic Filariasis

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Disease Term
Synonyms Bancroftian Elephantiases, Bancroftian Elephantiasis, ELEPHANTIASES BANCROFTIAN, Elephantiases Filarial, Elephantiasis Bancroftian, Elephantiasis Filarial, Filarial Elephantiases, Filarial Elephantiasis, Filariases Lymphatic, Filariasis Lymphatic, Lymphatic Filariases
Documents 105
Hot Single Events 65
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lymphatic Filariasis. They are ordered first by their relevance to Lymphatic Filariasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0 100.00
2 INT313687 Binding of BCR and IFIH1 1 0.09 0.23 0 98.52
3 INT197096 VEGFA Positive_regulation of FLT4 1 0.04 1.43 0 74.24
4 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 50.00
5 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 43.76
6 INT288376 IL17A Regulation of VEGFA 1 0.00 1.16 0.49 43.44
7 INT197099 Negative_regulation of Binding of FLT4 and VEGFA 1 0.04 1.04 0 13.84
8 INT191799 PROC Negative_regulation of Binding of F2r 1 0.00 0.92 0.3 5.00
9 INT191792 Binding of F2r and Serpinc1 1 0.00 3.74 0.24 5.00
10 INT197095 IL1B Regulation of Positive_regulation of TNF 1 0.01 0.64 0.19 5.00
11 INT175727 IL1B Regulation of VEGFA 2 0.04 0.7 0.19 5.00
12 INT197093 TNF Regulation of Positive_regulation of IL1B 1 0.01 0.64 0.19 5.00
13 INT197097 IL1B Regulation of FLT4 1 0.03 0.66 0.19 5.00
14 INT197098 TNF Regulation of FLT4 1 0.14 0.66 0.19 5.00
15 INT287266 EGF Positive_regulation of EGF Positive_regulation of CDC42 1 0.06 0.16 0.11 5.00
16 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11 5.00
17 INT275843 HPD Positive_regulation of Ncapg2 1 0.01 0.76 0 5.00
18 INT218240 Binding of SAE1 and Dync1h1 1 0.00 0.17 0 5.00
19 INT275842 HPD Positive_regulation of Tlr2 1 0.01 0.76 0 5.00
20 INT275841 Cfp Positive_regulation of Ncapg2 1 0.02 0.75 0 5.00
21 INT287269 Binding of ERBB3 and PIK3CG 1 0.11 0.74 0 5.00
22 INT275840 Cfp Positive_regulation of Tlr2 1 0.02 0.75 0 5.00
23 INT287268 Binding of ERBB2 and ERBB3 5 0.16 2.74 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lymphatic Filariasis. They are ordered first by their pain relevance and then by number of times they were reported in Lymphatic Filariasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT99524 Gene_expression of IFIH1 34 0.64 23.38 2.24 100.00
2 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 100.00
3 INT147113 Binding of LTF 14 0.29 18.24 0.98 100.00
4 INT10303 Regulation of STH 16 0.60 16.14 0.95 100.00
5 INT191783 Positive_regulation of Pnp 21 0.67 22.51 1.66 100.00
6 INT91106 Negative_regulation of LTF 9 0.51 5.73 1.09 100.00
7 INT297921 Regulation of Gene_expression of LTF 2 0.10 3.11 0.37 100.00
8 INT320196 Localization of IFIH1 1 0.12 0.72 0 100.00
9 INT297919 Negative_regulation of Gene_expression of LTF 2 0.09 3.27 0.79 100.00
10 INT32344 Localization of LTF 30 0.80 15.28 10.09 100.00
11 INT75648 Negative_regulation of CTD 4 0.07 3.91 0.25 100.00
12 INT23589 Positive_regulation of CALCR 9 0.67 6.73 1.25 100.00
13 INT229890 Negative_regulation of Gene_expression of IFIH1 2 0.08 1.06 0 99.80
14 INT188776 Positive_regulation of IFIH1 10 0.23 9.93 0.35 99.74
15 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 99.62
16 INT192676 Binding of PTEN 14 0.46 10.58 3.06 99.58
17 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.40
18 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.40
19 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.32
20 INT188775 Binding of IFIH1 11 0.16 12.4 0.61 99.28
21 INT59792 Gene_expression of STH 14 0.75 15.2 0.61 99.24
22 INT248744 Negative_regulation of STH 2 0.41 1.02 0 99.08
23 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 98.80
24 INT313688 Regulation of IFIH1 3 0.19 4.2 0.48 98.70
25 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 98.60
26 INT181790 Gene_expression of FLT4 13 0.72 11.73 0.56 98.28
27 INT47625 Negative_regulation of IFIH1 4 0.51 1.68 0.39 97.36
28 INT67389 Positive_regulation of SGCA 7 0.45 2.92 0.69 97.00
29 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43 96.48
30 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 95.52
31 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 95.52
32 INT197105 Negative_regulation of FLT4 13 0.42 11.48 0.92 95.20
33 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 94.84
34 INT320195 Positive_regulation of Binding of IFIH1 1 0.08 1.08 0 94.80
35 INT152643 Positive_regulation of Gene_expression of IFIH1 5 0.42 5.2 0.28 94.56
36 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 94.00
37 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 93.72
38 INT288383 Regulation of Gene_expression of CHIT1 1 0.18 2.99 0 93.68
39 INT183668 Binding of SGCA 15 0.36 9.86 2.42 93.36
40 INT241797 Gene_expression of CHIT1 10 0.24 9.75 0.69 92.80
41 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 92.48
42 INT196007 Positive_regulation of FLT4 2 0.56 5.44 0.08 92.04
43 INT178878 Regulation of Gene_expression of SRI 2 0.14 0.59 0.07 91.16
44 INT3127 Gene_expression of SRI 38 0.68 26.29 3.82 90.96
45 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 89.04
46 INT72798 Binding of ADA 12 0.47 7.84 3.39 89.04
47 INT288384 Binding of CHIT1 2 0.15 2.04 0.22 89.00
48 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 88.84
49 INT354758 Gene_expression of D6Uwa4 1 0.04 0.17 0 87.08
50 INT214808 Gene_expression of Ncapg2 20 0.58 27.52 1.58 86.88
51 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26 86.88
52 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05 86.88
53 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74 86.88
54 INT204528 Negative_regulation of Gene_expression of TLR9 5 0.52 4.47 0.27 86.88
55 INT253448 Negative_regulation of Gene_expression of Ncapg2 2 0.32 4.9 0.26 86.88
56 INT1430 Regulation of PDYN 88 0.60 16.99 60.32 86.76
57 INT10686 Regulation of Binding of PDYN 3 0.43 0.61 1.1 86.76
58 INT1510 Binding of PDYN 94 0.48 4.68 56.44 86.32
59 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 86.12
60 INT48418 Localization of Dync1h1 4 0.61 1.54 0.44 83.28
61 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 82.48
62 INT103020 Gene_expression of SGCA 22 0.56 14.29 2.75 81.12
63 INT15357 Positive_regulation of STH 7 0.49 4.55 1.6 80.96
64 INT228359 Binding of STH 1 0.09 0.28 0 80.24
65 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 80.24
66 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22 79.32
67 INT197104 Positive_regulation of Gene_expression of FLT4 1 0.56 3.45 0.19 78.80
68 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 78.68
69 INT154235 Gene_expression of KPNA1 2 0.78 1.77 0.1 78.08
70 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 77.92
71 INT148271 Regulation of SGCA 10 0.37 5.89 0.86 77.80
72 INT22095 Negative_regulation of Dync1h1 11 0.48 5.17 1.08 77.76
73 INT182438 Localization of MPG 3 0.30 1.43 0.04 76.88
74 INT35271 Negative_regulation of Apcs 12 0.59 8.05 1.36 76.56
75 INT114862 Gene_expression of BEST1 16 0.65 12.14 1.53 76.24
76 INT74446 Positive_regulation of Dync1h1 25 0.59 13 2.38 75.88
77 INT115214 Gene_expression of LSAMP 4 0.63 2.5 1.14 74.00
78 INT221711 Negative_regulation of Gene_expression of STH 1 0.06 0.81 0 72.64
79 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 72.12
80 INT162801 Localization of CALR 7 0.73 8.69 0.6 69.44
81 INT38268 Positive_regulation of BEST1 16 0.17 14.54 1.93 68.88
82 INT218247 Gene_expression of Cardf1 3 0.65 2.37 0.24 66.20
83 INT140708 Gene_expression of Tlr1 10 0.50 5.24 0.72 66.16
84 INT275828 Positive_regulation of Gene_expression of Tlr1 2 0.24 1.75 0.26 66.16
85 INT258097 Binding of Nr4a1 4 0.35 3.44 0 62.96
86 INT189063 Regulation of NDS9 1 0.01 0.8 0 62.52
87 INT196006 Regulation of FLT4 2 0.25 2.24 0.27 62.40
88 INT320197 Positive_regulation of Transcription of IFIH1 1 0.08 0.15 0 61.24
89 INT320193 Transcription of IFIH1 1 0.11 0.15 0 61.24
90 INT80939 Positive_regulation of PDR 8 0.55 5.43 0.67 59.84
91 INT246512 Positive_regulation of IL4I1 2 0.26 1.05 0 59.84
92 INT320194 Gene_expression of CSN1S1 1 0.13 0.15 0 59.04
93 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 58.36
94 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82 57.72
95 INT189062 Negative_regulation of NDS9 1 0.01 0.93 0 57.68
96 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 56.72
97 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 56.52
98 INT247954 Positive_regulation of Pdcd1 5 0.16 4.97 0.65 54.44
99 INT229557 Positive_regulation of Ctla4 5 0.43 3.83 0.17 54.44
100 INT264177 Positive_regulation of Gene_expression of Ctla4 2 0.49 3.59 0.17 54.44
101 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 54.12
102 INT157401 Gene_expression of Ctla4 21 0.65 15.43 3.2 54.04
103 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 53.80
104 INT200855 Positive_regulation of Kdr 14 0.45 11.14 0.77 53.68
105 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 53.60
106 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 52.96
107 INT253454 Positive_regulation of Gene_expression of Ncapg2 3 0.43 4.37 0.06 52.04
108 INT56687 Gene_expression of Pnp 19 0.49 11.75 2.08 51.96
109 INT6852 Localization of TNF 883 0.81 705.95 270.84 50.00
110 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 50.00
111 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 50.00
112 INT19775 Localization of Il1 183 0.78 145.5 50.91 50.00
113 INT145 Negative_regulation of H1 12 0.39 5.68 5.08 50.00
114 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 50.00
115 INT60957 Negative_regulation of Abcb1b 18 0.57 6 4.73 48.56
116 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 47.96
117 INT4534 Regulation of PROC 38 0.33 19.81 8.99 45.08
118 INT197102 Localization of FLT4 4 0.65 2.89 0.17 44.80
119 INT197103 Binding of FLT4 2 0.29 3.08 0.14 44.80
120 INT197101 Positive_regulation of Localization of FLT4 1 0.38 0.77 0.06 44.80
121 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67 44.16
122 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 43.84
123 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 43.56
124 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 42.64
125 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 42.64
126 INT246513 Regulation of IL4I1 2 0.10 2.06 0.15 41.76
127 INT89308 Positive_regulation of Binding of IFNA1 12 0.49 10.64 2.04 40.80
128 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 40.72
129 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 39.56
130 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 39.08
131 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 37.20
132 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 36.56
133 INT191772 Regulation of Pnp 1 0.06 1.05 0 36.40
134 INT191776 Regulation of Gene_expression of Pnp 3 0.06 2.11 0 36.40
135 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 32.56
136 INT191782 Gene_expression of Cel 1 0.04 2.88 0.77 28.96
137 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69 28.00
138 INT191797 Negative_regulation of Gene_expression of CALCR 2 0.03 1.37 0.17 28.00
139 INT39820 Gene_expression of CALCR 16 0.37 4.96 0.74 27.44
140 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 27.12
141 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81 27.04
142 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 26.12
143 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92 25.04
144 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 25.00
145 INT191774 Gene_expression of Amigo2 2 0.05 6.81 1.03 23.48
146 INT214807 Regulation of Ncapg2 5 0.29 3.6 0.48 18.56
147 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 16.28
148 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 16.28
149 INT23148 Gene_expression of RUNX1 10 0.10 6.58 1.71 16.28
150 INT191770 Positive_regulation of Positive_regulation of Pnp 1 0.07 1.35 0.14 13.08
151 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 11.00
152 INT16461 Negative_regulation of Gene_expression of PROC 13 0.24 4.39 2.17 7.28
153 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
154 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
155 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
156 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
157 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
158 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
159 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
160 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
161 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
162 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
163 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
164 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 5.00
165 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
166 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
167 INT9781 Binding of INSRR 64 0.31 19.1 25.2 5.00
168 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
169 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
170 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
171 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62 5.00
172 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52 5.00
173 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75 5.00
174 INT4047 Binding of F13A1 105 0.43 66.54 11.81 5.00
175 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
176 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 5.00
177 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
178 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74 5.00
179 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 5.00
180 INT3622 Regulation of CTSB 34 0.58 16.08 8.76 5.00
181 INT34372 Gene_expression of Cfp 102 0.67 37.66 8.72 5.00
182 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
183 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
184 INT27591 Negative_regulation of Gene_expression of Alb 30 0.58 17.03 5.99 5.00
185 INT49566 Positive_regulation of LMOD1 16 0.61 5.74 5.92 5.00
186 INT117189 Binding of CXCR4 34 0.37 24.27 5.81 5.00
187 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
188 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
189 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 5.00
190 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
191 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66 5.00
192 INT22009 Negative_regulation of Ctsa 12 0.58 3.14 3.59 5.00
193 INT24160 Gene_expression of TRIM13 7 0.65 1.42 3.46 5.00
194 INT52839 Regulation of Racgap1 14 0.25 9.46 3.37 5.00
195 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33 5.00
196 INT124569 Transcription of HPD 6 0.15 1.25 3.32 5.00
197 INT114276 Gene_expression of Nr4a1 20 0.77 7.71 3.14 5.00
198 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 5.00
199 INT124570 Gene_expression of HPD 14 0.78 6.76 3.07 5.00
200 INT202577 Localization of DIO2 9 0.56 1.3 2.97 5.00
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