D:Macromastia

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Disease Term
Synonyms BREAST ENLARGEMENT, Breast Enlargement Female, Breasts Enlarged, Hypertrophy Of Breast, Large Breast, Mammary Hypertrophy
Documents 94
Hot Single Events 19
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Macromastia. They are ordered first by their relevance to Macromastia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT258492 Binding of Ins1 and Cdipt 1 0.00 0.92 0 73.04
2 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07 69.00
3 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07 68.60
4 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31 5.00
5 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
6 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
7 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
8 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
9 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
10 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
11 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
12 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
13 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
14 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
15 INT260375 Binding of T2 and Htas2 1 0.00 0.18 0 5.00
16 INT260382 Das Negative_regulation of Gene_expression of IGLL1 1 0.00 0.94 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Macromastia. They are ordered first by their pain relevance and then by number of times they were reported in Macromastia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2138 Negative_regulation of Cga 5 0.43 3.37 2.1 99.44
2 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 98.68
3 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 98.44
4 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17 98.08
5 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 95.04
6 INT38557 Positive_regulation of Gene_expression of DBT 8 0.37 2.05 0.92 94.80
7 INT158 Localization of Prl 2431 0.81 378.96 952.2 94.44
8 INT44616 Positive_regulation of Klk1 2 0.02 2.12 0.98 94.12
9 INT44615 Positive_regulation of Gene_expression of Klk1 1 0.02 0.22 0.08 94.12
10 INT38556 Gene_expression of DBT 47 0.50 12.52 5.6 93.80
11 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 93.52
12 INT44617 Gene_expression of Klk1 2 0.07 0.38 0.08 93.12
13 INT2136 Gene_expression of Cga 21 0.77 9.83 2.62 91.56
14 INT162 Regulation of Prl 794 0.62 165.01 322.24 91.36
15 INT124940 Binding of MTNR1A 8 0.36 2.29 0.9 90.56
16 INT119098 Positive_regulation of TRPV3 20 0.68 10.12 9.01 90.48
17 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02 90.48
18 INT103547 Gene_expression of TRPV3 47 0.78 17.06 13.34 87.92
19 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01 87.92
20 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 78.60
21 INT85048 Regulation of NGF 19 0.62 11.61 10.5 78.60
22 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 77.36
23 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 74.72
24 INT43479 Positive_regulation of Positive_regulation of CGA 9 0.39 4.24 1.46 74.72
25 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06 74.32
26 INT124295 Positive_regulation of Positive_regulation of CGB 1 0.14 0.55 0.1 74.32
27 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 74.12
28 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 73.20
29 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 67.28
30 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32 66.76
31 INT232442 Negative_regulation of Gene_expression of DDC 1 0.05 1.44 0.58 66.76
32 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31 66.20
33 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 63.60
34 INT273471 Negative_regulation of PTBP1 7 0.34 9.2 1.1 63.52
35 INT425 Localization of PRL 455 0.81 189.64 144.8 60.80
36 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 60.80
37 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 60.40
38 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46 59.64
39 INT15887 Gene_expression of Nbr1 39 0.77 23.91 7.34 55.80
40 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 49.72
41 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 43.88
42 INT58883 Gene_expression of T2 12 0.63 2.56 0.71 25.36
43 INT260381 Gene_expression of TFPT 1 0.16 0.84 0.05 25.36
44 INT16114 Negative_regulation of LGR6 1 0.51 0.21 0.14 25.00
45 INT252 Localization of GH1 529 0.80 227.4 122.05 19.68
46 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
47 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
48 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
49 INT6761 Binding of CALCA 100 0.48 26.71 62.05 5.00
50 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
51 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
52 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
53 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
54 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
55 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
56 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 5.00
57 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 5.00
58 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
59 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
60 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
61 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
62 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
63 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
64 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
65 INT7383 Localization of VIP 53 0.81 17.7 22.65 5.00
66 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
67 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
68 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
69 INT18621 Binding of ABAT 28 0.36 9.88 18.04 5.00
70 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
71 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 5.00
72 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
73 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
74 INT75908 Regulation of LEP 77 0.60 60.16 15.19 5.00
75 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
76 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
77 INT7587 Localization of GAL 27 0.78 4.79 14.29 5.00
78 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 5.00
79 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 5.00
80 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 5.00
81 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 5.00
82 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
83 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 5.00
84 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
85 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
86 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 5.00
87 INT10237 Binding of EDN1 40 0.48 16 8.48 5.00
88 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 5.00
89 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 5.00
90 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 5.00
91 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 5.00
92 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 5.00
93 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 5.00
94 INT24191 Binding of VIP 14 0.40 2.16 6.2 5.00
95 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89 5.00
96 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 5.00
97 INT29290 Regulation of Gene_expression of PRL 13 0.49 6.46 5.23 5.00
98 INT58750 Binding of GAL 16 0.47 5.48 4.92 5.00
99 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 5.00
100 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
101 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
102 INT181495 Regulation of TRPV3 3 0.25 6.57 4.22 5.00
103 INT76149 Gene_expression of Das 18 0.37 6.55 3.92 5.00
104 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 5.00
105 INT20455 Positive_regulation of Bche 15 0.59 7.22 3.7 5.00
106 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23 5.00
107 INT31340 Positive_regulation of Gene_expression of Got1 20 0.46 10.5 3.17 5.00
108 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 5.00
109 INT34891 Transcription of PRL 4 0.72 0.69 2.36 5.00
110 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92 5.00
111 INT124322 Negative_regulation of PNLIP 11 0.31 6.53 1.88 5.00
112 INT223919 Gene_expression of Cdipt 5 0.20 0.89 1.85 5.00
113 INT4028 Regulation of HYAL1 8 0.54 1.55 1.8 5.00
114 INT45041 Gene_expression of IGLL1 18 0.66 15.45 1.59 5.00
115 INT31047 Localization of HRH2 5 0.75 1.84 1.53 5.00
116 INT80784 Regulation of BCS1L 9 0.39 7.63 1.47 5.00
117 INT232445 Positive_regulation of Transcription of PRL 1 0.50 0 1.32 5.00
118 INT36947 Gene_expression of PNLIP 13 0.45 11.04 1.23 5.00
119 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16 5.00
120 INT121788 Localization of BCS1L 11 0.73 10.16 1.14 5.00
121 INT105149 Gene_expression of PTBP1 10 0.75 12.27 1.09 5.00
122 INT181497 Regulation of Regulation of TRPV4 1 0.23 0.69 1.08 5.00
123 INT39955 Positive_regulation of Negative_regulation of PRL 3 0.70 0.47 0.9 5.00
124 INT157846 Gene_expression of BCS1L 13 0.50 15.89 0.83 5.00
125 INT27220 Binding of CYP3A5 4 0.47 0.53 0.73 5.00
126 INT28484 Regulation of Cog1 6 0.43 4.96 0.71 5.00
127 INT34889 Regulation of Transcription of PRL 2 0.42 0.55 0.67 5.00
128 INT290081 Regulation of NRG1 7 0.26 5.24 0.59 5.00
129 INT232453 Negative_regulation of DNAJA3 1 0.41 0 0.54 5.00
130 INT211807 Binding of PTBP1 11 0.31 6.09 0.45 5.00
131 INT42032 Localization of PNLIP 4 0.14 3.44 0.41 5.00
132 INT119271 Positive_regulation of BCS1L 13 0.50 7.56 0.39 5.00
133 INT45040 Positive_regulation of Gene_expression of IGLL1 4 0.59 1.59 0.33 5.00
134 INT81196 Regulation of T2 3 0.11 1.92 0.33 5.00
135 INT232449 Negative_regulation of Transcription of PRL 1 0.59 0 0.3 5.00
136 INT232452 Positive_regulation of Binding of PRL 1 0.50 0.18 0.27 5.00
137 INT232444 Regulation of Localization of GAL 1 0.44 0.28 0.27 5.00
138 INT28719 Binding of T2 3 0.20 1.55 0.21 5.00
139 INT81197 Transcription of T2 2 0.17 1.37 0.21 5.00
140 INT133858 Negative_regulation of BCS1L 13 0.51 8.65 0.2 5.00
141 INT260372 Transcription of Das 2 0.09 1.6 0.19 5.00
142 INT232448 Positive_regulation of Gene_expression of TRH 1 0.32 0.08 0.17 5.00
143 INT247099 Positive_regulation of PTBP1 7 0.50 9.21 0.16 5.00
144 INT205654 Gene_expression of FUS 9 0.32 11.53 0.16 5.00
145 INT144766 Binding of BCS1L 11 0.32 8.2 0.13 5.00
146 INT168503 Binding of FUS 5 0.29 5.12 0.12 5.00
147 INT247100 Positive_regulation of Gene_expression of PTBP1 2 0.25 1.33 0.08 5.00
148 INT260371 Gene_expression of Htas2 1 0.02 0.81 0.06 5.00
149 INT354032 Gene_expression of LEPROT 1 0.02 1.9 0 5.00
150 INT354031 Regulation of Gene_expression of ANKHD1 1 0.05 0.29 0 5.00
151 INT260380 Negative_regulation of Gene_expression of IGLL1 3 0.02 1.46 0 5.00
152 INT260379 Negative_regulation of TFPT 1 0.11 0.82 0 5.00
153 INT260376 Protein_catabolism of TERT 1 0.02 0.36 0 5.00
154 INT273473 Regulation of Gene_expression of PTBP1 1 0.23 0.88 0 5.00
155 INT273472 Regulation of Gene_expression of BCS1L 1 0.32 1.89 0 5.00
156 INT231623 Positive_regulation of SHE 6 0.44 1.04 0 5.00
157 INT260377 Positive_regulation of TFPT 1 0.11 0.17 0 5.00
158 INT354033 Gene_expression of ANKHD1 1 0.07 0.58 0 5.00
159 INT260378 Regulation of Gene_expression of TFPT 1 0.07 0.18 0 5.00
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