D:Malabsorption Syndromes

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Disease Term
Synonyms Alactasia, Carbohydrate Intolerance, CELIAC DISEASE, CELIAC SPRUE, CHRONIC PANCREATITIS, Coeliac, DISACCARIDASE DEFICIENCY, GLUTEN ENTEROPATHY, Gluten Intolerance, Idiopathic Hypoproteinaemia, IDIOPATHIC HYPOPROTEINEMIA
Documents 284
Hot Single Events 88
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Malabsorption Syndromes. They are ordered first by their relevance to Malabsorption Syndromes and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT298829 Binding of LCT and SUGT1 1 0.00 0.39 0.11 94.72
2 INT191816 Binding of ETFA and TGM2 1 0.01 0.66 0 86.16
3 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15 6.08
4 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
5 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33 5.00
6 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32 5.00
7 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3 5.00
8 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26 5.00
9 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 0.01 0.71 0.25 5.00
10 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25 5.00
11 INT214481 ROS1 Negative_regulation of Gene_expression of INS 1 0.00 0.37 0.22 5.00
12 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2 5.00
13 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17 5.00
14 INT214480 SELPLG Negative_regulation of Positive_regulation of NFKB1 1 0.00 0.6 0.14 5.00
15 INT230857 Negative_regulation of Binding of HSP90AA1 and NOS1 1 0.05 1.18 0.09 5.00
16 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
17 INT230856 Binding of HSP90AA1 and NOS1 1 0.04 1.17 0.09 5.00
18 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
19 INT230853 Binding of SELE and VWF 1 0.06 1.3 0.07 5.00
20 INT230854 INS Regulation of Positive_regulation of SNAP47 1 0.09 1.03 0.03 5.00
21 INT230851 INS Regulation of VCAM1 1 0.07 1.02 0.03 5.00
22 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
23 INT208410 IGF1 Positive_regulation of TXK 1 0.08 0.9 0.03 5.00
24 INT307054 RHCE Regulation of AKTIP 1 0.00 0.6 0 5.00
25 INT270770 Binding of DMD and PTH 1 0.10 0.16 0 5.00
26 INT300891 Binding of Atp9a and Tgm2 1 0.00 0.39 0 5.00
27 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
28 INT300892 Binding of Atp8a1 and Tgm2 1 0.01 0.68 0 5.00
29 INT300890 Binding of Atp9a and Cd79a 1 0.00 0 0 5.00
30 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
31 INT339217 MMP9 Negative_regulation of VEGFA 1 0.05 0.38 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Malabsorption Syndromes. They are ordered first by their pain relevance and then by number of times they were reported in Malabsorption Syndromes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2336 Negative_regulation of Lct 51 0.58 33.79 13.73 100.00
2 INT35359 Negative_regulation of LCT 23 0.59 9.13 2.29 100.00
3 INT42530 Gene_expression of Lct 11 0.66 9.37 1.37 100.00
4 INT159561 Positive_regulation of Gene_expression of Lct 4 0.49 4.11 0.4 100.00
5 INT46060 Regulation of Negative_regulation of Lct 1 0.27 0.96 0.45 100.00
6 INT18969 Gene_expression of HLA-DQA1 29 0.65 12.19 2.54 100.00
7 INT42479 Positive_regulation of Negative_regulation of Lct 2 0.50 1 0.89 100.00
8 INT78047 Negative_regulation of GLB1 2 0.51 1.3 0.25 100.00
9 INT64952 Binding of HLA-DQA2 11 0.10 7.23 1.39 99.92
10 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 99.90
11 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 99.90
12 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 99.72
13 INT252 Localization of GH1 529 0.80 227.4 122.05 99.72
14 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 99.72
15 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 99.64
16 INT255233 Negative_regulation of MCDR1 1 0.07 2.07 0 99.56
17 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 99.28
18 INT191823 Positive_regulation of TGM2 2 0.30 1.95 0.25 99.00
19 INT255234 Gene_expression of MCDR1 1 0.11 1.39 0 98.88
20 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74 98.86
21 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 98.84
22 INT92618 Positive_regulation of LCT 9 0.48 3.54 0.75 98.12
23 INT546 Binding of ALB 311 0.48 85.98 60.14 98.08
24 INT812 Localization of INS 1026 0.81 515.6 145.31 97.92
25 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 97.74
26 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 97.60
27 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 97.60
28 INT1114 Localization of Ins1 748 0.80 192.95 165.48 97.44
29 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 97.28
30 INT6891 Binding of TTR 72 0.48 22.81 6.51 97.22
31 INT39212 Binding of Ttr 14 0.48 9.62 2.31 97.22
32 INT84250 Positive_regulation of IDUA 8 0.56 15.89 0.62 96.92
33 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 96.72
34 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 96.52
35 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 96.40
36 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 95.76
37 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53 95.52
38 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 95.52
39 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 95.44
40 INT38546 Negative_regulation of Gene_expression of IV 1 0.38 1.19 0.18 95.00
41 INT38542 Negative_regulation of IV 1 0.51 1.19 0.17 95.00
42 INT104316 Positive_regulation of ETFA 2 0.17 2.4 0.12 94.44
43 INT38545 Gene_expression of IV 3 0.53 2.89 0.41 94.40
44 INT19966 Positive_regulation of C9orf3 19 0.67 21.88 4.38 94.28
45 INT19967 Gene_expression of C9orf3 18 0.75 26.51 4.6 94.20
46 INT255235 Regulation of Gene_expression of MCDR1 1 0.07 0.57 0 93.84
47 INT34777 Localization of IGF1 82 0.80 42.68 8.62 93.72
48 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62 93.68
49 INT4811 Positive_regulation of Gene_expression of LTC4S 5 0.65 3.29 2.92 93.68
50 INT42655 Regulation of LCT 4 0.59 1.13 0.8 92.92
51 INT19545 Positive_regulation of IV 5 0.61 4.22 0.83 92.52
52 INT38543 Positive_regulation of Positive_regulation of IV 1 0.44 1.18 0.16 92.52
53 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 92.36
54 INT140070 Positive_regulation of Negative_regulation of Cd4 7 0.30 3.65 0.54 92.36
55 INT140071 Negative_regulation of Positive_regulation of Cd4 5 0.39 3.9 0.42 92.36
56 INT179299 Binding of TGM2 3 0.24 1.02 0 92.20
57 INT191825 Regulation of Positive_regulation of CD8A 3 0.12 2.5 0.62 91.88
58 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 91.88
59 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 91.84
60 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94 90.64
61 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 90.52
62 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 89.76
63 INT38544 Regulation of IV 1 0.54 1.13 0.15 89.72
64 INT17182 Binding of Cea 25 0.48 14.98 4.16 88.48
65 INT17181 Positive_regulation of Binding of Cea 2 0.50 2.53 0.08 88.48
66 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 88.24
67 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 88.00
68 INT19964 Negative_regulation of Positive_regulation of C9orf3 3 0.42 4.06 0.67 87.36
69 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 87.04
70 INT36201 Gene_expression of ETFA 8 0.66 9.18 0.58 86.96
71 INT191826 Binding of ETFA 1 0.03 0.66 0 86.16
72 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98 85.76
73 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 85.60
74 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 84.72
75 INT47548 Negative_regulation of Glb1 3 0.55 1.59 0.21 83.52
76 INT255237 Positive_regulation of Gene_expression of MCDR1 1 0.08 0.4 0 82.76
77 INT128000 Gene_expression of RHCE 9 0.75 1.39 1.18 82.72
78 INT20509 Positive_regulation of Negative_regulation of Ins1 7 0.48 2.8 1.46 81.52
79 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 80.80
80 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 80.48
81 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04 80.48
82 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34 80.48
83 INT355463 Gene_expression of SPRED1 1 0.56 6.96 0.24 80.40
84 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 80.36
85 INT95048 Negative_regulation of ADHD1 61 0.51 56.01 5.62 80.32
86 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 80.28
87 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 80.16
88 INT18857 Negative_regulation of Positive_regulation of Cck 8 0.59 2.62 5.06 80.16
89 INT88070 Binding of Ema 7 0.18 7.39 0.31 79.92
90 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02 79.84
91 INT230866 Negative_regulation of Gene_expression of PIK3CG 2 0.28 1.37 0.07 79.84
92 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 79.40
93 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 79.36
94 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 79.04
95 INT120467 Negative_regulation of Gene_expression of LCT 3 0.59 1.34 0.15 77.52
96 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97 77.52
97 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 76.72
98 INT120466 Gene_expression of LCT 21 0.78 6 1.75 76.04
99 INT108917 Positive_regulation of CRX 23 0.50 21.32 10.5 75.52
100 INT92619 Binding of LCT 4 0.48 2.32 0.14 75.00
101 INT9779 Gene_expression of Glb1 23 0.58 8.01 6.04 75.00
102 INT90346 Negative_regulation of Mptx 1 0.37 0.84 0.22 75.00
103 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 74.64
104 INT67181 Positive_regulation of Positive_regulation of SERPINE1 3 0.49 3.02 0.14 74.64
105 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 74.16
106 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 73.72
107 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 72.48
108 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 71.68
109 INT347974 Negative_regulation of Gene_expression of Ema 1 0.15 1.27 0.55 71.68
110 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 71.12
111 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 71.04
112 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51 70.32
113 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 68.24
114 INT355461 Localization of SPRED1 1 0.63 3.48 0.04 67.20
115 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 67.12
116 INT2544 Localization of PTH 39 0.81 30.55 2.22 66.88
117 INT214056 Negative_regulation of NSD1 3 0.43 3.44 0.09 66.64
118 INT18340 Gene_expression of CRX 16 0.22 13.85 7.13 65.76
119 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 65.04
120 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 62.56
121 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 62.16
122 INT10671 Regulation of CRX 4 0.53 6.29 1.78 61.48
123 INT15752 Positive_regulation of Ema 15 0.40 14.57 2.34 59.12
124 INT255236 Regulation of MCDR1 1 0.10 0.06 0 57.60
125 INT176145 Positive_regulation of Gene_expression of PIK3CG 3 0.20 1.36 0.22 57.20
126 INT7867 Regulation of Negative_regulation of Gh 5 0.33 1.92 0.87 56.40
127 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 53.20
128 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 52.72
129 INT97391 Binding of Lep 18 0.48 8.97 4.47 51.68
130 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 50.40
131 INT9081 Positive_regulation of Positive_regulation of IGHE 5 0.42 7.13 1 50.40
132 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 48.04
133 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 48.04
134 INT8775 Binding of IGHE 167 0.48 102.61 23.54 46.32
135 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 45.24
136 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14 42.24
137 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67 41.68
138 INT75431 Binding of CRG 6 0.28 1.91 0.39 40.68
139 INT17227 Gene_expression of 16S 11 0.75 2.65 0.76 40.00
140 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 39.20
141 INT9256 Gene_expression of SELPLG 30 0.75 16.44 3.66 38.52
142 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 33.68
143 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 33.04
144 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 32.48
145 INT245945 Localization of CAP1 4 0.69 1.63 1.95 31.64
146 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 30.16
147 INT79281 Gene_expression of Tgm2 14 0.76 7.46 2.37 26.36
148 INT197 Gene_expression of Hrh2 24 0.63 12.35 8.37 25.00
149 INT228975 Gene_expression of SERPINA2 1 0.31 1.61 0 23.76
150 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5 21.24
151 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 18.72
152 INT129832 Positive_regulation of Positive_regulation of PTH 5 0.50 3.4 0.14 18.72
153 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 18.44
154 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 17.96
155 INT9210 Regulation of IL6 166 0.62 125.61 49.95 17.44
156 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 15.36
157 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 14.96
158 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 13.04
159 INT57728 Regulation of LDLR 25 0.41 13.18 3.46 13.04
160 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89 9.60
161 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 9.04
162 INT49371 Positive_regulation of Gene_expression of IGFBP3 27 0.70 23.13 1.9 5.80
163 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.40
164 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
165 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
166 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
167 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 5.00
168 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
169 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
170 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
171 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
172 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 5.00
173 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
174 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
175 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
176 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
177 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
178 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
179 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
180 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
181 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
182 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
183 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 5.00
184 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
185 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.00
186 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
187 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
188 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
189 INT3034 Localization of Ngf 126 0.81 50.81 72.84 5.00
190 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
191 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
192 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
193 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
194 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
195 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
196 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 5.00
197 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 5.00
198 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
199 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 5.00
200 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
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