D:Malignant Fibrous Histiocytoma

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Disease Term
Synonyms Fibrous Histiocytoma Malignant, Fibrous Histiocytomas Malignant, Histiocytomas Malignant Fibrous, Malignant Fibrous Histiocytomas
Documents 205
Hot Single Events 57
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Malignant Fibrous Histiocytoma. They are ordered first by their relevance to Malignant Fibrous Histiocytoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT97314 Binding of ETFA and KRT1 1 0.07 0.75 0.08 93.20
2 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 74.08
3 INT192955 Binding of KIT and VCAM1 1 0.05 0.63 0 40.24
4 INT192956 Binding of CD2 and KIT 1 0.03 0.62 0 39.60
5 INT242102 Nkx2-1 Regulation of Gene_expression of Ttf1 1 0.00 1.55 0 5.00
6 INT277703 Binding of Pdgfrb and Pdgfb 1 0.02 0.23 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Malignant Fibrous Histiocytoma. They are ordered first by their pain relevance and then by number of times they were reported in Malignant Fibrous Histiocytoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT160961 Gene_expression of Fth1 4 0.28 3.89 0.63 100.00
2 INT259193 Positive_regulation of Fth1 2 0.14 1.75 0.09 100.00
3 INT72031 Gene_expression of MFHAS1 1 0.25 1.04 0.14 100.00
4 INT207069 Localization of Fth1 2 0.31 1.94 0.33 100.00
5 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
6 INT15007 Gene_expression of Pbrgcsf1 31 0.49 17.82 6.99 99.96
7 INT152521 Gene_expression of Ezr 1 0.47 2.95 0.18 99.28
8 INT152522 Regulation of Gene_expression of Ezr 1 0.16 1.03 0.08 99.28
9 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.04
10 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 98.88
11 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17 98.88
12 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 98.88
13 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 98.88
14 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 98.88
15 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 98.88
16 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 98.68
17 INT192962 Positive_regulation of Transcription of KIT 1 0.46 2.74 0 98.68
18 INT192957 Transcription of KIT 5 0.69 2.19 0.23 98.68
19 INT74254 Binding of PTPRC 16 0.36 8.37 1.27 97.76
20 INT27935 Binding of Vim 21 0.36 15.65 2.61 97.00
21 INT21682 Binding of CD34 18 0.47 13.19 1.47 96.96
22 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 96.52
23 INT105021 Binding of GOPC 187 0.40 60.39 20.38 95.92
24 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 95.72
25 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 95.68
26 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 94.76
27 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 94.76
28 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 94.16
29 INT156738 Binding of SLC4A3 1 0.36 0.83 0.07 93.60
30 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 93.40
31 INT70449 Binding of SLC4A1 5 0.36 5.1 0.38 93.28
32 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 92.88
33 INT194992 Positive_regulation of CSF3R 1 0.46 1.61 0 91.56
34 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 91.04
35 INT195206 Binding of BCC1 15 0.41 21.3 0.62 90.84
36 INT49195 Binding of CSF3R 6 0.34 4.23 0.15 90.84
37 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 90.56
38 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 90.56
39 INT10048 Positive_regulation of SERPINA1 11 0.68 8.59 2.43 89.68
40 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 89.44
41 INT14301 Binding of CSF2 82 0.48 67.95 8.98 89.04
42 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 88.08
43 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 88.08
44 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 88.08
45 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 88.08
46 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 88.08
47 INT70297 Gene_expression of NEFH 12 0.75 4.85 2.33 88.08
48 INT66852 Gene_expression of Fcer2 15 0.14 9.74 1.27 88.08
49 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 87.40
50 INT97315 Positive_regulation of LGALS3 2 0.58 1.6 0.66 86.56
51 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 84.92
52 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 84.72
53 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 83.24
54 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 83.24
55 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 83.24
56 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 82.68
57 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 82.52
58 INT106097 Localization of pr 20 0.62 12.01 19.46 79.40
59 INT192960 Regulation of Gene_expression of KIT 3 0.45 4.16 0 79.16
60 INT83531 Gene_expression of KITLG 54 0.65 26 7.07 78.56
61 INT8103 Binding of TP53 46 0.44 40.2 2.96 78.48
62 INT14688 Gene_expression of CSF3R 7 0.46 3.93 0.06 78.16
63 INT70654 Gene_expression of Actg2 27 0.67 18.62 4.79 76.92
64 INT193820 Regulation of Positive_regulation of pr 1 0.02 1.54 0 76.00
65 INT177593 Positive_regulation of Gene_expression of MR1 17 0.43 9.36 1.13 75.28
66 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 74.92
67 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 74.60
68 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48 74.56
69 INT214458 Binding of ALK 1 0.17 1.84 0.46 72.80
70 INT36201 Gene_expression of ETFA 8 0.66 9.18 0.58 70.24
71 INT193821 Positive_regulation of Gene_expression of pr 3 0.24 2.8 0 63.04
72 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 54.88
73 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 53.20
74 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 53.20
75 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57 53.20
76 INT47311 Gene_expression of Sts 12 0.58 11.02 0.44 50.24
77 INT193822 Regulation of Gene_expression of Sts 1 0.03 1.04 0 50.24
78 INT76315 Gene_expression of Myog 15 0.41 6.79 0.6 50.00
79 INT145147 Negative_regulation of Gene_expression of TP63 4 0.42 2.91 0.15 43.92
80 INT59784 Binding of DES 22 0.47 19.48 2.27 41.48
81 INT183360 Binding of Cr2 13 0.27 7.68 2.19 41.48
82 INT183359 Binding of Sema4d 1 0.03 1.89 0.33 41.48
83 INT128376 Binding of KIT 26 0.48 14.24 0.47 41.04
84 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 35.80
85 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46 35.72
86 INT249062 Positive_regulation of Positive_regulation of DES 1 0.49 1.29 0.03 35.16
87 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 34.64
88 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 32.36
89 INT147796 Gene_expression of Ccndbp1 5 0.05 3.9 0.4 31.28
90 INT60585 Regulation of TP53 59 0.59 54.55 5.21 27.04
91 INT63905 Regulation of RB1 13 0.62 12.67 1.28 27.04
92 INT194993 Binding of RB1 15 0.37 10.96 0.4 27.04
93 INT194991 Positive_regulation of Regulation of FHIT 1 0.40 1.67 0 27.04
94 INT194990 Regulation of FHIT 1 0.23 1.66 0 27.04
95 INT194989 Binding of FHIT 1 0.32 1.66 0 27.04
96 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 25.80
97 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 23.48
98 INT178834 Localization of MR1 8 0.21 6.52 0.48 18.44
99 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 17.44
100 INT44872 Localization of Sts 5 0.64 5.2 0.2 16.32
101 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 15.04
102 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 15.04
103 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 15.04
104 INT8772 Positive_regulation of Gene_expression of HBG1 16 0.68 6.93 0.95 15.04
105 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 14.56
106 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 14.16
107 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 13.04
108 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 12.96
109 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 11.68
110 INT39000 Regulation of pr 24 0.44 12.51 4.36 6.64
111 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.84
112 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
113 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
114 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
115 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
116 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
117 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
118 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
119 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
120 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
121 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
122 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 5.00
123 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
124 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 5.00
125 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 5.00
126 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
127 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
128 INT5381 Gene_expression of FYN 18 0.75 7.65 7.35 5.00
129 INT15490 Negative_regulation of Gene_expression of COL7A1 40 0.58 25.97 7.18 5.00
130 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
131 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
132 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22 5.00
133 INT75688 Binding of KITLG 24 0.30 11.73 4.06 5.00
134 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
135 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 5.00
136 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
137 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 5.00
138 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 5.00
139 INT70885 Gene_expression of Pdgfb 48 0.67 42.27 3.19 5.00
140 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16 5.00
141 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 5.00
142 INT176892 Binding of MR1 36 0.32 15.55 2.58 5.00
143 INT68091 Localization of COL1A1 19 0.66 9.13 2.56 5.00
144 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 5.00
145 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45 5.00
146 INT55952 Transcription of TP53 16 0.61 12.14 2.36 5.00
147 INT91836 Negative_regulation of Gene_expression of BCL2L1 9 0.49 8.59 2.25 5.00
148 INT5844 Positive_regulation of Gene_expression of Vim 14 0.25 9.64 2.18 5.00
149 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92 5.00
150 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71 5.00
151 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
152 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 5.00
153 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 5.00
154 INT44529 Positive_regulation of Pdgfb 11 0.43 7.98 1.36 5.00
155 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26 5.00
156 INT203640 Regulation of MR1 7 0.34 3.8 1.26 5.00
157 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
158 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 5.00
159 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 5.00
160 INT183933 Binding of CD68 8 0.31 8.74 1.06 5.00
161 INT51066 Binding of S100B 24 0.48 13.5 0.97 5.00
162 INT99289 Localization of STS 8 0.79 6.5 0.92 5.00
163 INT125244 Gene_expression of Ril2 4 0.30 1.9 0.87 5.00
164 INT43160 Gene_expression of EOS 3 0.65 5.03 0.81 5.00
165 INT70019 Binding of BCL2 25 0.47 17.55 0.79 5.00
166 INT56955 Binding of MYOG 5 0.27 2.92 0.73 5.00
167 INT164756 Negative_regulation of PDGFRB 32 0.57 21.69 0.72 5.00
168 INT148291 Positive_regulation of CSF3 9 0.61 6.37 0.7 5.00
169 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66 5.00
170 INT277699 Gene_expression of Pdgfb 5 0.20 4.84 0.59 5.00
171 INT83909 Positive_regulation of Gene_expression of SERPINA3 4 0.67 3.04 0.56 5.00
172 INT144024 Negative_regulation of Phosphorylation of Pdgfrb 6 0.42 3.48 0.51 5.00
173 INT131931 Binding of KRT7 13 0.36 19.24 0.5 5.00
174 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 5.00
175 INT192342 Phosphorylation of PDGFRB 11 0.80 1.68 0.43 5.00
176 INT70884 Localization of Pdgfb 8 0.35 6.22 0.42 5.00
177 INT108650 Positive_regulation of Gene_expression of KITLG 2 0.33 2.57 0.41 5.00
178 INT185370 Gene_expression of ANC 28 0.65 13.28 0.4 5.00
179 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36 5.00
180 INT163489 Binding of CDH1 13 0.19 8.63 0.35 5.00
181 INT75504 Gene_expression of CDK4 9 0.72 7.43 0.3 5.00
182 INT244618 Regulation of TRERF1 2 0.07 1.43 0.28 5.00
183 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28 5.00
184 INT277701 Localization of Pdgfb 3 0.23 1.49 0.22 5.00
185 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21 5.00
186 INT180264 Positive_regulation of BCC1 11 0.59 12.81 0.2 5.00
187 INT153345 Gene_expression of CELP 2 0.65 3.62 0.19 5.00
188 INT111549 Phosphorylation of KITLG 2 0.37 1.13 0.15 5.00
189 INT284765 Gene_expression of BCC1 22 0.56 29.32 0.14 5.00
190 INT192338 Positive_regulation of Phosphorylation of PDGFRB 4 0.45 0.48 0.07 5.00
191 INT277162 Positive_regulation of Binding of Pdgfrb 1 0.06 1.1 0.07 5.00
192 INT242098 Negative_regulation of Ttf1 2 0.04 2.52 0.07 5.00
193 INT162271 Negative_regulation of Gene_expression of KITLG 4 0.28 2.31 0.07 5.00
194 INT192961 Positive_regulation of Negative_regulation of ERBB2 2 0.64 3.53 0.06 5.00
195 INT277702 Positive_regulation of Gene_expression of Pdgfb 2 0.10 0.55 0.05 5.00
196 INT93169 Binding of Ttf1 3 0.30 2.04 0.03 5.00
197 INT284763 Positive_regulation of Gene_expression of CELP 1 0.17 1.51 0 5.00
198 INT242099 Binding of Nkx2-1 1 0.02 1.15 0 5.00
199 INT284762 Positive_regulation of Gene_expression of BCC1 1 0.42 2.94 0 5.00
200 INT277700 Binding of Pdgfb 1 0.09 0.67 0 5.00
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