D:Mastocytoma

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Disease Term
Synonyms BENIGN MASTOCYTOMA, EXTRACUTANEOUS MASTOCYTOMA, Extracutaneous Mastocytomas, MASTOCYTOMA BENIGN, Mastocytoma Extracutaneous, MASTOCYTOMAS EXTRACUTANEOUS
Documents 21
Hot Single Events 23
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mastocytoma. They are ordered first by their relevance to Mastocytoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT134405 Binding of PTGS1 and HPGDS 1 0.01 0.33 0.14 97.12
2 INT35179 Binding of STT3A and LYZ 1 0.07 0.38 0.25 90.12
3 INT35178 Binding of STT3A and PSME3 1 0.01 0.38 0.25 90.12
4 INT35181 Binding of STT3A and POMC 1 0.29 0.75 0.57 87.36
5 INT35180 Binding of STT3A and PDYN 1 0.14 0.37 0.29 87.36
6 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11 5.00
7 INT330976 Igh-Dex Positive_regulation of Gene_expression of VDR 1 0.01 1.11 0.23 5.00
8 INT330955 HOMER1 Positive_regulation of Gene_expression of VDR 1 0.01 0.99 0.08 5.00
9 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06 5.00
10 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06 5.00
11 INT330958 Binding of VDR and BTG2 1 0.07 0.51 0 5.00
12 INT330956 Binding of TEP1 and NR1H4 1 0.00 1.07 0 5.00
13 INT330959 Binding of RXRB and VDR 1 0.05 0.14 0 5.00
14 INT330957 Binding of TEP1 and VDR 1 0.01 1.07 0 5.00
15 INT182950 Binding of VDR and NR1H4 5 0.03 1.16 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mastocytoma. They are ordered first by their pain relevance and then by number of times they were reported in Mastocytoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17 100.00
2 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82 100.00
3 INT29109 Negative_regulation of Gene_expression of Alox5 6 0.42 2.9 1.07 100.00
4 INT349876 Gene_expression of Trap1a 1 0.22 2.96 0 99.98
5 INT8530 Transcription of Penk 48 0.70 11.67 16.34 98.90
6 INT11279 Positive_regulation of Penk 65 0.70 18.72 30.29 98.90
7 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 97.96
8 INT44917 Negative_regulation of Gene_expression of PTGDS 6 0.50 2.98 1.27 97.96
9 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 97.12
10 INT134412 Binding of HPGDS 9 0.42 1.7 0.43 97.12
11 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57 97.08
12 INT60699 Negative_regulation of Gene_expression of Itgax 5 0.39 1.94 1.05 97.08
13 INT126827 Negative_regulation of Itgax 4 0.57 2.06 0.36 96.64
14 INT23986 Positive_regulation of Ifnb1 4 0.42 0.62 1.39 95.44
15 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82 93.52
16 INT84392 Localization of Hdc 2 0.70 0.98 0.34 93.24
17 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66 93.00
18 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 92.20
19 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76 90.52
20 INT4804 Positive_regulation of Gene_expression of PTGDS 10 0.68 21.43 11.14 89.68
21 INT185234 Transcription of Itgax 1 0.66 4.83 0.24 88.20
22 INT84395 Protein_catabolism of Pla2g4a 1 0.02 0.41 0.12 87.08
23 INT134413 Gene_expression of HPGDS 20 0.77 8.93 3.28 83.96
24 INT102639 Positive_regulation of VDR 31 0.69 18.05 2.38 79.12
25 INT185231 Transcription of Cd8a 5 0.47 2.79 0 77.52
26 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 76.00
27 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 76.00
28 INT7029 Regulation of Pdyn 51 0.61 12.89 40.34 72.72
29 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49 70.64
30 INT185227 Positive_regulation of Localization of Cd8a 2 0.19 1.77 0.07 70.64
31 INT185232 Positive_regulation of Localization of Itgax 1 0.46 0.47 0 70.64
32 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 69.40
33 INT20373 Localization of Cd8a 28 0.64 8.22 2.07 69.36
34 INT137204 Localization of Itgax 6 0.70 3.86 0.67 68.80
35 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 68.40
36 INT19134 Gene_expression of TPSAB1 16 0.66 11.61 2.48 67.84
37 INT153800 Positive_regulation of Protein_catabolism of PARP1 18 0.49 16.16 1.89 66.04
38 INT330974 Positive_regulation of Protein_catabolism of CASP10 1 0.05 1.86 0 66.04
39 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 65.96
40 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77 65.68
41 INT125868 Protein_catabolism of CASP10 2 0.64 2.9 0.08 65.68
42 INT96157 Gene_expression of Cd80 74 0.77 31.19 9.78 64.00
43 INT22835 Binding of STT3A 3 0.37 0.24 0.79 59.48
44 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 57.84
45 INT154151 Positive_regulation of TP73 5 0.67 5.71 0.52 57.84
46 INT135991 Positive_regulation of Gene_expression of Cd80 19 0.54 6.9 1.71 57.04
47 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 50.44
48 INT349882 Gene_expression of Pcyt1a 1 0.05 8.79 0.27 27.32
49 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 16.16
50 INT185230 Regulation of Itgax 1 0.56 3.32 0.07 11.48
51 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
52 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
53 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 5.00
54 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
55 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
56 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
57 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
58 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
59 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
60 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
61 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
62 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
63 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
64 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
65 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
66 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
67 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
68 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
69 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
70 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
71 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 5.00
72 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 5.00
73 INT15172 Positive_regulation of Itgam 45 0.67 23.54 10.3 5.00
74 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
75 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22 5.00
76 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
77 INT87434 Gene_expression of Sell 38 0.77 21.95 8.51 5.00
78 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
79 INT102512 Gene_expression of B3galt6 10 0.52 3.01 8.25 5.00
80 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 5.00
81 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39 5.00
82 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35 5.00
83 INT103824 Positive_regulation of SOD2 26 0.70 17.42 7.17 5.00
84 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
85 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52 5.00
86 INT8724 Positive_regulation of Mln 21 0.66 14.12 6.17 5.00
87 INT947 Regulation of Mln 20 0.59 4.09 5.87 5.00
88 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64 5.00
89 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43 5.00
90 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
91 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41 5.00
92 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 5.00
93 INT56445 Regulation of Icam1 14 0.39 15.4 5.32 5.00
94 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22 5.00
95 INT11805 Regulation of Gene_expression of Il2 19 0.62 6.62 5.2 5.00
96 INT156850 Binding of VDR 40 0.47 24.86 4.87 5.00
97 INT49405 Gene_expression of Itgal 40 0.75 27.3 4.8 5.00
98 INT127698 Localization of AIFM1 15 0.79 13.45 4.74 5.00
99 INT118274 Positive_regulation of Positive_regulation of PIK3CG 8 0.64 4.81 4.62 5.00
100 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19 5.00
101 INT97128 Localization of SPP1 32 0.80 21.75 4.02 5.00
102 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94 5.00
103 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 5.00
104 INT99453 Gene_expression of SOD2 25 0.77 13.28 3.6 5.00
105 INT103926 Gene_expression of Cd69 37 0.68 16.76 3.58 5.00
106 INT25386 Positive_regulation of Cd3e 30 0.62 13.91 3.41 5.00
107 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19 5.00
108 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 5.00
109 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 5.00
110 INT116540 Binding of Twist1 35 0.48 16.32 2.85 5.00
111 INT120717 Positive_regulation of TEP1 50 0.63 27.94 2.81 5.00
112 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8 5.00
113 INT77925 Negative_regulation of TEP1 21 0.53 15.23 2.62 5.00
114 INT179788 Gene_expression of Sparc 42 0.77 19.96 2.57 5.00
115 INT76713 Regulation of Gene_expression of PECAM1 16 0.40 14.52 2.51 5.00
116 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32 5.00
117 INT11476 Positive_regulation of H2-K1 17 0.26 9.48 2.23 5.00
118 INT109334 Regulation of SOD2 13 0.60 7.48 2.14 5.00
119 INT172874 Phosphorylation of Bad 31 0.80 27.46 2.07 5.00
120 INT212124 Gene_expression of Cl 18 0.11 6.72 1.93 5.00
121 INT167035 Regulation of Cd8a 25 0.41 16.78 1.9 5.00
122 INT170605 Gene_expression of RELB 12 0.65 8 1.7 5.00
123 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63 5.00
124 INT68094 Negative_regulation of SERPINB3 12 0.43 10.55 1.49 5.00
125 INT151450 Positive_regulation of Gene_expression of Kit 23 0.69 13.11 1.43 5.00
126 INT20397 Positive_regulation of Itgax 12 0.46 6.48 1.19 5.00
127 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02 5.00
128 INT182177 Transcription of RELB 4 0.48 3.56 1.01 5.00
129 INT87329 Positive_regulation of Gene_expression of Itgax 15 0.64 10.85 0.93 5.00
130 INT182968 Positive_regulation of Gene_expression of VDR 22 0.58 15.22 0.89 5.00
131 INT92117 Phosphorylation of BCL2 26 0.80 9.93 0.86 5.00
132 INT178183 Binding of Cd8a 16 0.32 7.8 0.85 5.00
133 INT294824 Positive_regulation of Gene_expression of Sparc 10 0.69 7.64 0.81 5.00
134 INT178175 Positive_regulation of Gene_expression of Cd8a 17 0.43 13.05 0.78 5.00
135 INT109404 Transcription of BCL2 6 0.69 4.49 0.77 5.00
136 INT157363 Gene_expression of DDX53 2 0.54 2.83 0.71 5.00
137 INT108857 Transcription of SOD2 5 0.70 3.51 0.66 5.00
138 INT150806 Localization of SPARC 4 0.53 2.64 0.53 5.00
139 INT142871 Negative_regulation of Gene_expression of Bad 7 0.51 6.52 0.49 5.00
140 INT96152 Regulation of Gene_expression of Itgax 2 0.41 1.15 0.46 5.00
141 INT213789 Phosphorylation of Kit 7 0.69 5.32 0.43 5.00
142 INT156845 Negative_regulation of CYP24A1 2 0.41 2.04 0.41 5.00
143 INT220187 Negative_regulation of RELB 3 0.21 2.16 0.39 5.00
144 INT330961 Negative_regulation of TFR2 1 0.03 2.02 0.35 5.00
145 INT178114 Positive_regulation of Phosphorylation of BCL2 11 0.49 4.44 0.28 5.00
146 INT91496 Binding of Itgax 4 0.34 2.14 0.26 5.00
147 INT213777 Positive_regulation of Phosphorylation of Kit 2 0.58 1.36 0.26 5.00
148 INT152888 Transcription of Itgam 4 0.44 1.29 0.25 5.00
149 INT238431 Binding of SRA1 8 0.37 2.53 0.25 5.00
150 INT154150 Regulation of TP73 3 0.15 2.81 0.24 5.00
151 INT330975 Negative_regulation of CYP11B1 1 0.04 1.07 0.23 5.00
152 INT258991 Gene_expression of Emb 2 0.43 2.55 0.23 5.00
153 INT79259 Regulation of Itgal 4 0.40 2.94 0.23 5.00
154 INT119705 Positive_regulation of CYP24A1 4 0.49 1.11 0.22 5.00
155 INT349874 Positive_regulation of Gene_expression of Pcyt1a 1 0.04 3.54 0.22 5.00
156 INT154147 Gene_expression of TP73 7 0.34 3.97 0.19 5.00
157 INT178199 Localization of Tnc 2 0.78 5.29 0.16 5.00
158 INT330973 Regulation of Phosphorylation of RAF1 1 0.30 1.09 0.14 5.00
159 INT349879 Transcription of Emb 1 0.46 0.98 0.1 5.00
160 INT229573 Positive_regulation of Positive_regulation of Kit 3 0.39 1.46 0.09 5.00
161 INT349881 Regulation of Gene_expression of Emb 1 0.29 1.13 0.09 5.00
162 INT292827 Positive_regulation of Pcyt1a 2 0.04 2.21 0.09 5.00
163 INT330971 Positive_regulation of Gene_expression of RELB 1 0.34 1.11 0.08 5.00
164 INT349877 Negative_regulation of Localization of Pcyt1a 1 0.03 1.09 0.05 5.00
165 INT349875 Positive_regulation of Localization of Pcyt1a 1 0.03 1.09 0.05 5.00
166 INT349878 Localization of Pcyt1a 1 0.05 1.09 0.05 5.00
167 INT185226 Regulation of Gene_expression of Cd69 2 0.33 1.21 0.04 5.00
168 INT330970 Phosphorylation of BTG2 1 0.16 1.28 0 5.00
169 INT349884 Positive_regulation of Lamp1 1 0.19 1.03 0 5.00
170 INT330965 Localization of CYP24A1 1 0.51 0.08 0 5.00
171 INT185229 Negative_regulation of Binding of Cd8a 1 0.16 0.9 0 5.00
172 INT349880 Regulation of Binding of Twist1 1 0.31 0.98 0 5.00
173 INT349883 Negative_regulation of Hhipl1 1 0.12 1.19 0 5.00
174 INT349873 Regulation of Regulation of Twist1 1 0.31 0.97 0 5.00
175 INT330962 Negative_regulation of Transcription of BCL2 1 0.10 1.21 0 5.00
176 INT330972 Positive_regulation of Negative_regulation of RELB 1 0.23 1.21 0 5.00
177 INT330966 Positive_regulation of Localization of CYP24A1 1 0.34 0.08 0 5.00
178 INT185233 Negative_regulation of Binding of Itgax 1 0.39 0.9 0 5.00
179 INT330968 Negative_regulation of Transcription of RELB 1 0.21 1.21 0 5.00
180 INT263106 Positive_regulation of Binding of Twist1 3 0.35 1.21 0 5.00
181 INT330964 Negative_regulation of Transcription of SOD2 1 0.15 1.22 0 5.00
182 INT185228 Gene_expression of Rasl2-9-ps 1 0.03 1.15 0 5.00
183 INT330963 Phosphorylation of PRL 1 0.42 2.37 0 5.00
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