D:Megacolon

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Disease Term
Synonyms Megacolons
Documents 65
Hot Single Events 11
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Megacolon. They are ordered first by their relevance to Megacolon and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT329323 ecs Positive_regulation of Gene_expression of Il6 1 0.00 0.52 0.21 5.00
2 INT305533 Runx1 Positive_regulation of Il3 1 0.03 0.28 0.19 5.00
3 INT329324 KNG1 Positive_regulation of Localization of ecs 1 0.00 1.16 0.17 5.00
4 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12 5.00
5 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12 5.00
6 INT305534 Binding of HPRT1 and Tg(CAG-EGFP)D4Nagy 1 0.03 0.7 0.1 5.00
7 INT305535 Binding of HPRT1 and Runx1 1 0.41 0.7 0.1 5.00
8 INT274233 Negative_regulation of Binding of Cd4 and Fasl 1 0.13 0.91 0.08 5.00
9 INT274232 Binding of Cd4 and Fasl 1 0.11 0.9 0.08 5.00
10 INT274231 Fasl Positive_regulation of Gene_expression of Cd8a 1 0.03 1.01 0.07 5.00
11 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Megacolon. They are ordered first by their pain relevance and then by number of times they were reported in Megacolon. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT133210 Positive_regulation of Runx1 33 0.69 18.25 10.12 98.48
2 INT305526 Negative_regulation of Positive_regulation of Runx1 1 0.42 2.7 1.65 98.00
3 INT133212 Negative_regulation of Runx1 21 0.58 11.16 11.89 98.00
4 INT305529 Negative_regulation of Positive_regulation of Sox10 1 0.33 0.36 0.11 98.00
5 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 97.92
6 INT305524 Positive_regulation of Sox10 2 0.39 0.36 0.14 97.40
7 INT245517 Positive_regulation of Gene_expression of Runx1 49 0.69 17.7 12.38 96.60
8 INT305525 Positive_regulation of Positive_regulation of Runx1 1 0.46 0.76 0.39 94.40
9 INT214 Localization of AVP 370 0.81 208.51 91.09 93.32
10 INT15509 Negative_regulation of HMBS 14 0.58 13.13 2.78 89.56
11 INT245515 Regulation of Runx1 14 0.61 5.07 6.22 89.04
12 INT14822 Positive_regulation of Binding of MET 3 0.49 1.35 1.94 79.60
13 INT12464 Binding of MET 38 0.47 10.3 13.15 79.20
14 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 75.80
15 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 67.20
16 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 64.76
17 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 61.08
18 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51 47.32
19 INT28576 Binding of MLN 18 0.48 5.45 2.26 46.48
20 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 45.12
21 INT15001 Localization of Gfap 29 0.75 6.71 4.1 41.36
22 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 36.00
23 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 36.00
24 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 35.48
25 INT2541 Binding of Calca 200 0.48 67.14 134.62 34.80
26 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 33.52
27 INT104395 Gene_expression of Cxcl9 83 0.76 73.1 19.79 33.44
28 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 32.96
29 INT305528 Regulation of Binding of Runx1 1 0.27 1.06 0.77 32.00
30 INT245529 Binding of Runx1 9 0.48 4.42 1.9 31.44
31 INT79693 Regulation of Il4 30 0.51 21.96 8.6 30.52
32 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39 30.52
33 INT98225 Regulation of Il5 8 0.45 5.07 2.06 30.52
34 INT142147 Regulation of Gene_expression of Il5 4 0.22 1.58 1.07 30.52
35 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 29.92
36 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 29.56
37 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 25.00
38 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 22.64
39 INT305522 Positive_regulation of Negative_regulation of Runx1 1 0.50 0.15 0 16.48
40 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 12.00
41 INT212271 Binding of ARMC9 14 0.27 3.29 0.43 9.48
42 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 6.00
43 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
44 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
45 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
46 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
47 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
48 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
49 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
50 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
51 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
52 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
53 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
54 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
55 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
56 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
57 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
58 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
59 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
60 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45 5.00
61 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
62 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 5.00
63 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
64 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
65 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
66 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
67 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
68 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 5.00
69 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
70 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
71 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 134 0.61 34.87 20.15 5.00
72 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
73 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 5.00
74 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
75 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 5.00
76 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
77 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
78 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
79 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
80 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
81 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
82 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
83 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 5.00
84 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
85 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53 5.00
86 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18 5.00
87 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
88 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
89 INT65009 Gene_expression of HTR3A 29 0.75 8.51 10.59 5.00
90 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 5.00
91 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 5.00
92 INT18145 Positive_regulation of Gene_expression of Tbxa2r 30 0.66 18.91 9.52 5.00
93 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 5.00
94 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11 5.00
95 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
96 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
97 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 5.00
98 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
99 INT77794 Binding of Gdnf 15 0.48 8.38 8.22 5.00
100 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 5.00
101 INT70814 Negative_regulation of Il2 40 0.56 13.36 7.22 5.00
102 INT16268 Binding of HTR3A 15 0.47 7.38 7.18 5.00
103 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 5.00
104 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 5.00
105 INT50255 Regulation of Cd4 39 0.49 29.73 6.77 5.00
106 INT126984 Positive_regulation of Gene_expression of Il5 29 0.69 20.61 6.72 5.00
107 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
108 INT123885 Positive_regulation of Lgals3 23 0.57 24.38 6.32 5.00
109 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 5.00
110 INT147263 Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 51 0.53 15.32 5.86 5.00
111 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73 5.00
112 INT32389 Regulation of ecs 11 0.49 7.23 5.43 5.00
113 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 5.00
114 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 5.00
115 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
116 INT10053 Localization of Paf 15 0.80 9.14 3.64 5.00
117 INT242569 Positive_regulation of Ret 17 0.55 3.61 3.54 5.00
118 INT188406 Binding of Fasl 19 0.44 24.67 3.17 5.00
119 INT22389 Regulation of MLN 9 0.61 4.39 3.08 5.00
120 INT116143 Positive_regulation of Casp9 32 0.67 30.34 3.04 5.00
121 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94 5.00
122 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9 5.00
123 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 5.00
124 INT181386 Positive_regulation of Cxcl12 12 0.69 15.35 2.84 5.00
125 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
126 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 5.00
127 INT92835 Gene_expression of Col4a1 22 0.49 13.5 2.27 5.00
128 INT39453 Negative_regulation of TCN2 12 0.59 3.98 2.13 5.00
129 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
130 INT184077 Positive_regulation of Il3 7 0.06 3.69 2 5.00
131 INT15580 Gene_expression of TCN2 16 0.44 7.59 1.97 5.00
132 INT167035 Regulation of Cd8a 25 0.41 16.78 1.9 5.00
133 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85 5.00
134 INT109973 Positive_regulation of Tnfrsf21 4 0.19 4.06 1.78 5.00
135 INT20377 Gene_expression of Il3 8 0.65 0.82 1.77 5.00
136 INT199146 Gene_expression of Pheo 3 0.18 3.57 1.63 5.00
137 INT252209 Positive_regulation of Gene_expression of Lgals3 10 0.57 8.29 1.62 5.00
138 INT117014 Binding of TCN2 11 0.13 1.6 1.38 5.00
139 INT151540 Regulation of Fmr1 8 0.59 6.08 1.34 5.00
140 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 5.00
141 INT17802 Transcription of Edn1 6 0.24 6.31 1.18 5.00
142 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12 5.00
143 INT39919 Negative_regulation of MLN 9 0.36 2.91 1.06 5.00
144 INT155156 Gene_expression of TCN1 13 0.58 3.25 0.99 5.00
145 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89 5.00
146 INT83461 Binding of RET 8 0.47 9.7 0.87 5.00
147 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87 5.00
148 INT178175 Positive_regulation of Gene_expression of Cd8a 17 0.43 13.05 0.78 5.00
149 INT132281 Binding of TCN1 2 0.33 0.95 0.74 5.00
150 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 5.00
151 INT246552 Transcription of Fmr1 11 0.72 6.72 0.71 5.00
152 INT268451 Positive_regulation of Gene_expression of ECE1 3 0.49 1.99 0.67 5.00
153 INT108911 Negative_regulation of Gene_expression of HTR3A 2 0.41 1.81 0.6 5.00
154 INT152200 Positive_regulation of Pheo 3 0.11 1.59 0.52 5.00
155 INT245546 Negative_regulation of Positive_regulation of Ret 2 0.34 0.89 0.49 5.00
156 INT170314 Positive_regulation of Gene_expression of Col4a1 7 0.18 3.52 0.49 5.00
157 INT329319 Positive_regulation of Transcription of Ece1 1 0.08 2.64 0.48 5.00
158 INT93926 Gene_expression of Ece1 3 0.27 2.31 0.42 5.00
159 INT324886 Transcription of Ece1 2 0.37 1.95 0.4 5.00
160 INT208643 Gene_expression of Gt(ROSA)26Sor 11 0.65 4.85 0.37 5.00
161 INT151274 Negative_regulation of Gene_expression of Cd40lg 3 0.32 2.16 0.3 5.00
162 INT167206 Positive_regulation of Positive_regulation of Casp8 4 0.49 2.11 0.26 5.00
163 INT181133 Negative_regulation of Gene_expression of Cd8a 7 0.37 2.65 0.25 5.00
164 INT88725 Regulation of HPRT1 5 0.62 1.28 0.24 5.00
165 INT329320 Positive_regulation of Gene_expression of Ece1 1 0.09 1.31 0.24 5.00
166 INT274228 Positive_regulation of Positive_regulation of Cxcl12 4 0.44 2.82 0.23 5.00
167 INT165643 Regulation of TCN1 4 0.39 0.56 0.22 5.00
168 INT244083 Positive_regulation of Positive_regulation of Tg(CAG-EGFP)D4Nagy 2 0.15 0.35 0.2 5.00
169 INT246551 Negative_regulation of Serpinb12 1 0.01 2.57 0.17 5.00
170 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1 5.00
171 INT274227 Negative_regulation of Binding of Fasl 2 0.37 1.96 0.08 5.00
172 INT329321 Positive_regulation of Positive_regulation of Tbxa2r 1 0.26 1.76 0.07 5.00
173 INT185437 Negative_regulation of Gene_expression of CYLD 3 0.52 2.41 0.05 5.00
174 INT199153 Phosphorylation of RET 1 0.44 1.73 0.04 5.00
175 INT274229 Negative_regulation of Tnnc2 1 0.11 0.8 0.04 5.00
176 INT274230 Localization of Tnnc2 1 0.14 0.56 0 5.00
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