D:Mast Cell Leukemia

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pChart

Disease Term
Synonyms Leukemia Mast Cell, Leukemias Mast Cell, Mast Cell Leukaemia, Mast Cell Leukemias, Noncutaneous Systemic Mastocytosis
Documents 13
Hot Single Events 20
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mast Cell Leukemia. They are ordered first by their relevance to Mast Cell Leukemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT138515 Drd3 Negative_regulation of Localization of Tnf 1 0.06 0.4 0.36 60.52
2 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
3 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98 5.00
4 INT179166 TFPI Positive_regulation of Gene_expression of IL6 1 0.03 0.18 0.25 5.00
5 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18 5.00
6 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18 5.00
7 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18 5.00
8 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18 5.00
9 INT179160 IL6 Regulation of Gene_expression of IL13 1 0.03 0.12 0.11 5.00
10 INT179159 IL8 Regulation of Gene_expression of IL6 1 0.02 0.12 0.11 5.00
11 INT179165 IL8 Regulation of Gene_expression of IL13 1 0.02 0.12 0.11 5.00
12 INT192956 Binding of CD2 and KIT 1 0.03 0.62 0 5.00
13 INT192955 Binding of KIT and VCAM1 1 0.05 0.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mast Cell Leukemia. They are ordered first by their pain relevance and then by number of times they were reported in Mast Cell Leukemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT138512 Positive_regulation of Rbl2 1 0.02 0.45 0.23 99.86
2 INT232639 Positive_regulation of Jag2 4 0.14 10.63 1.03 99.76
3 INT51378 Positive_regulation of Localization of Hexb 4 0.69 0.65 1.18 98.96
4 INT51377 Localization of Hexb 10 0.80 3.02 2.8 98.78
5 INT192960 Regulation of Gene_expression of KIT 3 0.45 4.16 0 98.32
6 INT83531 Gene_expression of KITLG 54 0.65 26 7.07 97.96
7 INT5870 Negative_regulation of IFNA2 20 0.49 12 4.3 96.92
8 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 96.56
9 INT10166 Localization of Tnf 237 0.81 153.95 88.64 96.08
10 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78 96.08
11 INT232628 Gene_expression of Opa1 10 0.78 17.01 0.26 87.64
12 INT232635 Positive_regulation of Gene_expression of Opa1 1 0.06 0.6 0.1 87.64
13 INT128230 Negative_regulation of tryptase 3 0.57 5.77 0.88 86.44
14 INT10189 Negative_regulation of Gene_expression of Il2ra 8 0.32 8.05 2.91 86.44
15 INT232641 Negative_regulation of Gene_expression of tryptase 1 0.40 2.4 0.12 86.44
16 INT232631 Negative_regulation of Gene_expression of Cd2 1 0.27 2.25 0.12 86.44
17 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 80.76
18 INT49488 Gene_expression of mMCP-7 37 0.75 26.11 7.68 80.76
19 INT41423 Gene_expression of Cd2 3 0.53 2.06 0.16 80.76
20 INT60423 Positive_regulation of TPSG1 11 0.57 11.02 2.55 80.16
21 INT138513 Regulation of Olr756 1 0.06 0.44 0.27 78.20
22 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 76.56
23 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36 75.04
24 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 73.04
25 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 73.04
26 INT69761 Gene_expression of Jag2 5 0.67 6.17 0.53 70.20
27 INT232640 Binding of Jag2 1 0.12 4.1 0.49 68.72
28 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 67.84
29 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 67.84
30 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 67.84
31 INT128376 Binding of KIT 26 0.48 14.24 0.47 67.04
32 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46 61.72
33 INT207134 Positive_regulation of tryptase 11 0.47 11.16 1.21 61.60
34 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 51.80
35 INT232630 Regulation of Opa1 1 0.05 0.91 0.06 48.00
36 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 47.36
37 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 46.48
38 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 46.00
39 INT192957 Transcription of KIT 5 0.69 2.19 0.23 44.32
40 INT192962 Positive_regulation of Transcription of KIT 1 0.46 2.74 0 44.32
41 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 38.88
42 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 34.76
43 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
44 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
45 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
46 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
47 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
48 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
49 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
50 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
51 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
52 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
53 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
54 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
55 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
56 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
57 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
58 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
59 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
60 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
61 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
62 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62 5.00
63 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
64 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 5.00
65 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 5.00
66 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 5.00
67 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
68 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 5.00
69 INT36054 Transcription of IL1B 53 0.72 32.64 17.31 5.00
70 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
71 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 5.00
72 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
73 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
74 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 5.00
75 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
76 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
77 INT5381 Gene_expression of FYN 18 0.75 7.65 7.35 5.00
78 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
79 INT12039 Localization of TFPI 22 0.68 9.88 5.35 5.00
80 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
81 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22 5.00
82 INT75831 Positive_regulation of Transcription of IL8 21 0.63 13.56 4.98 5.00
83 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 5.00
84 INT73503 Positive_regulation of Gene_expression of IL13 16 0.37 14.6 4.23 5.00
85 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
86 INT75688 Binding of KITLG 24 0.30 11.73 4.06 5.00
87 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 5.00
88 INT170606 Regulation of Gene_expression of GOPC 31 0.37 6.08 3.31 5.00
89 INT15179 Positive_regulation of Gene_expression of SELL 18 0.61 14.35 2.84 5.00
90 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
91 INT91836 Negative_regulation of Gene_expression of BCL2L1 9 0.49 8.59 2.25 5.00
92 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 5.00
93 INT94628 Gene_expression of CD1D 12 0.75 5.58 2.13 5.00
94 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05 5.00
95 INT99572 Localization of Kit 13 0.75 5.23 1.95 5.00
96 INT178572 Negative_regulation of Gene_expression of IL13 9 0.14 4.51 1.94 5.00
97 INT94084 Regulation of Gene_expression of IL13 6 0.22 3.55 1.9 5.00
98 INT173173 Regulation of Positive_regulation of MAPK14 6 0.38 2.59 1.64 5.00
99 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 5.00
100 INT179169 Transcription of IL13 11 0.15 4.22 1.37 5.00
101 INT58761 Regulation of CD1D 3 0.26 1.54 1.33 5.00
102 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
103 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 5.00
104 INT232636 Positive_regulation of Binding of Kit 4 0.39 1.98 0.98 5.00
105 INT22004 Positive_regulation of Binding of IGHE 7 0.49 3.29 0.96 5.00
106 INT24860 Positive_regulation of CD1D 6 0.49 2.13 0.83 5.00
107 INT70019 Binding of BCL2 25 0.47 17.55 0.79 5.00
108 INT57008 Positive_regulation of HPRT1 11 0.50 2.81 0.74 5.00
109 INT179168 Regulation of Transcription of IL8 4 0.43 1.88 0.63 5.00
110 INT132104 Positive_regulation of Gene_expression of CD1D 2 0.03 0.55 0.57 5.00
111 INT179170 Protein_catabolism of MAPK14 3 0.43 0.88 0.43 5.00
112 INT108650 Positive_regulation of Gene_expression of KITLG 2 0.33 2.57 0.41 5.00
113 INT163489 Binding of CDH1 13 0.19 8.63 0.35 5.00
114 INT232637 Localization of Jag2 2 0.21 2.07 0.32 5.00
115 INT179171 Positive_regulation of Transcription of IL13 4 0.11 0.72 0.29 5.00
116 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21 5.00
117 INT111549 Phosphorylation of KITLG 2 0.37 1.13 0.15 5.00
118 INT232638 Negative_regulation of Gene_expression of Opa1 1 0.31 0.96 0.1 5.00
119 INT162271 Negative_regulation of Gene_expression of KITLG 4 0.28 2.31 0.07 5.00
120 INT230873 Regulation of Gene_expression of tryptase 2 0.42 1.02 0.06 5.00
121 INT192961 Positive_regulation of Negative_regulation of ERBB2 2 0.64 3.53 0.06 5.00
122 INT232629 Positive_regulation of Localization of Kit 1 0.44 0.8 0 5.00
123 INT232634 Localization of Opa1 2 0.75 1.11 0 5.00
124 INT232632 Regulation of Localization of Kit 1 0.40 0.81 0 5.00
125 INT192959 Regulation of Gene_expression of FYN 1 0.05 1.06 0 5.00
126 INT232633 Regulation of Gene_expression of Opa1 2 0.27 2.6 0 5.00
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