D:Merkel Cell Carcinoma

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pChart

Disease Term
Synonyms Merkel Cell Tumor, TUMOR MERKEL CELL
Documents 42
Hot Single Events 38
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Merkel Cell Carcinoma. They are ordered first by their relevance to Merkel Cell Carcinoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT71392 KRT8 Positive_regulation of Krt13 1 0.01 0.84 0.08 75.00
2 INT71391 KRT8 Positive_regulation of Krt20 1 0.01 0.84 0.08 75.00
3 INT71390 KRT8 Positive_regulation of Cea 1 0.01 0.84 0.08 75.00
4 INT71387 Krt20 Positive_regulation of Cea 1 0.00 0.84 0.08 75.00
5 INT71388 Krt13 Positive_regulation of Cea 1 0.00 0.84 0.08 75.00
6 INT278264 Gene_expression of Ntf3 Positive_regulation of Smcp 1 0.02 0.32 0 73.60
7 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
8 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 5.00
9 INT278265 Binding of Fgf2 and Smcp 1 0.03 0.26 0.14 5.00
10 INT214437 NCAM1 Regulation of CHGA 1 0.05 1.21 0.07 5.00
11 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 5.00
12 INT322413 Binding of ATF1 and EWSR1 1 0.26 1.3 0 5.00
13 INT263918 Binding of PTPRC and Cea 1 0.00 0.37 0 5.00
14 INT263899 Binding of PTPRC and TMED7-TICAM2 1 0.00 0.85 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Merkel Cell Carcinoma. They are ordered first by their pain relevance and then by number of times they were reported in Merkel Cell Carcinoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 99.78
2 INT263905 Gene_expression of SLN 33 0.63 23.21 0.74 99.76
3 INT88278 Binding of Kit 33 0.37 24.45 4.13 99.64
4 INT212176 Gene_expression of CEACAM5 7 0.75 6.05 0.24 99.52
5 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 99.10
6 INT93166 Positive_regulation of Ttf1 4 0.41 3.62 0.08 98.96
7 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 98.92
8 INT159232 Negative_regulation of SYP 4 0.41 4.45 0.38 98.92
9 INT263873 Positive_regulation of Gene_expression of Rigs1 1 0.05 1.27 0.03 97.92
10 INT263877 Gene_expression of Rigs1 1 0.08 11.58 0.03 97.92
11 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 97.68
12 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 96.50
13 INT99572 Localization of Kit 13 0.75 5.23 1.95 96.24
14 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47 95.72
15 INT174424 Binding of Smcp 9 0.25 2.68 0.94 94.56
16 INT174434 Localization of Smcp 6 0.53 2.45 1.46 94.56
17 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 93.60
18 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 93.60
19 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 90.64
20 INT134822 Gene_expression of Gja1 18 0.72 4.2 1 90.48
21 INT2491 Regulation of Cea 38 0.61 26.18 10.95 90.04
22 INT23775 Regulation of S100B 24 0.62 16.75 2.57 90.04
23 INT23773 Regulation of cla 1 0.02 1.02 0.2 90.04
24 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 89.96
25 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 89.96
26 INT48960 Gene_expression of SCG2 16 0.68 4.41 4.33 89.96
27 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 89.52
28 INT179856 Gene_expression of Sdc1 4 0.75 3.88 0.03 88.88
29 INT14497 Gene_expression of GRP 82 0.78 17.67 32.27 88.76
30 INT11919 Regulation of KRT1 9 0.10 4.97 0.77 88.76
31 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 87.04
32 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 83.40
33 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 83.20
34 INT97871 Gene_expression of Ntf3 47 0.78 25.9 15.94 82.84
35 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 82.60
36 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 82.36
37 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77 82.00
38 INT186181 Gene_expression of ZC3H12A 4 0.08 2.91 0.85 81.04
39 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 77.84
40 INT71389 Positive_regulation of KRT19 3 0.38 4.91 0.13 77.84
41 INT116427 Negative_regulation of Smcp 10 0.31 2.72 0.41 77.08
42 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 73.60
43 INT97870 Positive_regulation of Gene_expression of Ntf3 19 0.70 9.56 7.8 73.60
44 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 51.44
45 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 50.00
46 INT174423 Gene_expression of Smcp 39 0.48 29.45 6.06 48.52
47 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 19.76
48 INT20611 Gene_expression of Asap1 55 0.65 23.71 14.62 11.28
49 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 10.48
50 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 8.88
51 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 8.40
52 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
53 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
54 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 5.00
55 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
56 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 5.00
57 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
58 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
59 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
60 INT3982 Gene_expression of Acot1 53 0.56 7.61 10.46 5.00
61 INT25989 Localization of Vip 31 0.68 10.53 10.35 5.00
62 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
63 INT86867 Regulation of CREB1 15 0.46 4.95 7.28 5.00
64 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84 5.00
65 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
66 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 5.00
67 INT17182 Binding of Cea 25 0.48 14.98 4.16 5.00
68 INT135316 Gene_expression of Hrh3 9 0.74 5.66 3.14 5.00
69 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 5.00
70 INT174446 Positive_regulation of Smcp 7 0.33 5.47 2.24 5.00
71 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17 5.00
72 INT71644 Gene_expression of MLANA 16 0.75 11.55 1.82 5.00
73 INT104524 Localization of FSCN1 3 0.13 1.76 1.75 5.00
74 INT167692 Binding of NCAM1 11 0.36 6.73 1.59 5.00
75 INT104777 Regulation of DES 4 0.38 2.38 1.2 5.00
76 INT237247 Regulation of Mri1 6 0.27 4.64 1.2 5.00
77 INT28083 Negative_regulation of Gene_expression of VIM 9 0.41 7.23 1.17 5.00
78 INT166261 Localization of SLN 2 0.66 1.23 1.07 5.00
79 INT86834 Positive_regulation of Tg 10 0.69 4.9 1.04 5.00
80 INT142829 Transcription of CREB1 9 0.46 3.37 1.03 5.00
81 INT263912 Positive_regulation of SLN 6 0.39 0.66 0.99 5.00
82 INT78877 Gene_expression of EWSR1 10 0.75 11.16 0.97 5.00
83 INT278254 Positive_regulation of Localization of Smcp 1 0.24 0 0.85 5.00
84 INT56955 Binding of MYOG 5 0.27 2.92 0.73 5.00
85 INT54546 Binding of CREB1 9 0.41 3.44 0.72 5.00
86 INT61910 Binding of Slc3a2 6 0.01 3 0.7 5.00
87 INT246036 Positive_regulation of GRN 3 0.17 2.04 0.69 5.00
88 INT214707 Gene_expression of Slc2a8 5 0.24 2.76 0.61 5.00
89 INT263904 Negative_regulation of Gene_expression of SLN 1 0.14 7.18 0.47 5.00
90 INT88005 Binding of MYOD1 6 0.30 2.08 0.42 5.00
91 INT104143 Transcription of EWSR1 7 0.67 8.1 0.42 5.00
92 INT278253 Positive_regulation of Gene_expression of Smcp 3 0.29 1.24 0.39 5.00
93 INT104005 Negative_regulation of Gene_expression of DES 6 0.42 4.82 0.37 5.00
94 INT158766 Localization of GRN 2 0.73 1.59 0.28 5.00
95 INT175002 Positive_regulation of Mki67 10 0.31 5.7 0.26 5.00
96 INT263884 Gene_expression of Slc2a3 2 0.18 0.86 0.19 5.00
97 INT20214 Localization of Slc3a2 5 0.14 4.91 0.16 5.00
98 INT263871 Negative_regulation of Car9 1 0.07 0.54 0.12 5.00
99 INT263908 Positive_regulation of Gene_expression of SLN 1 0.16 1.4 0.12 5.00
100 INT263872 Localization of Adra1d 1 0.01 2.5 0.11 5.00
101 INT98920 Localization of CREB1 4 0.52 1.77 0.1 5.00
102 INT278252 Regulation of Smcp 2 0.29 1.58 0.09 5.00
103 INT214445 Positive_regulation of Clcn1 1 0.02 2.54 0.08 5.00
104 INT263878 Positive_regulation of Rigs1 1 0.05 2.57 0.07 5.00
105 INT143945 Localization of EWSR1 5 0.78 3.39 0.06 5.00
106 INT322421 Gene_expression of ATF1 2 0.39 1.41 0.05 5.00
107 INT214703 Positive_regulation of Gene_expression of Slc2a8 2 0.09 1.4 0.05 5.00
108 INT263879 Positive_regulation of Adra1d 1 0.00 0.47 0.04 5.00
109 INT93169 Binding of Ttf1 3 0.30 2.04 0.03 5.00
110 INT201549 Regulation of CD99 3 0.23 3.6 0.03 5.00
111 INT263911 Localization of TMED7-TICAM2 1 0.01 1.02 0 5.00
112 INT263906 Gene_expression of TMED7-TICAM2 1 0.01 2.8 0 5.00
113 INT322420 Binding of FEV 1 0.18 0.29 0 5.00
114 INT263874 Regulation of Rigs1 1 0.03 1.36 0 5.00
115 INT263914 Binding of TMED7-TICAM2 1 0.01 1.56 0 5.00
116 INT322422 Localization of FEV 1 0.40 0.82 0 5.00
117 INT263910 Regulation of SLN 1 0.15 1.01 0 5.00
118 INT322423 Negative_regulation of PAX3 1 0.41 1.09 0 5.00
119 INT231530 Localization of PAX3 2 0.68 2.52 0 5.00
120 INT263883 Localization of Rigs1 1 0.08 2.36 0 5.00
121 INT263881 Binding of Rigs1 1 0.04 0.99 0 5.00
122 INT263876 Negative_regulation of Rigs1 1 0.04 0.98 0 5.00
123 INT263909 Positive_regulation of Gene_expression of TMED7-TICAM2 1 0.01 0.87 0 5.00
124 INT263880 Regulation of Gene_expression of Rigs1 1 0.05 0.48 0 5.00
125 INT263915 Binding of SLN 2 0.12 0.81 0 5.00
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