D:Malocclusion

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Disease Term
Synonyms Angle Classification, ANGLE S CLASSIFICATION, Angles Classification, Bite Cross, Bites Cross, Classification Angle S, Cross Bite, Cross Bites, Crossbite, Crossbites, Crowding Tooth
Documents 540
Hot Single Events 14
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Malocclusion. They are ordered first by their relevance to Malocclusion and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT267685 Binding of CENPJ and ARID1B 1 0.09 0.58 0.04 62.92
2 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 5.00
3 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29 5.00
4 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27 5.00
5 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26 5.00
6 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26 5.00
7 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
8 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
9 INT278020 Binding of Gh and Sst 1 0.18 0.16 0.15 5.00
10 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09 5.00
11 INT267686 Binding of RYBP and CENPJ 1 0.01 0.12 0.03 5.00
12 INT278014 Ptprf Regulation of Localization of Gh 1 0.61 0.31 0 5.00
13 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00
14 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0 5.00
15 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Malocclusion. They are ordered first by their pain relevance and then by number of times they were reported in Malocclusion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT163133 Gene_expression of ZBP1 28 0.65 18.59 1.25 99.12
2 INT14872 Gene_expression of TGFB3 15 0.55 12.45 2.96 93.64
3 INT319339 Localization of ZBP1 3 0.18 3.09 0.2 93.20
4 INT252 Localization of GH1 529 0.80 227.4 122.05 91.60
5 INT277258 Localization of Satb2 1 0.81 3.59 0.04 90.16
6 INT9344 Regulation of Atp9a 6 0.28 1.74 0.37 89.96
7 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 89.20
8 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 88.64
9 INT249 Localization of GHRH 215 0.80 78.02 51.87 88.48
10 INT6852 Localization of TNF 883 0.81 705.95 270.84 85.84
11 INT17997 Positive_regulation of Mch 23 0.49 12.71 6.67 85.76
12 INT267703 Regulation of ARID1B 6 0.21 6.85 0.45 83.32
13 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 82.56
14 INT284977 Binding of DNMT1 3 0.17 0.86 0 80.92
15 INT277254 Negative_regulation of Satb2 1 0.43 3.26 0.04 79.60
16 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 78.52
17 INT1893 Localization of Gh 1041 0.79 340.23 256.58 77.32
18 INT10240 Gene_expression of Gap43 58 0.78 22.11 24.45 76.44
19 INT103257 Regulation of Folr2 1 0.09 0.17 0.13 72.32
20 INT274682 Localization of PTMS 1 0.64 0.32 0 72.08
21 INT178834 Localization of MR1 8 0.21 6.52 0.48 71.84
22 INT103258 Regulation of Afteq2 1 0.00 0.17 0.13 71.76
23 INT277257 Binding of Satb2 1 0.37 2.51 0 71.16
24 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 70.00
25 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 70.00
26 INT57957 Localization of TXNRD1 14 0.64 4.01 2.7 69.64
27 INT27269 Localization of Ghrh 29 0.76 15.42 2.19 68.08
28 INT144099 Gene_expression of Zbp1 6 0.51 4.55 1.6 67.92
29 INT267702 Localization of ARID1B 1 0.29 1.45 0.04 66.48
30 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 64.92
31 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 64.92
32 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 64.92
33 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 64.92
34 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 64.56
35 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 64.32
36 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 64.28
37 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 64.16
38 INT211511 Binding of AHRR 2 0.28 0.77 0 62.68
39 INT92343 Negative_regulation of CENPJ 20 0.57 6.25 0.2 60.60
40 INT192805 Binding of PTMS 2 0.36 0.65 0 60.40
41 INT34777 Localization of IGF1 82 0.80 42.68 8.62 59.36
42 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 59.28
43 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 57.84
44 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 54.04
45 INT178282 Localization of SEMG1 3 0.65 1.08 0.14 41.88
46 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 35.52
47 INT65056 Binding of Ntrk2 20 0.36 3.72 4.42 32.88
48 INT244771 Gene_expression of Satb2 4 0.68 1.27 0.03 31.24
49 INT53906 Positive_regulation of Negative_regulation of Gh 9 0.50 6.72 2.73 23.64
50 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22 23.64
51 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 23.20
52 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 23.20
53 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 18.84
54 INT151032 Localization of Igf1 49 0.76 26.32 5.71 12.56
55 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.64
56 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
57 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
58 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
59 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
60 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
61 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
62 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
63 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 5.00
64 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
65 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
66 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
67 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
68 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
69 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
70 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
71 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 5.00
72 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
73 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
74 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
75 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
76 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 5.00
77 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
78 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
79 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
80 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
81 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
82 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
83 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
84 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
85 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
86 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
87 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
88 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 5.00
89 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 5.00
90 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
91 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
92 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
93 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
94 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
95 INT13897 Localization of Sst 65 0.81 14.91 32.24 5.00
96 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
97 INT7832 Localization of Cck 39 0.81 6.81 26.54 5.00
98 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
99 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
100 INT19986 Negative_regulation of Cck 31 0.59 4.32 24.99 5.00
101 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
102 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
103 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04 5.00
104 INT14506 Regulation of Sst 46 0.62 15.02 22.66 5.00
105 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
106 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
107 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
108 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
109 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
110 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
111 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 5.00
112 INT3362 Negative_regulation of Emg1 21 0.57 10.03 15.93 5.00
113 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
114 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
115 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
116 INT71510 Positive_regulation of Selp 47 0.68 30.43 12.8 5.00
117 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
118 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32 5.00
119 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
120 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
121 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
122 INT15350 Localization of Prl 22 0.81 6.86 10.74 5.00
123 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
124 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16 5.00
125 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
126 INT148703 Gene_expression of NOVA2 73 0.65 18.05 8.3 5.00
127 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
128 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
129 INT39301 Gene_expression of Chd7 50 0.26 27.06 8.13 5.00
130 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 5.00
131 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 5.00
132 INT66099 Transcription of Sst 8 0.25 4.86 6.96 5.00
133 INT142344 Transcription of Igf1 22 0.69 7.55 6.77 5.00
134 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
135 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
136 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
137 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
138 INT13857 Binding of Sst 11 0.24 2.48 5.76 5.00
139 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 5.00
140 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85 5.00
141 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
142 INT68216 Binding of NF1 40 0.48 51.24 4.59 5.00
143 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 5.00
144 INT36502 Positive_regulation of asp1 10 0.40 6.26 4.45 5.00
145 INT31419 Positive_regulation of Localization of Sst 10 0.70 0.77 3.94 5.00
146 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88 5.00
147 INT38560 Positive_regulation of SEMG1 13 0.60 4.37 3.81 5.00
148 INT38561 Regulation of SEMG1 19 0.51 3.75 3.66 5.00
149 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 5.00
150 INT13896 Negative_regulation of Localization of Sst 8 0.59 0.77 3.5 5.00
151 INT20179 Positive_regulation of Regulation of Gh 12 0.54 3.99 3.42 5.00
152 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
153 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 5.00
154 INT70049 Positive_regulation of Gene_expression of LTA 7 0.32 4.66 3.25 5.00
155 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 5.00
156 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
157 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
158 INT118156 Binding of Prkcz 2 0.08 2.68 2.89 5.00
159 INT31412 Negative_regulation of Positive_regulation of Ins1 10 0.40 7.14 2.82 5.00
160 INT185407 Binding of PER1 13 0.42 9.32 2.6 5.00
161 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 5.00
162 INT173236 Binding of Sstr2 8 0.25 1.64 2.41 5.00
163 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 5.00
164 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
165 INT61784 Positive_regulation of CENPJ 27 0.51 11.46 2.28 5.00
166 INT269217 Gene_expression of SNAI1 81 0.76 80.49 2.26 5.00
167 INT149451 Gene_expression of Sstr5 3 0.39 1.5 2.24 5.00
168 INT139498 Gene_expression of SEMG1 13 0.67 3.67 1.98 5.00
169 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95 5.00
170 INT80798 Positive_regulation of Chd7 16 0.14 7.95 1.95 5.00
171 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
172 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
173 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
174 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
175 INT149762 Regulation of MAS1 8 0.31 5.34 1.61 5.00
176 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
177 INT161574 Localization of CENPJ 7 0.73 6.11 1.54 5.00
178 INT154104 Binding of ARID1B 47 0.39 69.82 1.49 5.00
179 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 5.00
180 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41 5.00
181 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
182 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
183 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 5.00
184 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 5.00
185 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
186 INT62237 Gene_expression of Ptprf 2 0.65 1.63 1.08 5.00
187 INT78050 Positive_regulation of Positive_regulation of Selp 3 0.43 3.63 1.02 5.00
188 INT131488 Binding of MAS1 9 0.36 8.49 1.01 5.00
189 INT46470 Positive_regulation of Regulation of Ins1 8 0.46 4.51 1.01 5.00
190 INT27813 Regulation of CENPJ 12 0.29 14.26 0.99 5.00
191 INT253106 Negative_regulation of Phosphorylation of Ins1 6 0.17 5.62 0.87 5.00
192 INT253811 Negative_regulation of Localization of Cck 2 0.41 0.76 0.86 5.00
193 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 5.00
194 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
195 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81 5.00
196 INT100458 Positive_regulation of LTA 11 0.49 6.55 0.8 5.00
197 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 5.00
198 INT278006 Binding of Sstr3 2 0.33 1.07 0.71 5.00
199 INT249049 Positive_regulation of ARID1B 14 0.56 24.77 0.71 5.00
200 INT22096 Negative_regulation of SOS1 4 0.25 1.63 0.71 5.00
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