D:Malignant Hyperthermia

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Disease Term
Synonyms Hyperpyrexia Malignant, Hyperpyrexias Malignant, Hyperthermia Malignant, Malignant Hyperpyrexia, Malignant Hyperpyrexias, Malignant Hyperthermias
Documents 745
Hot Single Events 92
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Malignant Hyperthermia. They are ordered first by their relevance to Malignant Hyperthermia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13 100.00
2 INT207784 Ap3d1 Regulation of CACNA1S 1 0.05 0.97 0.16 100.00
3 INT316647 Ryr1 Regulation of Qdpr 1 0.19 0.68 0 100.00
4 INT207783 Binding of MRC1 and Ap3d1 1 0.00 2.54 0.22 100.00
5 INT170517 Binding of Ryr1 and Qdpr 2 0.15 0.36 0.05 98.44
6 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12 97.04
7 INT315035 Binding of NAE1 and Cav1 1 0.01 0.7 0 71.60
8 INT271025 Binding of Car2 and Casq1 1 0.03 0.7 0.03 54.16
9 INT271027 Binding of RYR1 and Car2 1 0.03 0.46 0 54.16
10 INT316648 Safb Positive_regulation of Car2 1 0.02 0 0 50.00
11 INT316649 Safb Positive_regulation of Localization of Car2 1 0.02 0 0 50.00
12 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14 32.56
13 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14 30.88
14 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09 15.28
15 INT204943 Il6 Regulation of Slc39a14 1 0.00 0.54 0.36 5.00
16 INT315034 Ass1 Positive_regulation of Cacna1f 1 0.00 0 0.03 5.00
17 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
18 INT315033 Binding of Calm3 and Vsig2 1 0.00 0 0 5.00
19 INT266704 Binding of RYR1 and TRDN 1 0.34 0 0 5.00
20 INT265964 TNNI2 Regulation of CA2 1 0.22 0.09 0 5.00
21 INT315029 Binding of Calm3 and Cacna1f 1 0.04 0 0 5.00
22 INT271026 Binding of Car2 and Dnahc8 1 0.00 0.44 0 5.00
23 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
24 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0 5.00
25 INT315031 Binding of Cacna1f and Vsig2 1 0.02 0 0 5.00
26 INT266703 Binding of RYR1 and DIXDC1 1 0.26 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Malignant Hyperthermia. They are ordered first by their pain relevance and then by number of times they were reported in Malignant Hyperthermia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT207777 Binding of Ap3d1 1 0.07 14.51 1.91 100.00
2 INT21855 Gene_expression of Ap3d1 4 0.32 12.21 4.66 100.00
3 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26 100.00
4 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04 100.00
5 INT24712 Positive_regulation of Ap3d1 18 0.54 8.58 2.71 100.00
6 INT207779 Localization of Ap3d1 1 0.11 3.16 0.14 100.00
7 INT21853 Regulation of Ap3d1 3 0.10 1.4 2.95 100.00
8 INT21852 Regulation of Gene_expression of Ap3d1 2 0.18 1.34 1.54 100.00
9 INT207782 Binding of CACNA1S 1 0.30 0.53 0.03 100.00
10 INT207778 Positive_regulation of Binding of Ap3d1 1 0.06 1.26 0.52 100.00
11 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 99.98
12 INT20072 Positive_regulation of Positive_regulation of HTR2A 5 0.67 2.96 2.33 99.96
13 INT170509 Regulation of Qdpr 1 0.27 1.11 0.2 99.88
14 INT24800 Negative_regulation of AMPD1 44 0.59 21.19 6.76 99.80
15 INT1189 Gene_expression of AMPD1 7 0.59 4.1 0.9 99.80
16 INT47186 Localization of SCTR 8 0.50 5.07 1.55 99.72
17 INT60209 Transcription of RYR1 3 0.69 3.06 0.16 99.68
18 INT11713 Localization of RYR1 22 0.76 10.42 1.64 99.64
19 INT211758 Binding of Mmd 1 0.13 3.09 0.1 99.60
20 INT55305 Regulation of RYR1 14 0.45 5.27 1.33 99.58
21 INT1755 Gene_expression of GBE1 28 0.26 8.32 5.18 99.50
22 INT5536 Regulation of NA 74 0.59 16.61 15.36 99.44
23 INT59555 Binding of RYR1 39 0.42 8.65 4.92 99.42
24 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 99.32
25 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14 99.24
26 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11 98.96
27 INT120216 Regulation of RYR2 2 0.28 1.03 0.22 98.84
28 INT17561 Localization of Car2 303 0.79 60.95 44.52 98.82
29 INT170507 Localization of Tmie 27 0.43 6.25 1.31 98.72
30 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 98.70
31 INT170514 Gene_expression of Ryr1 4 0.49 0.56 0.12 98.44
32 INT36413 Regulation of NMS 2 0.23 1.97 0.27 98.44
33 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 98.12
34 INT4160 Gene_expression of Ces2a 3 0.17 2.64 1.1 98.00
35 INT174229 Binding of CPA1 3 0.07 2 0.46 98.00
36 INT5489 Localization of CA2 172 0.80 39.46 33.56 97.84
37 INT11367 Localization of MB 9 0.78 9.34 1.24 97.76
38 INT265969 Regulation of TNNI2 1 0.45 1.35 0.09 97.76
39 INT265966 Regulation of MYH3 1 0.44 1.35 0.09 97.76
40 INT39972 Gene_expression of CPA1 7 0.65 3.17 0.26 97.72
41 INT51869 Negative_regulation of Dmd 24 0.52 10.4 2.18 97.20
42 INT86127 Positive_regulation of Safb 5 0.50 0.35 0.68 97.20
43 INT22076 Positive_regulation of Positive_regulation of Mb 7 0.46 2.9 0.64 97.16
44 INT74051 Negative_regulation of Localization of Car2 27 0.38 9.58 5.1 97.04
45 INT167913 Gene_expression of CACNA1C 3 0.75 0.38 3.34 96.84
46 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 96.68
47 INT119803 Localization of Cir1 12 0.70 3.39 2 96.40
48 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 96.24
49 INT119804 Regulation of Cir1 1 0.15 0.19 0.47 96.12
50 INT167911 Gene_expression of Cacna1s 1 0.40 0.17 0.05 96.04
51 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 96.00
52 INT78659 Gene_expression of Thim 17 0.28 14.34 4.4 95.88
53 INT273279 Negative_regulation of Localization of Tmie 2 0.07 1.72 0.2 95.68
54 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43 95.60
55 INT207781 Gene_expression of CACNA1S 3 0.63 0.9 0.03 94.88
56 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 94.80
57 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06 94.44
58 INT58856 Positive_regulation of Gene_expression of MB 4 0.50 4.56 1.06 94.44
59 INT28784 Positive_regulation of Gene_expression of CNDP1 3 0.22 3.87 1 94.44
60 INT23954 Negative_regulation of Mb 24 0.49 11.27 2.55 94.44
61 INT4210 Gene_expression of MB 24 0.78 11.74 2.32 94.04
62 INT3957 Gene_expression of CNDP1 6 0.52 3.7 0.96 94.04
63 INT165787 Positive_regulation of RYR2 2 0.23 1.3 0.11 93.68
64 INT139009 Positive_regulation of Localization of Cir1 10 0.44 2.98 1.55 93.56
65 INT18396 Positive_regulation of Ryr1 10 0.58 2.45 3.38 93.44
66 INT63009 Localization of CACNA2D1 1 0.75 0.78 0.13 93.36
67 INT211753 Negative_regulation of ACADS 1 0.03 1.49 0.08 93.34
68 INT49908 Regulation of Gene_expression of RYR1 3 0.45 0.32 0.19 92.96
69 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97 92.72
70 INT315011 Gene_expression of Cacna1d 1 0.57 4.47 0.29 92.44
71 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 91.76
72 INT170503 Positive_regulation of Localization of Tmie 11 0.29 3.27 0.61 91.76
73 INT119806 Negative_regulation of Cir1 2 0.23 0.18 0.5 91.72
74 INT11737 Negative_regulation of Ampd1 2 0.13 1.26 0.18 90.80
75 INT243771 Negative_regulation of Safb 7 0.26 0.77 1.23 90.68
76 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 89.72
77 INT315007 Positive_regulation of Cacna1d 1 0.42 0.55 0 89.56
78 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 89.52
79 INT68500 Regulation of Ar 6 0.27 4.16 1.32 88.00
80 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 87.44
81 INT119805 Regulation of Localization of Cir1 1 0.17 0.17 0.33 87.36
82 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 87.28
83 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69 87.24
84 INT108117 Regulation of CACNA1S 1 0.39 0.25 0.05 86.88
85 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78 86.16
86 INT10799 Localization of ENG 63 0.78 18.67 27.28 84.56
87 INT220506 Binding of Cav1 13 0.45 5.46 0.38 84.48
88 INT316642 Negative_regulation of Gene_expression of Qdpr 1 0.26 0.08 0.14 84.08
89 INT170515 Gene_expression of Qdpr 8 0.34 0.27 0.14 84.08
90 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 83.44
91 INT315028 Regulation of Cav2 2 0.43 0.86 0.54 83.16
92 INT184579 Negative_regulation of SCTR 3 0.03 1.31 0.11 82.96
93 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 79.88
94 INT211757 Negative_regulation of Mmd 1 0.11 1.02 0.08 79.60
95 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 78.80
96 INT315005 Binding of Hmgcs2 1 0.11 0.73 0.11 77.32
97 INT207780 Positive_regulation of NMS 2 0.28 3.2 0.61 76.96
98 INT294504 Gene_expression of Safb 9 0.41 0.97 1.72 76.20
99 INT3535 Regulation of CA2 61 0.32 16.48 10.8 75.00
100 INT35325 Regulation of Localization of CA2 10 0.32 1.13 1.69 75.00
101 INT170516 Negative_regulation of Gene_expression of Car2 35 0.35 9.4 5.48 74.80
102 INT76467 Regulation of Gene_expression of Car2 41 0.37 12.88 4.21 74.20
103 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 73.64
104 INT13021 Positive_regulation of SCN4A 7 0.49 1.61 2.42 73.00
105 INT202716 Gene_expression of NMS 4 0.49 4.56 0.57 70.84
106 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 69.40
107 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 69.12
108 INT112328 Negative_regulation of PHKG1 2 0.46 0.83 0.1 69.04
109 INT107771 Localization of HSPG2 10 0.78 8.47 4.3 68.80
110 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 68.40
111 INT170511 Regulation of Localization of Car2 11 0.21 2.18 1.09 68.08
112 INT315006 Regulation of Localization of Tmie 2 0.04 0.26 0.37 68.08
113 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 66.32
114 INT17962 Regulation of Car2 124 0.41 33.98 22.71 66.08
115 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 65.92
116 INT70104 Positive_regulation of CACNA1S 6 0.47 5.92 0.68 63.44
117 INT5757 Gene_expression of SCN4A 6 0.75 1.73 2.73 62.96
118 INT315004 Positive_regulation of Psmc1 1 0.10 0.85 0 62.80
119 INT202715 Binding of NMS 3 0.27 6.92 0.65 61.04
120 INT170508 Binding of Qdpr 4 0.16 0.06 0.03 57.96
121 INT35744 Binding of MAOB 13 0.46 7.52 4.26 57.40
122 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 54.56
123 INT35745 Negative_regulation of AGL 29 0.50 9.16 2.03 54.56
124 INT315009 Regulation of Phosphorylation of Cav1 1 0.36 0.2 0.05 54.36
125 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 54.04
126 INT42425 Gene_expression of Mmd 2 0.75 1.68 0.91 53.88
127 INT145253 Negative_regulation of Cav1 9 0.46 3.02 0.15 53.84
128 INT135954 Positive_regulation of Phosphorylation of Cav1 2 0.40 0.64 0.22 53.76
129 INT1129 Binding of Car2 69 0.35 14.01 9.2 53.44
130 INT271021 Binding of Casq1 1 0.03 0.64 0.03 53.44
131 INT135956 Phosphorylation of Cav1 5 0.64 2.24 0.22 52.84
132 INT173693 Localization of Gopc 249 0.65 70.49 38.81 50.00
133 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 50.00
134 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 50.00
135 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 50.00
136 INT23873 Regulation of Gm8644 2 0.16 0.27 1.54 50.00
137 INT38446 Localization of Ryr1 3 0.64 0.28 0.86 50.00
138 INT170505 Positive_regulation of Qdpr 2 0.22 0.15 0.16 50.00
139 INT316643 Negative_regulation of Gene_expression of Safb 1 0.13 0.08 0.12 50.00
140 INT316641 Positive_regulation of Localization of Ryr1 1 0.42 0 0.04 50.00
141 INT316640 Gene_expression of 3B1 1 0.65 0 0 50.00
142 INT316639 Negative_regulation of Gene_expression of 3B1 1 0.41 0 0 50.00
143 INT316638 Positive_regulation of Gene_expression of Qdpr 1 0.22 0 0 50.00
144 INT33431 Localization of Dnahc8 8 0.67 3.49 1.68 48.96
145 INT220497 Regulation of Gene_expression of Cav1 4 0.36 1.84 0.18 48.40
146 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 44.64
147 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 44.64
148 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 44.24
149 INT98609 Negative_regulation of PYGM 11 0.43 6.21 0.6 42.96
150 INT20470 Positive_regulation of Acsl1 5 0.40 3.76 1.03 42.56
151 INT116831 Binding of Ryr1 11 0.47 0.12 0.9 41.60
152 INT315025 Gene_expression of Cacna1s 3 0.48 2.3 0.18 37.92
153 INT315023 Transcription of Cacna1d 1 0.50 0.26 0.13 37.84
154 INT220504 Positive_regulation of Gene_expression of Cav1 11 0.39 6.26 0.43 35.88
155 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 33.12
156 INT11937 Localization of Il6 228 0.81 139.83 64.39 32.64
157 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61 30.96
158 INT262276 Negative_regulation of CASP2 1 0.01 2.98 0.73 26.28
159 INT236517 Gene_expression of Cacna1f 8 0.65 5.18 0.77 25.68
160 INT211756 Phosphorylation of Mmd 1 0.17 1.44 0.03 23.20
161 INT174101 Protein_catabolism of Ache 3 0.66 2.45 0.22 22.36
162 INT82913 Regulation of Ppara 15 0.61 10.66 3.03 18.88
163 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56 18.88
164 INT9660 Regulation of TNF 363 0.62 312.94 139.99 16.96
165 INT65057 Regulation of Nfkb1 28 0.47 16.48 11.62 15.80
166 INT38814 Positive_regulation of Aspt1 9 0.63 6.89 3.06 12.76
167 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 6.72
168 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
169 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
170 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
171 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
172 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
173 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
174 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
175 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
176 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
177 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 5.00
178 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
179 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
180 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
181 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 5.00
182 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
183 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
184 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
185 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
186 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
187 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 5.00
188 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
189 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 5.00
190 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
191 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
192 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
193 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 5.00
194 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
195 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
196 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 5.00
197 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
198 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
199 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
200 INT2791 Regulation of Mb 53 0.61 23.03 10.73 5.00
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