D:Marinesco Sjogren Syndrome

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Disease Term
Synonyms ATAXIA HEREDITARY, Ataxias Hereditary, CEREBELLAR ATAXIA EARLY ONSET, CEREBELLAR ATAXIA LATE ONSET, Cerebellar Ataxia Marie, Cerebellar Ataxia Marie S, Cerebellar Degeneration Primary, Cerebellar Degenerations Primary, Corticostriatal Spinal Degeneration, Corticostriatal Spinal Degenerations, Degeneration Corticostriatal Spinal
Documents 35
Hot Single Events 18
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Marinesco Sjogren Syndrome. They are ordered first by their relevance to Marinesco Sjogren Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
2 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
3 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
4 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0 5.00
5 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0 5.00
6 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0 5.00
7 INT315535 Binding of ABCB7 and FECH 1 0.28 0.7 0 5.00
8 INT315533 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2 1 0.38 1.06 0 5.00
9 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0 5.00
10 INT315538 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Marinesco Sjogren Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Marinesco Sjogren Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3854 Binding of SCD 16 0.41 11.14 3.7 100.00
2 INT339 Regulation of Trh 156 0.62 39.27 83.55 99.08
3 INT403 Localization of Trh 241 0.81 28.55 81.45 98.16
4 INT27267 Localization of Trh 11 0.80 1.76 2.47 97.84
5 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 97.72
6 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 97.72
7 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 97.44
8 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 97.36
9 INT274268 Localization of OPA2 1 0.12 1.48 0 92.96
10 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14 85.28
11 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14 85.00
12 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8 83.68
13 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34 83.68
14 INT199644 Positive_regulation of Gene_expression of H2-Q10 3 0.37 2.6 0.15 83.56
15 INT82177 Negative_regulation of H2-Q10 5 0.58 5.83 0.45 83.20
16 INT94563 Gene_expression of H2-Q10 7 0.42 7 0.88 83.20
17 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82 83.04
18 INT158837 Binding of POLG 4 0.37 4.69 0.44 80.88
19 INT194794 Binding of TTPA 7 0.08 2.56 0.57 77.24
20 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08 76.08
21 INT315643 Negative_regulation of Gene_expression of FECH 1 0.29 0.71 0.1 76.08
22 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44 75.60
23 INT105021 Binding of GOPC 187 0.40 60.39 20.38 75.20
24 INT10100 Binding of ELANE 22 0.47 15.32 5.19 75.20
25 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 75.00
26 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 75.00
27 INT3439 Localization of Abat 1017 0.78 112.39 727.06 75.00
28 INT199661 Negative_regulation of TTPA 2 0.04 1.84 0 74.40
29 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 70.48
30 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 68.80
31 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 60.64
32 INT315554 Localization of NFS1 1 0.43 0.28 0.07 47.76
33 INT315598 Localization of FXN 1 0.43 1.04 0.07 47.40
34 INT2323 Gene_expression of Trh 146 0.78 29.92 49.5 25.00
35 INT315640 Gene_expression of NUBP1 1 0.41 0.32 0 20.92
36 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 20.68
37 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
38 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
39 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
40 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
41 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
42 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
43 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
44 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
45 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
46 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
47 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
48 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
49 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
50 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
51 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
52 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
53 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
54 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
55 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
56 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52 5.00
57 INT157959 Binding of AQP4 32 0.48 43.44 7.44 5.00
58 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
59 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
60 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 5.00
61 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
62 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
63 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
64 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
65 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
66 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
67 INT78203 Gene_expression of PMP22 12 0.63 7.49 3.58 5.00
68 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 5.00
69 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3 5.00
70 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
71 INT76092 Localization of ISYNA1 10 0.66 7.72 3.11 5.00
72 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 5.00
73 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
74 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
75 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 5.00
76 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
77 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
78 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 5.00
79 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
80 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
81 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 5.00
82 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42 5.00
83 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
84 INT162467 Gene_expression of ERN1 10 0.56 5.11 1.26 5.00
85 INT302084 Negative_regulation of WNT2 2 0.09 0.83 1.26 5.00
86 INT115264 Binding of FECH 9 0.41 7.93 1.1 5.00
87 INT162471 Positive_regulation of ERN1 7 0.34 3.02 1.08 5.00
88 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 5.00
89 INT4436 Gene_expression of ABCB7 7 0.65 9.26 0.93 5.00
90 INT46403 Gene_expression of ATN1 2 0.75 3.33 0.93 5.00
91 INT85624 Gene_expression of GJB1 5 0.78 3.03 0.93 5.00
92 INT85623 Gene_expression of ATXN1 6 0.58 5.14 0.9 5.00
93 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 5.00
94 INT50687 Gene_expression of Aldoc 6 0.78 0.17 0.78 5.00
95 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 5.00
96 INT158136 Binding of FGFR2 9 0.26 4.5 0.63 5.00
97 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 5.00
98 INT94423 Binding of ALAS2 4 0.32 2.1 0.61 5.00
99 INT309253 Negative_regulation of Transcription of LMOD1 1 0.03 0.2 0.57 5.00
100 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 5.00
101 INT309242 Localization of Nat1 1 0.01 0.17 0.42 5.00
102 INT302086 Gene_expression of WNT2 3 0.14 0.97 0.38 5.00
103 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 5.00
104 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 5.00
105 INT3321 Positive_regulation of ALAS2 10 0.51 3.08 0.32 5.00
106 INT309249 Regulation of OGDHL 1 0.01 0.6 0.3 5.00
107 INT309251 Gene_expression of OGDHL 1 0.01 0.64 0.29 5.00
108 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 5.00
109 INT166958 Gene_expression of LYRM4 4 0.18 2.9 0.27 5.00
110 INT221496 Localization of ISCA1 4 0.73 2.12 0.23 5.00
111 INT243267 Positive_regulation of SLC40A1 4 0.41 2.72 0.22 5.00
112 INT241863 Binding of SLC40A1 4 0.28 3.86 0.22 5.00
113 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21 5.00
114 INT236980 Gene_expression of ISCA1 9 0.53 2.43 0.19 5.00
115 INT170629 Negative_regulation of Gene_expression of ABCB7 2 0.37 1.32 0.17 5.00
116 INT243268 Gene_expression of SLC40A1 6 0.60 4.18 0.13 5.00
117 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11 5.00
118 INT131139 Binding of ACO1 3 0.27 1.81 0.1 5.00
119 INT95756 Gene_expression of ACO1 3 0.27 2.49 0.1 5.00
120 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 5.00
121 INT199643 Phosphorylation of Fxn 1 0.40 1.04 0.08 5.00
122 INT174848 Gene_expression of ISCU 2 0.59 2.79 0.08 5.00
123 INT315622 Protein_catabolism of FECH 1 0.77 0.49 0.07 5.00
124 INT199656 Binding of Pnkp 1 0.07 1.36 0.07 5.00
125 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07 5.00
126 INT315626 Localization of DLEU1 2 0.35 4.17 0.07 5.00
127 INT261026 Localization of Gclc 3 0.36 0.88 0.06 5.00
128 INT261017 Regulation of Gclc 2 0.22 0.88 0.06 5.00
129 INT309245 Binding of SETX 1 0.08 1.98 0.06 5.00
130 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05 5.00
131 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05 5.00
132 INT199650 Negative_regulation of Phyh 1 0.42 2.2 0.04 5.00
133 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04 5.00
134 INT199648 Regulation of Fxn 1 0.29 2.14 0.04 5.00
135 INT309246 Localization of ATXN2 1 0.10 1.45 0.03 5.00
136 INT309254 Localization of ATXN1 1 0.09 1.45 0.03 5.00
137 INT309258 Localization of TBP 2 0.27 1.78 0.03 5.00
138 INT164193 Localization of ATN1 2 0.73 1.47 0.03 5.00
139 INT315624 Positive_regulation of Gene_expression of ISCU 1 0.38 0.23 0.03 5.00
140 INT309250 Localization of ATXN3 1 0.14 1.46 0.03 5.00
141 INT199651 Binding of Fxn 3 0.30 1.45 0.03 5.00
142 INT309256 Localization of ATXN7 1 0.11 1.46 0.03 5.00
143 INT315583 Positive_regulation of Binding of NFS1 1 0.25 0 0 5.00
144 INT315551 Negative_regulation of Gene_expression of ALAS2 1 0.37 1.11 0 5.00
145 INT315585 Localization of SLC25A37 1 0.13 0.47 0 5.00
146 INT315581 Positive_regulation of Phosphorylation of ISCU 1 0.44 0.33 0 5.00
147 INT315617 Positive_regulation of Gene_expression of SLC25A37 1 0.10 0.39 0 5.00
148 INT315565 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.73 0 5.00
149 INT315631 Protein_catabolism of IREB2 1 0.44 0.4 0 5.00
150 INT315614 Negative_regulation of Transcription of FXN 1 0.25 0.82 0 5.00
151 INT315602 Binding of ISCA1 1 0.30 0 0 5.00
152 INT315562 Gene_expression of GLRX5 1 0.69 4.92 0 5.00
153 INT309255 Gene_expression of NDUFV1 1 0.01 2.33 0 5.00
154 INT315587 Positive_regulation of Gene_expression of CIAO1 1 0.22 1.6 0 5.00
155 INT315591 Negative_regulation of Positive_regulation of SLC40A1 1 0.25 0.46 0 5.00
156 INT315620 Regulation of Gene_expression of GLRX5 1 0.40 0.5 0 5.00
157 INT315550 Transcription of GLRX5 1 0.53 0.66 0 5.00
158 INT315575 Transcription of SLC40A1 1 0.40 0.85 0 5.00
159 INT315637 Transcription of FXN 1 0.40 1.44 0 5.00
160 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0 5.00
161 INT315634 Negative_regulation of Binding of ISCU 1 0.33 0.28 0 5.00
162 INT315597 Negative_regulation of ISCU 1 0.51 0.22 0 5.00
163 INT199653 Positive_regulation of Tfrc 2 0.13 1.57 0 5.00
164 INT315600 Regulation of CIAO1 1 0.20 0.39 0 5.00
165 INT315571 Binding of NFS1 1 0.19 0 0 5.00
166 INT315613 Positive_regulation of WNT2 1 0.09 0.41 0 5.00
167 INT315627 Binding of GLRX5 1 0.33 0 0 5.00
168 INT315606 Regulation of Gene_expression of WNT2 1 0.08 0.84 0 5.00
169 INT315644 Negative_regulation of Transcription of DLEU1 1 0.21 0.64 0 5.00
170 INT315555 Binding of FXN 1 0.28 1.29 0 5.00
171 INT315605 Binding of ABCB7 1 0.33 1.84 0 5.00
172 INT315592 Positive_regulation of Gene_expression of SLC40A1 1 0.41 3.52 0 5.00
173 INT315567 Positive_regulation of Negative_regulation of CIAO1 1 0.22 1.29 0 5.00
174 INT315556 Positive_regulation of Binding of ALAS2 1 0.43 1.05 0 5.00
175 INT315623 Positive_regulation of Localization of ACO1 1 0.20 0.79 0 5.00
176 INT315635 Positive_regulation of FXN 2 0.41 5.76 0 5.00
177 INT315608 Localization of NFU1 1 0.14 0 0 5.00
178 INT252722 Binding of IREB2 2 0.16 1.31 0 5.00
179 INT315596 Localization of ISCA2 1 0.11 0 0 5.00
180 INT315601 Positive_regulation of NFU1 1 0.22 0.13 0 5.00
181 INT315642 Negative_regulation of Gene_expression of NFU1 1 0.16 0.37 0 5.00
182 INT315636 Negative_regulation of ABCB7 1 0.38 0.17 0 5.00
183 INT315588 Regulation of ACO1 1 0.18 0.57 0 5.00
184 INT315570 Negative_regulation of Positive_regulation of TFRC 1 0.19 0.08 0 5.00
185 INT315573 Negative_regulation of Gene_expression of NFS1 1 0.24 0.74 0 5.00
186 INT315568 Regulation of Gene_expression of CIAO1 1 0.20 0.15 0 5.00
187 INT174850 Binding of ISCU 2 0.33 0.51 0 5.00
188 INT315638 Gene_expression of GLRX3 1 0.25 0 0 5.00
189 INT315564 Binding of NFU1 1 0.16 0 0 5.00
190 INT315619 Regulation of Gene_expression of NFS1 1 0.26 0.74 0 5.00
191 INT315607 Positive_regulation of Gene_expression of GLRX5 1 0.61 2.28 0 5.00
192 INT315593 Regulation of Transcription of SLC40A1 1 0.26 1.7 0 5.00
193 INT315549 Negative_regulation of Binding of WNT2 1 0.08 0.65 0 5.00
194 INT315580 Negative_regulation of Localization of SLC40A1 1 0.25 0.64 0 5.00
195 INT315641 Gene_expression of ISCA2 1 0.22 0 0 5.00
196 INT315590 Negative_regulation of Transcription of CIAO1 1 0.19 0.33 0 5.00
197 INT315612 Gene_expression of NFS1 1 0.39 1.68 0 5.00
198 INT315610 Transcription of DLEU1 1 0.25 0.64 0 5.00
199 INT315576 Positive_regulation of Binding of CIAO1 1 0.22 0.67 0 5.00
200 INT315615 Positive_regulation of ISCU 1 0.44 0.11 0 5.00
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