D:Membranoproliferative Glomerulonephritis

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Disease Term
Synonyms Dense Deposit Disease, Glomerulonephritides Hypocomplementemic, GLOMERULONEPHRITIDES MEMBRANOPROLIFERATIVE, Glomerulonephritides Mesangiocapillary, Glomerulonephritis Hypocomplementemic, GLOMERULONEPHRITIS MESANGIOCAPILLARY, Hypocomplementemic Glomerulonephritides, Hypocomplementemic Glomerulonephritis, MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIDES, Membranoproliferative Glomerulonephritis Subendothelial, Membranoproliferative Glomerulonephritis Type I
Documents 44
Hot Single Events 19
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Membranoproliferative Glomerulonephritis. They are ordered first by their relevance to Membranoproliferative Glomerulonephritis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251645 Binding of SERPING1 and CD79A 1 0.10 1.31 0.06 92.00
2 INT277835 EPO Positive_regulation of Localization of VEGFA 1 0.03 1.36 0.08 88.24
3 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17 25.00
4 INT128214 Binding of Il6 and Stap1 1 0.00 0 0.04 25.00
5 INT198595 Binding of CFH and CFHR1 3 0.41 1.36 0.03 7.04
6 INT312726 AASS Positive_regulation of FGD1 1 0.02 0.08 0.24 5.00
7 INT279503 Binding of C1s and C1ra 1 0.03 0.58 0.22 5.00
8 INT249665 Binding of GOPC and PSS 1 0.02 3.13 0.21 5.00
9 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19 5.00
10 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19 5.00
11 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13 5.00
12 INT279511 Binding of Serping1 and C1ra 1 0.01 0.3 0.11 5.00
13 INT279502 Binding of C2 and Hc 1 0.01 0.2 0.07 5.00
14 INT279515 Daf2 Negative_regulation of INCENP 1 0.00 0 0 5.00
15 INT198593 Binding of CFH and VHL 1 0.02 0.27 0 5.00
16 INT249666 Binding of CD81 and GOPC 1 0.06 1.31 0 5.00
17 INT279501 C3ar1 Positive_regulation of C3 1 0.01 0 0 5.00
18 INT279504 Binding of C1ra and Positive_regulation of C1s 1 0.04 0.33 0 5.00
19 INT249664 Binding of CD81 and CHCHD2 1 0.00 2.51 0 5.00
20 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
21 INT198594 Binding of CFH and MIR1197 1 0.01 0.48 0 5.00
22 INT229983 Binding of CFH and Crp 2 0.14 1.48 0 5.00
23 INT279508 Binding of Arhgap4 and Positive_regulation of C1s 1 0.01 0.33 0 5.00
24 INT279509 Binding of C2 and Abpz 1 0.01 0.21 0 5.00
25 INT279505 Binding of C4b and Abpz 1 0.01 0.21 0 5.00
26 INT279510 Binding of C1qa and fc 1 0.01 0.36 0 5.00
27 INT277836 EGFR Positive_regulation of VEGFA 1 0.24 0.47 0 5.00
28 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
29 INT279514 Cr1l Negative_regulation of INCENP 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Membranoproliferative Glomerulonephritis. They are ordered first by their pain relevance and then by number of times they were reported in Membranoproliferative Glomerulonephritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89 99.88
2 INT156130 Binding of SERPING1 29 0.42 26.16 2.52 99.00
3 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 97.68
4 INT135963 Negative_regulation of Hc 19 0.42 12.36 3.63 96.48
5 INT5789 Gene_expression of PMEL 23 0.75 13.18 2.67 95.84
6 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 95.44
7 INT97767 Positive_regulation of Adra2b 3 0.45 1.75 0.34 94.72
8 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 92.04
9 INT279457 Negative_regulation of Daf2 1 0.14 3.17 0.09 91.92
10 INT43931 Binding of CFH 49 0.48 31.85 3.96 91.48
11 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 87.92
12 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 87.20
13 INT7368 Positive_regulation of Negative_regulation of IgG 2 0.36 1.36 0.09 83.92
14 INT30870 Negative_regulation of Adra2b 8 0.44 4.5 2.8 83.32
15 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 81.36
16 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 80.52
17 INT46045 Negative_regulation of Gene_expression of C3 5 0.30 3.15 0.45 80.52
18 INT756 Gene_expression of C3 138 0.75 100.6 19.2 80.12
19 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 80.12
20 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 75.00
21 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 75.00
22 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 66.84
23 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 57.60
24 INT151695 Positive_regulation of FBL 2 0.49 0.65 0.36 56.32
25 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 46.12
26 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11 38.64
27 INT279456 Binding of Ly76 1 0.02 1.26 0.18 37.12
28 INT103527 Positive_regulation of Smcp 5 0.41 2.25 1.26 30.48
29 INT17598 Positive_regulation of CFHR1 11 0.50 2.6 2.38 26.48
30 INT198602 Positive_regulation of Positive_regulation of CFHR1 1 0.50 0.23 0 26.48
31 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 26.00
32 INT146899 Positive_regulation of Positive_regulation of CFH 2 0.50 1.37 0.17 26.00
33 INT3962 Regulation of AGT 50 0.62 20.96 13.01 25.00
34 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 21.84
35 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03 16.64
36 INT132492 Gene_expression of UGT2B15 3 0.56 0.11 0.17 14.64
37 INT158083 Gene_expression of FGD1 24 0.67 6.82 2.83 11.84
38 INT279443 Binding of Cd59a 1 0.14 0.92 0.17 9.92
39 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 6.24
40 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
41 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
42 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
43 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
44 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
45 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
46 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
47 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
48 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
49 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
50 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
51 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
52 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
53 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
54 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
55 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
56 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
57 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
58 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 5.00
59 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
60 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
61 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
62 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
63 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
64 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 5.00
65 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
66 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
67 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
68 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
69 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65 5.00
70 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
71 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
72 INT120828 Localization of CXCL10 29 0.68 18.01 12.17 5.00
73 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
74 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
75 INT19428 Gene_expression of MTRF1 42 0.08 27.17 10.43 5.00
76 INT4297 Negative_regulation of CFP 21 0.42 12.7 10.29 5.00
77 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
78 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 5.00
79 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 5.00
80 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
81 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
82 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 5.00
83 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17 5.00
84 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 5.00
85 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 5.00
86 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
87 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
88 INT115594 Gene_expression of Cd80 9 0.67 7.8 5.92 5.00
89 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92 5.00
90 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
91 INT177467 Negative_regulation of MTRF1 22 0.05 11.84 5.57 5.00
92 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 5.00
93 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
94 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
95 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 5.00
96 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 5.00
97 INT127667 Positive_regulation of Localization of CXCL10 5 0.59 5.89 4.09 5.00
98 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83 5.00
99 INT69904 Binding of Hc 11 0.35 7.79 3.69 5.00
100 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 5.00
101 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
102 INT184390 Binding of Arhgap4 13 0.36 3.29 3.35 5.00
103 INT144068 Binding of Nsf 9 0.48 7.67 3.16 5.00
104 INT28923 Negative_regulation of Ldha 8 0.58 4.94 3.11 5.00
105 INT68846 Gene_expression of Tfrc 22 0.32 10.1 3.06 5.00
106 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
107 INT116228 Binding of C1qa 26 0.47 15.72 3 5.00
108 INT155160 Binding of C3 20 0.47 7.77 2.61 5.00
109 INT82966 Transcription of Crp 14 0.70 9.91 2.61 5.00
110 INT21516 Negative_regulation of Positive_regulation of Ldha 13 0.43 4.73 2.53 5.00
111 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44 5.00
112 INT184378 Binding of Cfb 54 0.20 12.49 2.36 5.00
113 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35 5.00
114 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
115 INT181015 Gene_expression of C3ar1 12 0.58 8.9 2.18 5.00
116 INT23748 Localization of Ltf 15 0.79 5.43 2.07 5.00
117 INT30531 Gene_expression of C2 15 0.66 5.5 1.99 5.00
118 INT45004 Gene_expression of Cfb 28 0.37 15.06 1.99 5.00
119 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 5.00
120 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 5.00
121 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 5.00
122 INT125743 Negative_regulation of Nsf 5 0.58 3.07 1.71 5.00
123 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
124 INT565 Negative_regulation of Cfb 18 0.13 6.77 1.69 5.00
125 INT200835 Gene_expression of Cd59a 5 0.77 9.02 1.64 5.00
126 INT179548 Gene_expression of C4b 17 0.58 9.88 1.62 5.00
127 INT17596 Gene_expression of CFHR1 24 0.67 3.07 1.61 5.00
128 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 5.00
129 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 5.00
130 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 5.00
131 INT22075 Positive_regulation of Gene_expression of IFNA2 7 0.64 4.7 1.45 5.00
132 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45 5.00
133 INT179539 Positive_regulation of Gene_expression of C3 9 0.70 5.98 1.32 5.00
134 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 5.00
135 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
136 INT118131 Negative_regulation of C1s 10 0.07 2.92 1.15 5.00
137 INT74166 Positive_regulation of C2 10 0.55 2.83 1.05 5.00
138 INT179535 Negative_regulation of C1qa 10 0.57 4.7 1.03 5.00
139 INT161974 Regulation of UGT2B15 2 0.26 0.31 0.99 5.00
140 INT184352 Positive_regulation of Cr2 6 0.42 2.81 0.96 5.00
141 INT19431 Positive_regulation of Gene_expression of MTRF1 5 0.05 3.13 0.95 5.00
142 INT82702 Positive_regulation of Positive_regulation of LDLR 4 0.45 1.08 0.95 5.00
143 INT312731 Negative_regulation of UGT2B15 1 0.36 0.38 0.94 5.00
144 INT312738 Regulation of UGT2B17 1 0.45 1.04 0.94 5.00
145 INT184665 Positive_regulation of C4b 7 0.28 5.84 0.9 5.00
146 INT17597 Positive_regulation of Gene_expression of CFHR1 3 0.50 0 0.85 5.00
147 INT15870 Regulation of PSS 6 0.25 3.22 0.85 5.00
148 INT70744 Regulation of CFH 12 0.41 7.38 0.8 5.00
149 INT257400 Positive_regulation of Gene_expression of FGD1 3 0.50 0.79 0.78 5.00
150 INT220888 Negative_regulation of Arhgap4 5 0.42 2.19 0.78 5.00
151 INT184341 Negative_regulation of C4b 12 0.50 7.66 0.75 5.00
152 INT200531 Gene_expression of Tnni1 8 0.58 4.68 0.75 5.00
153 INT166010 Positive_regulation of Nsf 2 0.38 1.76 0.72 5.00
154 INT94442 Gene_expression of Tcf21 2 0.25 2.32 0.72 5.00
155 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 5.00
156 INT179530 Transcription of C3 4 0.69 2.59 0.7 5.00
157 INT184367 Protein_catabolism of Hc 4 0.26 2.66 0.6 5.00
158 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 5.00
159 INT87458 Binding of CD81 4 0.18 6.02 0.59 5.00
160 INT279499 Negative_regulation of Tnni1 5 0.57 4.35 0.53 5.00
161 INT161973 Binding of UGT2B17 1 0.47 0.62 0.51 5.00
162 INT149027 Positive_regulation of C1s 8 0.36 4.27 0.51 5.00
163 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 5.00
164 INT279459 Negative_regulation of Cd59a 3 0.58 5.76 0.5 5.00
165 INT312739 Negative_regulation of UGT2B17 1 0.59 0.22 0.5 5.00
166 INT312740 Localization of UGT2B17 1 0.75 0.15 0.47 5.00
167 INT312734 Localization of UGT2B15 1 0.62 0.15 0.47 5.00
168 INT68701 Positive_regulation of C4bp 7 0.67 3.02 0.46 5.00
169 INT220894 Positive_regulation of C3ar1 4 0.09 3.75 0.41 5.00
170 INT94026 Regulation of SERPING1 12 0.61 10.28 0.37 5.00
171 INT148797 Phosphorylation of KDR 7 0.80 5.15 0.36 5.00
172 INT179532 Protein_catabolism of C3 5 0.26 1.61 0.34 5.00
173 INT44942 Positive_regulation of Localization of HSD11B1 5 0.49 4.18 0.31 5.00
174 INT95446 Gene_expression of PHC2 2 0.32 1.59 0.3 5.00
175 INT131301 Binding of Serping1 3 0.28 1.86 0.3 5.00
176 INT102114 Negative_regulation of Chkb 6 0.39 2.05 0.28 5.00
177 INT263705 Binding of C1ra 2 0.36 0.62 0.26 5.00
178 INT279445 Binding of C7 2 0.23 0.85 0.25 5.00
179 INT279440 Binding of C6 2 0.22 0.85 0.25 5.00
180 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23 5.00
181 INT236354 Negative_regulation of Negative_regulation of C3 2 0.25 2.19 0.21 5.00
182 INT279464 Regulation of Chkb 2 0.20 1.48 0.21 5.00
183 INT209345 Negative_regulation of AGTR2 5 0.17 4.83 0.2 5.00
184 INT244789 Positive_regulation of Cdca3 2 0.04 1.41 0.2 5.00
185 INT146898 Positive_regulation of Binding of CFH 3 0.44 2.01 0.17 5.00
186 INT220895 Negative_regulation of Binding of C3 3 0.28 0.95 0.16 5.00
187 INT277845 Negative_regulation of Gene_expression of TXK 2 0.04 0.92 0.16 5.00
188 INT244793 Gene_expression of Cdca3 2 0.12 1.38 0.16 5.00
189 INT279448 Binding of Cdca3 1 0.05 0.32 0.12 5.00
190 INT198600 Negative_regulation of Gene_expression of CFH 4 0.41 3.25 0.12 5.00
191 INT279439 Binding of C1s 2 0.11 0.39 0.11 5.00
192 INT184511 Positive_regulation of Negative_regulation of VEGFA 5 0.46 2.86 0.09 5.00
193 INT224335 Negative_regulation of Phosphorylation of KDR 5 0.35 5.24 0.09 5.00
194 INT269716 Binding of HPD 3 0.31 1.42 0.08 5.00
195 INT279438 Negative_regulation of Localization of Ltf 1 0.09 0.35 0.08 5.00
196 INT179307 Regulation of GNAS 7 0.01 1.93 0.05 5.00
197 INT312733 Negative_regulation of Negative_regulation of UGT2B17 1 0.43 0.07 0.05 5.00
198 INT198598 Transcription of CFH 3 0.69 3.21 0.05 5.00
199 INT312736 Transcription of UGT2B17 1 0.69 0.09 0.04 5.00
200 INT198606 Localization of CFH 8 0.65 4.37 0.04 5.00
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