D:Lymphatic Metastasis

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Disease Term
Synonyms Lymphatic Metastases, Metastases Lymphatic, Metastasis Lymphatic
Documents 49
Hot Single Events 3
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lymphatic Metastasis. They are ordered first by their relevance to Lymphatic Metastasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT230761 VEGFA Positive_regulation of Kdr 2 0.02 2.16 0.12 75.76
2 INT345375 VEGFA Positive_regulation of Gene_expression of Kdr 1 0.02 1.2 0 75.76
3 INT345374 VEGFA Positive_regulation of Flt4 1 0.01 2.95 0 75.76
4 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
5 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
6 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69 5.00
7 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
8 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 5.00
9 INT347531 Binding of Nrp2 and Sema3b 1 0.04 0.99 0.28 5.00
10 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27 5.00
11 INT223570 Binding of Mri1 and Uhrf2 1 0.02 0.56 0.22 5.00
12 INT223569 Binding of cy and Mri1 1 0.00 0.57 0.22 5.00
13 INT296036 IL6 Positive_regulation of IL17A 1 0.04 0.05 0.17 5.00
14 INT266616 Il4 Positive_regulation of Il12a 1 0.01 0.4 0.17 5.00
15 INT296037 TGFB1 Positive_regulation of IL17A 1 0.02 0 0.17 5.00
16 INT296081 Binding of FOXP3 and Gtf3a 1 0.00 1.16 0.16 5.00
17 INT296030 Binding of NFKB1 and FOXP3 1 0.17 1.18 0.16 5.00
18 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 5.00
19 INT296078 Binding of NFKB1 and Gtf3a 1 0.00 1.18 0.16 5.00
20 INT296082 Binding of Rel and FOXP3 1 0.35 1.14 0.15 5.00
21 INT296031 Negative_regulation of TGFB1 Regulation of IL10 1 0.01 1.01 0.13 5.00
22 INT296027 TGFB1 Regulation of TH1L 1 0.02 1 0.13 5.00
23 INT296079 IL17A Negative_regulation of Positive_regulation of Gtf3a 1 0.00 0.77 0.13 5.00
24 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12 5.00
25 INT296029 Binding of HLA-DQA2 and LAG3 1 0.02 0.43 0.12 5.00
26 INT296028 TGFB1 Regulation of IL10 1 0.01 1 0.12 5.00
27 INT296040 IL17A Regulation of TH1L 1 0.07 0.7 0.12 5.00
28 INT296038 TGFB1 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11 5.00
29 INT296032 IL6 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11 5.00
30 INT127143 Binding of IL6 and TGFB1 2 0.01 0.16 0.08 5.00
31 INT296041 Binding of TGFB1 and IL21 1 0.01 0.05 0.08 5.00
32 INT296026 Binding of FOXP3 and IL17RB Negative_regulation of Gene_expression of IL7R 1 0.01 0.63 0.08 5.00
33 INT296035 IL21 Positive_regulation of Gene_expression of IL23R 1 0.01 0.05 0.08 5.00
34 INT345370 Binding of Vegfa and Insrr 1 0.01 2.29 0.08 5.00
35 INT296039 Binding of FOXP3 and IL17RB 1 0.01 0.63 0.08 5.00
36 INT296034 FOXP3 Negative_regulation of Gene_expression of IL7R 1 0.10 0.63 0.08 5.00
37 INT345371 Binding of Flt4 and Kdr 1 0.10 1.12 0.05 5.00
38 INT266617 Binding of GJC1 and Tjp1 1 0.41 0.28 0.03 5.00
39 INT347533 Tmem131 Negative_regulation of Gene_expression of Nrp2 1 0.04 0 0 5.00
40 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 5.00
41 INT263918 Binding of PTPRC and Cea 1 0.00 0.37 0 5.00
42 INT345372 Col18a1 Positive_regulation of Kdr 1 0.20 1.42 0 5.00
43 INT263899 Binding of PTPRC and TMED7-TICAM2 1 0.00 0.85 0 5.00
44 INT339217 MMP9 Negative_regulation of VEGFA 1 0.05 0.38 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lymphatic Metastasis. They are ordered first by their pain relevance and then by number of times they were reported in Lymphatic Metastasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT263915 Binding of SLN 2 0.12 0.81 0 97.48
2 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 97.12
3 INT15968 Negative_regulation of Sln 6 0.37 3.03 0.32 84.16
4 INT200855 Positive_regulation of Kdr 14 0.45 11.14 0.77 79.68
5 INT156351 Positive_regulation of Flt1 22 0.51 20.05 0.91 79.68
6 INT263904 Negative_regulation of Gene_expression of SLN 1 0.14 7.18 0.47 77.92
7 INT263905 Gene_expression of SLN 33 0.63 23.21 0.74 77.44
8 INT10763 Localization of IL2 157 0.80 81.11 33.21 75.56
9 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 75.20
10 INT134629 Positive_regulation of Gene_expression of Flt4 3 0.32 2.13 0.52 75.20
11 INT196002 Positive_regulation of Flt4 4 0.22 3.51 0.37 75.20
12 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 74.80
13 INT134628 Gene_expression of Flt4 9 0.48 7.52 1.94 74.32
14 INT107042 Regulation of Ts1 3 0.44 1.68 0.22 73.96
15 INT107043 Positive_regulation of Phosphorylation of Ts1 1 0.19 0.5 0.12 73.96
16 INT107044 Phosphorylation of Ts1 1 0.31 0.5 0.12 73.96
17 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 67.36
18 INT131931 Binding of KRT7 13 0.36 19.24 0.5 65.84
19 INT223563 Gene_expression of Uhrf2 4 0.48 1.15 1.04 64.16
20 INT320783 Binding of Flt4 2 0.26 0.98 0.05 60.72
21 INT197765 Gene_expression of Sln 26 0.58 12.11 0.45 57.76
22 INT140053 Positive_regulation of Cish 9 0.41 2.4 2 52.60
23 INT302039 Negative_regulation of Nrp2 6 0.51 1.65 0.19 51.84
24 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 49.28
25 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 49.28
26 INT178489 Negative_regulation of Kdr 31 0.42 25.65 0.66 48.76
27 INT347528 Negative_regulation of Flt4 1 0.29 0.13 0 40.56
28 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 20.88
29 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 20.24
30 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 14.48
31 INT263877 Gene_expression of Rigs1 1 0.08 11.58 0.03 12.40
32 INT263876 Negative_regulation of Rigs1 1 0.04 0.98 0 12.40
33 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 6.80
34 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 6.80
35 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
36 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
37 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
38 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
39 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
40 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
41 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
42 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
43 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
44 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
45 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
46 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 5.00
47 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
48 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
49 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
50 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
51 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
52 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
53 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
54 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
55 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
56 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 5.00
57 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
58 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
59 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
60 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 5.00
61 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
62 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
63 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
64 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
65 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47 5.00
66 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
67 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
68 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
69 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
70 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
71 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
72 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 5.00
73 INT34487 Localization of MMP2 56 0.81 31.41 23.61 5.00
74 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
75 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
76 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
77 INT4535 Localization of PROC 106 0.73 76.24 21.1 5.00
78 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
79 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
80 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
81 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
82 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
83 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
84 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 5.00
85 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
86 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
87 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
88 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
89 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 5.00
90 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
91 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 5.00
92 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 5.00
93 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
94 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
95 INT61946 Positive_regulation of HGF 57 0.69 38.93 11.99 5.00
96 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
97 INT2491 Regulation of Cea 38 0.61 26.18 10.95 5.00
98 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64 5.00
99 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 5.00
100 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
101 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87 5.00
102 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18 5.00
103 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
104 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88 5.00
105 INT87434 Gene_expression of Sell 38 0.77 21.95 8.51 5.00
106 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
107 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 5.00
108 INT50212 Gene_expression of Ifx 33 0.75 32.17 7.26 5.00
109 INT144945 Negative_regulation of Icam1 27 0.50 26.23 7.08 5.00
110 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
111 INT211701 Positive_regulation of Mri1 20 0.34 20.64 6.69 5.00
112 INT77945 Regulation of Gene_expression of Il12a 19 0.58 6.55 6.4 5.00
113 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
114 INT223568 Gene_expression of GYPE 21 0.65 5.83 6.12 5.00
115 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 5.00
116 INT146808 Positive_regulation of CCL18 25 0.69 11.98 5.71 5.00
117 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22 5.00
118 INT90350 Gene_expression of Gast 27 0.78 14.07 4.74 5.00
119 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
120 INT17182 Binding of Cea 25 0.48 14.98 4.16 5.00
121 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 5.00
122 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
123 INT59900 Binding of MATN3 13 0.42 17.19 3.59 5.00
124 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 5.00
125 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29 5.00
126 INT250884 Binding of IL23A 5 0.19 7.17 3.17 5.00
127 INT137609 Localization of Vegfa 22 0.78 14.67 3.01 5.00
128 INT240544 Gene_expression of TBX21 12 0.75 5.96 2.97 5.00
129 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92 5.00
130 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81 5.00
131 INT130705 Gene_expression of TFAM 50 0.77 38.85 2.79 5.00
132 INT89929 Positive_regulation of Positive_regulation of STAT3 22 0.65 9.21 2.54 5.00
133 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 5.00
134 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
135 INT187851 Gene_expression of Hbb-ar 40 0.65 16.34 2.3 5.00
136 INT160673 Gene_expression of Ambp 16 0.49 19.49 2.3 5.00
137 INT98376 Gene_expression of tk 27 0.51 21.9 2.23 5.00
138 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 5.00
139 INT250888 Negative_regulation of IL23A 4 0.30 6.13 2.15 5.00
140 INT157400 Gene_expression of Tnfrsf18 15 0.39 7.3 2.13 5.00
141 INT149031 Gene_expression of Tjp1 43 0.75 19.1 2.06 5.00
142 INT15799 Positive_regulation of ISG20 18 0.38 9.78 2.01 5.00
143 INT77805 Regulation of Gene_expression of Ptgs2 6 0.51 2.7 1.92 5.00
144 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86 5.00
145 INT104524 Localization of FSCN1 3 0.13 1.76 1.75 5.00
146 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72 5.00
147 INT219781 Gene_expression of IL17F 6 0.65 3.32 1.59 5.00
148 INT146511 Gene_expression of Nrp2 25 0.78 8.67 1.55 5.00
149 INT345367 Negative_regulation of Phosphorylation of Insrr 2 0.01 2.9 1.53 5.00
150 INT250890 Gene_expression of IL23R 2 0.12 3.11 1.53 5.00
151 INT108798 Negative_regulation of Positive_regulation of ALPP 9 0.25 4.26 1.46 5.00
152 INT46736 Negative_regulation of Odc1 10 0.51 7.6 1.39 5.00
153 INT112068 Gene_expression of GIF 8 0.58 2.6 1.35 5.00
154 INT199567 Binding of Kdr 18 0.47 13.81 1.34 5.00
155 INT97280 Gene_expression of Tk1 11 0.77 16.17 1.32 5.00
156 INT214704 Phosphorylation of Tk1 4 0.80 4.27 1.29 5.00
157 INT181961 Gene_expression of IL7R 10 0.75 3.9 1.29 5.00
158 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21 5.00
159 INT237247 Regulation of Mri1 6 0.27 4.64 1.2 5.00
160 INT18897 Binding of CHGA 11 0.36 10.12 1.17 5.00
161 INT137981 Gene_expression of ENTPD1 10 0.65 6.84 1.1 5.00
162 INT166261 Localization of SLN 2 0.66 1.23 1.07 5.00
163 INT250886 Positive_regulation of Gene_expression of IL23R 2 0.08 1.91 1.07 5.00
164 INT233561 Gene_expression of Clu 14 0.66 45.63 1.07 5.00
165 INT199308 Gene_expression of Krt8 37 0.75 23.17 1.06 5.00
166 INT235939 Gene_expression of Aqp5 8 0.45 4.7 1.06 5.00
167 INT211700 Negative_regulation of Mri1 5 0.29 2.06 1.04 5.00
168 INT86834 Positive_regulation of Tg 10 0.69 4.9 1.04 5.00
169 INT178483 Gene_expression of Col18a1 12 0.75 11.87 1.03 5.00
170 INT134822 Gene_expression of Gja1 18 0.72 4.2 1 5.00
171 INT231560 Negative_regulation of Gene_expression of IL23A 3 0.11 2.41 0.99 5.00
172 INT263912 Positive_regulation of SLN 6 0.39 0.66 0.99 5.00
173 INT35713 Gene_expression of Tmem131 9 0.50 6.13 0.96 5.00
174 INT91324 Localization of CCL4 3 0.73 2.08 0.94 5.00
175 INT240542 Positive_regulation of TBX21 3 0.45 2.11 0.89 5.00
176 INT199345 Gene_expression of Lyve1 11 0.50 8.44 0.89 5.00
177 INT90351 Negative_regulation of Gast 5 0.59 2.85 0.89 5.00
178 INT266793 Positive_regulation of IL17F 2 0.04 2.55 0.89 5.00
179 INT221427 Positive_regulation of FOXP3 6 0.45 2.74 0.83 5.00
180 INT178175 Positive_regulation of Gene_expression of Cd8a 17 0.43 13.05 0.78 5.00
181 INT150251 Transcription of FOXP3 7 0.61 0.43 0.76 5.00
182 INT69775 Gene_expression of cy 2 0.05 0.77 0.71 5.00
183 INT61910 Binding of Slc3a2 6 0.01 3 0.7 5.00
184 INT292653 Positive_regulation of IL21 2 0.27 1.96 0.69 5.00
185 INT246036 Positive_regulation of GRN 3 0.17 2.04 0.69 5.00
186 INT202023 Gene_expression of KLRB1 2 0.75 0.78 0.65 5.00
187 INT178196 Gene_expression of Vegfc 7 0.27 7.47 0.64 5.00
188 INT203724 Binding of Col18a1 3 0.20 4.69 0.62 5.00
189 INT214707 Gene_expression of Slc2a8 5 0.24 2.76 0.61 5.00
190 INT205470 Positive_regulation of GATA3 4 0.33 2.53 0.61 5.00
191 INT194903 Binding of Cd34 12 0.37 5.06 0.56 5.00
192 INT172964 Binding of Vegfa 14 0.47 10.62 0.53 5.00
193 INT140905 Localization of Rel 5 0.73 2.26 0.5 5.00
194 INT159140 Positive_regulation of Gene_expression of Tjp1 11 0.61 5.04 0.5 5.00
195 INT202426 Transcription of CD4 6 0.69 3.96 0.49 5.00
196 INT97446 Localization of Mki67 9 0.46 3.74 0.46 5.00
197 INT324645 Regulation of Col18a1 3 0.14 2.69 0.46 5.00
198 INT274481 Gene_expression of IL12RB2 7 0.75 3.14 0.46 5.00
199 INT159146 Regulation of Gene_expression of Tjp1 13 0.44 6.91 0.45 5.00
200 INT264192 Positive_regulation of Gene_expression of CTLA4 6 0.43 2.06 0.45 5.00
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