D:Metabolic Bone Disease

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Disease Term
Synonyms BONE DISEASE METABOLIC, Bone Diseases Metabolic, BONE METABOLISM DISORDER, DISEASE METABOLIC BONE, DISEASES METABOLIC BONE, Metabolic Bone Diseases, Metabolic Disorder Of Bone, OSTEOPENIA, Osteopenias
Documents 156
Hot Single Events 35
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Metabolic Bone Disease. They are ordered first by their relevance to Metabolic Bone Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT262216 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Vdr 1 0.29 0.44 0.08 82.12
2 INT262145 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.45 0.06 69.20
3 INT262151 Vdr Regulation of Cyp24a1 1 0.24 0.24 0.23 62.08
4 INT262170 Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.4 0 51.04
5 INT270777 Binding of DMD and BPs 1 0.01 0.33 0.09 44.80
6 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 44.68
7 INT334044 Cdt1 Regulation of Gene_expression of ALPP 1 0.04 0.72 0.12 43.28
8 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7 11.32
9 INT172125 Binding of Tnfrsf11b and Tnfrsf11a 2 0.17 2.12 0.39 11.32
10 INT262196 Nr1i2 Negative_regulation of Vdr 1 0.27 0.14 0.04 7.16
11 INT262221 Nr1i2 Negative_regulation of Cyp24a1 1 0.27 0.15 0.04 7.16
12 INT262166 Binding of Nr1i2 and Vdr 1 0.23 0.14 0.04 7.16
13 INT262154 Vdr Negative_regulation of Cyp24a1 1 0.16 0.14 0.04 5.44
14 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
15 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95 5.00
16 INT188803 Il1 Positive_regulation of Gene_expression of Crp 1 0.03 2.95 0.94 5.00
17 INT262165 Nr0b2 Negative_regulation of Nr5a2 1 0.02 0.5 0.92 5.00
18 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
19 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 5.00
20 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45 5.00
21 INT262220 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Abcc2 1 0.14 0.25 0.44 5.00
22 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4 5.00
23 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38 5.00
24 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38 5.00
25 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36 5.00
26 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36 5.00
27 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34 5.00
28 INT188804 S100a8 Positive_regulation of Gene_expression of Tnfsf11 1 0.00 0.7 0.31 5.00
29 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29 5.00
30 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27 5.00
31 INT262194 Rhof Positive_regulation of Nr1i2 1 0.15 0.64 0.27 5.00
32 INT262164 Positive_regulation of Rhof Positive_regulation of Nr1i2 1 0.11 0.65 0.27 5.00
33 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
34 INT188802 Il1 Negative_regulation of Gene_expression of Col7a1 1 0.00 0.71 0.26 5.00
35 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26 5.00
36 INT262202 Nr1i2 Regulation of Abcc2 1 0.19 0.12 0.25 5.00
37 INT262180 Nr1h4 Regulation of Sult2a1 1 0.11 0.11 0.25 5.00
38 INT262152 Nr1h4 Regulation of Abcc2 1 0.07 0.12 0.25 5.00
39 INT262200 Nr1i2 Regulation of Sult2a1 1 0.31 0.12 0.25 5.00
40 INT262167 Binding of Nr1i2 and Nr0b2 1 0.15 0.11 0.25 5.00
41 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24 5.00
42 INT262179 Nr1i2 Regulation of Gene_expression of Nr0b2 1 0.09 0.07 0.24 5.00
43 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
44 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
45 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
46 INT262178 Binding of Nr1i2 and Abcb1b 1 0.07 1.68 0.21 5.00
47 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21 5.00
48 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2 5.00
49 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2 5.00
50 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 5.00
51 INT264868 Binding of COL1A2 and GOPC 1 0.02 0.3 0.15 5.00
52 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14 5.00
53 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14 5.00
54 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13 5.00
55 INT262193 Binding of Nr1i2 and Sfn 1 0.15 0.26 0.13 5.00
56 INT262185 Positive_regulation of Binding of Ncoa1 and Nr1i2 1 0.04 0.56 0.12 5.00
57 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12 5.00
58 INT262148 Positive_regulation of Nr1i2 Positive_regulation of Abcb1b 1 0.09 0.69 0.12 5.00
59 INT262197 Nr1i2 Positive_regulation of Insig1 2 0.23 0 0.12 5.00
60 INT262206 Sfn Negative_regulation of Nr1i2 1 0.17 0.28 0.12 5.00
61 INT262146 Binding of Ncoa1 and Nr1i2 1 0.03 0.56 0.11 5.00
62 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11 5.00
63 INT262141 Edcs1 Positive_regulation of Nr1i2 1 0.02 0 0.1 5.00
64 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
65 INT262163 Positive_regulation of Binding of Nr1i2 and Plec 1 0.04 0.31 0.09 5.00
66 INT262142 Edcs1 Regulation of Nr1i2 1 0.01 0 0.09 5.00
67 INT262157 Binding of Nr1i2 and Plec 1 0.03 0.3 0.09 5.00
68 INT262176 Nr1i2 Regulation of Regulation of Casr 1 0.11 0.17 0.07 5.00
69 INT262219 Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07 5.00
70 INT262161 Nr1i2 Positive_regulation of Gene_expression of Cyp27a1 1 0.29 0.24 0.07 5.00
71 INT262168 Nr1i2 Regulation of Casr 1 0.07 0.17 0.07 5.00
72 INT262147 Nr1i2 Regulation of Gene_expression of Cyp2j8 1 0.00 0.07 0.07 5.00
73 INT262143 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07 5.00
74 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
75 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06 5.00
76 INT262190 Foxo1 Positive_regulation of Pck1 1 0.04 0.15 0.06 5.00
77 INT262175 Nr1i2 Positive_regulation of Gene_expression of Abca1 1 0.24 0.21 0.06 5.00
78 INT262187 Nr1i2 Positive_regulation of Gene_expression of Abcg1 1 0.24 0.21 0.06 5.00
79 INT262209 Positive_regulation of Nr1i2 Positive_regulation of Transcription of Ppig 1 0.03 0 0.06 5.00
80 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06 5.00
81 INT262233 Nr1i2 Negative_regulation of SOD1 1 0.03 0.23 0.05 5.00
82 INT334043 Cdt1 Positive_regulation of Gene_expression of ALPP 1 0.08 0.39 0.05 5.00
83 INT262230 SOD1 Regulation of Nr1i2 1 0.02 0.3 0.05 5.00
84 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
85 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04 5.00
86 INT262162 Nr1i2 Regulation of Cyp2b9 1 0.14 0.14 0.03 5.00
87 INT262195 Nr1i2 Positive_regulation of Srebf1 1 0.08 0.18 0.03 5.00
88 INT262198 Foxo1 Positive_regulation of Igfbp1 1 0.11 0.08 0.03 5.00
89 INT262177 Nr1i2 Positive_regulation of Cd36 1 0.16 0.18 0.03 5.00
90 INT262171 Binding of Cyp3a11 and Rare1 1 0.02 0.15 0.03 5.00
91 INT262217 Casr Regulation of Cyp3a11 1 0.05 0.13 0.03 5.00
92 INT316598 Pth Regulation of Fgf23 1 0.10 0.28 0.03 5.00
93 INT262149 Binding of Nfe2l2 and Rare1 1 0.03 0.32 0.03 5.00
94 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
95 INT270775 PTH Regulation of DMD 1 0.09 0.64 0.03 5.00
96 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 5.00
97 INT270776 PTH Regulation of Negative_regulation of DMD 1 0.09 0.3 0.03 5.00
98 INT262150 Binding of Rare1 and Sfn 1 0.01 0.33 0.03 5.00
99 INT262184 Binding of Nr1i2 and Rare1 1 0.03 0.15 0.03 5.00
100 INT262169 Binding of Foxa2 and Nr1i2 1 0.17 0.33 0 5.00
101 INT262203 Nr1i2 Positive_regulation of Gene_expression of Hmgcs2 1 0.23 0.22 0 5.00
102 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 1 0.10 0.22 0 5.00
103 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0 5.00
104 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0 5.00
105 INT262212 Positive_regulation of Nr1i2 Positive_regulation of Insig1 1 0.12 0 0 5.00
106 INT262204 Nr1i2 Positive_regulation of Cyp3a11 1 0.33 0.08 0 5.00
107 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0 5.00
108 INT270780 BPs Positive_regulation of DMD 1 0.02 0 0 5.00
109 INT257589 Negative_regulation of Pth Positive_regulation of DMD 1 0.01 0 0 5.00
110 INT262213 Plec Positive_regulation of Cyp3a11 1 0.02 0 0 5.00
111 INT270770 Binding of DMD and PTH 1 0.10 0.16 0 5.00
112 INT257590 Pth Positive_regulation of DMD 2 0.02 0.44 0 5.00
113 INT304618 Binding of Lta and Omt2a 1 0.01 0.19 0 5.00
114 INT316600 Binding of Acp5 and Matk 1 0.01 0 0 5.00
115 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0 5.00
116 INT262215 Binding of Nr1i2 and Dnajc7 1 0.08 0.26 0 5.00
117 INT188435 PDB1 Negative_regulation of Binding of SQSTM1 1 0.41 0.49 0 5.00
118 INT188436 Negative_regulation of NUP62 Positive_regulation of TNFRSF11A 1 0.39 1.6 0 5.00
119 INT290861 MNT Positive_regulation of INS 1 0.03 1.78 0 5.00
120 INT262191 Binding of Nr1i2 and Foxo1 1 0.22 0.09 0 5.00
121 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0 5.00
122 INT270122 Binding of Pth and Pc 1 0.05 0.1 0 5.00
123 INT262156 Nr1i2 Negative_regulation of Gene_expression of Hmgcs2 1 0.22 0.22 0 5.00
124 INT262174 Binding of Casr and Foxo1 1 0.05 0.09 0 5.00
125 INT262192 Nr1i2 Regulation of Positive_regulation of Cyp3a11 1 0.32 0 0 5.00
126 INT270121 Binding of Pth and Pthlh 1 0.08 0.56 0 5.00
127 INT316599 Positive_regulation of Binding of Acp5 and Matk 1 0.01 0 0 5.00
128 INT262199 Binding of Cyp2b9 and Rare1 1 0.01 0.15 0 5.00
129 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Metabolic Bone Disease. They are ordered first by their pain relevance and then by number of times they were reported in Metabolic Bone Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 100.00
2 INT9089 Positive_regulation of Ceacam1 17 0.69 7.09 2.49 98.96
3 INT27575 Positive_regulation of CEACAM1 2 0.45 1.57 0.03 98.96
4 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 98.92
5 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 97.72
6 INT54835 Regulation of Col2a1 5 0.59 2.08 1.07 97.00
7 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 96.44
8 INT9655 Regulation of Il6 98 0.62 70.92 31.95 96.44
9 INT174687 Regulation of Positive_regulation of Il6 10 0.61 9.07 2.61 96.44
10 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46 96.24
11 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 96.12
12 INT227416 Positive_regulation of DLAT 4 0.45 17.02 1.11 95.56
13 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 95.20
14 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 93.28
15 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 92.64
16 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 92.64
17 INT121943 Positive_regulation of Nr1i2 64 0.68 19.22 8.39 92.20
18 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 92.00
19 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 90.56
20 INT4342 Localization of ALPP 27 0.69 15.19 5.32 90.56
21 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 90.44
22 INT283508 Negative_regulation of Negative_regulation of DLAT 1 0.28 1.87 0.19 88.64
23 INT182666 Negative_regulation of DLAT 2 0.38 9.01 1.16 88.12
24 INT68216 Binding of NF1 40 0.48 51.24 4.59 87.56
25 INT57117 Negative_regulation of Transcription of BGLAP 1 0.35 0.83 0.09 87.36
26 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 87.16
27 INT262095 Positive_regulation of Gene_expression of Cyp24a1 1 0.40 2.58 0.44 85.92
28 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 85.48
29 INT262123 Gene_expression of Cyp24a1 17 0.67 6.67 1.38 85.36
30 INT47371 Negative_regulation of ap 32 0.32 9.8 1.96 85.36
31 INT16165 Regulation of DMD 114 0.60 35.13 3.64 84.68
32 INT136982 Positive_regulation of Positive_regulation of Nr1i2 3 0.65 4.66 2.89 82.12
33 INT57118 Transcription of BGLAP 4 0.56 1.65 0.37 82.12
34 INT160642 Positive_regulation of Gene_expression of Vdr 5 0.62 1.61 0.42 81.24
35 INT160633 Gene_expression of Vdr 21 0.77 10.01 2.73 80.76
36 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 79.76
37 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 78.24
38 INT188456 Negative_regulation of Gene_expression of NUP62 1 0.33 0.99 0.05 76.80
39 INT175226 Gene_expression of NUP62 4 0.52 1.26 0.05 76.80
40 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 75.84
41 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 75.08
42 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 75.08
43 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 75.00
44 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 75.00
45 INT36041 Negative_regulation of Gene_expression of IL36RN 11 0.11 9.47 4.46 75.00
46 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18 74.20
47 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 73.84
48 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 73.84
49 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 73.84
50 INT182667 Binding of DLAT 11 0.31 40.75 2.8 73.80
51 INT262040 Negative_regulation of Gene_expression of Vdr 1 0.25 0.26 0.21 72.80
52 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 70.12
53 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 69.80
54 INT51014 Transcription of IL2 42 0.71 21.56 12.7 69.60
55 INT141367 Negative_regulation of Transcription of IL2 9 0.32 2.07 2.43 69.60
56 INT262063 Localization of Vdr 3 0.75 1.76 0.33 67.52
57 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 64.68
58 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 63.48
59 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 58.56
60 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04 57.88
61 INT13397 Localization of DMD 21 0.78 7.96 1.08 56.88
62 INT18773 Localization of ALB 117 0.80 69.18 13.8 53.04
63 INT62044 Binding of Lta 16 0.30 7.49 1.01 51.40
64 INT157252 Binding of Omt2a 3 0.32 1.83 0.2 51.40
65 INT188447 Negative_regulation of Negative_regulation of PDB1 1 0.36 1.02 0.04 51.16
66 INT136981 Positive_regulation of Gene_expression of Nr1i2 2 0.65 3.63 1.34 51.04
67 INT24458 Negative_regulation of PDB1 8 0.41 4.5 1.5 50.64
68 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 50.00
69 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43 47.44
70 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 45.08
71 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96 45.08
72 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45 44.68
73 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02 44.44
74 INT38908 Phosphorylation of PDB1 2 0.46 1.56 0.23 44.12
75 INT180145 Gene_expression of THOP1 15 0.28 5.94 0.36 44.04
76 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 43.88
77 INT93017 Binding of PDB1 8 0.36 6.36 0.51 43.80
78 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 43.04
79 INT334041 Gene_expression of Cdt1 5 0.29 2.69 0.32 42.88
80 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 40.60
81 INT283514 Localization of NR1I2 2 0.74 3.15 0.87 39.12
82 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35 36.12
83 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 36.04
84 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 35.84
85 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 34.04
86 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 33.48
87 INT262060 Positive_regulation of Vdr 8 0.58 2.84 0.67 30.88
88 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 30.64
89 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 30.64
90 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41 28.00
91 INT82265 Gene_expression of Lif 7 0.50 6.17 3.4 25.28
92 INT333439 Positive_regulation of Gene_expression of Lif 1 0.18 0.18 0.04 25.28
93 INT171998 Binding of DMD 58 0.47 38.13 3.35 24.96
94 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34 24.88
95 INT76240 Positive_regulation of Lif 6 0.69 6.04 3.13 23.84
96 INT108798 Negative_regulation of Positive_regulation of ALPP 9 0.25 4.26 1.46 19.88
97 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 16.08
98 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 10.16
99 INT334039 Positive_regulation of Gene_expression of Cdt1 1 0.26 0.78 0.07 10.16
100 INT158566 Positive_regulation of Cyp24a1 2 0.27 0.68 0.12 9.72
101 INT269465 Positive_regulation of Positive_regulation of HHIP 4 0.11 0.5 0.62 9.12
102 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75 6.80
103 INT2544 Localization of PTH 39 0.81 30.55 2.22 5.20
104 INT262133 Negative_regulation of Cyp24a1 1 0.24 0.14 0.04 5.16
105 INT262079 Negative_regulation of Vdr 2 0.42 0.71 0.04 5.16
106 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 5.00
107 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
108 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
109 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 5.00
110 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
111 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
112 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
113 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
114 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 5.00
115 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
116 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
117 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
118 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
119 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
120 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
121 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
122 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
123 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
124 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
125 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
126 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 5.00
127 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
128 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
129 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
130 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 5.00
131 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
132 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
133 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
134 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
135 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
136 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
137 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
138 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
139 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
140 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
141 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
142 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
143 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 5.00
144 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
145 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
146 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
147 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
148 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
149 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
150 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
151 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
152 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
153 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
154 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
155 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
156 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
157 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
158 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
159 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 5.00
160 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
161 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
162 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
163 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
164 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
165 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
166 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
167 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
168 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
169 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
170 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
171 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
172 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
173 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
174 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
175 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
176 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
177 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
178 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 5.00
179 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 5.00
180 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
181 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 5.00
182 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 5.00
183 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89 5.00
184 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 5.00
185 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
186 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
187 INT4535 Localization of PROC 106 0.73 76.24 21.1 5.00
188 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 5.00
189 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
190 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 5.00
191 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
192 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 5.00
193 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 5.00
194 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 5.00
195 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
196 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
197 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
198 INT22068 Binding of CALCRL 53 0.41 6.14 17.32 5.00
199 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
200 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
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