D:Machado-joseph Disease

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Disease Term
Synonyms Autosomal Dominant Striatonigral Degeneration, Azorean Disease, Azorean Disease Machado Joseph, Azorean Disease Nervous System, AZOREAN DISEASES MACHADO JOSEPH, Disease Azorean, Disease Azorean Machado Joseph, Disease Joseph, Disease Joseph Azorean, Disease Machado Joseph, Disease Machado Joseph Azorean
Documents 21
Hot Single Events 24
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Machado-joseph Disease. They are ordered first by their relevance to Machado-joseph Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT235165 Atxn3 Regulation of Transcription of Crebbp 1 0.02 0.3 0 29.04
2 INT235168 Binding of Crx and Atxn7 1 0.11 0.81 0.03 5.00
3 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 5.00
4 INT235166 Binding of Hdac3 and Atxn1 1 0.02 0.28 0 5.00
5 INT308854 Bcl2a1a Positive_regulation of Gene_expression of HTT 1 0.14 0 0 5.00
6 INT235167 Binding of Hdac3 and Ncor2 1 0.01 0.28 0 5.00
7 INT235164 Binding of Atxn1 and Ncor2 1 0.15 0.42 0 5.00
8 INT235169 Gene_expression of Dnaja1 Negative_regulation of Binding of Atxn1 1 0.09 0.47 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Machado-joseph Disease. They are ordered first by their pain relevance and then by number of times they were reported in Machado-joseph Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT75299 Binding of Atxn3 8 0.43 5.3 0.26 100.00
2 INT69142 Positive_regulation of Atxn3 3 0.50 1.52 0.53 100.00
3 INT189811 Negative_regulation of ATXN3 1 0.35 3.09 0 100.00
4 INT340699 Positive_regulation of Positive_regulation of Atxn3 1 0.50 0.66 0 100.00
5 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 99.96
6 INT189809 Negative_regulation of HEXA 1 0.57 3.93 0 99.76
7 INT135045 Gene_expression of Atxn3 34 0.78 11.59 0.36 99.36
8 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 99.36
9 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 98.80
10 INT340692 Positive_regulation of Gene_expression of Atxn3 4 0.47 1.65 0.03 97.08
11 INT340687 Regulation of Gene_expression of Atxn3 1 0.45 0.67 0 97.08
12 INT13790 Binding of HTR1A 52 0.47 18.83 17.59 96.64
13 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 92.64
14 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 91.40
15 INT235130 Localization of Atxn3 4 0.75 2.91 0.03 89.68
16 INT340694 Negative_regulation of Localization of Atxn3 1 0.43 1.36 0 89.68
17 INT49209 Positive_regulation of GAD1 17 0.70 15.39 5.59 88.32
18 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 88.32
19 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 87.60
20 INT62652 Binding of HTR7 9 0.47 2.79 3.06 86.56
21 INT340698 Regulation of Atxn3 1 0.39 1.04 0 83.56
22 INT340690 Regulation of Phosphorylation of Atxn3 1 0.39 0.57 0 83.56
23 INT236705 Phosphorylation of Cdk2 2 0.31 1.39 0 83.56
24 INT340700 Phosphorylation of Atxn3 1 0.72 1.34 0 82.80
25 INT235155 Regulation of Localization of Efemp2 1 0.00 0.42 0 78.88
26 INT202920 Localization of Efemp2 2 0.80 1.2 0.05 77.88
27 INT123903 Gene_expression of ATXN3 7 0.75 6.71 1.85 70.88
28 INT89928 Gene_expression of CSF2RA 19 0.75 6.78 1.27 65.20
29 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 64.88
30 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 56.52
31 INT341938 Positive_regulation of Negative_regulation of Htt 1 0.07 0.65 0 55.20
32 INT98239 Negative_regulation of Htt 13 0.43 7.84 0.6 54.68
33 INT308845 Gene_expression of Nisch 1 0.10 3.32 1.92 51.80
34 INT308851 Regulation of Gene_expression of Nisch 1 0.04 2.35 1.86 51.80
35 INT8101 Binding of INCENP 42 0.31 16.2 6.68 49.72
36 INT55315 Gene_expression of Tbp 32 0.74 14.6 1.17 44.36
37 INT287206 Regulation of Gene_expression of Htt 6 0.50 3.27 0.57 40.32
38 INT102255 Regulation of Prnp 35 0.62 18.97 3.25 37.72
39 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 36.88
40 INT215340 Localization of Htt 10 0.61 5.12 0.55 33.44
41 INT235154 Transcription of Ep300 2 0.24 1.38 0 26.76
42 INT235158 Transcription of Crebbp 1 0.05 0.29 0 26.76
43 INT235157 Gene_expression of Atxn2 3 0.68 6.74 1.23 13.52
44 INT157305 Gene_expression of Map1lc3a 47 0.75 18.04 1.93 9.32
45 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
46 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
47 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 5.00
48 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
49 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
50 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
51 INT1728 Negative_regulation of Cndp2 36 0.57 3.76 25.39 5.00
52 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35 5.00
53 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
54 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
55 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
56 INT13840 Negative_regulation of CPQ 19 0.57 1.25 8.36 5.00
57 INT175526 Phosphorylation of Gopc 73 0.53 21.08 7.86 5.00
58 INT228659 Phosphorylation of Eif4ebp1 10 0.80 27.53 6.87 5.00
59 INT31598 Gene_expression of Mgst1 41 0.78 6.44 6.3 5.00
60 INT199692 Gene_expression of Mkrn1 48 0.75 15.2 3.84 5.00
61 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 5.00
62 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 5.00
63 INT154937 Positive_regulation of MAP1LC3A 4 0.60 4.42 2.1 5.00
64 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 5.00
65 INT154938 Gene_expression of MAP1LC3A 11 0.62 8.08 2.03 5.00
66 INT181809 Gene_expression of Atxn1 81 0.77 28.66 1.42 5.00
67 INT73180 Positive_regulation of Hspa8 7 0.37 3.41 1.37 5.00
68 INT228661 Negative_regulation of Phosphorylation of Eif4ebp1 6 0.41 2.25 1.16 5.00
69 INT154936 Positive_regulation of Positive_regulation of MAP1LC3A 3 0.40 1.01 1.14 5.00
70 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 5.00
71 INT235138 Gene_expression of Atxn8os 2 0.76 6.89 1.05 5.00
72 INT129398 Negative_regulation of Gene_expression of SOD1 22 0.43 7.11 1.02 5.00
73 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
74 INT254875 Positive_regulation of Htt 10 0.47 4.07 0.96 5.00
75 INT68692 Regulation of HTT 8 0.60 4.06 0.89 5.00
76 INT92117 Phosphorylation of BCL2 26 0.80 9.93 0.86 5.00
77 INT157303 Positive_regulation of Gene_expression of Map1lc3a 15 0.53 4.12 0.85 5.00
78 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79 5.00
79 INT70019 Binding of BCL2 25 0.47 17.55 0.79 5.00
80 INT271917 Phosphorylation of Mtor 11 0.13 6.76 0.78 5.00
81 INT50855 Gene_expression of TRIM21 4 0.65 3.07 0.71 5.00
82 INT28561 Regulation of Gene_expression of SOD1 9 0.61 2.83 0.71 5.00
83 INT281333 Negative_regulation of MAP1LC3A 9 0.24 2.69 0.56 5.00
84 INT178128 Negative_regulation of Phosphorylation of BCL2 7 0.27 3.94 0.56 5.00
85 INT287204 Protein_catabolism of Htt 6 0.99 2.8 0.53 5.00
86 INT243418 Binding of Htt 14 0.30 5.94 0.44 5.00
87 INT30733 Localization of Atxn2 4 0.55 0.83 0.41 5.00
88 INT308847 Regulation of Phosphorylation of Eif4ebp1 3 0.27 2.11 0.41 5.00
89 INT157301 Negative_regulation of Map1lc3a 5 0.28 3.2 0.41 5.00
90 INT157309 Regulation of MAP1LC3A 2 0.44 1.49 0.4 5.00
91 INT235142 Gene_expression of Crx 2 0.17 0.82 0.34 5.00
92 INT237038 Gene_expression of Becn1 18 0.36 13.68 0.31 5.00
93 INT181803 Binding of Atxn1 12 0.48 7 0.3 5.00
94 INT68694 Positive_regulation of Gene_expression of HTT 7 0.49 4.29 0.29 5.00
95 INT244082 Protein_catabolism of Tg(CAG-EGFP)D4Nagy 4 0.23 1.48 0.29 5.00
96 INT254877 Positive_regulation of Gene_expression of Htt 15 0.64 6.29 0.28 5.00
97 INT178114 Positive_regulation of Phosphorylation of BCL2 11 0.49 4.44 0.28 5.00
98 INT287205 Regulation of Htt 5 0.45 3.56 0.22 5.00
99 INT181806 Positive_regulation of Gene_expression of Atxn1 6 0.41 2.85 0.21 5.00
100 INT282732 Positive_regulation of Phosphorylation of Mtor 4 0.06 2.09 0.2 5.00
101 INT192857 Gene_expression of Ppp2r1a 6 0.47 1.74 0.19 5.00
102 INT341947 Gene_expression of DPEP3 1 0.58 0 0.14 5.00
103 INT341939 Positive_regulation of Npepps 1 0.06 0 0.12 5.00
104 INT192856 Regulation of Gene_expression of Ppp2r1a 2 0.16 0.62 0.12 5.00
105 INT235150 Regulation of Gene_expression of Ppp2r2b 1 0.32 0.48 0.11 5.00
106 INT235132 Gene_expression of Ppp2r2b 1 0.55 2.31 0.11 5.00
107 INT325720 Binding of MAP1LC3A 1 0.05 0.39 0.09 5.00
108 INT325724 Positive_regulation of Binding of MAP1LC3A 1 0.07 0.39 0.09 5.00
109 INT287203 Negative_regulation of Gene_expression of Htt 7 0.37 5.08 0.07 5.00
110 INT200842 Negative_regulation of Binding of Atxn1 2 0.35 0.71 0.06 5.00
111 INT282981 Positive_regulation of Gene_expression of Becn1 8 0.13 6.2 0.06 5.00
112 INT235160 Gene_expression of Atxn7 1 0.56 2 0.04 5.00
113 INT235144 Binding of Anp32a 3 0.44 1.79 0.04 5.00
114 INT282977 Regulation of Becn1 4 0.25 2.29 0.04 5.00
115 INT235137 Positive_regulation of Atxn7 1 0.42 0.71 0.03 5.00
116 INT235159 Positive_regulation of Crx 1 0.14 0.7 0.03 5.00
117 INT235139 Localization of Atxn7 1 0.67 0.7 0.03 5.00
118 INT254873 Regulation of Map1lc3a 5 0.58 1.24 0.03 5.00
119 INT235133 Localization of Crx 1 0.21 0.71 0.03 5.00
120 INT325725 Phosphorylation of TAS2R63P 1 0.02 0 0 5.00
121 INT235153 Negative_regulation of Gene_expression of Dnaja1 1 0.09 0.47 0 5.00
122 INT308844 Phosphorylation of Map1lc3a 1 0.77 0 0 5.00
123 INT325713 Phosphorylation of 4E 1 0.61 0.13 0 5.00
124 INT235152 Localization of Dnaja1 1 0.17 0.72 0 5.00
125 INT308848 Regulation of Phosphorylation of Gopc 4 0.28 0.48 0 5.00
126 INT181802 Localization of Atxn1 6 0.65 3.15 0 5.00
127 INT282974 Binding of Becn1 24 0.07 7.43 0 5.00
128 INT123521 Phosphorylation of Bcl2 8 0.81 5 0 5.00
129 INT340693 Transcription of Atxn3 1 0.46 0.38 0 5.00
130 INT235141 Binding of Atxn7 1 0.40 0.81 0 5.00
131 INT325719 Negative_regulation of Positive_regulation of MAP1LC3A 1 0.06 0.58 0 5.00
132 INT258094 Negative_regulation of Atxn3 2 0.38 0.24 0 5.00
133 INT235151 Gene_expression of Atxn10 1 0.34 0.73 0 5.00
134 INT308852 Phosphorylation of Rps6kb2 1 0.36 0.16 0 5.00
135 INT340695 Negative_regulation of Protein_catabolism of Atxn3 1 0.59 0 0 5.00
136 INT235147 Negative_regulation of Localization of Atxn2 1 0.31 0.46 0 5.00
137 INT235143 Gene_expression of Dnaja1 1 0.17 0.47 0 5.00
138 INT340691 Protein_catabolism of Om 1 0.01 0 0 5.00
139 INT235161 Gene_expression of Anp32a 1 0.20 0.73 0 5.00
140 INT341937 Negative_regulation of Protein_catabolism of Tg(CAG-EGFP)D4Nagy 1 0.01 0.47 0 5.00
141 INT235140 Binding of Atr 1 0.00 1.28 0 5.00
142 INT235136 Positive_regulation of Localization of Atxn1 1 0.38 0.78 0 5.00
143 INT325712 Regulation of Gene_expression of Becn1 1 0.03 0.35 0 5.00
144 INT239157 Positive_regulation of Negative_regulation of Mtor 2 0.11 0.89 0 5.00
145 INT313014 Positive_regulation of Binding of Htt 2 0.13 0.91 0 5.00
146 INT235148 Positive_regulation of Binding of Atxn1 1 0.38 0.74 0 5.00
147 INT235131 Positive_regulation of Gene_expression of Dnaja1 1 0.15 0.47 0 5.00
148 INT308850 Protein_catabolism of Bcl2a1a 1 0.24 0.06 0 5.00
149 INT340688 Protein_catabolism of Atxn3 1 1.00 0.29 0 5.00
150 INT340697 Regulation of Dub1 1 0.01 0 0 5.00
151 INT325722 Positive_regulation of Phosphorylation of MAP1LC3A 1 0.07 0.34 0 5.00
152 INT183821 Gene_expression of AMCN 5 0.65 1.89 0 5.00
153 INT341935 Regulation of Phosphorylation of Bcl2 1 0.04 0 0 5.00
154 INT308843 Regulation of Phosphorylation of Rps6 1 0.03 0.16 0 5.00
155 INT341936 Gene_expression of Kth1 1 0.01 0 0 5.00
156 INT341940 Regulation of Fk 1 0.60 0 0 5.00
157 INT325723 Phosphorylation of MAP1LC3A 1 0.11 0.34 0 5.00
158 INT325721 Positive_regulation of Negative_regulation of MAP1LC3A 1 0.06 0.58 0 5.00
159 INT303277 Protein_catabolism of Map1lc3a 3 0.94 0.31 0 5.00
160 INT308849 Regulation of Phosphorylation of Rps6kb2 1 0.20 0.16 0 5.00
161 INT235156 Phosphorylation of Atxn1 1 0.66 0.85 0 5.00
162 INT271907 Phosphorylation of Rps6 4 0.09 0.67 0 5.00
163 INT282988 Regulation of Binding of Becn1 2 0.05 0 0 5.00
164 INT185909 Regulation of Phosphorylation of BCL2 3 0.24 1.63 0 5.00
165 INT308846 Negative_regulation of Protein_catabolism of Map1lc3a 1 0.41 0.06 0 5.00
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