D:Macular Edema

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Disease Term
Synonyms Central Retinal Edema Cystoid, CYSTOID MACULAR EDEMA, Cystoid Macular Edema Postoperative, Edema Cystoid Macular, Edema Macular, Irvine Gass Syndrome, Macular Edema Cystoid, Syndrome Irvine Gass
Documents 123
Hot Single Events 33
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Macular Edema. They are ordered first by their relevance to Macular Edema and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT245722 Binding of Vsx2 and Mfrp 1 0.24 1.2 0 89.32
2 INT285077 CCL16 Positive_regulation of ITK 1 0.05 1.95 0.31 89.00
3 INT285076 CCL16 Positive_regulation of Gene_expression of ITK 1 0.05 1.8 0.14 89.00
4 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03 75.32
5 INT285068 ITK Regulation of CCL16 1 0.02 1.86 0.03 47.64
6 INT285067 Negative_regulation of ITK Regulation of CCL16 1 0.04 1.1 0.03 47.64
7 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 5.00
8 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
9 INT229928 Binding of C3 and CFH 1 0.07 1.35 0.17 5.00
10 INT229931 Negative_regulation of Binding of C3 and CFH 1 0.08 1.35 0.17 5.00
11 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09 5.00
12 INT229977 Binding of amd and Cfb 1 0.03 2.78 0.06 5.00
13 INT229982 Binding of C3 and amd 1 0.02 1.14 0.06 5.00
14 INT229985 Binding of C2 and amd 1 0.01 1.89 0.06 5.00
15 INT229927 CD59 Negative_regulation of Binding of ABCA1 1 0.01 0 0 5.00
16 INT285071 EGF Positive_regulation of CCL16 1 0.03 0.77 0 5.00
17 INT229934 Binding of C3 and GPI 1 0.01 0 0 5.00
18 INT229923 Binding of ABCA1 and C9 1 0.00 0.74 0 5.00
19 INT229921 CD55 Negative_regulation of C4B 1 0.11 0 0 5.00
20 INT229925 Binding of C1S and TRGC1 1 0.01 0 0 5.00
21 INT229984 Binding of CD59 and Cdca3 1 0.03 0.73 0 5.00
22 INT229935 YBX1 Negative_regulation of C4B 1 0.00 0 0 5.00
23 INT285074 Positive_regulation of ITK Regulation of CCL16 1 0.04 0.77 0 5.00
24 INT229930 C3AR1 Positive_regulation of C3 1 0.00 0 0 5.00
25 INT274099 Binding of FANCB and VEGFA 1 0.10 0.33 0 5.00
26 INT229981 Binding of ABCA1 and Cdca3 1 0.00 0.74 0 5.00
27 INT229922 Binding of C9 and CD59 1 0.08 0.72 0 5.00
28 INT229983 Binding of CFH and Crp 2 0.14 1.48 0 5.00
29 INT285072 EGF Positive_regulation of ITK 1 0.03 0.77 0 5.00
30 INT229924 CD55 Positive_regulation of C4B 1 0.12 0 0 5.00
31 INT229932 C4B Positive_regulation of C3 1 0.07 0 0 5.00
32 INT229929 Binding of C4B and CFH 1 0.09 0 0 5.00
33 INT229920 Binding of C4B and CD55 1 0.09 0 0 5.00
34 INT229919 GPI Negative_regulation of Binding of C3 and GPI 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Macular Edema. They are ordered first by their pain relevance and then by number of times they were reported in Macular Edema. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 97.28
2 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 96.80
3 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 96.16
4 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 94.00
5 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 91.32
6 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 91.04
7 INT115802 Positive_regulation of Positive_regulation of HRASLS 2 0.12 3.06 1.03 91.04
8 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 90.92
9 INT245717 Binding of Vsx2 2 0.27 1.2 0 89.32
10 INT245715 Binding of Mfrp 1 0.48 3.46 0 88.92
11 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 88.84
12 INT267894 Gene_expression of ITK 13 0.57 9.71 0.9 88.04
13 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 86.52
14 INT109910 Gene_expression of CCL16 104 0.74 76.1 43.97 86.16
15 INT116540 Binding of Twist1 35 0.48 16.32 2.85 85.92
16 INT24519 Negative_regulation of ERG 15 0.38 6.98 1.33 85.76
17 INT66198 Negative_regulation of Gene_expression of Gfap 13 0.59 10.33 3.41 85.76
18 INT228607 Negative_regulation of Gene_expression of ERG 2 0.03 1.1 0.15 85.76
19 INT285097 Negative_regulation of CCL16 3 0.13 3.88 0.24 85.68
20 INT109470 Negative_regulation of ITK 3 0.24 2.13 0.96 85.68
21 INT209417 Gene_expression of ERG 21 0.20 6.69 1.26 85.44
22 INT228606 Positive_regulation of Gene_expression of ERG 4 0.02 1.96 0.37 85.44
23 INT101474 Positive_regulation of Gene_expression of Gfap 61 0.70 38.3 10.35 84.88
24 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 84.88
25 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08 84.76
26 INT122950 Binding of BAK1 16 0.41 12.85 0.31 84.76
27 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 84.48
28 INT184743 Localization of BTG3 4 0.68 3.6 0.78 83.84
29 INT308261 Positive_regulation of Localization of BTG3 1 0.39 1.61 0.32 83.84
30 INT22383 Binding of IL2 59 0.48 39.06 8.56 83.76
31 INT285094 Binding of ITK 4 0.11 2.14 0.05 83.60
32 INT17885 Negative_regulation of YWHAZ 6 0.56 2.74 1.58 81.52
33 INT99965 Positive_regulation of Negative_regulation of NARFL 6 0.40 4.5 0.04 80.68
34 INT229940 Positive_regulation of amd 10 0.49 27.97 0.15 77.20
35 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 77.12
36 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 77.12
37 INT109917 Positive_regulation of Gene_expression of CCL16 17 0.66 11.87 2.94 74.80
38 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 73.36
39 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 73.08
40 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 73.04
41 INT6282 Negative_regulation of Del(7)Tyr<c-1DThWb>-p 10 0.57 6.74 2.38 70.96
42 INT208589 Negative_regulation of Gene_expression of CCL16 3 0.40 2.1 0.52 67.44
43 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 67.04
44 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14 64.36
45 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49 59.88
46 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 57.24
47 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 56.96
48 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 56.96
49 INT285095 Regulation of GSPT1 1 0.00 0.83 0.03 56.96
50 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 54.84
51 INT325465 Positive_regulation of CDC7 1 0.03 3.47 0.18 45.48
52 INT245716 Gene_expression of Mfrp 1 0.78 2.35 0 39.60
53 INT272415 Negative_regulation of Gene_expression of NARFL 14 0.34 17.62 0.73 35.60
54 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 34.36
55 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 33.00
56 INT273474 Positive_regulation of Gene_expression of Lefty1 1 0.01 1.61 0.26 32.96
57 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 31.84
58 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 31.84
59 INT172959 Gene_expression of Lefty1 4 0.21 5.15 0.76 31.84
60 INT245721 Localization of FRZB 6 0.78 4.3 0.6 30.72
61 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 28.16
62 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 26.88
63 INT245718 Positive_regulation of Mfrp 1 0.44 0.5 0 23.20
64 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 18.40
65 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15 18.40
66 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 18.00
67 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 12.60
68 INT269220 Positive_regulation of Gene_expression of ITK 4 0.14 3.07 0.41 11.24
69 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 10.88
70 INT274271 Negative_regulation of Negative_regulation of NARFL 1 0.06 5.13 0.22 8.40
71 INT274273 Regulation of Gene_expression of NARFL 3 0.10 4.39 0.2 8.40
72 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
73 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
74 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
75 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
76 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
77 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
78 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
79 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
80 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
81 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
82 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
83 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
84 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
85 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
86 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
87 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
88 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
89 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
90 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
91 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
92 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
93 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
94 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
95 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
96 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
97 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
98 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
99 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
100 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
101 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
102 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
103 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
104 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
105 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
106 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 5.00
107 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
108 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
109 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
110 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
111 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 5.00
112 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 5.00
113 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
114 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
115 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
116 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
117 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
118 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
119 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
120 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
121 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 5.00
122 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
123 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 5.00
124 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 5.00
125 INT81194 Binding of CPOX 40 0.29 23.7 18.95 5.00
126 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
127 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 5.00
128 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
129 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 5.00
130 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
131 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
132 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
133 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
134 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
135 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 5.00
136 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 5.00
137 INT99586 Binding of IRF6 60 0.36 27.87 13.2 5.00
138 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
139 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39 5.00
140 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 5.00
141 INT1763 Regulation of Gene_expression of PTGER2 43 0.36 23.98 10.95 5.00
142 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
143 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
144 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
145 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
146 INT860 Regulation of ALB 48 0.60 25.11 8.95 5.00
147 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
148 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 5.00
149 INT182229 Positive_regulation of CCL16 15 0.66 12.19 8.21 5.00
150 INT32579 Binding of C4B 14 0.36 14.99 7.79 5.00
151 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 5.00
152 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58 5.00
153 INT173537 Binding of CCL16 18 0.40 13.02 7.36 5.00
154 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
155 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7 5.00
156 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
157 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 5.00
158 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 5.00
159 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
160 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87 5.00
161 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84 5.00
162 INT127062 Positive_regulation of Gene_expression of LTB4R 18 0.34 15.9 5.64 5.00
163 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37 5.00
164 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
165 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
166 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
167 INT131152 Gene_expression of Cr1l 17 0.75 10.83 4.88 5.00
168 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 5.00
169 INT23045 Positive_regulation of Hbb 31 0.64 19.35 4.54 5.00
170 INT124136 Positive_regulation of YWHAZ 7 0.67 1.85 4.51 5.00
171 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51 5.00
172 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5 5.00
173 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
174 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 5.00
175 INT43931 Binding of CFH 49 0.48 31.85 3.96 5.00
176 INT171040 Transcription of CCL16 11 0.68 7.09 3.86 5.00
177 INT97638 Localization of CCL16 11 0.66 4.89 3.74 5.00
178 INT194846 Positive_regulation of Positive_regulation of Il10 9 0.57 5.07 3.71 5.00
179 INT170755 Positive_regulation of Positive_regulation of IFN1@ 17 0.67 8.72 3.65 5.00
180 INT14837 Gene_expression of PLA2G1B 12 0.60 10.69 3.58 5.00
181 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 5.00
182 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53 5.00
183 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47 5.00
184 INT3183 Negative_regulation of MRXS5 15 0.41 6.56 3.45 5.00
185 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 5.00
186 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
187 INT78297 Gene_expression of CD59 31 0.72 24.11 3.18 5.00
188 INT173535 Regulation of CCL16 6 0.10 4.93 2.81 5.00
189 INT44150 Regulation of TBXA2R 10 0.19 3.94 2.62 5.00
190 INT10795 Positive_regulation of CD59 9 0.36 2.11 2.52 5.00
191 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
192 INT2731 Negative_regulation of LTBR 7 0.58 5.35 2.44 5.00
193 INT22916 Negative_regulation of CR1 12 0.57 6.31 2.42 5.00
194 INT184378 Binding of Cfb 54 0.20 12.49 2.36 5.00
195 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
196 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21 5.00
197 INT148576 Gene_expression of rs 26 0.37 8.96 2.17 5.00
198 INT173090 Regulation of INCENP 24 0.09 9.45 2.16 5.00
199 INT25463 Negative_regulation of Gene_expression of MRXS5 7 0.38 4.75 2.12 5.00
200 INT78429 Positive_regulation of TRGC1 11 0.44 4.6 2.1 5.00
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