D:Major Depressive Disorder

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Depression Involutional, Depressive Disorders Major, Disorder Major Depressive, DISORDERS MAJOR DEPRESSIVE, INVOLUTIONAL DEPRESSION, Involutional Melancholia, INVOLUTIONAL PARAPHRENIA, Involutional Psychoses, Involutional Psychosis, Major Depressive Disorders, MELANCHOLIA INVOLUTIONAL
Documents 100
Hot Single Events 52
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Major Depressive Disorder. They are ordered first by their relevance to Major Depressive Disorder and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT117203 Binding of IL1B and IL6 2 0.20 1.4 0.51 90.24
2 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 78.80
3 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 18.80
4 INT304575 Creb1 Regulation of Gene_expression of Bdnf 1 0.04 1 0.84 5.00
5 INT304576 Binding of Arntl and Clock 6 0.37 0.43 0.5 5.00
6 INT304578 Negative_regulation of HDAC9 Positive_regulation of Gene_expression of Bdnf 1 0.06 0.9 0.49 5.00
7 INT320451 ECT Positive_regulation of Gene_expression of BDNF 1 0.05 1.21 0.49 5.00
8 INT304577 Binding of Arntl and Clock Regulation of Gene_expression of Maoa 1 0.01 0.3 0.44 5.00
9 INT349951 Grm7 Regulation of pcp 1 0.00 0.56 0.28 5.00
10 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
11 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Major Depressive Disorder. They are ordered first by their pain relevance and then by number of times they were reported in Major Depressive Disorder. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 100.00
2 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 100.00
3 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 99.96
4 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 99.96
5 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83 99.88
6 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 99.84
7 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42 99.84
8 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 99.76
9 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 99.56
10 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 99.40
11 INT108931 Negative_regulation of BDNF 38 0.59 19.61 8.84 99.34
12 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 99.32
13 INT36678 Binding of TIMP1 33 0.36 14.99 7.87 99.20
14 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 99.20
15 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 98.98
16 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27 98.20
17 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 98.04
18 INT113251 Negative_regulation of soc 5 0.50 4.11 0.24 98.00
19 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15 97.80
20 INT158 Localization of Prl 2431 0.81 378.96 952.2 97.74
21 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 96.40
22 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 95.88
23 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 93.28
24 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59 93.28
25 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 93.28
26 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07 93.00
27 INT62141 Positive_regulation of Gene_expression of HTR2A 8 0.67 2.47 2.42 93.00
28 INT74509 Positive_regulation of Datd 2 0.18 0.85 1.81 92.68
29 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 92.64
30 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 92.64
31 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 92.64
32 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 92.64
33 INT71465 Gene_expression of HIST1H1B 9 0.58 4.69 0.36 91.08
34 INT6484 Binding of IL1B 122 0.47 75.84 35.07 90.24
35 INT86437 Binding of IL6 154 0.48 121.22 29.3 90.24
36 INT14572 Binding of INS 205 0.48 175.43 13.38 89.68
37 INT133312 Binding of MMP9 25 0.42 16.79 3.83 89.68
38 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 89.44
39 INT119711 Positive_regulation of Slc6a4 16 0.69 4.44 5.21 89.28
40 INT139662 Gene_expression of FGF9 7 0.65 2.26 0.17 89.04
41 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 87.12
42 INT32007 Gene_expression of ECT 56 0.62 18.94 11.13 86.08
43 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 86.04
44 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 86.04
45 INT213154 Positive_regulation of Binding of TIMP1 2 0.41 1.33 0.55 85.76
46 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 85.16
47 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 83.88
48 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 83.88
49 INT812 Localization of INS 1026 0.81 515.6 145.31 83.52
50 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96 82.96
51 INT155683 Gene_expression of Slc1a2 27 0.73 9.86 15.34 80.80
52 INT193436 Localization of soc 5 0.65 2.17 0.15 80.72
53 INT155680 Gene_expression of Slc1a3 22 0.66 6.76 7.23 80.00
54 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 79.08
55 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 78.84
56 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 78.52
57 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 78.48
58 INT92574 Gene_expression of CXCL5 51 0.78 24.87 11.89 78.00
59 INT104356 Negative_regulation of Pgp 15 0.43 6.64 4.89 77.60
60 INT347736 Negative_regulation of MBD5 1 0.42 2.11 0.43 77.60
61 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 77.44
62 INT37949 Positive_regulation of CTSC 3 0.42 1.05 0.09 77.44
63 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 77.32
64 INT121946 Positive_regulation of Pld3 1 0.08 0.15 1.55 77.32
65 INT77793 Positive_regulation of Gdnf 54 0.70 23.76 25.08 77.32
66 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27 76.16
67 INT322095 Protein_catabolism of soc 1 0.68 1.79 0.34 75.96
68 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 75.00
69 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84 75.00
70 INT6177 Binding of Htr1a 65 0.47 17.65 30.59 75.00
71 INT935 Localization of Gtf3a 124 0.70 35.72 43.3 74.20
72 INT57150 Regulation of SCLY 3 0.45 4.2 1.12 73.92
73 INT76698 Positive_regulation of Pgp 7 0.42 7.37 6.02 73.88
74 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 72.00
75 INT121948 Negative_regulation of Positive_regulation of Pld3 1 0.06 0.07 0.77 71.08
76 INT54602 Regulation of MCS 22 0.24 10.41 5.75 70.48
77 INT210125 Regulation of Axin1 1 0.02 2.45 0.46 66.44
78 INT121947 Negative_regulation of Positive_regulation of Gdnf 1 0.20 0.07 0.76 66.28
79 INT77252 Gene_expression of Nr3c1 17 0.67 9.71 5.38 65.44
80 INT100655 Regulation of BDNF 51 0.60 21.49 13.14 64.72
81 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 64.08
82 INT9660 Regulation of TNF 363 0.62 312.94 139.99 64.00
83 INT49712 Regulation of Nr3c1 10 0.28 5.65 4.06 63.76
84 INT2415 Binding of MAOA 26 0.47 13.26 11.86 62.80
85 INT170385 Regulation of Clock 29 0.49 4.95 6.39 60.92
86 INT47685 Positive_regulation of Positive_regulation of Bdnf 32 0.70 20.05 27.03 60.52
87 INT217950 Positive_regulation of Negative_regulation of CYP21A2 2 0.03 1.34 0.97 60.48
88 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 60.20
89 INT331007 Negative_regulation of Gene_expression of CYP21A2 1 0.02 1.34 0.97 60.20
90 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77 59.64
91 INT201606 Negative_regulation of Glo1 2 0.29 1.7 1.05 59.04
92 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 58.44
93 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 58.32
94 INT108264 Positive_regulation of RARB 2 0.67 0.06 0.83 56.00
95 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01 55.16
96 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38 55.16
97 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 54.44
98 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 54.04
99 INT168658 Regulation of Gene_expression of HTR1B 2 0.44 2.11 2.44 50.56
100 INT331005 Regulation of Gene_expression of HTR1A 1 0.44 1.84 1.83 50.56
101 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94 49.28
102 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 49.28
103 INT35744 Binding of MAOB 13 0.46 7.52 4.26 45.80
104 INT88571 Positive_regulation of Tcas1 4 0.34 2.08 4.42 43.92
105 INT202577 Localization of DIO2 9 0.56 1.3 2.97 42.96
106 INT216731 Localization of HIST1H1B 2 0.19 1 0.59 41.88
107 INT240680 Negative_regulation of Binding of HIST1H1B 2 0.10 0.55 0.41 40.44
108 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 39.36
109 INT6481 Binding of TNF 624 0.48 510.2 214.82 35.28
110 INT6852 Localization of TNF 883 0.81 705.95 270.84 33.48
111 INT4148 Gene_expression of HRH1 11 0.77 2.71 4.22 29.64
112 INT546 Binding of ALB 311 0.48 85.98 60.14 23.80
113 INT11937 Localization of Il6 228 0.81 139.83 64.39 21.04
114 INT304787 Transcription of Hspa2 1 0.05 0.77 0.13 20.72
115 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 19.84
116 INT210124 Binding of Brsk1 1 0.01 1.47 0.11 18.72
117 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 18.28
118 INT62653 Positive_regulation of CYP2C19 8 0.54 1.23 2.41 18.28
119 INT330997 Regulation of Positive_regulation of CYP2C19 1 0.35 0.3 0.47 18.28
120 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47 18.28
121 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 17.92
122 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 17.76
123 INT235710 Binding of SSR1 2 0.36 0.86 1.75 16.20
124 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 15.12
125 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 12.60
126 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76 9.44
127 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7 9.44
128 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 8.08
129 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 7.68
130 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 6.32
131 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
132 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
133 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
134 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
135 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
136 INT477 Localization of Avp 813 0.81 131.58 300.4 5.00
137 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
138 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
139 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
140 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 5.00
141 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
142 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
143 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
144 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
145 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
146 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 5.00
147 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 5.00
148 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
149 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
150 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
151 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 5.00
152 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
153 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
154 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 5.00
155 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 5.00
156 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 5.00
157 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 5.00
158 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 5.00
159 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
160 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 5.00
161 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29 5.00
162 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66 5.00
163 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 5.00
164 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 5.00
165 INT16714 Regulation of Creb1 64 0.62 22.23 33.56 5.00
166 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 5.00
167 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 5.00
168 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 5.00
169 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25 5.00
170 INT102206 Regulation of Bdnf 37 0.62 28.54 28.78 5.00
171 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59 5.00
172 INT67620 Negative_regulation of Gene_expression of Bdnf 53 0.59 22.45 28.5 5.00
173 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
174 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23 5.00
175 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
176 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
177 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
178 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
179 INT54467 Localization of Ltp 41 0.58 8.86 26.88 5.00
180 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 5.00
181 INT36428 Binding of Chdh 42 0.47 48.04 26.54 5.00
182 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
183 INT48240 Binding of Ngf 46 0.46 23.51 24.42 5.00
184 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 5.00
185 INT101225 Positive_regulation of Gria2 62 0.64 28.1 23.93 5.00
186 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88 5.00
187 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42 5.00
188 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 5.00
189 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28 5.00
190 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17 5.00
191 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46 5.00
192 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 5.00
193 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 5.00
194 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
195 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 5.00
196 INT7561 Positive_regulation of gr 70 0.57 31.92 20.22 5.00
197 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
198 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 5.00
199 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
200 INT8075 Localization of Crh 64 0.81 25.41 19.45 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox