D:Melanoma

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Disease Term
Synonyms MALIGNANT MELANOMA, Malignant Melanomas, Melanoma Malignant, MELANOMAS, Melanomas Malignant
Documents 287
Hot Single Events 200
Hot Interactions 46

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Melanoma. They are ordered first by their relevance to Melanoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76 100.00
2 INT349537 Smcp Positive_regulation of Tnfsf10 1 0.38 3.48 0.28 100.00
3 INT71642 Binding of HLA-A and PMEL 2 0.20 1.05 0.26 100.00
4 INT71640 Binding of HLA-A and TYR 1 0.16 0.36 0.27 100.00
5 INT71643 Binding of HLA-A and TYRP1 1 0.24 0.36 0.26 100.00
6 INT71641 Binding of MLANA and HLA-A 1 0.28 0.36 0.26 100.00
7 INT71639 Binding of MLANA and PMEL 1 0.27 0.36 0.26 100.00
8 INT290475 POU3F2 Negative_regulation of Mitf 1 0.43 1.14 0 99.92
9 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0 99.52
10 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57 99.44
11 INT154674 Binding of MC1R and SNRPE 1 0.38 0.27 0.28 99.44
12 INT290479 Binding of HIF1A and Mitf 1 0.30 1.29 0 99.40
13 INT290478 Mitf Positive_regulation of HIF1A 1 0.57 0.61 0 99.40
14 INT285289 TNF Positive_regulation of Icam1 1 0.23 1.44 0 99.40
15 INT271853 Ngf Positive_regulation of Gene_expression of Egr1 1 0.53 1.36 0.21 99.36
16 INT271852 Ngf Positive_regulation of Gene_expression of tf 1 0.34 1.36 0.21 99.36
17 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42 99.12
18 INT349535 Binding of Smcp and Tnfsf10 1 0.36 6.79 0 99.04
19 INT203591 Positive_regulation of PIK3CG Positive_regulation of Protein_catabolism of LAMB2 1 0.00 0.46 0.14 98.58
20 INT290444 S100A4 Regulation of TIMP1 1 0.00 1.3 0.14 97.72
21 INT335242 Binding of PMEL and CD160 1 0.36 0.85 0 97.58
22 INT60746 Ltbr Negative_regulation of TNF 1 0.16 1.23 0.11 96.56
23 INT290480 MLANA Regulation of Gene_expression of Mitf 1 0.27 0.64 0 95.84
24 INT290483 RAB27A Regulation of Gene_expression of Mitf 1 0.25 0.64 0 95.84
25 INT290482 GPR143 Regulation of Gene_expression of Mitf 1 0.36 0.64 0 95.84
26 INT285291 TNF Positive_regulation of Gene_expression of Vcam1 2 0.10 3.1 0 95.52
27 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3 94.96
28 INT285288 TNF Positive_regulation of Gene_expression of Icam1 1 0.17 2.83 0 93.20
29 INT199581 Braf Negative_regulation of Phosphorylation of tk 1 0.05 0.6 0 91.96
30 INT199580 Braf Negative_regulation of Phosphorylation of Mdk 1 0.11 0.6 0 91.96
31 INT349530 Tnfsf10 Negative_regulation of Smcp 1 0.28 0.88 0 91.12
32 INT305877 Pcx Regulation of Gene_expression of Atp6v0a2 1 0.01 1.45 0.04 90.76
33 INT305885 Pcx Positive_regulation of Gene_expression of Atp6v0a2 1 0.01 1.45 0.04 90.76
34 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02 90.48
35 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 89.36
36 INT335239 Binding of HLA-DOA and PMEL 1 0.04 0.68 0 88.48
37 INT349543 Tnfsf10 Positive_regulation of NGFR 1 0.01 0.43 0 88.48
38 INT349532 Positive_regulation of Binding of Smcp and Tnfsf10 1 0.35 2.16 0 87.84
39 INT201614 Mc1r Regulation of Uvbi1 1 0.04 1.42 0.98 87.84
40 INT290477 POU3F2 Negative_regulation of Gene_expression of Mitf 1 0.43 0.36 0 86.00
41 INT290474 MAPK1 Regulation of Mitf 1 0.04 0.15 0 85.88
42 INT178501 Angpt1 Positive_regulation of Tek 1 0.06 0.78 0.04 85.44
43 INT295048 Bad Regulation of RYBP 1 0.00 1.64 0 85.08
44 INT349538 Smcp Positive_regulation of Positive_regulation of Casp9 1 0.04 0.68 0.18 82.60
45 INT349539 Smcp Positive_regulation of Positive_regulation of Casp8 1 0.04 0.68 0.18 82.60
46 INT335240 Binding of CD8A and PMEL 1 0.28 0.81 0 80.72
47 INT203733 Thbs1 Positive_regulation of Negative_regulation of Ppara 1 0.36 1.55 0.26 79.04
48 INT351029 AGK Regulation of VEGFA 1 0.00 0.82 0 78.64
49 INT351030 AGK Regulation of ARAF 1 0.00 0.82 0 78.64
50 INT290476 Mitf Regulation of Gene_expression of CD200 1 0.34 0.2 0 77.92
51 INT335241 Binding of GZMA and HLA-DOA 1 0.00 0.13 0 76.72
52 INT239643 Binding of BCL2 and BCL2L11 3 0.16 2.26 0.09 74.96
53 INT290443 Gene_expression of TIMP2 Negative_regulation of MMP2 1 0.06 1.56 0.13 74.80
54 INT349540 Tnfsf10 Positive_regulation of Positive_regulation of Casp8 1 0.05 0.65 0.15 74.24
55 INT290481 MLANA Regulation of Mitf 1 0.16 0.2 0 73.84
56 INT331091 Tert Positive_regulation of Positive_regulation of Cd4 1 0.24 0.76 0 73.52
57 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 72.12
58 INT349542 SCFV Positive_regulation of Tnfsf10 1 0.12 0.56 0 71.20
59 INT225652 Gene_expression of IL4 Positive_regulation of Positive_regulation of IL12A 1 0.06 1.2 0.25 71.20
60 INT305882 Binding of Pcx and Alms1 1 0.03 0.62 0 70.72
61 INT314867 Binding of Cdc7 and Cdkn2b 1 0.25 1.16 0.14 70.56
62 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14 70.56
63 INT320713 NRAS Positive_regulation of AKT1 1 0.37 0.84 0 70.48
64 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14 70.28
65 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14 70.28
66 INT295044 Klra8 Positive_regulation of Gene_expression of Sae1 1 0.00 2.18 0 68.96
67 INT320712 Binding of NRAS and PIK3CD 1 0.21 1.66 0 68.16
68 INT320715 NRAS Positive_regulation of PIK3CD 1 0.27 1.66 0 68.16
69 INT203732 Thbs1 Regulation of Gene_expression of Ppara 1 0.33 0.94 0.05 65.20
70 INT279278 NCOR2 Regulation of CDCP1 1 0.00 5.41 0.25 64.32
71 INT248387 CHD5 Regulation of Gene_expression of TP53 1 0.20 0.83 0 63.36
72 INT225650 DCPS Positive_regulation of PDHA1 1 0.00 0.41 0.07 56.84
73 INT225649 IL4 Positive_regulation of Localization of DCPS 1 0.02 1.03 0.19 56.16
74 INT285290 TNF Positive_regulation of Gene_expression of H2-D1 1 0.01 1.41 0.06 53.56
75 INT279287 PDGFRB Regulation of CDCP1 1 0.01 0.98 0.05 53.36
76 INT336404 Binding of Cd3e and ALPK1 1 0.01 0.55 0.03 53.12
77 INT279290 EGFR Regulation of CDCP1 1 0.01 0.98 0.05 52.80
78 INT279281 TXK Regulation of CDCP1 1 0.00 1.61 0.05 51.52
79 INT305876 ras Regulation of Regulation of Tjp2 1 0.00 0.39 0.04 50.72
80 INT331087 Csf2 Positive_regulation of Gene_expression of Il2 1 0.00 0.22 0.24 50.00
81 INT329102 Binding of CD4 and HLA-DQA2 2 0.04 0.92 0.04 50.00
82 INT331089 Binding of Cd3e and Itga2 1 0.09 0.2 0 50.00
83 INT331088 Binding of Itga2 and Klrb1c 1 0.11 0.2 0 50.00
84 INT331090 Binding of Ctsl and Itga2 1 0.10 0.2 0 50.00
85 INT325945 Binding of Cd44 and Ezr 1 0.25 0.39 0 45.60
86 INT325942 Binding of Icam1 and Ezr 1 0.15 0.39 0 45.60
87 INT325949 Binding of Spn and Ezr 1 0.14 0.39 0 45.60
88 INT325950 Binding of Icam2 and Ezr 1 0.17 0.39 0 45.60
89 INT340741 Binding of ATP5G3 and Gma3 1 0.00 0.96 0.03 37.68
90 INT314858 Binding of Gdf11 and Ltbp3 1 0.39 0.31 0 35.20
91 INT340727 Binding of ATP5G3 and CSPG5 1 0.01 2.03 0.06 33.12
92 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 29.60
93 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11 27.60
94 INT301674 Binding of APC and CD80 1 0.01 0.53 0 27.60
95 INT291354 CXCL12 Positive_regulation of EPHB2 1 0.42 2.02 0.16 25.92
96 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 25.52
97 INT291355 CXCL12 Positive_regulation of Gene_expression of HGF 1 0.06 1.53 0.06 25.20
98 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 25.00
99 INT325954 Binding of Cttn and Ezr 1 0.22 1.61 0.07 24.72
100 INT191693 Igh-Dex Regulation of Bag1 Regulation of gr 1 0.01 1.31 0.21 24.48
101 INT191688 Igh-Dex Regulation of Gene_expression of Bag1 1 0.04 1.21 0.16 24.48
102 INT225648 IL4 Positive_regulation of Gene_expression of IL12A 1 0.06 0.89 0.03 19.64
103 INT265346 Binding of Ocln and Tjp1 7 0.05 1.11 0.09 18.96
104 INT199576 Raf1 Negative_regulation of Akt1 1 0.00 0.79 0 18.96
105 INT199577 Tnk1 Negative_regulation of Akt1 1 0.00 0.79 0 18.96
106 INT199582 Braf Negative_regulation of Akt1 1 0.00 0.79 0 18.96
107 INT191685 Bag1 Regulation of gr 1 0.08 1.1 0.21 17.68
108 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0 17.20
109 INT314855 Binding of Gdf11 and Atoh7 1 0.40 0.14 0 17.20
110 INT199579 Tnk1 Negative_regulation of Raf1 1 0.01 0.78 0 16.96
111 INT199578 Tnk1 Negative_regulation of Braf 1 0.01 0.78 0 16.96
112 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0 16.32
113 INT224310 EPAS1 Positive_regulation of CXCL12 1 0.02 0.63 0.05 15.84
114 INT191686 Igh-Dex Positive_regulation of Sgk1 1 0.04 1.79 0.46 15.36
115 INT191691 Igh-Dex Positive_regulation of Dusp1 1 0.02 1.8 0.46 15.36
116 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0 15.20
117 INT208019 Gbp1 Positive_regulation of Gene_expression of Egf 1 0.09 0.56 0 10.08
118 INT305879 Binding of Ocln and Pcx 1 0.03 0 0 7.92
119 INT305881 Positive_regulation of Binding of Ocln and Tjp1 1 0.01 0 0 7.92
120 INT305874 Binding of Pcx and Tjp1 1 0.03 0 0 6.88
121 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
122 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08 5.00
123 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
124 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
125 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 5.00
126 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
127 INT291377 Binding of CX3CR1 and Cx3cl1 2 0.36 3.57 1.02 5.00
128 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
129 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9 5.00
130 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
131 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71 5.00
132 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
133 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48 5.00
134 INT225738 Binding of RANBP9 and Entpd1 1 0.13 0.3 0.42 5.00
135 INT191690 Igh-Dex Positive_regulation of Gene_expression of exf 1 0.01 0.79 0.41 5.00
136 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33 5.00
137 INT191692 Binding of Bag1 and gr 1 0.07 0.76 0.29 5.00
138 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
139 INT191687 Igh-Dex Positive_regulation of Gene_expression of Xiap 1 0.01 0.63 0.24 5.00
140 INT191689 Igh-Dex Positive_regulation of Xiap 1 0.01 0.63 0.24 5.00
141 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24 5.00
142 INT252213 INCENP Regulation of Lgals3 1 0.00 1.91 0.23 5.00
143 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22 5.00
144 INT303606 Binding of IL18 and SOAT1 1 0.05 0.52 0.22 5.00
145 INT263339 Ptger2 Regulation of Ppara 1 0.09 0.44 0.21 5.00
146 INT291348 IL8 Positive_regulation of Phosphorylation of SHC1 1 0.11 1.16 0.2 5.00
147 INT291346 IL8 Positive_regulation of Binding of EGFR and GRB2 1 0.15 1.17 0.2 5.00
148 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19 5.00
149 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19 5.00
150 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
151 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17 5.00
152 INT201609 Uvbi1 Positive_regulation of Gene_expression of Mc1r 1 0.05 0.57 0.17 5.00
153 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16 5.00
154 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16 5.00
155 INT224308 INSRR Regulation of VEGFA 1 0.00 1.42 0.16 5.00
156 INT201608 Binding of Mc1r and Uvbi1 1 0.03 0.93 0.15 5.00
157 INT206070 ANG Positive_regulation of Transcription of IL6 1 0.05 1.5 0.15 5.00
158 INT201622 Binding of Mark3 and Mc1r 1 0.33 0.74 0.15 5.00
159 INT325952 Gene_expression of Ezr Positive_regulation of Mapk1 1 0.02 1.69 0.15 5.00
160 INT201619 Binding of Cdk11b and Mc1r 1 0.28 0.74 0.15 5.00
161 INT276228 Nrtim1 Positive_regulation of PPARG 1 0.01 2.18 0.14 5.00
162 INT291347 Positive_regulation of TXK Positive_regulation of CXCR4 Positive_regulation of EPHB2 1 0.02 0.61 0.13 5.00
163 INT291349 CXCR4 Positive_regulation of EPHB2 1 0.42 1.87 0.13 5.00
164 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12 5.00
165 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11 5.00
166 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11 5.00
167 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11 5.00
168 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1 5.00
169 INT203629 IL8 Negative_regulation of Timp1 1 0.05 0 0.1 5.00
170 INT203628 Cxcl1 Negative_regulation of TIMP2 1 0.01 0 0.1 5.00
171 INT203588 IL6 Negative_regulation of VEGFC 1 0.00 0 0.1 5.00
172 INT203589 IL8 Negative_regulation of VEGFA 1 0.03 0 0.1 5.00
173 INT225731 Binding of RANBP9 and Entpd1 Regulation of Positive_regulation of ras 1 0.01 0.1 0.1 5.00
174 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1 5.00
175 INT203583 IL8 Negative_regulation of TIMP2 1 0.03 0 0.1 5.00
176 INT225743 Binding of SOS1 and RANBP9 1 0.00 0.09 0.1 5.00
177 INT203625 Cxcl1 Negative_regulation of VEGFC 1 0.00 0 0.1 5.00
178 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1 5.00
179 INT225737 Binding of RANBP9 and ras 1 0.01 0.09 0.1 5.00
180 INT225736 Entpd1 Regulation of Positive_regulation of ras 1 0.02 0.1 0.1 5.00
181 INT203630 Cxcl1 Negative_regulation of IL6 1 0.00 0 0.1 5.00
182 INT203624 Cxcl1 Negative_regulation of VEGFA 1 0.00 0 0.1 5.00
183 INT203592 IL6 Negative_regulation of VEGFA 1 0.03 0 0.1 5.00
184 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1 5.00
185 INT225740 RYR1 Positive_regulation of Binding of Entpd1 1 0.08 0.08 0.1 5.00
186 INT203590 Negative_regulation of IL6 Negative_regulation of TIMP2 1 0.07 0 0.1 5.00
187 INT203626 IL6 Negative_regulation of Timp1 1 0.12 0 0.1 5.00
188 INT203586 IL6 Negative_regulation of TIMP2 1 0.07 0 0.1 5.00
189 INT263340 Ptger2 Positive_regulation of IL8 1 0.01 0.15 0.1 5.00
190 INT203623 Cxcl1 Negative_regulation of Timp1 1 0.01 0 0.1 5.00
191 INT203593 IL8 Negative_regulation of VEGFC 1 0.00 0 0.1 5.00
192 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1 5.00
193 INT203627 Cxcl1 Negative_regulation of IL8 1 0.00 0 0.1 5.00
194 INT203584 IL6 Negative_regulation of IL8 1 0.03 0 0.1 5.00
195 INT291358 Binding of CXCL12 and CXCR7 1 0.20 0.11 0.09 5.00
196 INT206042 Negative_regulation of FDPS Negative_regulation of Binding of FDPS and GGPS1 1 0.00 0 0.09 5.00
197 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 5.00
198 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 5.00
199 INT206054 RAC1 Positive_regulation of STAT3 1 0.07 0.11 0.09 5.00
200 INT201618 Uvbi1 Positive_regulation of Phb 1 0.04 0.28 0.09 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Melanoma. They are ordered first by their pain relevance and then by number of times they were reported in Melanoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT174423 Gene_expression of Smcp 39 0.48 29.45 6.06 100.00
2 INT203253 Protein_catabolism of Xiap 1 0.92 20.16 0.43 100.00
3 INT190610 Gene_expression of Tceanc 19 0.07 15.24 1.48 100.00
4 INT201652 Positive_regulation of Tnfsf10 26 0.68 26.79 2.14 100.00
5 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 100.00
6 INT71644 Gene_expression of MLANA 16 0.75 11.55 1.82 100.00
7 INT68181 Binding of Nf1 6 0.48 8.14 1.88 100.00
8 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 100.00
9 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 100.00
10 INT5789 Gene_expression of PMEL 23 0.75 13.18 2.67 100.00
11 INT271851 Regulation of Gene_expression of Tceanc 1 0.04 3.48 0.07 100.00
12 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84 100.00
13 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 100.00
14 INT48240 Binding of Ngf 46 0.46 23.51 24.42 100.00
15 INT186628 Gene_expression of DCT 5 0.46 3.79 0.21 100.00
16 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 100.00
17 INT81264 Positive_regulation of Localization of Ngf 13 0.58 9.82 9.53 100.00
18 INT340730 Gene_expression of Gma3 1 0.01 6.67 0.21 100.00
19 INT109006 Regulation of Gene_expression of Proc 2 0.60 1.73 0.16 100.00
20 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 100.00
21 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06 100.00
22 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67 100.00
23 INT290467 Gene_expression of GPR143 1 0.21 0.32 0 100.00
24 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46 100.00
25 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 99.98
26 INT21737 Binding of MC1R 129 0.48 45.45 56.54 99.98
27 INT122041 Binding of Ppara 308 0.48 189.17 51.48 99.98
28 INT158667 Regulation of Transcription of Gtf3a 5 0.03 4.9 1.56 99.98
29 INT234171 Positive_regulation of Pcdha1 1 0.09 2.25 0.56 99.98
30 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 99.96
31 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 99.96
32 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 99.92
33 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 99.90
34 INT191678 Gene_expression of Xiap 60 0.71 57.25 1.37 99.84
35 INT97450 Gene_expression of Mitf 36 0.75 17.22 0.39 99.84
36 INT193102 Positive_regulation of Gene_expression of Xiap 9 0.64 10.62 0.15 99.84
37 INT178027 Negative_regulation of Xiap 14 0.54 11.62 0.24 99.84
38 INT20210 Localization of Ngf 69 0.79 46.22 38.57 99.84
39 INT203265 Regulation of Xiap 1 0.41 7.93 0 99.84
40 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 99.84
41 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 99.84
42 INT131612 Negative_regulation of Mitf 3 0.56 3.91 0.23 99.84
43 INT290461 Regulation of Gene_expression of Mitf 3 0.59 3.13 0 99.84
44 INT213771 Positive_regulation of Gene_expression of Mitf 4 0.48 2.01 0.12 99.84
45 INT203260 Negative_regulation of Gene_expression of Xiap 4 0.54 4.54 0.1 99.84
46 INT186460 Transcription of ASAP1 5 0.56 3.02 0.03 99.84
47 INT67796 Negative_regulation of CTLA4 13 0.39 8.36 2.39 99.84
48 INT181107 Gene_expression of Epcam 45 0.73 44.33 1.96 99.84
49 INT325934 Localization of Ezr 1 0.80 3.78 0.27 99.84
50 INT178510 Localization of EML2 1 0.02 1.24 0.1 99.84
51 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61 99.84
52 INT278252 Regulation of Smcp 2 0.29 1.58 0.09 99.80
53 INT197766 Binding of Sln 5 0.32 1.6 0.25 99.80
54 INT210 Positive_regulation of Sln 10 0.43 4.06 0.49 99.80
55 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 99.78
56 INT203254 Positive_regulation of Protein_catabolism of Xiap 1 0.64 7.46 0.12 99.76
57 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26 99.76
58 INT203266 Positive_regulation of Protein_catabolism of Casp2 1 0.08 1.03 0 99.76
59 INT145127 Positive_regulation of Gene_expression of Trpc1 4 0.30 3.56 1.46 99.76
60 INT145129 Positive_regulation of Gene_expression of Trpc6 4 0.67 2.91 0.51 99.76
61 INT145128 Gene_expression of Trpc6 12 0.75 5.59 1.17 99.76
62 INT127981 Gene_expression of Trpc1 25 0.77 10.51 11.67 99.76
63 INT248397 Positive_regulation of CHD5 1 0.39 0.24 0 99.76
64 INT178511 Gene_expression of EML2 1 0.01 1.35 0.19 99.72
65 INT36943 Binding of CHKB 14 0.37 4.09 2.75 99.70
66 INT234010 Binding of KLF9 1 0.36 1.39 0 99.70
67 INT91209 Binding of VIM 15 0.36 12.02 0.53 99.70
68 INT51066 Binding of S100B 24 0.48 13.5 0.97 99.70
69 INT234012 Binding of MEPE 1 0.02 1.35 0 99.70
70 INT203263 Binding of Clptm1l 1 0.00 0.52 0 99.70
71 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.68
72 INT308522 Positive_regulation of Positive_regulation of Ptk2 2 0.22 2.37 0.21 99.68
73 INT1317 Negative_regulation of Sds 23 0.48 6.97 5.03 99.68
74 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 99.68
75 INT13063 Binding of RHCE 16 0.38 6.54 1.22 99.66
76 INT260803 Regulation of Tnfsf10 4 0.44 5.04 0.76 99.64
77 INT139807 Gene_expression of Braf 7 0.51 8.78 3.34 99.60
78 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1 99.58
79 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 99.56
80 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16 99.56
81 INT320730 Positive_regulation of Gene_expression of NBN 1 0.60 1.84 0 99.56
82 INT159616 Negative_regulation of Transcription of Trpm1 1 0.31 1.74 0.13 99.56
83 INT159618 Transcription of Trpm1 8 0.69 11.42 1.21 99.54
84 INT191671 Positive_regulation of Xiap 5 0.67 4.63 0.49 99.54
85 INT97451 Negative_regulation of Gene_expression of Mitf 3 0.41 0.88 0.17 99.54
86 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 99.52
87 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24 99.52
88 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 99.52
89 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.52
90 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15 99.52
91 INT73626 Positive_regulation of Gene_expression of PPARG 22 0.70 18.82 4.4 99.52
92 INT19359 Binding of BRCA2 5 0.47 2.63 0.19 99.52
93 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.50
94 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 99.48
95 INT139549 Positive_regulation of Mc1r 2 0.17 0.7 0.94 99.48
96 INT161378 Binding of BRAF 1 0.08 2.24 0.48 99.44
97 INT148050 Positive_regulation of SCFV 6 0.49 3.4 0.3 99.44
98 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01 99.44
99 INT154675 Binding of SNRPE 1 0.36 0.54 0.38 99.44
100 INT14881 Gene_expression of Car3 49 0.73 14.89 9.94 99.44
101 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 99.44
102 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92 99.44
103 INT14883 Regulation of Car3 8 0.58 5.57 2.75 99.44
104 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 99.42
105 INT320720 Gene_expression of TBX3 1 0.29 3.53 0 99.40
106 INT156501 Gene_expression of MAGEA1 8 0.18 10.26 0.08 99.38
107 INT106318 Gene_expression of S100A4 21 0.75 12.13 3.23 99.36
108 INT58755 Binding of PAM 6 0.34 3.09 0.97 99.36
109 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 99.36
110 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 99.32
111 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12 99.32
112 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3 99.32
113 INT104549 Localization of Il18 16 0.78 13.01 4.64 99.30
114 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 99.28
115 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41 99.28
116 INT203267 Protein_catabolism of Casp2 1 0.11 0.97 0 99.26
117 INT101189 Transcription of Gtf3a 49 0.17 24.39 7.93 99.24
118 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22 99.24
119 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 99.20
120 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 99.20
121 INT197765 Gene_expression of Sln 26 0.58 12.11 0.45 99.20
122 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52 99.20
123 INT97076 Positive_regulation of Gene_expression of Entpd1 2 0.64 2.52 0.97 99.20
124 INT236620 Regulation of BRAF 2 0.46 1.96 0 99.16
125 INT319367 Negative_regulation of Gene_expression of Smcp 2 0.30 0.71 0 99.16
126 INT156500 Gene_expression of MAGEA3 1 0.11 1.02 0.08 99.14
127 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22 99.14
128 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09 99.12
129 INT159615 Negative_regulation of Trpm1 1 0.43 1.68 0.13 99.12
130 INT199560 Binding of Braf 4 0.30 8.83 4.8 99.12
131 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45 99.06
132 INT271844 Transcription of Tceanc 1 0.06 2.03 0.04 99.04
133 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 99.04
134 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 99.02
135 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61 99.02
136 INT203264 Binding of Xiap 5 0.39 5.3 0.03 99.00
137 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 98.96
138 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 98.96
139 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 98.96
140 INT17584 Regulation of tf 12 0.50 4.69 10.39 98.96
141 INT4756 Positive_regulation of Nrtim1 37 0.33 14.6 24.12 98.96
142 INT295039 Positive_regulation of Gene_expression of Ad 4 0.06 6.5 0.17 98.96
143 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 98.96
144 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95 98.92
145 INT271841 Positive_regulation of Gene_expression of Tceanc 1 0.07 6.54 1.32 98.92
146 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 98.92
147 INT159614 Gene_expression of Trpm1 13 0.77 9.47 1.25 98.92
148 INT159620 Gene_expression of TRPM1 7 0.75 7.96 1.65 98.92
149 INT23224 Gene_expression of tf 99 0.56 60.22 22.03 98.92
150 INT159621 Transcription of TRPM1 1 0.52 2.49 0.39 98.92
151 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 98.90
152 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 98.90
153 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89 98.86
154 INT149821 Gene_expression of Nr1d1 5 0.63 4.46 1.17 98.84
155 INT64450 Gene_expression of Mc1r 13 0.77 9.22 5.43 98.84
156 INT202316 Gene_expression of SCGB3A1 1 0.11 1.62 0 98.84
157 INT23257 Regulation of CRP 127 0.62 100.05 21.87 98.84
158 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 98.80
159 INT68652 Regulation of Positive_regulation of JUN 4 0.54 4.95 1.26 98.80
160 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98 98.80
161 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 98.80
162 INT349527 Phosphorylation of Smcp 1 0.58 1.93 0 98.76
163 INT290473 Positive_regulation of Regulation of PLAUR 1 0.24 1.71 0 98.76
164 INT260793 Binding of Tnfsf10 12 0.36 11.93 0.47 98.72
165 INT97449 Transcription of Mitf 4 0.69 4.28 0.09 98.72
166 INT199569 Negative_regulation of Braf 4 0.36 3.73 0.23 98.72
167 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9 98.72
168 INT97078 Positive_regulation of Entpd1 16 0.64 8.54 4.49 98.72
169 INT695 Binding of POMC 304 0.48 56.66 126.85 98.68
170 INT97077 Gene_expression of Entpd1 16 0.78 11.89 6.47 98.68
171 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97 98.68
172 INT443 Localization of POMC 1020 0.81 284.52 443.17 98.64
173 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46 98.64
174 INT69700 Transcription of MC1R 15 0.71 4.32 5.62 98.60
175 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 98.60
176 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62 98.58
177 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 98.58
178 INT271850 Gene_expression of Tbx1 1 0.59 2.5 0.27 98.56
179 INT290464 Transcription of POU3F2 1 0.64 1.08 0 98.54
180 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 98.52
181 INT140296 Negative_regulation of XIAP 9 0.45 13.61 1.37 98.48
182 INT10712 Localization of RHCE 3 0.28 1.15 1.69 98.48
183 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53 98.48
184 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0 98.48
185 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59 98.44
186 INT9660 Regulation of TNF 363 0.62 312.94 139.99 98.40
187 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28 98.36
188 INT349529 Phosphorylation of Tnfsf10 1 0.74 1.32 0 98.36
189 INT196426 Gene_expression of Cdkn2b 6 0.67 4.29 0.29 98.36
190 INT158452 Negative_regulation of GIT1 3 0.22 1.16 2.13 98.36
191 INT258556 Negative_regulation of BRAF 4 0.42 2.48 0.03 98.36
192 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0 98.36
193 INT45093 Binding of PMEL 10 0.37 4.77 0.89 98.32
194 INT4785 Gene_expression of PAM 6 0.58 3.47 0.64 98.32
195 INT148382 Positive_regulation of JAG1 5 0.23 3.88 0.63 98.32
196 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 98.32
197 INT196919 Regulation of Braf 3 0.32 6.14 2.55 98.32
198 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32 98.32
199 INT167381 Localization of DES 4 0.73 4.15 0.77 98.32
200 INT204254 Localization of KIT 8 0.73 6.78 0.61 98.32
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