D:Marfan Syndrome

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Disease Term
Synonyms Arachnodactyl, ARACHNODACTYLIES, ARACHNODACTYLY, Contractural Arachnodactyl, Dolichostenomelia, Marfan S Disease, Marfan S Syndrome, MARFANOID HYPERMOBILITY SYNDROME, Marfans Syndrome, Syndrome Marfan, SYNDROME MARFAN S
Documents 165
Hot Single Events 23
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Marfan Syndrome. They are ordered first by their relevance to Marfan Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12 5.00
2 INT289794 Binding of Comp and Fn1 1 0.07 2.59 0.12 5.00
3 INT213421 Binding of CXCL2 and SET 1 0.11 0.17 0.1 5.00
4 INT213417 Binding of CCL7 and SET 1 0.11 0.17 0.1 5.00
5 INT213414 Binding of CXCL1 and SET 1 0.10 0.17 0.1 5.00
6 INT213415 Binding of CCL8 and SET 1 0.11 0.17 0.1 5.00
7 INT213420 Binding of IL6 and SET 1 0.10 0.17 0.1 5.00
8 INT213416 Binding of CCL2 and SET 1 0.11 0.17 0.1 5.00
9 INT213418 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of VCAM1 1 0.29 0.15 0.08 5.00
10 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08 5.00
11 INT202930 Binding of LAMB1 and Fbln5 1 0.01 0.45 0.05 5.00
12 INT202927 Binding of Fbln2 and Fbn1 1 0.14 0.29 0.04 5.00
13 INT202928 Binding of Eln and Fbln2 1 0.11 0.29 0.04 5.00
14 INT202929 Binding of Eln and Fbln1 1 0.09 0.21 0.03 5.00
15 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03 5.00
16 INT213422 MITF Negative_regulation of PROC 1 0.00 0.52 0.03 5.00
17 INT319219 Bmpr2 Positive_regulation of Smad1 1 0.18 0.29 0.03 5.00
18 INT319217 Bmpr2 Positive_regulation of Gene_expression of Smad1 1 0.19 0.11 0.03 5.00
19 INT312289 Binding of Col9a1 and Comp 1 0.09 1.38 0 5.00
20 INT263538 Binding of GPR19 and RS1 1 0.00 0.22 0 5.00
21 INT263540 Binding of MECP2 and RS1 1 0.00 0.18 0 5.00
22 INT312290 Binding of Col9a1 and Matn3 1 0.02 0.65 0 5.00
23 INT263539 Positive_regulation of Binding of MECP2 and RS1 1 0.00 0.18 0 5.00
24 INT312291 Binding of Comp and Matn3 1 0.06 1.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Marfan Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Marfan Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT39948 Binding of FLNA 45 0.42 58.05 4.27 100.00
2 INT269104 Positive_regulation of AOX1 1 0.19 4.25 0.4 99.64
3 INT101487 Gene_expression of Fbn1 3 0.77 3.54 0 99.62
4 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 99.34
5 INT23468 Gene_expression of Fbn1 7 0.76 8.04 0.76 99.32
6 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 99.28
7 INT968 Gene_expression of MMVP1 2 0.52 2.3 0.27 99.10
8 INT339058 Binding of Fbn1 1 0.48 3.13 0.03 97.56
9 INT259244 Negative_regulation of TNXB 1 0.42 2.15 0.13 96.96
10 INT95641 Regulation of Fbn1 3 0.45 3.67 0.91 96.72
11 INT269103 Gene_expression of AOX1 2 0.26 1.97 0.46 95.36
12 INT171686 Binding of asp1 8 0.31 11.88 1.07 94.64
13 INT50268 Gene_expression of FBN1 13 0.65 10.73 2.72 92.72
14 INT207739 Positive_regulation of Gene_expression of FBN1 2 0.22 2.11 0.06 92.72
15 INT88415 Gene_expression of DYM 3 0.58 5.26 0.43 91.52
16 INT213441 Positive_regulation of Gene_expression of DYM 1 0.15 1 0.03 91.52
17 INT13696 Regulation of COL3A1 2 0.45 2.97 0.95 89.04
18 INT93939 Binding of FBN1 4 0.33 4.05 0.67 87.24
19 INT190190 Protein_catabolism of ELN 5 0.22 2.81 1.27 87.12
20 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 84.96
21 INT269105 Localization of AOX1 1 0.31 2.16 0.5 82.80
22 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 82.36
23 INT339057 Positive_regulation of Gene_expression of Fbn1 1 0.50 0.52 0 80.28
24 INT151522 Binding of NSD1 2 0.37 4.28 0.09 79.96
25 INT339056 Negative_regulation of Gene_expression of Fbn1 1 0.42 1.17 0 77.04
26 INT199127 Gene_expression of FBN2 2 0.65 2.55 0.12 77.04
27 INT2836 Positive_regulation of PAEP 51 0.67 26.69 4.57 76.60
28 INT269102 Binding of AOX1 1 0.21 1.99 0.35 74.64
29 INT202591 Regulation of AVL9 2 0.02 1.58 0.19 74.20
30 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 73.72
31 INT3590 Positive_regulation of AVL9 7 0.40 7.94 2.36 73.52
32 INT214056 Negative_regulation of NSD1 3 0.43 3.44 0.09 73.36
33 INT214055 Gene_expression of NSD1 8 0.67 4.46 0 72.88
34 INT3811 Negative_regulation of PAEP 36 0.50 23.7 5.18 72.52
35 INT255189 Positive_regulation of Localization of Fbn1 1 0.45 1.03 0.19 70.08
36 INT255190 Positive_regulation of Gene_expression of Fbn1 1 0.68 1.03 0.19 70.08
37 INT202924 Localization of Fbn1 2 0.69 1.12 0.19 70.08
38 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 66.28
39 INT263542 Binding of IGKV2-30 1 0.03 4.4 0.05 61.04
40 INT198406 Localization of C2 5 0.65 1.42 1.01 57.24
41 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 56.80
42 INT1708 Gene_expression of OXTR 56 0.78 6.92 10.69 56.20
43 INT142340 Positive_regulation of Chkb 3 0.47 6.44 0.38 55.40
44 INT339055 Binding of Tgfbr2 1 0.07 0.92 0 53.56
45 INT155565 Gene_expression of Efemp2 22 0.67 7.24 0.13 53.12
46 INT202921 Negative_regulation of Gene_expression of Efemp2 3 0.43 1.6 0.05 53.12
47 INT155564 Negative_regulation of Efemp2 4 0.43 0.53 0.03 52.96
48 INT140270 Localization of CLEC4F 2 0.03 2.24 0.47 52.80
49 INT281657 Positive_regulation of CLEC4F 2 0.10 2.02 0.49 52.44
50 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 52.00
51 INT238458 Binding of GFM1 2 0.47 1.44 0 50.28
52 INT100746 Localization of sar 2 0.62 13.88 2.61 49.40
53 INT81328 Gene_expression of sar 7 0.66 2.86 1.85 49.40
54 INT255194 Binding of Fbn1 2 0.35 4.26 0.34 46.84
55 INT29094 Binding of C3 39 0.37 12.65 2.27 46.64
56 INT46384 Binding of TRGC1 16 0.41 4.87 1.28 46.64
57 INT131066 Binding of C6 4 0.31 1.81 0.86 46.64
58 INT64824 Negative_regulation of sar 11 0.42 18.7 5.6 45.96
59 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 37.56
60 INT331605 Negative_regulation of Localization of sar 1 0.35 0.88 0.13 36.24
61 INT44775 Gene_expression of ap 33 0.51 6.2 8.65 35.60
62 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 31.36
63 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12 30.72
64 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 30.68
65 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76 29.88
66 INT81695 Gene_expression of OSM 14 0.75 7.29 3.58 29.88
67 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28 29.88
68 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 27.76
69 INT35642 Regulation of BPIFA4P 4 0.26 3.85 1.6 24.56
70 INT2250 Binding of REG3A 3 0.47 3.58 1.33 22.52
71 INT332543 Gene_expression of Atp2b2 1 0.04 1.81 0 21.12
72 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 19.96
73 INT255191 Negative_regulation of Fbn1 1 0.37 1.2 0.25 19.28
74 INT185240 Binding of Fgf2 14 0.37 7.39 0.59 16.16
75 INT119540 Binding of Nfe2l2 29 0.48 6.34 1.74 15.68
76 INT184434 Localization of Adamts1 5 0.63 1.95 0.41 12.72
77 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 7.12
78 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.20
79 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
80 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
81 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
82 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
83 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
84 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
85 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
86 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
87 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
88 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
89 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 5.00
90 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
91 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
92 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
93 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
94 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
95 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
96 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
97 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 5.00
98 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
99 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 5.00
100 INT22481 Gene_expression of CADM1 28 0.65 30.26 8.5 5.00
101 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 5.00
102 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 5.00
103 INT127691 Gene_expression of CXCL1 23 0.66 18.11 7.04 5.00
104 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 5.00
105 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58 5.00
106 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
107 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2 5.00
108 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
109 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 5.00
110 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 5.00
111 INT21650 Regulation of OXTR 29 0.61 5.99 4.91 5.00
112 INT142162 Binding of IL10 30 0.37 21.9 4.84 5.00
113 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 5.00
114 INT62821 Negative_regulation of Gene_expression of VCAM1 21 0.54 12.24 4.41 5.00
115 INT47992 Gene_expression of Scn8a 14 0.78 4.15 3.83 5.00
116 INT47372 Regulation of ap 12 0.18 2.14 3.76 5.00
117 INT3854 Binding of SCD 16 0.41 11.14 3.7 5.00
118 INT113996 Gene_expression of RS1 23 0.72 7.7 3.16 5.00
119 INT146300 Binding of RS1 31 0.22 29.55 3.04 5.00
120 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65 5.00
121 INT167556 Binding of MECP2 7 0.27 4.57 2.6 5.00
122 INT72165 Gene_expression of CXCL6 8 0.52 4.76 2.6 5.00
123 INT39414 Gene_expression of SNRPB 37 0.59 14.07 2.52 5.00
124 INT33895 Positive_regulation of LIF 9 0.67 2.47 2.34 5.00
125 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
126 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25 5.00
127 INT156694 Binding of SET 10 0.36 3.77 2.21 5.00
128 INT184305 Gene_expression of Comp 53 0.77 31.66 2.2 5.00
129 INT9749 Positive_regulation of sar 25 0.50 9.96 2.09 5.00
130 INT76813 Gene_expression of Hgf 20 0.75 10.96 2.08 5.00
131 INT213431 Positive_regulation of Gene_expression of MMRN1 15 0.24 9.91 1.96 5.00
132 INT178841 Localization of SNRNP70 27 0.78 10.35 1.71 5.00
133 INT127145 Gene_expression of SET 46 0.65 10.39 1.7 5.00
134 INT168304 Positive_regulation of SNRPB 17 0.25 9.62 1.64 5.00
135 INT99150 Localization of VCAM1 7 0.79 6.2 1.6 5.00
136 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55 5.00
137 INT121335 Localization of SCD 10 0.68 6.81 1.51 5.00
138 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44 5.00
139 INT213442 Gene_expression of CXCL3 8 0.57 6.3 1.41 5.00
140 INT164915 Gene_expression of CXCL2 7 0.55 5.25 1.4 5.00
141 INT69785 Positive_regulation of MYOC 8 0.70 6.24 1.36 5.00
142 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 5.00
143 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34 5.00
144 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 5.00
145 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 5.00
146 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21 5.00
147 INT57619 Gene_expression of GTPBP4 3 0.04 0.22 1.2 5.00
148 INT80305 Gene_expression of IGKV2-30 6 0.04 3.68 1.01 5.00
149 INT170163 Negative_regulation of ACSM3 5 0.16 3.56 0.96 5.00
150 INT76057 Regulation of sar 9 0.23 2.05 0.96 5.00
151 INT188232 Positive_regulation of OSM 7 0.41 1.57 0.94 5.00
152 INT80296 Gene_expression of CCL7 4 0.43 1.65 0.93 5.00
153 INT126725 Gene_expression of CNN1 5 0.53 2.77 0.91 5.00
154 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8 5.00
155 INT205401 Gene_expression of Chkb 32 0.51 13.99 0.77 5.00
156 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72 5.00
157 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72 5.00
158 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71 5.00
159 INT68794 Negative_regulation of LIF 6 0.41 1.38 0.7 5.00
160 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69 5.00
161 INT69782 Gene_expression of MYOC 12 0.78 8.44 0.61 5.00
162 INT78999 Binding of AKR1C1 3 0.36 1.75 0.58 5.00
163 INT85388 Positive_regulation of Bmc1 8 0.25 3.74 0.56 5.00
164 INT187090 Positive_regulation of Localization of Col7a1 4 0.07 3.16 0.51 5.00
165 INT4597 Regulation of SCD 5 0.39 2.25 0.5 5.00
166 INT213434 Gene_expression of HNMT 4 0.64 4.33 0.46 5.00
167 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45 5.00
168 INT171037 Gene_expression of CCL8 2 0.45 0.42 0.42 5.00
169 INT285501 Gene_expression of Smad1 6 0.42 3.09 0.41 5.00
170 INT15762 Negative_regulation of asp1 6 0.37 0.71 0.4 5.00
171 INT128446 Positive_regulation of DYM 4 0.14 4.01 0.39 5.00
172 INT214618 Transcription of FLNA 4 0.51 8.06 0.37 5.00
173 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34 5.00
174 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34 5.00
175 INT162046 Negative_regulation of OSM 2 0.41 1.12 0.31 5.00
176 INT157605 Localization of COL3A1 3 0.80 0.55 0.29 5.00
177 INT336270 Localization of AKR1C1 1 0.06 1.56 0.29 5.00
178 INT45510 Binding of Scn8a 4 0.31 3.89 0.25 5.00
179 INT179671 Binding of Eln 5 0.31 5.32 0.23 5.00
180 INT213447 Gene_expression of APOLD1 1 0.09 2.98 0.22 5.00
181 INT140639 Gene_expression of FOXF1 3 0.52 0.89 0.22 5.00
182 INT265311 Localization of Smad2 5 0.50 1.57 0.21 5.00
183 INT206746 Gene_expression of TPM1 7 0.75 2.15 0.21 5.00
184 INT213438 Gene_expression of CALD1 2 0.31 0.39 0.21 5.00
185 INT69784 Binding of MYOC 8 0.48 5.67 0.21 5.00
186 INT272889 Negative_regulation of Smad6 2 0.20 1.31 0.19 5.00
187 INT311891 Phosphorylation of Smad1 4 0.51 1.34 0.18 5.00
188 INT251821 Negative_regulation of COL11A1 3 0.42 3.45 0.16 5.00
189 INT261721 Negative_regulation of Stl2 1 0.07 1.38 0.16 5.00
190 INT213436 Gene_expression of FOXP1 1 0.53 0.66 0.16 5.00
191 INT202918 Binding of Efemp2 1 0.37 1.23 0.14 5.00
192 INT310174 Positive_regulation of Smad1 9 0.45 2.16 0.14 5.00
193 INT167724 Phosphorylation of ap 2 0.61 0.84 0.13 5.00
194 INT179664 Negative_regulation of Eln 3 0.19 2.35 0.12 5.00
195 INT202922 Regulation of Efemp2 1 0.45 0.67 0.12 5.00
196 INT195744 Gene_expression of XIST 3 0.65 1.61 0.12 5.00
197 INT213435 Localization of DYM 1 0.23 0.15 0.11 5.00
198 INT181313 Regulation of Bmc1 6 0.04 1.59 0.11 5.00
199 INT213448 Localization of FOXF1 1 0.58 0.15 0.1 5.00
200 INT201962 Transcription of Bmpr2 6 0.37 3.51 0.09 5.00
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