D:Lymphedema

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Disease Term
Synonyms Disease Milroy, Disease Milroy S, Lymph Edema, Lymph Oedema, Lymphatic Edema, LYMPHATIC OEDEMA, Lymphedemas, Lymphoedema, MILROY DISEASE, Milroy S Disease, MILROYS DISEASE
Documents 411
Hot Single Events 120
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lymphedema. They are ordered first by their relevance to Lymphedema and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT289658 Tnfrsf1a Positive_regulation of Mcpt1 1 0.02 0.76 0.81 100.00
2 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 97.60
3 INT197099 Negative_regulation of Binding of FLT4 and VEGFA 1 0.04 1.04 0 97.12
4 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 96.24
5 INT289661 Tnfrsf1a Positive_regulation of TNF 1 0.01 1.2 0.37 95.40
6 INT197096 VEGFA Positive_regulation of FLT4 1 0.04 1.43 0 94.32
7 INT289659 Tnfrsf1b Negative_regulation of Mcpt3 1 0.02 0.82 1.13 83.92
8 INT289657 Tnfrsf1a Negative_regulation of Gene_expression of Flt4 1 0.03 0.63 0.12 75.04
9 INT289660 Tnfrsf1a Negative_regulation of Transcription of Flt4 1 0.03 0.62 0.12 73.84
10 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0 70.56
11 INT197097 IL1B Regulation of FLT4 1 0.03 0.66 0.19 61.52
12 INT197098 TNF Regulation of FLT4 1 0.14 0.66 0.19 61.52
13 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 59.28
14 INT175727 IL1B Regulation of VEGFA 2 0.04 0.7 0.19 59.28
15 INT197095 IL1B Regulation of Positive_regulation of TNF 1 0.01 0.64 0.19 57.12
16 INT197093 TNF Regulation of Positive_regulation of IL1B 1 0.01 0.64 0.19 57.12
17 INT313687 Binding of BCR and IFIH1 1 0.09 0.23 0 42.96
18 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
19 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
20 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
21 INT288376 IL17A Regulation of VEGFA 1 0.00 1.16 0.49 5.00
22 INT223570 Binding of Mri1 and Uhrf2 1 0.02 0.56 0.22 5.00
23 INT223569 Binding of cy and Mri1 1 0.00 0.57 0.22 5.00
24 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
25 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
26 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
27 INT188356 Binding of Cd28 and Positive_regulation of Localization of Cd4 1 0.30 0.18 0.11 5.00
28 INT188360 Binding of Cd28 and Positive_regulation of Localization of Cd8a 1 0.09 0.18 0.11 5.00
29 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 0.34 0.19 0.11 5.00
30 INT188357 Csf2 Positive_regulation of Socs3 1 0.36 0.15 0.1 5.00
31 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 5.00
32 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 5.00
33 INT188361 Il4 Positive_regulation of Socs1 1 0.14 0.15 0.08 5.00
34 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
35 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
36 INT188359 Csf2 Regulation of Cish 1 0.13 0.52 0.07 5.00
37 INT244328 ELF3 Negative_regulation of Positive_regulation of SH3GL3 3 0.20 1.26 0.04 5.00
38 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
39 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
40 INT351029 AGK Regulation of VEGFA 1 0.00 0.82 0 5.00
41 INT244329 ELF3 Positive_regulation of Gene_expression of SH3GL3 1 0.27 0.66 0 5.00
42 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
43 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
44 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00
45 INT351030 AGK Regulation of ARAF 1 0.00 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lymphedema. They are ordered first by their pain relevance and then by number of times they were reported in Lymphedema. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 100.00
2 INT351585 Gene_expression of BCRP5 1 0.43 3.25 0.4 100.00
3 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 100.00
4 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 100.00
5 INT289648 Negative_regulation of Mcpt3 1 0.26 1.95 2.08 100.00
6 INT351584 Positive_regulation of BCRP5 1 0.26 0.57 0 100.00
7 INT351582 Binding of BCRP5 1 0.21 0.82 0.1 100.00
8 INT351583 Negative_regulation of BCRP5 1 0.24 0.56 0.14 100.00
9 INT78319 Binding of EPCAM 8 0.36 10.12 1.14 99.98
10 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41 99.96
11 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 99.92
12 INT228977 Binding of SERPINA2 1 0.25 5.42 0.35 99.92
13 INT118054 Regulation of ARMC9 23 0.34 11.32 1.06 99.84
14 INT196007 Positive_regulation of FLT4 2 0.56 5.44 0.08 99.84
15 INT289645 Positive_regulation of Mcpt3 2 0.31 1.26 0.85 99.84
16 INT959 Regulation of ATRX 5 0.47 5.04 0.89 99.84
17 INT257478 Gene_expression of Is(HSR;1)1Icg 9 0.25 2.5 2.23 99.80
18 INT197721 Positive_regulation of ARMC9 36 0.35 20.08 1.03 99.78
19 INT320196 Localization of IFIH1 1 0.12 0.72 0 99.76
20 INT197104 Positive_regulation of Gene_expression of FLT4 1 0.56 3.45 0.19 99.72
21 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.70
22 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 99.52
23 INT297919 Negative_regulation of Gene_expression of LTF 2 0.09 3.27 0.79 99.52
24 INT103020 Gene_expression of SGCA 22 0.56 14.29 2.75 99.44
25 INT313688 Regulation of IFIH1 3 0.19 4.2 0.48 99.36
26 INT181790 Gene_expression of FLT4 13 0.72 11.73 0.56 99.32
27 INT181357 Negative_regulation of Ccl3 12 0.59 13.09 3.38 99.08
28 INT318437 Negative_regulation of Pdpn 1 0.47 0.87 0.25 99.08
29 INT91106 Negative_regulation of LTF 9 0.51 5.73 1.09 99.00
30 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 98.96
31 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 98.76
32 INT289647 Regulation of Mcpt3 1 0.20 1.14 1.28 98.68
33 INT166878 Regulation of Ccl3 9 0.44 8.21 4.81 98.68
34 INT99524 Gene_expression of IFIH1 34 0.64 23.38 2.24 98.62
35 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 98.60
36 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 98.52
37 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 98.34
38 INT197102 Localization of FLT4 4 0.65 2.89 0.17 98.16
39 INT188775 Binding of IFIH1 11 0.16 12.4 0.61 97.72
40 INT320195 Positive_regulation of Binding of IFIH1 1 0.08 1.08 0 97.72
41 INT192676 Binding of PTEN 14 0.46 10.58 3.06 97.56
42 INT96907 Positive_regulation of ABCA4 16 0.49 4.59 0.52 97.56
43 INT197105 Negative_regulation of FLT4 13 0.42 11.48 0.92 97.44
44 INT6481 Binding of TNF 624 0.48 510.2 214.82 97.28
45 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33 97.28
46 INT47625 Negative_regulation of IFIH1 4 0.51 1.68 0.39 97.04
47 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 97.00
48 INT170056 Binding of Cxcl10 11 0.45 12.72 5.32 96.88
49 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 96.68
50 INT142908 Localization of FGFR1 18 0.38 11.46 2.57 96.66
51 INT169057 Localization of VEGFC 4 0.78 2.79 0.51 96.66
52 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.36
53 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 96.00
54 INT350959 Transcription of NOTCH1 2 0.05 0.84 0.03 95.80
55 INT289650 Gene_expression of Mcpt3 2 0.30 1.73 1.4 95.44
56 INT108978 Positive_regulation of CUX1 16 0.57 5.93 1.73 95.20
57 INT6852 Localization of TNF 883 0.81 705.95 270.84 94.92
58 INT228976 Binding of MCAT 3 0.06 3.45 0.17 94.72
59 INT181361 Localization of Ccl11 5 0.54 3.67 2.16 94.20
60 INT186731 Positive_regulation of Ccl11 10 0.45 10.09 2.44 94.20
61 INT316977 Transcription of ARMC9 2 0.27 0.68 0 94.16
62 INT188776 Positive_regulation of IFIH1 10 0.23 9.93 0.35 93.96
63 INT9660 Regulation of TNF 363 0.62 312.94 139.99 93.64
64 INT636 Binding of MRAP 54 0.48 40.36 18.77 93.56
65 INT113603 Negative_regulation of Gene_expression of Mcpt1 26 0.41 22.82 9.91 93.48
66 INT229890 Negative_regulation of Gene_expression of IFIH1 2 0.08 1.06 0 93.28
67 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 93.04
68 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 92.96
69 INT89116 Regulation of Positive_regulation of VEGFA 8 0.43 6.62 1.5 92.96
70 INT112110 Positive_regulation of FIGF 3 0.18 5.28 0.37 92.96
71 INT245880 Positive_regulation of Positive_regulation of FIGF 1 0.05 1.61 0.06 92.96
72 INT196006 Regulation of FLT4 2 0.25 2.24 0.27 92.72
73 INT197103 Binding of FLT4 2 0.29 3.08 0.14 92.64
74 INT197101 Positive_regulation of Localization of FLT4 1 0.38 0.77 0.06 92.64
75 INT45201 Negative_regulation of ABCA4 6 0.42 4.02 0.51 92.20
76 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 92.08
77 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58 92.08
78 INT13354 Transcription of TNF 108 0.72 85.81 42.32 92.08
79 INT134628 Gene_expression of Flt4 9 0.48 7.52 1.94 92.00
80 INT152643 Positive_regulation of Gene_expression of IFIH1 5 0.42 5.2 0.28 91.36
81 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 91.28
82 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 91.16
83 INT289649 Regulation of Gene_expression of Flt4 1 0.21 0.66 0.72 90.96
84 INT289656 Regulation of Gene_expression of Prox1 1 0.32 0.66 0.72 90.96
85 INT147113 Binding of LTF 14 0.29 18.24 0.98 90.96
86 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81 90.64
87 INT247710 Gene_expression of Ccbp2 3 0.34 10.57 1.75 90.64
88 INT19775 Localization of Il1 183 0.78 145.5 50.91 90.56
89 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 88.72
90 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 88.72
91 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 88.36
92 INT288383 Regulation of Gene_expression of CHIT1 1 0.18 2.99 0 87.36
93 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 87.36
94 INT178878 Regulation of Gene_expression of SRI 2 0.14 0.59 0.07 87.36
95 INT289646 Regulation of Prox1 1 0.19 0.64 0.6 87.32
96 INT289655 Regulation of Flt4 1 0.29 0.63 0.6 87.32
97 INT3127 Gene_expression of SRI 38 0.68 26.29 3.82 87.16
98 INT241797 Gene_expression of CHIT1 10 0.24 9.75 0.69 86.48
99 INT16066 Positive_regulation of Cxcl3 3 0.65 1.59 0.49 86.36
100 INT206477 Gene_expression of Prox1 7 0.56 4.34 1.65 85.92
101 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 85.80
102 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 85.80
103 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 85.80
104 INT159740 Protein_catabolism of LASP1 1 0.63 0.56 0.12 85.72
105 INT188176 Positive_regulation of Gene_expression of CDH5 3 0.32 0.75 0.07 85.28
106 INT67389 Positive_regulation of SGCA 7 0.45 2.92 0.69 85.28
107 INT199345 Gene_expression of Lyve1 11 0.50 8.44 0.89 85.20
108 INT196002 Positive_regulation of Flt4 4 0.22 3.51 0.37 85.04
109 INT188173 Gene_expression of CDH5 14 0.49 3.17 0.44 84.88
110 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 84.24
111 INT297921 Regulation of Gene_expression of LTF 2 0.10 3.11 0.37 83.52
112 INT288384 Binding of CHIT1 2 0.15 2.04 0.22 82.68
113 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 81.40
114 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 81.40
115 INT51066 Binding of S100B 24 0.48 13.5 0.97 81.40
116 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 81.40
117 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 81.40
118 INT128376 Binding of KIT 26 0.48 14.24 0.47 81.40
119 INT76479 Binding of CD99 5 0.33 4.66 0.44 81.40
120 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 80.76
121 INT318434 Negative_regulation of Rad23b 1 0.55 2.25 0.45 79.24
122 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 77.20
123 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 76.96
124 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 76.52
125 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 76.52
126 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 76.52
127 INT23176 Gene_expression of Pdpn 6 0.75 4.06 1.65 76.24
128 INT183668 Binding of SGCA 15 0.36 9.86 2.42 74.88
129 INT289653 Negative_regulation of Transcription of Flt4 1 0.20 0.62 0.12 73.84
130 INT289652 Transcription of Flt4 1 0.34 0.62 0.12 73.84
131 INT32344 Localization of LTF 30 0.80 15.28 10.09 72.12
132 INT958 Negative_regulation of ATRX 6 0.58 2.92 1.25 71.36
133 INT228975 Gene_expression of SERPINA2 1 0.31 1.61 0 70.64
134 INT318432 Negative_regulation of Negative_regulation of Rad23b 1 0.41 1.03 0.17 70.12
135 INT318451 Negative_regulation of Olr373 1 0.02 1.01 0.16 66.52
136 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 66.20
137 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 64.68
138 INT9473 Binding of MUC1 66 0.48 46.77 2.36 64.68
139 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 63.52
140 INT318429 Gene_expression of Rad23b 1 0.57 2.33 0.39 63.12
141 INT148271 Regulation of SGCA 10 0.37 5.89 0.86 59.80
142 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 58.16
143 INT318444 Regulation of Gene_expression of Rad23b 1 0.26 0.97 0.14 56.16
144 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 55.56
145 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 55.04
146 INT3809 Negative_regulation of Ubtf 5 0.28 0.22 0.34 54.76
147 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 54.24
148 INT210058 Regulation of ELF3 11 0.29 7.93 2.51 53.92
149 INT145 Negative_regulation of H1 12 0.39 5.68 5.08 51.84
150 INT245878 Binding of FLI1 2 0.11 2.57 0.1 50.60
151 INT245877 Binding of HBA1 2 0.11 2.59 0.04 50.60
152 INT245879 Binding of IGLV3-1 2 0.36 1.6 0.04 50.60
153 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 50.00
154 INT320194 Gene_expression of CSN1S1 1 0.13 0.15 0 50.00
155 INT320197 Positive_regulation of Transcription of IFIH1 1 0.08 0.15 0 50.00
156 INT320193 Transcription of IFIH1 1 0.11 0.15 0 50.00
157 INT210065 Positive_regulation of SH3GL3 8 0.45 6.45 0.96 49.36
158 INT145884 Negative_regulation of SH3GL3 19 0.43 12.67 1.72 46.52
159 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 46.36
160 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 46.20
161 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 45.84
162 INT347444 Gene_expression of KRTAP5-2 1 0.16 1.4 0.09 42.88
163 INT162478 Gene_expression of KRT6B 2 0.75 1.39 0.08 42.88
164 INT59784 Binding of DES 22 0.47 19.48 2.27 41.60
165 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 38.76
166 INT152681 Gene_expression of PDPN 29 0.65 23.06 0.18 33.68
167 INT154235 Gene_expression of KPNA1 2 0.78 1.77 0.1 33.60
168 INT41627 Gene_expression of Nqo1 33 0.65 4.58 10.48 29.96
169 INT69943 Regulation of Gene_expression of Nqo1 3 0.26 0.98 3.56 29.96
170 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 25.80
171 INT329073 Regulation of Myt1 1 0.42 0.34 0.08 24.88
172 INT138270 Positive_regulation of Keap1 3 0.17 1.69 2.33 24.32
173 INT329074 Transcription of Pcmtd2 1 0.66 0.37 0.08 22.64
174 INT352185 Negative_regulation of PCDH11X 1 0.01 0.83 0 21.92
175 INT329075 Transcription of MYT1 1 0.27 0.37 0.08 15.44
176 INT317881 Transcription of Eef1a1 2 0.03 1.38 0.18 14.96
177 INT278654 Phosphorylation of SULT2A1 2 0.60 0.29 0.08 14.20
178 INT35599 Negative_regulation of Nqo1 25 0.54 4.6 4.42 13.32
179 INT75648 Negative_regulation of CTD 4 0.07 3.91 0.25 12.56
180 INT318449 Gene_expression of Mir21 18 0.37 11.92 1.46 9.20
181 INT318448 Positive_regulation of Gene_expression of Mir21 11 0.33 6.31 1.12 9.20
182 INT150384 Binding of RCT 10 0.25 3.1 2.05 5.56
183 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
184 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
185 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
186 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
187 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
188 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
189 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
190 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
191 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
192 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
193 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
194 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
195 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
196 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
197 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
198 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
199 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
200 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
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