D:Macrocephaly

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Disease Term
Synonyms Macrocephalies
Documents 55
Hot Single Events 27
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Macrocephaly. They are ordered first by their relevance to Macrocephaly and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT239081 Binding of GH1 and MAS1 1 0.03 1.41 0.15 100.00
2 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21 99.80
3 INT191612 Nf1 Positive_regulation of ras 1 0.25 2.6 0.11 53.32
4 INT191614 Adcyap1 Positive_regulation of Rtcd1 1 0.01 0.93 0 30.40
5 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65 5.00
6 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3 5.00
7 INT281482 Drd2 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.21 0.27 0.87 5.00
8 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86 5.00
9 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8 5.00
10 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42 5.00
11 INT311616 Binding of MET and Comt 1 0.01 0.2 0.37 5.00
12 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32 5.00
13 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32 5.00
14 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3 5.00
15 INT191619 Binding of App and Flna 1 0.04 0.18 0.24 5.00
16 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
17 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19 5.00
18 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17 5.00
19 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17 5.00
20 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17 5.00
21 INT257937 Binding of CSF2 and INVS 1 0.04 1.1 0.14 5.00
22 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 5.00
23 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
24 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 5.00
25 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
26 INT191617 Binding of Nf1 and Rtcd1 1 0.01 0.95 0.08 5.00
27 INT337072 Binding of Fmr1 and Gusb 1 0.19 1.55 0.08 5.00
28 INT355542 Binding of XRCC3 and BCC1 1 0.00 1.19 0.07 5.00
29 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
30 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
31 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
32 INT191613 Binding of Nf1 and Rasa1 1 0.06 0.88 0.03 5.00
33 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00
34 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0 5.00
35 INT304020 AR Regulation of TP53 1 0.24 1.11 0 5.00
36 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0 5.00
37 INT239080 Binding of PPY and KAT2B 1 0.02 2.38 0 5.00
38 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
39 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0 5.00
40 INT304014 Binding of MSI1 and SGCG 1 0.00 1.92 0 5.00
41 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0 5.00
42 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0 5.00
43 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0 5.00
44 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00
45 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0 5.00
46 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00
47 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 5.00
48 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0 5.00
49 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0 5.00
50 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
51 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0 5.00
52 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0 5.00
53 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
54 INT304016 SFRP4 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
55 INT304013 Binding of SUZ12 and JAZF1 1 0.30 1.89 0 5.00
56 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Macrocephaly. They are ordered first by their pain relevance and then by number of times they were reported in Macrocephaly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT276199 Binding of Pten 2 0.30 0.4 0.67 99.80
2 INT47744 Binding of Slc6a4 21 0.48 5.52 9.45 99.44
3 INT9683 Binding of GH1 57 0.47 21.14 5.99 98.60
4 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 97.64
5 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 97.52
6 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 96.96
7 INT85462 Binding of KTWS 3 0.31 2.91 0.54 96.52
8 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 94.16
9 INT313892 Localization of CADPS 1 0.48 2.37 0.2 94.08
10 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 93.56
11 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 92.16
12 INT228249 Binding of Pten 7 0.48 3.26 1.45 91.32
13 INT246552 Transcription of Fmr1 11 0.72 6.72 0.71 90.84
14 INT287577 Positive_regulation of Transcription of Fmr1 2 0.48 2.5 0.16 90.84
15 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 90.60
16 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 89.12
17 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 86.56
18 INT183556 Gene_expression of SNURF 1 0.47 1.83 0.25 86.44
19 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54 86.28
20 INT183537 Gene_expression of SNRPN 16 0.64 5.07 0.28 86.20
21 INT183555 Gene_expression of SNORD108 1 0.44 1.61 0.25 85.24
22 INT183544 Gene_expression of SNORD64 1 0.11 1.61 0.25 84.72
23 INT183536 Gene_expression of SNORD109A 5 0.50 2.7 0.32 84.24
24 INT183551 Gene_expression of SNORD116-1 1 0.56 1.77 0.24 84.24
25 INT183539 Gene_expression of SNORD116@ 1 0.10 1.76 0.24 84.24
26 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54 82.40
27 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53 82.40
28 INT301374 Localization of Stk11 1 0.23 1.58 0 79.36
29 INT206482 Positive_regulation of Nes 5 0.46 1.6 0.44 79.04
30 INT257940 Gene_expression of HYDIN 1 0.02 1.46 0.31 78.24
31 INT67133 Gene_expression of Gusb 14 0.75 18.57 1.37 77.20
32 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 73.56
33 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0 73.56
34 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24 67.92
35 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 67.64
36 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8 66.80
37 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 66.68
38 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84 66.68
39 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22 66.36
40 INT181973 Positive_regulation of MAS1 8 0.49 7.64 1.07 63.60
41 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68 63.40
42 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 63.12
43 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 57.20
44 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 57.04
45 INT146546 Gene_expression of MSI1 22 0.48 22.91 1.15 55.52
46 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 55.12
47 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 47.76
48 INT277884 Binding of Tas2r111-ps2 1 0.09 0.95 0.19 45.20
49 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63 43.08
50 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 42.08
51 INT256627 Regulation of Negative_regulation of Ptch2 1 0.32 1.33 0 40.32
52 INT256625 Negative_regulation of Ptch2 1 0.42 1.27 0 38.88
53 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 35.88
54 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 35.88
55 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 32.72
56 INT252 Localization of GH1 529 0.80 227.4 122.05 29.16
57 INT425 Localization of PRL 455 0.81 189.64 144.8 29.04
58 INT29086 Negative_regulation of Sert1 37 0.58 7.49 14.98 25.88
59 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 19.60
60 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 19.48
61 INT55185 Binding of Sert1 26 0.48 4.43 7.57 19.32
62 INT24453 Binding of NLRP3 18 0.48 13.7 1.93 18.56
63 INT256626 Regulation of Ptch2 1 0.28 1.11 0 17.76
64 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93 15.16
65 INT190026 Positive_regulation of Gene_expression of Nf1 3 0.53 2.45 0.07 15.16
66 INT236277 Positive_regulation of Gene_expression of CADPS 5 0.42 9.17 1.29 14.00
67 INT2544 Localization of PTH 39 0.81 30.55 2.22 12.72
68 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 7.40
69 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13 5.96
70 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
71 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
72 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
73 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 5.00
74 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
75 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76 5.00
76 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
77 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
78 INT442 Localization of PDYN 99 0.81 11.87 72.75 5.00
79 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
80 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 5.00
81 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
82 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 5.00
83 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
84 INT1430 Regulation of PDYN 88 0.60 16.99 60.32 5.00
85 INT7032 Positive_regulation of Pdyn 94 0.66 26.51 58.83 5.00
86 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
87 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 5.00
88 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 5.00
89 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
90 INT6823 Negative_regulation of Pdyn 68 0.58 13.95 46.12 5.00
91 INT5214 Localization of Cpe 49 0.73 13.3 44.36 5.00
92 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
93 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
94 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 5.00
95 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 5.00
96 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01 5.00
97 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
98 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
99 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
100 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
101 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 5.00
102 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
103 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 5.00
104 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
105 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
106 INT102206 Regulation of Bdnf 37 0.62 28.54 28.78 5.00
107 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
108 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
109 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
110 INT93360 Gene_expression of Slc6a3 63 0.78 19.54 26.55 5.00
111 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
112 INT17625 Localization of GCG 210 0.80 55.69 24.97 5.00
113 INT30276 Positive_regulation of Gene_expression of Pdyn 39 0.67 11.28 24.89 5.00
114 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
115 INT12484 Binding of Drd2 45 0.48 15.17 24.72 5.00
116 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
117 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
118 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42 5.00
119 INT7715 Regulation of Drd2 35 0.62 10.79 22.3 5.00
120 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
121 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
122 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
123 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
124 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
125 INT101537 Gene_expression of Vta1 19 0.50 1.88 20.76 5.00
126 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
127 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
128 INT79349 Gene_expression of Sert1 58 0.77 12.7 20.65 5.00
129 INT102203 Transcription of Bdnf 35 0.71 18.26 20.59 5.00
130 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
131 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18 5.00
132 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
133 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
134 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
135 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
136 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
137 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
138 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
139 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51 5.00
140 INT7644 Positive_regulation of Gene_expression of PDYN 27 0.69 10.19 17.47 5.00
141 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
142 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
143 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
144 INT8530 Transcription of Penk 48 0.70 11.67 16.34 5.00
145 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
146 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
147 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
148 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
149 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
150 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17 5.00
151 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
152 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
153 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
154 INT28314 Negative_regulation of Gene_expression of Gabrg1 29 0.44 12.56 13.8 5.00
155 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
156 INT7031 Transcription of Pdyn 43 0.71 5.82 13.58 5.00
157 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
158 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
159 INT10585 Localization of NAGLU 53 0.80 23.32 12.75 5.00
160 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
161 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54 5.00
162 INT29964 Positive_regulation of Positive_regulation of PDYN 9 0.67 1.56 11.31 5.00
163 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
164 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 5.00
165 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75 5.00
166 INT93967 Binding of Slc6a3 22 0.48 6.81 10.74 5.00
167 INT114393 Positive_regulation of Vta1 15 0.29 0.75 10.64 5.00
168 INT90639 Positive_regulation of Slc6a3 25 0.61 10.95 10.41 5.00
169 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 5.00
170 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07 5.00
171 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48 5.00
172 INT129585 Gene_expression of St13 17 0.59 4.46 9.3 5.00
173 INT136012 Regulation of Transcription of Bdnf 6 0.45 2.76 9.2 5.00
174 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 5.00
175 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
176 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
177 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
178 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
179 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 5.00
180 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 5.00
181 INT97623 Negative_regulation of Adc 17 0.56 3.81 8.14 5.00
182 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
183 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
184 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38 5.00
185 INT73760 Transcription of Drd2 14 0.72 2.11 7.19 5.00
186 INT102207 Positive_regulation of Transcription of Bdnf 13 0.69 5.49 7.18 5.00
187 INT28315 Regulation of Gene_expression of Gabrg1 20 0.60 4.78 7 5.00
188 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87 5.00
189 INT66987 Regulation of Th 23 0.61 7.86 6.8 5.00
190 INT79348 Positive_regulation of Sert1 11 0.64 4.32 6.17 5.00
191 INT86772 Localization of Drd2 14 0.80 1.93 6.17 5.00
192 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 5.00
193 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
194 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
195 INT10006 Regulation of Mtr 9 0.23 3.56 5.42 5.00
196 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35 5.00
197 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
198 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
199 INT79346 Regulation of Sert1 10 0.58 2.36 5.18 5.00
200 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 5.00
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