D:Macrophage Activation Syndrome

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Disease Term
Synonyms Syndrome Macrophage Activation
Documents 23
Hot Single Events 25
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Macrophage Activation Syndrome. They are ordered first by their relevance to Macrophage Activation Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT181976 TNF Regulation of Transcription of Gpi1 1 0.00 0.64 0.26 74.16
2 INT181977 TNF Regulation of Gene_expression of Gpi1 1 0.00 0.64 0.25 74.16
3 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4 70.84
4 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43 65.48
5 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 65.48
6 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 65.12
7 INT352986 IL10 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 65.12
8 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 59.28
9 INT188432 Negative_regulation of Binding of ABCA1 and IL6 1 0.02 0.47 0.05 18.24
10 INT188431 Binding of ABCA1 and IL6 1 0.02 0.47 0.05 18.24
11 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66 11.12
12 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
13 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
14 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
15 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
16 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23 5.00
17 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72 5.00
18 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72 5.00
19 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69 5.00
20 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69 5.00
21 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68 5.00
22 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68 5.00
23 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63 5.00
24 INT172145 IL10 Negative_regulation of Gene_expression of CSF2 1 0.04 0.69 0.59 5.00
25 INT172144 IL4 Negative_regulation of Transcription of PLA2G4A 1 0.02 0.82 0.58 5.00
26 INT172133 IL4 Negative_regulation of Gene_expression of HMOX2 1 0.00 0.81 0.58 5.00
27 INT172137 IL11 Negative_regulation of Gene_expression of TNF 1 0.09 0.73 0.47 5.00
28 INT172149 IL17A Positive_regulation of Gene_expression of IL1B 1 0.01 0.5 0.43 5.00
29 INT172138 IL17A Positive_regulation of Gene_expression of TNF 1 0.07 0.5 0.43 5.00
30 INT172136 IL18 Positive_regulation of Gene_expression of IFN1@ 1 0.09 0.63 0.42 5.00
31 INT172135 Binding of IL2 and IL6 1 0.01 0.57 0.37 5.00
32 INT172148 Binding of IL2 and TNF 2 0.05 0.67 0.37 5.00
33 INT172140 CSF2 Positive_regulation of Gene_expression of TIMP1 1 0.07 0.72 0.27 5.00
34 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24 5.00
35 INT260318 Binding of PROC and Anxa5 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Macrophage Activation Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Macrophage Activation Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT181973 Positive_regulation of MAS1 8 0.49 7.64 1.07 100.00
2 INT131488 Binding of MAS1 9 0.36 8.49 1.01 100.00
3 INT181974 Positive_regulation of Positive_regulation of MAS1 1 0.01 1.28 0.14 100.00
4 INT20044 Negative_regulation of Gpi1 50 0.59 29.96 26 99.84
5 INT87844 Binding of IL1RN 40 0.41 24.37 11.92 99.70
6 INT113186 Gene_expression of Prf1 46 0.53 21.06 5.32 98.96
7 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 97.30
8 INT181969 Regulation of Gene_expression of Prf1 7 0.23 3.62 0.85 96.84
9 INT6852 Localization of TNF 883 0.81 705.95 270.84 96.80
10 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 96.16
11 INT37430 Gene_expression of Gpi1 61 0.63 54.63 13.87 95.68
12 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 93.76
13 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 92.88
14 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 92.88
15 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 92.64
16 INT15012 Regulation of Gpi1 18 0.60 11.64 6.91 91.32
17 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 90.56
18 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 90.24
19 INT181966 Negative_regulation of Gene_expression of Prf1 8 0.21 5.41 1.42 90.16
20 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 87.60
21 INT171223 Regulation of Ncam1 5 0.20 3.81 0.43 87.52
22 INT92476 Gene_expression of Gzmb 19 0.58 7.78 1.94 86.68
23 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 85.20
24 INT352983 Protein_catabolism of IL10 1 0.13 1.04 0.41 82.04
25 INT181968 Negative_regulation of Prf1 3 0.16 4.27 0.15 80.88
26 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 79.80
27 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 77.84
28 INT133905 Gene_expression of Ncam1 24 0.78 10.2 4.62 77.04
29 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 76.84
30 INT167035 Regulation of Cd8a 25 0.41 16.78 1.9 76.24
31 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 75.92
32 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 75.92
33 INT181972 Regulation of Gene_expression of Gzmb 3 0.16 1.81 0.36 75.88
34 INT181967 Regulation of Gzmb 1 0.09 0.35 0.04 75.88
35 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 75.08
36 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 73.84
37 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 70.12
38 INT181964 Positive_regulation of Gene_expression of Gzmb 1 0.10 0.57 0.08 69.72
39 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 68.56
40 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 68.24
41 INT6481 Binding of TNF 624 0.48 510.2 214.82 68.08
42 INT181970 Positive_regulation of Transcription of Gpi1 1 0.04 1.1 0.44 67.64
43 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 67.28
44 INT181971 Transcription of Gpi1 3 0.37 1.29 0.67 66.88
45 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 63.88
46 INT140337 Negative_regulation of Cd8a 42 0.50 25.4 3.66 63.48
47 INT60527 Transcription of IL10 16 0.56 13.57 6.42 60.96
48 INT56299 Transcription of IL4 15 0.64 10.2 5.44 60.96
49 INT320154 Phosphorylation of IL6R 1 0.04 1.13 0.21 60.76
50 INT86437 Binding of IL6 154 0.48 121.22 29.3 59.28
51 INT174816 Binding of IL6R 14 0.09 11.26 3.63 59.28
52 INT254237 Negative_regulation of trm 1 0.04 0.88 0.06 56.56
53 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 55.60
54 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 55.48
55 INT292298 Positive_regulation of GOT2 5 0.45 3.7 1.46 54.08
56 INT188434 Positive_regulation of IL6R 2 0.02 2.17 0.49 52.68
57 INT135722 Positive_regulation of Gene_expression of ANGPTL5 5 0.39 4.52 1.05 51.48
58 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 51.12
59 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98 50.92
60 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 50.44
61 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 50.44
62 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 50.44
63 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64 48.72
64 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 48.16
65 INT20373 Localization of Cd8a 28 0.64 8.22 2.07 47.84
66 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 44.08
67 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 37.12
68 INT181965 Negative_regulation of Gene_expression of Gpi1 3 0.07 2.83 0.51 34.56
69 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 34.52
70 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 34.16
71 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 34.16
72 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 28.00
73 INT148894 Binding of Cytl1 2 0.47 0.99 0.77 24.44
74 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19 23.48
75 INT99149 Negative_regulation of VCAM1 4 0.36 3.29 0.93 23.48
76 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 19.72
77 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 19.28
78 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 19.28
79 INT89240 Gene_expression of VEGFC 23 0.75 15.94 2.03 19.28
80 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 17.64
81 INT13354 Transcription of TNF 108 0.72 85.81 42.32 17.20
82 INT188433 Negative_regulation of Binding of IL6 6 0.42 2.03 0.56 15.76
83 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 8.52
84 INT54763 Binding of Il6 82 0.48 63.27 12.89 7.08
85 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
86 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
87 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
88 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
89 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
90 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
91 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
92 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
93 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
94 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
95 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
96 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
97 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
98 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
99 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
100 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
101 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
102 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
103 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
104 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
105 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
106 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
107 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
108 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
109 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
110 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
111 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
112 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
113 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
114 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
115 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
116 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
117 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
118 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
119 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
120 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
121 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
122 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
123 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
124 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
125 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
126 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
127 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
128 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
129 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
130 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
131 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
132 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
133 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
134 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 5.00
135 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
136 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
137 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
138 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
139 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 5.00
140 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
141 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
142 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
143 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 5.00
144 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09 5.00
145 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08 5.00
146 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 5.00
147 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
148 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
149 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
150 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 5.00
151 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 5.00
152 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
153 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 5.00
154 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
155 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
156 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 5.00
157 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62 5.00
158 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
159 INT100821 Localization of Ros1 59 0.60 45.26 11.92 5.00
160 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
161 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
162 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78 5.00
163 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 5.00
164 INT9385 Localization of LDHA 74 0.81 31.67 10.5 5.00
165 INT35460 Gene_expression of IL16 45 0.75 48.71 10.5 5.00
166 INT56292 Negative_regulation of Gene_expression of Ros1 70 0.38 36.14 9.17 5.00
167 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12 5.00
168 INT1168 Binding of PROC 62 0.38 44.15 9.04 5.00
169 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 5.00
170 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 5.00
171 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 5.00
172 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64 5.00
173 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16 5.00
174 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 5.00
175 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 5.00
176 INT8101 Binding of INCENP 42 0.31 16.2 6.68 5.00
177 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 5.00
178 INT11048 Gene_expression of CD69 59 0.67 42.85 6.4 5.00
179 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 5.00
180 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 5.00
181 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 5.00
182 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 5.00
183 INT132573 Negative_regulation of Gene_expression of TH1L 16 0.42 11.52 5.76 5.00
184 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44 5.00
185 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 5.00
186 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4 5.00
187 INT171562 Regulation of IL4 19 0.36 12.12 5.33 5.00
188 INT170470 Binding of CD14 27 0.35 14.89 5.16 5.00
189 INT24886 Negative_regulation of SFTPA1 11 0.12 4.35 5.03 5.00
190 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
191 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
192 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09 5.00
193 INT83887 Gene_expression of HMOX2 10 0.77 7.99 3.85 5.00
194 INT172131 Positive_regulation of Gene_expression of fc 20 0.14 14.23 3.84 5.00
195 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79 5.00
196 INT60415 Regulation of NPEPPS 13 0.27 5.81 3.78 5.00
197 INT160828 Regulation of Gene_expression of Ros1 29 0.21 13.97 3.75 5.00
198 INT65072 Gene_expression of TKT 16 0.65 17.58 3.55 5.00
199 INT80656 Regulation of SLC17A5 15 0.26 6.89 3.19 5.00
200 INT181018 Binding of S100a8 20 0.45 22.14 3.18 5.00
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