D:Male Breast Neoplasms

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Disease Term
Synonyms Breast Cancer Male, Breast Carcinoma Male, Breast Neoplasm Male, BREAST TUMOR MALE, Breast Tumors Male, Cancer Male Breast, CARCINOMA MALE BREAST, MALE BREAST CANCER, Male Breast Carcinoma, MALE BREAST NEOPLASM, MALE BREAST TUMOR
Documents 18
Hot Single Events 10
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Male Breast Neoplasms. They are ordered first by their relevance to Male Breast Neoplasms and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT314745 Binding of TP53 and Brca1 1 0.18 1.17 0 82.20
2 INT314743 Binding of RAD51 and Brca1 1 0.06 1.06 0 66.52
3 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0 66.12
4 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0 44.40
5 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
6 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27 5.00
7 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03 5.00
8 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03 5.00
9 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03 5.00
10 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0 5.00
11 INT313597 Binding of BRCA2 and TOX3 1 0.11 0.7 0 5.00
12 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0 5.00
13 INT314741 Binding of VEGFA and Akt1 1 0.36 0.66 0 5.00
14 INT314692 Binding of TBX2 and TBX3 1 0.27 0.84 0 5.00
15 INT256825 Binding of Atp2b4 and Chordc1 1 0.02 0.27 0 5.00
16 INT314693 Binding of TBX2 and TBX5 1 0.16 0.84 0 5.00
17 INT313596 ESR1 Positive_regulation of Gene_expression of PGR 1 0.05 1 0 5.00
18 INT314682 Binding of TBX2 and TBX4 1 0.16 0.84 0 5.00
19 INT314687 ESR1 Regulation of PGR 1 0.27 0.88 0 5.00
20 INT314683 NUDT6 Positive_regulation of FGF1 1 0.02 1.17 0 5.00
21 INT314744 Binding of KDR and Akt1 1 0.13 0.66 0 5.00
22 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0 5.00
23 INT314678 Binding of CCNE1 and CCNE2 1 0.03 1.41 0 5.00
24 INT314689 Binding of KITLG and UBR1 1 0.00 0.71 0 5.00
25 INT314691 ERBB2 Negative_regulation of TP53 1 0.28 1.23 0 5.00
26 INT287268 Binding of ERBB2 and ERBB3 5 0.16 2.74 0 5.00
27 INT256882 Binding of Atp2b4 and Chordc1 Regulation of Nod1 1 0.01 0.27 0 5.00
28 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0 5.00
29 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0 5.00
30 INT314679 NEU1 Negative_regulation of TP53 1 0.12 1.23 0 5.00
31 INT314684 Binding of CCND1 and ESR1 1 0.22 0.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Male Breast Neoplasms. They are ordered first by their pain relevance and then by number of times they were reported in Male Breast Neoplasms. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 100.00
2 INT13507 Gene_expression of Erbb2 17 0.77 34.23 7.58 98.88
3 INT51150 Positive_regulation of HTC2 10 0.67 6.8 2.95 91.72
4 INT187590 Gene_expression of Brca1 12 0.65 4.94 0.11 87.40
5 INT314708 Gene_expression of Brca2 1 0.41 1.75 0 87.40
6 INT314738 Gene_expression of BRCA3 1 0.30 1.29 0 87.40
7 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31 85.40
8 INT89689 Binding of Brca1 2 0.37 2.55 0.18 84.40
9 INT8103 Binding of TP53 46 0.44 40.2 2.96 81.52
10 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 80.28
11 INT54546 Binding of CREB1 9 0.41 3.44 0.72 75.48
12 INT12485 Binding of DNAH8 17 0.48 4.24 2.54 75.16
13 INT264851 Regulation of Binding of DNAH8 1 0.10 0.45 0.04 75.16
14 INT264850 Positive_regulation of Binding of DNAH8 1 0.19 0.45 0.04 75.16
15 INT142829 Transcription of CREB1 9 0.46 3.37 1.03 75.12
16 INT89690 Binding of Brca2 2 0.37 1.8 0.18 74.32
17 INT314720 Positive_regulation of BARD1 1 0.17 1.18 0 73.32
18 INT314727 Positive_regulation of BAP1 1 0.14 1.18 0 73.32
19 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 70.08
20 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29 70.08
21 INT212457 Phosphorylation of Brca1 2 0.51 0.96 0 60.68
22 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06 60.32
23 INT244404 Binding of HEPACAM 21 0.02 35.88 0.09 30.44
24 INT182440 Gene_expression of CCNE2 39 0.53 22.07 7.44 27.20
25 INT201466 Positive_regulation of Gene_expression of CCNE2 13 0.20 8.62 1.26 27.20
26 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 25.92
27 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 25.92
28 INT256851 Regulation of Hspa8 4 0.19 3.71 0.03 10.00
29 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
30 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 5.00
31 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
32 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
33 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
34 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
35 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
36 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
37 INT935 Localization of Gtf3a 124 0.70 35.72 43.3 5.00
38 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
39 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
40 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 5.00
41 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
42 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 5.00
43 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
44 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
45 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
46 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
47 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
48 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
49 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
50 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
51 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
52 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
53 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
54 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
55 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
56 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
57 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
58 INT15307 Regulation of Mtor 27 0.48 4.7 9.34 5.00
59 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
60 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
61 INT74629 Gene_expression of Mmp7 17 0.55 12.78 7.58 5.00
62 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
63 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
64 INT8157 Binding of Tyr 14 0.09 0.64 5.89 5.00
65 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
66 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53 5.00
67 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 5.00
68 INT113516 Negative_regulation of Fas 16 0.51 8.37 5.32 5.00
69 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
70 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
71 INT23611 Gene_expression of Mtor 23 0.66 3.57 5.02 5.00
72 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
73 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 5.00
74 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 5.00
75 INT75688 Binding of KITLG 24 0.30 11.73 4.06 5.00
76 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74 5.00
77 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 5.00
78 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36 5.00
79 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 5.00
80 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24 5.00
81 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 5.00
82 INT140929 Gene_expression of Cd40 9 0.72 8.76 2.88 5.00
83 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
84 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
85 INT105598 Negative_regulation of Mtpn 15 0.16 11.83 2.65 5.00
86 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
87 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 5.00
88 INT281624 Gene_expression of Tag 2 0.58 8 2.4 5.00
89 INT34830 Regulation of PGR 14 0.45 6.99 2.32 5.00
90 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3 5.00
91 INT88017 Regulation of Fas 12 0.62 8.27 2.29 5.00
92 INT77784 Regulation of Tnfrsf1b 7 0.57 4.61 2.17 5.00
93 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92 5.00
94 INT120220 Gene_expression of ANIB1 4 0.65 1.82 1.92 5.00
95 INT65855 Localization of TP53 18 0.76 17.08 1.89 5.00
96 INT93886 Positive_regulation of Gene_expression of PGR 19 0.52 15.78 1.89 5.00
97 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
98 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7 5.00
99 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68 5.00
100 INT91043 Regulation of NDRG1 7 0.25 2.66 1.65 5.00
101 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 5.00
102 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
103 INT306844 Localization of CCNE2 6 0.21 3.81 1.52 5.00
104 INT52962 Binding of ERBB2 77 0.47 50.03 1.49 5.00
105 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 5.00
106 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 5.00
107 INT53735 Regulation of FGFR3 4 0.26 0.76 1.45 5.00
108 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 5.00
109 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34 5.00
110 INT63905 Regulation of RB1 13 0.62 12.67 1.28 5.00
111 INT98976 Regulation of F2r 7 0.60 0.71 1.22 5.00
112 INT160013 Gene_expression of CCND2 7 0.42 5.98 1.18 5.00
113 INT180580 Binding of HEYL 7 0.17 4.49 1.15 5.00
114 INT86908 Negative_regulation of MLH1 7 0.43 6.98 1.12 5.00
115 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 5.00
116 INT156805 Gene_expression of Ebp 6 0.40 6.09 1.07 5.00
117 INT92139 Binding of MLH1 12 0.42 15.62 1 5.00
118 INT86559 Negative_regulation of KITLG 8 0.41 3.54 0.99 5.00
119 INT44375 Negative_regulation of ZBTB7A 3 0.57 0.95 0.95 5.00
120 INT86907 Negative_regulation of MSH6 8 0.33 6.76 0.93 5.00
121 INT201465 Positive_regulation of CCNE2 6 0.13 3.13 0.92 5.00
122 INT88000 Gene_expression of LAP 15 0.55 6.94 0.91 5.00
123 INT264849 Gene_expression of HTs 9 0.68 2.23 0.84 5.00
124 INT71649 Localization of ERBB2 23 0.78 13.63 0.83 5.00
125 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 5.00
126 INT112947 Regulation of Il1r1 2 0.24 0.36 0.78 5.00
127 INT159982 Negative_regulation of ERBB3 11 0.26 8.44 0.75 5.00
128 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 5.00
129 INT174537 Positive_regulation of HEYL 7 0.39 3.07 0.68 5.00
130 INT53214 Regulation of Tyr 3 0.05 0.8 0.66 5.00
131 INT241621 Regulation of Cdkn1b 2 0.06 0.36 0.62 5.00
132 INT128498 Regulation of CCND1 17 0.39 12.51 0.58 5.00
133 INT64928 Regulation of LEPRE1 2 0.24 1.26 0.54 5.00
134 INT79212 Gene_expression of Ccnd2 5 0.67 2.32 0.53 5.00
135 INT36632 Regulation of Esrrb 4 0.54 0.67 0.53 5.00
136 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 5.00
137 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51 5.00
138 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 5.00
139 INT256860 Negative_regulation of Negative_regulation of Mtpn 2 0.16 1.31 0.5 5.00
140 INT128924 Regulation of Map2k7 3 0.08 0.87 0.5 5.00
141 INT183629 Gene_expression of Ctnnd2 14 0.75 11.78 0.48 5.00
142 INT45878 Gene_expression of NEU1 14 0.65 7.28 0.47 5.00
143 INT168793 Regulation of CSDA 2 0.60 0.36 0.43 5.00
144 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43 5.00
145 INT155490 Binding of Mki67 13 0.19 13.38 0.41 5.00
146 INT189755 Gene_expression of CCND3 42 0.65 10.88 0.39 5.00
147 INT83212 Positive_regulation of Gene_expression of Mki67 21 0.55 17.53 0.39 5.00
148 INT101902 Negative_regulation of Mki67 12 0.39 7.92 0.34 5.00
149 INT33009 Gene_expression of Cdk2ap1 6 0.31 6.69 0.33 5.00
150 INT36797 Regulation of Mki67 13 0.24 8.76 0.3 5.00
151 INT151864 Regulation of Nmt1 2 0.35 0 0.28 5.00
152 INT153772 Negative_regulation of Localization of ESR1 7 0.54 4.42 0.27 5.00
153 INT186057 Binding of CCND1 8 0.31 5.92 0.26 5.00
154 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25 5.00
155 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25 5.00
156 INT212176 Gene_expression of CEACAM5 7 0.75 6.05 0.24 5.00
157 INT113989 Regulation of Gene_expression of CCND1 11 0.44 7.57 0.24 5.00
158 INT79253 Positive_regulation of ST3GAL4 3 0.61 1.2 0.23 5.00
159 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21 5.00
160 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2 5.00
161 INT256823 Regulation of Mta3 1 0.26 0.31 0.2 5.00
162 INT63067 Localization of MYC 13 0.78 6.93 0.19 5.00
163 INT19359 Binding of BRCA2 5 0.47 2.63 0.19 5.00
164 INT133525 Regulation of Sptbn1 3 0.10 0.44 0.18 5.00
165 INT6838 Binding of Atp2b4 4 0.08 0.8 0.18 5.00
166 INT176266 Negative_regulation of Negative_regulation of Fas 2 0.22 0.33 0.17 5.00
167 INT256866 Regulation of Tob1 1 0.35 0.13 0.16 5.00
168 INT201464 Regulation of CCNE2 3 0.08 2.79 0.16 5.00
169 INT256864 Gene_expression of Tp63 1 0.14 0.47 0.14 5.00
170 INT256849 Regulation of Pcna 1 0.05 0.3 0.13 5.00
171 INT314724 Regulation of Localization of RB1 1 0.15 1.25 0.13 5.00
172 INT197627 Localization of RB1 3 0.69 4.16 0.13 5.00
173 INT181744 Negative_regulation of Gene_expression of MLH1 3 0.05 7.67 0.12 5.00
174 INT256850 Regulation of Psen1 1 0.00 0.25 0.12 5.00
175 INT201462 Binding of CDK2 12 0.39 5.2 0.12 5.00
176 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12 5.00
177 INT314712 Negative_regulation of Localization of MYC 2 0.22 1.43 0.11 5.00
178 INT284989 Localization of INTS2 2 0.43 1.64 0.11 5.00
179 INT314718 Negative_regulation of Localization of ERBB2 1 0.37 1.13 0.11 5.00
180 INT314714 Negative_regulation of Localization of INTS2 1 0.24 1.14 0.11 5.00
181 INT211679 Positive_regulation of HEPACAM 6 0.02 8.25 0.11 5.00
182 INT213913 Gene_expression of NCOA3 3 0.50 1.11 0.1 5.00
183 INT225189 Binding of CCNE2 5 0.10 2.27 0.1 5.00
184 INT256836 Gene_expression of Adamts19 1 0.38 0.41 0.1 5.00
185 INT211941 Regulation of Ad 4 0.02 0.82 0.09 5.00
186 INT256841 Gene_expression of Gluco4 1 0.10 0.3 0.09 5.00
187 INT256822 Binding of Gm3813 2 0.36 1.81 0.08 5.00
188 INT8099 Binding of ERBB3 7 0.36 3.09 0.08 5.00
189 INT256871 Regulation of Regulation of Fas 1 0.22 0.06 0.08 5.00
190 INT256859 Regulation of Sept10 1 0.13 0.25 0.08 5.00
191 INT256854 Regulation of Tp63 1 0.06 0.06 0.08 5.00
192 INT256876 Negative_regulation of Negative_regulation of Sept10 1 0.12 0.25 0.08 5.00
193 INT256853 Negative_regulation of Sept10 1 0.12 0.25 0.08 5.00
194 INT313598 Regulation of Gene_expression of CEACAM5 2 0.44 0.98 0.07 5.00
195 INT256862 Regulation of Shh 1 0.25 0 0.07 5.00
196 INT174155 Negative_regulation of Brca1 4 0.36 1.77 0.07 5.00
197 INT171527 Gene_expression of NCOR1 3 0.51 0.49 0.06 5.00
198 INT256847 Regulation of Nek7 1 0.21 0.32 0.06 5.00
199 INT256865 Positive_regulation of Gdf9 1 0.46 0.18 0.06 5.00
200 INT187612 Regulation of Ccnd2 2 0.47 1.07 0.05 5.00
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