D:Membranous Glomerulonephritis

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Disease Term
Synonyms Extramembranous Glomerulopathy, GLOMERULONEPHRITIDES IDIOPATHIC MEMBRANOUS, Glomerulonephritides Membranous, Glomerulonephritis Idiopathic Membranous, GLOMERULONEPHROPATHY MEMBRANOUS, GLOMERULOPATHY EXTRAMEMBRANOUS, Glomerulopathy Membranous, Heymann Nephritis, IDIOPATHIC MEMBRANOUS GLOMERULONEPHRITIDES, IDIOPATHIC MEMBRANOUS GLOMERULONEPHRITIS, Idiopathic Membranous Nephropathy
Documents 91
Hot Single Events 39
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Membranous Glomerulonephritis. They are ordered first by their relevance to Membranous Glomerulonephritis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251645 Binding of SERPING1 and CD79A 1 0.10 1.31 0.06 93.04
2 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55 62.60
3 INT173905 Binding of CD69 and LRP2 1 0.14 0.32 0 19.04
4 INT329841 Il4 Regulation of Hand1 1 0.04 0.87 0.18 6.96
5 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18 6.96
6 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 5.00
7 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 5.00
8 INT265213 Binding of Ctla4 and Cd86 2 0.13 1.93 1.31 5.00
9 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22 5.00
10 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17 5.00
11 INT265210 Binding of Ctla4 and Cd28 2 0.16 1.45 0.93 5.00
12 INT185997 Binding of FANCB and fc 2 0.01 2.51 0.63 5.00
13 INT225065 Binding of ETF1 and FANCB 1 0.01 2.07 0.59 5.00
14 INT225083 Binding of ETF1 and fc 1 0.00 2.13 0.57 5.00
15 INT279503 Binding of C1s and C1ra 1 0.03 0.58 0.22 5.00
16 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19 5.00
17 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19 5.00
18 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14 5.00
19 INT279511 Binding of Serping1 and C1ra 1 0.01 0.3 0.11 5.00
20 INT199031 Binding of ALB and F2 1 0.05 1.78 0.08 5.00
21 INT279502 Binding of C2 and Hc 1 0.01 0.2 0.07 5.00
22 INT225068 Binding of FCAR and IGHG3 1 0.02 0.27 0.07 5.00
23 INT225081 Binding of FCAR and fc 1 0.00 0.27 0.07 5.00
24 INT225064 Binding of IGHA1 and IGHG3 1 0.01 1.54 0.07 5.00
25 INT329839 Negative_regulation of Tnfsf13b Negative_regulation of Gene_expression of Ighm 1 0.05 2.28 0.06 5.00
26 INT218240 Binding of SAE1 and Dync1h1 1 0.00 0.17 0 5.00
27 INT279515 Daf2 Negative_regulation of INCENP 1 0.00 0 0 5.00
28 INT225084 IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
29 INT206824 Binding of Muc5b and Gopc 1 0.07 0.05 0 5.00
30 INT279501 C3ar1 Positive_regulation of C3 1 0.01 0 0 5.00
31 INT279504 Binding of C1ra and Positive_regulation of C1s 1 0.04 0.33 0 5.00
32 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
33 INT206825 Binding of Muc2 and Gopc 1 0.08 0.05 0 5.00
34 INT229983 Binding of CFH and Crp 2 0.14 1.48 0 5.00
35 INT279508 Binding of Arhgap4 and Positive_regulation of C1s 1 0.01 0.33 0 5.00
36 INT279509 Binding of C2 and Abpz 1 0.01 0.21 0 5.00
37 INT279505 Binding of C4b and Abpz 1 0.01 0.21 0 5.00
38 INT279510 Binding of C1qa and fc 1 0.01 0.36 0 5.00
39 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
40 INT225080 Positive_regulation of IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
41 INT279514 Cr1l Negative_regulation of INCENP 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Membranous Glomerulonephritis. They are ordered first by their pain relevance and then by number of times they were reported in Membranous Glomerulonephritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT156130 Binding of SERPING1 29 0.42 26.16 2.52 99.76
2 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 99.48
3 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 98.96
4 INT36575 Gene_expression of TNFRSF10A 10 0.65 10.1 4.17 98.96
5 INT615 Regulation of Alb 66 0.62 33.43 15.33 98.96
6 INT3513 Negative_regulation of Igha 9 0.38 7.43 0.56 98.92
7 INT327486 Binding of Dpa 1 0.02 1.74 0 98.40
8 INT209345 Negative_regulation of AGTR2 5 0.17 4.83 0.2 98.00
9 INT94026 Regulation of SERPING1 12 0.61 10.28 0.37 97.72
10 INT168469 Localization of Lgals3 5 0.28 2.46 0.23 97.52
11 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 97.12
12 INT1591 Negative_regulation of Binding of POMC 18 0.59 1.74 7.91 96.20
13 INT695 Binding of POMC 304 0.48 56.66 126.85 96.20
14 INT78297 Gene_expression of CD59 31 0.72 24.11 3.18 95.92
15 INT277912 Positive_regulation of Gene_expression of CD59 2 0.19 2.76 0.49 95.92
16 INT64450 Gene_expression of Mc1r 13 0.77 9.22 5.43 95.76
17 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 95.52
18 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 94.60
19 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 93.44
20 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 93.24
21 INT3512 Gene_expression of Igha 9 0.60 7.71 1.13 93.24
22 INT168470 Localization of Mc1r 1 0.74 1.06 0.2 92.56
23 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 91.52
24 INT756 Gene_expression of C3 138 0.75 100.6 19.2 91.36
25 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 89.88
26 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67 89.56
27 INT1143 Positive_regulation of OTOR 7 0.67 5.38 1 89.48
28 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 89.12
29 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 89.12
30 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23 89.12
31 INT277914 Positive_regulation of Negative_regulation of CD59 1 0.11 1.01 0.12 89.12
32 INT29777 Negative_regulation of CD59 16 0.42 14.88 1.56 88.36
33 INT31994 Negative_regulation of Nbr1 7 0.41 5.54 2.29 86.96
34 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 86.76
35 INT227519 Positive_regulation of Hspa9 22 0.55 16.38 3.83 84.96
36 INT673 Positive_regulation of B2m 24 0.68 24.24 4.82 81.64
37 INT47095 Positive_regulation of Naglu 3 0.66 1.5 0.53 81.64
38 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 81.24
39 INT47550 Gene_expression of Naglu 4 0.44 2.02 0.23 80.92
40 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 79.44
41 INT76426 Positive_regulation of Negative_regulation of Cpox 18 0.35 6.84 9.95 79.44
42 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 79.04
43 INT25130 Positive_regulation of Negative_regulation of Ptgs1 14 0.50 5.07 6.29 79.04
44 INT670 Gene_expression of B2m 31 0.66 27.32 8.49 78.76
45 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 76.48
46 INT206822 Localization of Muc2 11 0.70 5.59 0.58 76.24
47 INT197250 Localization of Muc5ac 7 0.71 4.83 0.55 76.24
48 INT206823 Localization of Muc5b 5 0.78 5.15 0.43 76.24
49 INT225069 Localization of NKRF 1 0.31 0.66 0 75.84
50 INT16385 Regulation of C3 20 0.41 9.98 1.92 75.68
51 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 75.56
52 INT45253 Positive_regulation of Ltf 20 0.69 10.22 2.77 75.00
53 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 75.00
54 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 74.88
55 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 70.32
56 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 70.32
57 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58 69.44
58 INT5408 Localization of Alb 30 0.73 12.1 3.84 69.40
59 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 66.32
60 INT103683 Gene_expression of Muc2 18 0.73 12.47 2.43 66.32
61 INT206820 Gene_expression of Muc1 17 0.60 13.48 0.36 66.32
62 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 65.68
63 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 65.48
64 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 64.80
65 INT88948 Localization of Ace 9 0.69 9.18 1.11 64.00
66 INT654 Localization of REN 250 0.81 75.12 47.86 62.96
67 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 62.96
68 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 62.60
69 INT59165 Binding of fc 67 0.36 37.51 8.68 62.40
70 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 61.12
71 INT23045 Positive_regulation of Hbb 31 0.64 19.35 4.54 53.36
72 INT18773 Localization of ALB 117 0.80 69.18 13.8 50.92
73 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 50.00
74 INT53949 Positive_regulation of Gene_expression of Cpox 82 0.65 38.12 25.93 50.00
75 INT73599 Negative_regulation of Gene_expression of Cpox 47 0.55 19.89 17.26 50.00
76 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87 50.00
77 INT332984 Negative_regulation of Gene_expression of Ads1 2 0.42 1.9 0.11 49.92
78 INT22434 Gene_expression of Ads1 10 0.75 9.16 1.4 49.48
79 INT11052 Positive_regulation of Gene_expression of CD69 23 0.43 16.66 2.54 48.48
80 INT173909 Positive_regulation of Gene_expression of LRP2 1 0.41 1.05 0.16 48.48
81 INT11048 Gene_expression of CD69 59 0.67 42.85 6.4 47.64
82 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09 47.64
83 INT173914 Regulation of Gene_expression of LRP2 3 0.60 6.49 0.78 47.64
84 INT173922 Regulation of Gene_expression of CD69 2 0.30 1.2 0.19 47.64
85 INT173916 Regulation of LRP2 6 0.44 7.96 1.14 47.08
86 INT173911 Regulation of CD69 3 0.22 2.95 0.25 46.24
87 INT99610 Localization of MMP9 126 0.79 48.46 32.67 46.08
88 INT78901 Localization of CCL5 67 0.78 40.79 20.59 46.08
89 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 46.08
90 INT35175 Localization of IL18 18 0.80 12.96 3.83 46.08
91 INT59719 Localization of SELP 12 0.78 8.4 2.95 46.08
92 INT31162 Localization of SELL 10 0.78 7.38 1.94 46.08
93 INT59884 Gene_expression of UMOD 4 0.78 2.32 0.82 43.36
94 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 43.12
95 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 37.24
96 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 37.24
97 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 34.72
98 INT341655 Gene_expression of FGA 1 0.56 4.48 1.07 34.12
99 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 33.36
100 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 33.04
101 INT341662 Gene_expression of FGB 1 0.48 3.06 0.6 33.04
102 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 32.48
103 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 31.56
104 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 31.56
105 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 31.04
106 INT70815 Negative_regulation of Positive_regulation of Il2 4 0.40 1.37 0.76 28.28
107 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 28.20
108 INT89661 Gene_expression of Hrec 102 0.21 69.91 39.57 28.20
109 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 28.20
110 INT38266 Localization of PTPRC 30 0.68 17.05 1.68 25.20
111 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 24.40
112 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 24.40
113 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 24.40
114 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 24.40
115 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12 24.40
116 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12 24.40
117 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19 24.40
118 INT118305 Negative_regulation of Gene_expression of IL18 7 0.39 6.52 2.05 24.40
119 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 24.08
120 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 23.76
121 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 23.48
122 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 23.00
123 INT225075 Positive_regulation of Gene_expression of NKRF 1 0.18 0.26 0.04 22.72
124 INT225074 Gene_expression of NKRF 1 0.24 0.26 0.04 22.72
125 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 22.60
126 INT119018 Gene_expression of TREH 22 0.65 12.44 1.95 22.16
127 INT129302 Positive_regulation of Gene_expression of TREH 4 0.49 1.28 0.37 22.16
128 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 19.68
129 INT332991 Positive_regulation of Positive_regulation of Sle1 1 0.03 1.16 0.17 18.72
130 INT220885 Positive_regulation of Sle1 3 0.13 3.06 0.42 18.36
131 INT113420 Positive_regulation of Gene_expression of IL18 22 0.69 19.96 5.53 17.52
132 INT128769 Negative_regulation of Localization of IFNA1 8 0.24 6.85 1.35 14.32
133 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 13.76
134 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 11.24
135 INT152552 Gene_expression of Muc5ac 24 0.73 19.44 4 9.04
136 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 6.96
137 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88 6.96
138 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01 6.96
139 INT206819 Gene_expression of Muc6 7 0.61 4.22 0.19 6.80
140 INT95446 Gene_expression of PHC2 2 0.32 1.59 0.3 5.52
141 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
142 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
143 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
144 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
145 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
146 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
147 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
148 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
149 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
150 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
151 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
152 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
153 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
154 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
155 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
156 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
157 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
158 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
159 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
160 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
161 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
162 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
163 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
164 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
165 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
166 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
167 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
168 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
169 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
170 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
171 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
172 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
173 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
174 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01 5.00
175 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
176 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
177 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
178 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
179 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
180 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
181 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
182 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 5.00
183 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 5.00
184 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
185 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
186 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
187 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
188 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 5.00
189 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
190 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
191 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 5.00
192 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
193 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
194 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
195 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
196 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 5.00
197 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
198 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 5.00
199 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
200 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 5.00
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