D:Mastocytosis

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Disease Term
Synonyms Disease Mast Cell, Diseases Mast Cell, MAST CELL DISEASE, Mast Cell Diseases, MASTOCYTOSES
Documents 114
Hot Single Events 47
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mastocytosis. They are ordered first by their relevance to Mastocytosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT195195 IL4 Regulation of Gene_expression of IGHE 1 0.10 0.68 0.04 97.68
2 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11 96.76
3 INT323027 Binding of Il9 and Gtf3a 1 0.03 0.66 0.03 76.40
4 INT213809 F2 Positive_regulation of F2rl3 2 0.12 0.61 0.5 47.12
5 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16 46.40
6 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 17.08
7 INT195196 IL13 Positive_regulation of Gene_expression of IGHE 1 0.06 1.79 0 13.04
8 INT195200 IL10 Positive_regulation of Gene_expression of IGHE 1 0.07 1.78 0 12.24
9 INT195197 Gene_expression of IL9 Positive_regulation of Gene_expression of IGHE 1 0.05 1.77 0 11.28
10 INT195198 Gene_expression of IL5 Positive_regulation of Gene_expression of IGHE 1 0.09 1.76 0 10.80
11 INT195199 Gene_expression of IL4 Positive_regulation of Gene_expression of IGHE 1 0.08 1.76 0 10.32
12 INT213802 Il4 Regulation of Gene_expression of Insrr 1 0.00 0.76 0.29 5.00
13 INT213808 Il12a Regulation of Gene_expression of Insrr 1 0.00 0.76 0.28 5.00
14 INT213816 Binding of Tcf12 and Tfeb 1 0.01 1.91 0.27 5.00
15 INT213798 Sh2b2 Regulation of tf 1 0.12 0.53 0.27 5.00
16 INT213799 Sh2b2 Regulation of Tfeb 1 0.26 0.54 0.27 5.00
17 INT213804 Binding of Mitf and Tfeb 1 0.24 0.81 0.24 5.00
18 INT213813 Binding of Tcf4 and Tfeb 1 0.14 0.81 0.24 5.00
19 INT213805 Binding of Tcf12 and Tcf4 1 0.00 0.79 0.23 5.00
20 INT213814 F3 Positive_regulation of Pars2 1 0.01 0.58 0.21 5.00
21 INT213812 Sh2b2 Positive_regulation of Tfeb 1 0.44 0.45 0.2 5.00
22 INT249962 Binding of KIT and KITLG 6 0.19 3.69 0.17 5.00
23 INT213817 Phosphorylation of Tfe3 Positive_regulation of Mitf 1 0.22 1.22 0.15 5.00
24 INT213800 Kit Positive_regulation of Mitf 1 0.30 1.24 0.15 5.00
25 INT213807 Mitf Positive_regulation of Spg21 1 0.05 1.2 0.15 5.00
26 INT213811 Tfe3 Positive_regulation of Spg21 1 0.05 1.21 0.15 5.00
27 INT213797 Kit Positive_regulation of Tfe3 1 0.28 1.24 0.14 5.00
28 INT213815 Binding of Tfeb and Stub1 1 0.13 0.09 0.04 5.00
29 INT213803 Binding of Foxm1 and Tfe3 1 0.00 1.09 0.03 5.00
30 INT213810 Binding of Foxm1 and Tfeb 1 0.00 1.09 0.03 5.00
31 INT213801 Binding of Tcf12 and Tfe3 1 0.01 1.11 0.03 5.00
32 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 5.00
33 INT202431 Binding of IGF2 and INSRR 1 0.01 0.85 0 5.00
34 INT330735 GSTK1 Regulation of HMOX1 1 0.08 0.25 0 5.00
35 INT202430 Binding of IGF2 and INS 1 0.16 0.85 0 5.00
36 INT295426 Binding of KIT and PDGFRB 1 0.24 0.4 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mastocytosis. They are ordered first by their pain relevance and then by number of times they were reported in Mastocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT14600 Positive_regulation of Tpsab1 51 0.68 22.1 7.7 100.00
2 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 99.40
3 INT99572 Localization of Kit 13 0.75 5.23 1.95 99.18
4 INT49807 Regulation of tryptase 3 0.05 1.99 0.19 98.96
5 INT213766 Regulation of Mitf 6 0.44 3.18 0.1 98.96
6 INT207134 Positive_regulation of tryptase 11 0.47 11.16 1.21 98.76
7 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 98.72
8 INT232640 Binding of Jag2 1 0.12 4.1 0.49 98.72
9 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 98.64
10 INT232634 Localization of Opa1 2 0.75 1.11 0 98.56
11 INT19134 Gene_expression of TPSAB1 16 0.66 11.61 2.48 98.54
12 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49 98.54
13 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 98.54
14 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 98.32
15 INT173505 Localization of Hand2 63 0.57 45.32 13.66 98.08
16 INT232639 Positive_regulation of Jag2 4 0.14 10.63 1.03 98.04
17 INT132822 Localization of IL13 26 0.67 22.85 6.66 97.52
18 INT232630 Regulation of Opa1 1 0.05 0.91 0.06 97.16
19 INT51474 Binding of Il6 55 0.48 44.99 20.52 97.12
20 INT14599 Localization of Tpsab1 36 0.79 14.58 7.18 96.88
21 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 96.32
22 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84 96.16
23 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 94.92
24 INT232632 Regulation of Localization of Kit 1 0.40 0.81 0 94.84
25 INT18843 Binding of H1 10 0.47 5.44 2.4 94.08
26 INT232628 Gene_expression of Opa1 10 0.78 17.01 0.26 93.44
27 INT132010 Localization of Atpif1 1 0.05 1.1 0.27 92.64
28 INT207082 Positive_regulation of Pars2 10 0.14 5.45 2.22 92.40
29 INT213777 Positive_regulation of Phosphorylation of Kit 2 0.58 1.36 0.26 92.32
30 INT229573 Positive_regulation of Positive_regulation of Kit 3 0.39 1.46 0.09 92.32
31 INT213789 Phosphorylation of Kit 7 0.69 5.32 0.43 92.32
32 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 92.32
33 INT232629 Positive_regulation of Localization of Kit 1 0.44 0.8 0 91.68
34 INT232635 Positive_regulation of Gene_expression of Opa1 1 0.06 0.6 0.1 91.52
35 INT701 Localization of IGHE 87 0.80 40.5 10.62 90.92
36 INT232633 Regulation of Gene_expression of Opa1 2 0.27 2.6 0 90.88
37 INT230873 Regulation of Gene_expression of tryptase 2 0.42 1.02 0.06 90.88
38 INT49488 Gene_expression of mMCP-7 37 0.75 26.11 7.68 90.20
39 INT213769 Binding of Spg21 18 0.03 7.96 6.77 90.04
40 INT128230 Negative_regulation of tryptase 3 0.57 5.77 0.88 89.80
41 INT68216 Binding of NF1 40 0.48 51.24 4.59 88.08
42 INT309937 Positive_regulation of Il9 8 0.49 4.36 0.48 87.16
43 INT66792 Binding of TPSAB1 7 0.16 4.93 1.45 87.04
44 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23 84.08
45 INT122675 Negative_regulation of Gene_expression of Slc6a4 14 0.59 6.4 4.69 84.08
46 INT60423 Positive_regulation of TPSG1 11 0.57 11.02 2.55 83.80
47 INT232637 Localization of Jag2 2 0.21 2.07 0.32 83.24
48 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 79.48
49 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 79.32
50 INT117687 Positive_regulation of TPSD1 5 0.44 2.63 0.46 79.20
51 INT84019 Gene_expression of TPSD1 2 0.07 1.84 0.1 78.60
52 INT11794 Gene_expression of Cd2 27 0.76 17.31 10.99 77.08
53 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 77.08
54 INT10189 Negative_regulation of Gene_expression of Il2ra 8 0.32 8.05 2.91 77.00
55 INT232641 Negative_regulation of Gene_expression of tryptase 1 0.40 2.4 0.12 77.00
56 INT232631 Negative_regulation of Gene_expression of Cd2 1 0.27 2.25 0.12 77.00
57 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 76.40
58 INT59387 Binding of Il9 3 0.36 0.91 0.64 76.40
59 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 76.00
60 INT116819 Negative_regulation of Localization of TRPV1 3 0.43 1.75 2.71 76.00
61 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 75.00
62 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 75.00
63 INT62510 Positive_regulation of MCS 32 0.60 11.79 5.45 75.00
64 INT88867 Localization of MCS 19 0.62 28.31 3.88 75.00
65 INT166731 Positive_regulation of Localization of MCS 1 0.28 0.19 0.04 75.00
66 INT232638 Negative_regulation of Gene_expression of Opa1 1 0.31 0.96 0.1 74.04
67 INT14598 Gene_expression of Tpsab1 40 0.73 14.55 5.4 74.00
68 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 73.12
69 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 71.32
70 INT41423 Gene_expression of Cd2 3 0.53 2.06 0.16 71.32
71 INT67283 Binding of Serpinc1 8 0.47 5.02 1.01 68.72
72 INT81954 Positive_regulation of Binding of Serpinc1 1 0.01 1.69 0.12 68.72
73 INT14960 Positive_regulation of Serpinc1 17 0.68 12.71 3.02 67.92
74 INT155426 Gene_expression of Kit 3 0.49 2.71 0.31 67.48
75 INT69761 Gene_expression of Jag2 5 0.67 6.17 0.53 63.84
76 INT74777 Positive_regulation of Gene_expression of TPSAB1 4 0.50 3.7 0.92 62.96
77 INT310935 Negative_regulation of Gene_expression of TPSAB1 1 0.13 1.08 0 62.96
78 INT14477 Positive_regulation of TPSAB1 10 0.69 5.88 1.46 62.40
79 INT3797 Positive_regulation of Gene_expression of Ighm 16 0.47 9.4 2.01 60.04
80 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 59.96
81 INT10130 Positive_regulation of Serpinf1 10 0.53 5.62 0.7 58.88
82 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 57.72
83 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 57.52
84 INT108260 Positive_regulation of Par2 20 0.54 10.77 5.94 51.60
85 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 50.68
86 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 50.40
87 INT151450 Positive_regulation of Gene_expression of Kit 23 0.69 13.11 1.43 50.00
88 INT23770 Binding of Tpsab1 5 0.19 0 0.8 50.00
89 INT213764 Binding of F2rl3 2 0.21 0.37 0.11 47.12
90 INT156231 Binding of F2r 9 0.23 3.78 1.57 46.40
91 INT59388 Gene_expression of Il9 16 0.66 21.79 6.42 44.64
92 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 44.04
93 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 44.04
94 INT124944 Regulation of KIT 15 0.60 11.84 0.24 40.36
95 INT174442 Positive_regulation of Gene_expression of tryptase 3 0.17 1.63 0.87 37.92
96 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 37.44
97 INT43907 Binding of CD79A 28 0.48 28.11 3.04 37.44
98 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39 35.12
99 INT63365 Gene_expression of Spg21 21 0.65 12.9 7.37 33.32
100 INT213776 Positive_regulation of Gene_expression of Spg21 1 0.05 0.95 0.45 33.32
101 INT10513 Gene_expression of Plat 44 0.76 19.49 7.17 27.68
102 INT195194 Regulation of Positive_regulation of Ighm 1 0.05 0.86 0 27.28
103 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 26.88
104 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 25.00
105 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 25.00
106 INT155833 Gene_expression of Cma1 9 0.58 15.28 2.04 21.84
107 INT213793 Gene_expression of Tpsb2 1 0.02 1.03 0.45 21.84
108 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52 21.36
109 INT213783 Positive_regulation of Positive_regulation of tryptase 1 0.03 1.41 0.51 18.04
110 INT213778 Positive_regulation of Positive_regulation of Pars2 1 0.10 1.4 0.5 17.68
111 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 17.08
112 INT332592 Binding of MND1 1 0.08 9.21 0.16 17.08
113 INT213763 Positive_regulation of Positive_regulation of Tfeb 1 0.39 0.7 0.23 16.40
114 INT213772 Positive_regulation of Tfeb 1 0.39 3.5 1.35 16.08
115 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 13.04
116 INT181488 Positive_regulation of Spg21 13 0.12 15.52 10.03 12.84
117 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 12.24
118 INT75929 Gene_expression of IL9 61 0.43 24.71 16.17 11.28
119 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 11.00
120 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 10.80
121 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 10.32
122 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
123 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
124 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
125 INT1160 Positive_regulation of Rbm39 122 0.57 28.19 90.28 5.00
126 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9 5.00
127 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 5.00
128 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
129 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
130 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
131 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
132 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
133 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
134 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
135 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
136 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
137 INT9781 Binding of INSRR 64 0.31 19.1 25.2 5.00
138 INT23224 Gene_expression of tf 99 0.56 60.22 22.03 5.00
139 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
140 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26 5.00
141 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
142 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
143 INT23226 Positive_regulation of tf 23 0.43 15.55 14.37 5.00
144 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 5.00
145 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
146 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
147 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
148 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92 5.00
149 INT17584 Regulation of tf 12 0.50 4.69 10.39 5.00
150 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 5.00
151 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
152 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
153 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
154 INT117496 Gene_expression of Par2 18 0.61 9.2 8.61 5.00
155 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 5.00
156 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
157 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 5.00
158 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13 5.00
159 INT181489 Localization of Spg21 16 0.12 10.89 6.84 5.00
160 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
161 INT22839 Gene_expression of F2 31 0.74 15.53 5.56 5.00
162 INT69156 Localization of IL5 21 0.68 14.95 5.37 5.00
163 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33 5.00
164 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
165 INT159819 Gene_expression of F2rl3 5 0.45 5.53 5.24 5.00
166 INT78515 Negative_regulation of Mag 10 0.54 9.4 5.06 5.00
167 INT117495 Gene_expression of Pars2 13 0.38 7.93 4.24 5.00
168 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
169 INT76227 Binding of NPC1 30 0.41 32.31 4.05 5.00
170 INT60541 Regulation of GSTK1 12 0.61 6.76 3.31 5.00
171 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 5.00
172 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 5.00
173 INT49808 Localization of tryptase 11 0.78 8.74 2.67 5.00
174 INT82653 Regulation of F2r 8 0.36 3.78 2.62 5.00
175 INT74064 Gene_expression of SPG21 9 0.75 4.14 2.45 5.00
176 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38 5.00
177 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
178 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 5.00
179 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
180 INT39453 Negative_regulation of TCN2 12 0.59 3.98 2.13 5.00
181 INT213788 Gene_expression of Tfeb 18 0.66 7.9 2.07 5.00
182 INT15580 Gene_expression of TCN2 16 0.44 7.59 1.97 5.00
183 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 5.00
184 INT56221 Regulation of MPO 8 0.61 8.44 1.84 5.00
185 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75 5.00
186 INT103767 Phosphorylation of DDR1 6 0.20 4.67 1.56 5.00
187 INT14048 Negative_regulation of TKT 13 0.34 5.05 1.51 5.00
188 INT22836 Regulation of F2 9 0.59 2.3 1.49 5.00
189 INT100420 Regulation of HMOX1 10 0.35 6.68 1.48 5.00
190 INT190610 Gene_expression of Tceanc 19 0.07 15.24 1.48 5.00
191 INT158311 Positive_regulation of F2rl3 7 0.51 1.77 1.44 5.00
192 INT125320 Negative_regulation of HSP90AA1 20 0.45 23.93 1.42 5.00
193 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 5.00
194 INT199004 Gene_expression of ARMC9 43 0.58 17.72 1.32 5.00
195 INT153757 Positive_regulation of Mitf 10 0.46 8.38 1.22 5.00
196 INT81776 Positive_regulation of F3 8 0.07 3.77 1.21 5.00
197 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 5.00
198 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
199 INT171848 Positive_regulation of Ctsa 8 0.27 5.24 1.13 5.00
200 INT16172 Protein_catabolism of Insrr 5 0.18 1.39 1.11 5.00
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