D:Melena

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Disease Term
Synonyms Melenas
Documents 367
Hot Single Events 40
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Melena. They are ordered first by their relevance to Melena and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26 5.00
2 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 0.01 0.71 0.25 5.00
3 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25 5.00
4 INT292621 Binding of IL6 and Gpt 1 0.01 3.88 0.24 5.00
5 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2 5.00
6 INT292615 Binding of IL6 and SLC17A5 1 0.01 1.8 0.16 5.00
7 INT351099 EPAS1 Regulation of Gene_expression of CRTC1 1 0.00 0.8 0 5.00
8 INT351097 RRAD Negative_regulation of EIF4EBP1 1 0.00 0 0 5.00
9 INT282743 Hsp90aa1 Positive_regulation of Kit 1 0.22 0.54 0 5.00
10 INT351093 RRAD Regulation of RRAD Negative_regulation of EIF4EBP1 1 0.00 0 0 5.00
11 INT351100 RRAD Regulation of EIF4EBP1 1 0.00 0 0 5.00
12 INT351098 MTOR Regulation of Binding of EPAS1 1 0.08 0.95 0 5.00
13 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
14 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
15 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0 5.00
16 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0 5.00
17 INT351094 RRAD Negative_regulation of RRAD Regulation of EIF4EBP1 1 0.00 0 0 5.00
18 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Melena. They are ordered first by their pain relevance and then by number of times they were reported in Melena. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 96.12
2 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 96.04
3 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 96.04
4 INT1143 Positive_regulation of OTOR 7 0.67 5.38 1 94.96
5 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 94.60
6 INT63880 Positive_regulation of FLNA 29 0.59 13.88 3.97 93.92
7 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 93.28
8 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 92.84
9 INT103327 Gene_expression of F8 45 0.71 32.5 2.12 92.08
10 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 91.36
11 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 91.36
12 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 90.72
13 INT159531 Positive_regulation of Gene_expression of SLC17A5 8 0.49 9.3 0.77 90.72
14 INT84250 Positive_regulation of IDUA 8 0.56 15.89 0.62 89.76
15 INT279349 Localization of IDUA 7 0.76 4.97 0.07 89.76
16 INT124943 Regulation of NCAM1 10 0.44 5.25 1.27 89.72
17 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 89.20
18 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 88.92
19 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 88.84
20 INT14301 Binding of CSF2 82 0.48 67.95 8.98 88.84
21 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 88.28
22 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 87.20
23 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 87.08
24 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 87.08
25 INT27591 Negative_regulation of Gene_expression of Alb 30 0.58 17.03 5.99 87.08
26 INT282734 Localization of Gspt1 1 0.73 2.13 0.18 86.00
27 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 85.40
28 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75 85.40
29 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 85.08
30 INT17489 Regulation of F13A1 28 0.45 15.79 4.93 84.72
31 INT717 Regulation of F2 29 0.61 17.46 6.99 84.72
32 INT159232 Negative_regulation of SYP 4 0.41 4.45 0.38 84.48
33 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 84.08
34 INT82374 Binding of SYP 13 0.36 13.69 0.85 83.96
35 INT36702 Gene_expression of CEACAM3 4 0.68 4.56 0.58 83.60
36 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 83.36
37 INT233108 Gene_expression of ADAM2 1 0.17 1.32 0.17 82.00
38 INT119818 Negative_regulation of CHGA 10 0.57 8.21 2.04 81.92
39 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 81.20
40 INT7351 Gene_expression of NPS 5 0.58 1.87 0.88 80.92
41 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 79.92
42 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 79.12
43 INT16385 Regulation of C3 20 0.41 9.98 1.92 79.04
44 INT246352 Positive_regulation of Regulation of C3 1 0.03 1.05 0.03 79.04
45 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 78.48
46 INT10146 Negative_regulation of Vwf 27 0.40 17.11 3.69 77.76
47 INT176618 Gene_expression of HEY1 29 0.59 36 4.37 77.76
48 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 75.44
49 INT124944 Regulation of KIT 15 0.60 11.84 0.24 74.44
50 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13 74.04
51 INT354484 Negative_regulation of Evl 1 0.31 3.86 0 73.20
52 INT354486 Negative_regulation of Positive_regulation of Evl 1 0.31 1.95 0 73.20
53 INT3808 Positive_regulation of Gif 3 0.41 2.51 0.75 71.40
54 INT25353 Negative_regulation of F8 22 0.59 18.51 1.4 70.96
55 INT8792 Gene_expression of GBA 20 0.78 14.73 1.98 69.52
56 INT171435 Gene_expression of SDHD 14 0.58 26.55 0.91 68.24
57 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05 68.00
58 INT245996 Binding of Gda 1 0.09 0.63 0.12 66.88
59 INT354485 Positive_regulation of Evl 1 0.36 1.72 0 65.68
60 INT41874 Positive_regulation of GPI 9 0.49 9.97 2.79 63.68
61 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 58.16
62 INT296385 Binding of IDUA 12 0.39 20.73 0.93 54.00
63 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 53.12
64 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 52.80
65 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 52.24
66 INT179325 Negative_regulation of Regulation of KIT 1 0.43 0.82 0.04 52.00
67 INT47806 Binding of Gspt1 3 0.47 2.25 0.62 51.12
68 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 50.56
69 INT189960 Gene_expression of SENP8 9 0.54 17.54 0.64 50.20
70 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 46.40
71 INT128376 Binding of KIT 26 0.48 14.24 0.47 46.16
72 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98 43.64
73 INT192073 Positive_regulation of Gene_expression of ADA 8 0.47 10.35 1.12 43.64
74 INT172677 Gene_expression of SHE 65 0.59 25.86 3.85 42.76
75 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18 42.72
76 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 38.72
77 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 35.20
78 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 34.80
79 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 32.88
80 INT100495 Localization of Gda 2 0.78 0.12 0.38 32.12
81 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 28.24
82 INT202591 Regulation of AVL9 2 0.02 1.58 0.19 26.08
83 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48 25.72
84 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 25.68
85 INT90876 Negative_regulation of RPS6KB1 2 0.47 1.29 0.36 24.60
86 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 24.20
87 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 22.92
88 INT9840 Positive_regulation of F7 17 0.57 17.83 2.08 21.92
89 INT86998 Regulation of HIVEP1 49 0.44 37.83 4 21.12
90 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 20.88
91 INT625 Localization of PGC 35 0.80 11.33 3.05 20.48
92 INT114412 Localization of HCL1 18 0.56 3.69 2.96 19.60
93 INT166227 Negative_regulation of Localization of HCL1 2 0.05 1.26 1.03 19.60
94 INT245995 Protein_catabolism of Gda 1 0.21 0.05 0 18.60
95 INT295943 Negative_regulation of MTNR1A 4 0.21 2.66 0.24 18.00
96 INT178037 Gene_expression of Del(7)Tyr<c-23DVT>-p 18 0.22 23.44 4.07 17.92
97 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 17.68
98 INT196603 Gene_expression of STK11 5 0.55 6.75 0.15 14.64
99 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34 13.80
100 INT12339 Localization of IL8 437 0.81 251.87 117.39 11.00
101 INT15610 Localization of GOPC 223 0.65 68.26 28.7 11.00
102 INT279351 Regulation of IDUA 2 0.36 1.71 0 10.72
103 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 10.28
104 INT3892 Positive_regulation of XDH 8 0.67 8.57 1.5 9.28
105 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 8.92
106 INT71374 Positive_regulation of Gene_expression of Il12a 5 0.22 7.49 3.8 8.92
107 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 8.64
108 INT67401 Gene_expression of Il12a 25 0.55 20.04 11.12 8.28
109 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 7.00
110 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
111 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
112 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
113 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
114 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
115 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
116 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
117 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
118 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 5.00
119 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
120 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 5.00
121 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
122 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
123 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
124 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
125 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
126 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
127 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
128 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
129 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
130 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
131 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
132 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
133 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
134 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
135 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
136 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
137 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
138 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
139 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
140 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
141 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
142 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
143 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
144 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
145 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.00
146 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
147 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
148 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
149 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
150 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
151 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 5.00
152 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
153 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
154 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
155 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
156 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
157 INT2243 Localization of GAST 67 0.81 34.54 16.19 5.00
158 INT14152 Gene_expression of Slc17a5 46 0.61 20.01 15.9 5.00
159 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
160 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
161 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 5.00
162 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
163 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
164 INT22213 Localization of Gpt 52 0.78 34.05 12.94 5.00
165 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
166 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
167 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 5.00
168 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
169 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
170 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
171 INT6574 Negative_regulation of Pla2g1b 35 0.59 11.4 10.44 5.00
172 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
173 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
174 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
175 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
176 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
177 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
178 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78 5.00
179 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
180 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
181 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
182 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
183 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
184 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
185 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
186 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
187 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75 5.00
188 INT25022 Binding of PAEP 66 0.42 22.83 6.59 5.00
189 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 5.00
190 INT8803 Gene_expression of IL3 32 0.78 21.06 6.01 5.00
191 INT69153 Positive_regulation of Gene_expression of IL5 22 0.32 23.59 5.7 5.00
192 INT53684 Negative_regulation of Gene_expression of ITGAM 23 0.59 14.36 5.66 5.00
193 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63 5.00
194 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
195 INT56299 Transcription of IL4 15 0.64 10.2 5.44 5.00
196 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
197 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
198 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 5.00
199 INT624 Positive_regulation of GAST 28 0.70 15.61 4.73 5.00
200 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 5.00
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