D:Metabolic Disorder

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pChart

Disease Term
Synonyms DISEASE METABOLIC, Diseases Metabolic, DISORDER OF METABOLISM, Generalised Metabolic Disorder, Generalized Metabolic Disorder, Metabolic Disease, METABOLIC DISEASES, METABOLIC DISORDERS, Thesaurismoses, Thesaurismosis
Documents 1030
Hot Single Events 200
Hot Interactions 32

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Metabolic Disorder. They are ordered first by their relevance to Metabolic Disorder and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT240620 Binding of INS and SHBG 4 0.12 3.35 0.15 100.00
2 INT332970 Binding of Ppara and Tmed4 1 0.05 1.91 0.03 98.52
3 INT278250 Binding of PCOS1 and Ins1 1 0.00 1.23 0.04 97.36
4 INT278251 Binding of PCOS1 and Hypism 1 0.00 1.22 0.04 96.84
5 INT225787 Ppi-rs Positive_regulation of Gene_expression of Ank 1 0.06 1.44 0.19 93.60
6 INT238034 Binding of DMD and SNRNP70 1 0.00 1.18 0.04 93.04
7 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03 92.64
8 INT184098 Binding of Il4 and Socs5 1 0.09 2.05 0.15 91.64
9 INT236588 Binding of Esr1 and Ins1 1 0.05 0.73 0.12 91.44
10 INT338988 SULT2A1 Positive_regulation of PPARA 1 0.00 0.42 0.05 91.12
11 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78 90.08
12 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14 90.00
13 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28 89.44
14 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0 88.00
15 INT319735 Positive_regulation of Binding of IL6 and IL8 1 0.01 1.35 0.11 87.48
16 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09 87.16
17 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11 87.08
18 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15 85.76
19 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08 85.76
20 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08 85.76
21 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08 85.76
22 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07 85.76
23 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07 85.76
24 INT184093 Negative_regulation of Il4 Positive_regulation of Stat6 1 0.08 0.93 0 85.32
25 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67 84.80
26 INT291254 MAP3K3 Regulation of Mapk1 1 0.00 1.25 0.29 84.52
27 INT229293 Positive_regulation of FXR1 Positive_regulation of Gene_expression of NR0B2 1 0.02 0.59 0.04 84.36
28 INT291242 Positive_regulation of Mdk Regulation of Mapk1 1 0.03 1.28 0.29 83.96
29 INT236591 Binding of Esr1 and Positive_regulation of Tmed4 1 0.04 0.52 0.05 83.60
30 INT127966 GPT Positive_regulation of SLC17A5 1 0.50 1.81 0.14 81.44
31 INT229329 NR0B2 Negative_regulation of Nr1h2 1 0.03 0.58 0.05 81.44
32 INT159538 SERPINB1 Regulation of Gene_expression of CALCA 1 0.01 0.8 0.45 81.20
33 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15 79.16
34 INT332960 Atp6v1e1 Negative_regulation of Ppara 1 0.18 0.99 0 78.88
35 INT229275 Binding of FXR1 and BAS Negative_regulation of FXR1 1 0.00 0.59 0.05 78.08
36 INT229288 Binding of FXR1 and BAS 1 0.01 0.59 0.05 77.68
37 INT229331 Binding of FXR1 and Nr1h2 1 0.02 0.61 0.05 77.68
38 INT236147 Binding of Ins1 and Ptpn1 2 0.03 1.29 0.05 75.56
39 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0 72.96
40 INT329224 Prkag1 Positive_regulation of Localization of Ins1 1 0.03 1.14 0 68.52
41 INT91391 Crh Regulation of Localization of Gnrh1 2 0.36 1.78 0.61 68.08
42 INT59540 Crh Regulation of Gnrh1 2 0.36 2.61 0.58 68.08
43 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 67.44
44 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29 67.44
45 INT290026 Binding of PPARG and CHDH 1 0.10 6.61 0 67.32
46 INT242035 Binding of SNRNP70 and CHDH 1 0.02 3.41 0.06 67.32
47 INT334901 LDLR Positive_regulation of Crp 1 0.00 1.48 0.51 66.36
48 INT291040 Binding of CFH and INS 1 0.25 1.32 0.08 65.04
49 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05 64.88
50 INT330620 S100a8 Positive_regulation of Positive_regulation of TNF 1 0.03 1.92 0.32 64.72
51 INT136143 Positive_regulation of Binding of Agrp and Hsd11b1 1 0.43 0.56 0.3 63.12
52 INT201512 Binding of PRSS1 and hcp 1 0.09 1.9 0.57 62.36
53 INT136142 Binding of Agrp and Hsd11b1 1 0.33 0.56 0.3 62.20
54 INT329225 Prkag1 Positive_regulation of Akt1 1 0.09 1.27 0.07 61.36
55 INT351332 Positive_regulation of Il4 Positive_regulation of Gene_expression of Il10 1 0.09 1.78 0.53 58.44
56 INT229330 Binding of Nr1h2 and Positive_regulation of Gene_expression of GCK 1 0.01 0.62 0.07 57.92
57 INT229333 Binding of Nr1h2 and Positive_regulation of Gene_expression of SLC2A4 1 0.02 0.62 0.07 57.92
58 INT172824 Positive_regulation of Binding of Tnfsf4 and T2dm2 1 0.00 2.97 0.12 56.36
59 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58 56.16
60 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22 55.88
61 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58 55.52
62 INT290029 Binding of INS and NR1H4 1 0.01 0.47 0 53.20
63 INT290031 Binding of INS and PPARG 1 0.11 0.47 0 53.20
64 INT290025 Binding of INS and PPARD 1 0.03 0.47 0 53.20
65 INT290032 Binding of INS and RXRG 1 0.03 0.47 0 53.20
66 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0 51.80
67 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0 51.80
68 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11 51.00
69 INT239407 Binding of MTTP and PADI1 1 0.23 0.5 0 50.60
70 INT329218 Phosphorylation of Ppara Positive_regulation of Prkag1 1 0.34 0.2 0.05 50.32
71 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44 48.48
72 INT225786 Enpp3 Positive_regulation of Ppi-rs 1 0.00 0.32 0.05 48.12
73 INT350823 Binding of SAA1 and SELS 1 0.17 2.75 0.05 47.28
74 INT290033 Binding of PPARD and NR1H4 1 0.01 0.39 0 47.12
75 INT290027 Binding of PPARG and NR1H4 1 0.03 0.39 0 47.12
76 INT290024 Binding of PPARG and RXRG 1 0.15 0.39 0 46.72
77 INT290023 Binding of PPARD and RXRG 1 0.03 0.39 0 46.72
78 INT225776 Enpp1 Positive_regulation of Positive_regulation of Ppi-rs 1 0.08 1.67 0.28 46.08
79 INT290030 Binding of PPARD and PPARG 1 0.09 0.38 0 44.40
80 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 43.28
81 INT229286 BAS Negative_regulation of FXR1 1 0.02 0.55 0.09 42.44
82 INT229274 BAS Positive_regulation of BAS Negative_regulation of FXR1 1 0.00 0.55 0.09 42.44
83 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37 40.88
84 INT356349 Ins1 Positive_regulation of Lpl 1 0.10 0.45 0 40.68
85 INT238826 Binding of INS and RBP4 1 0.10 2.07 0 39.12
86 INT266659 Binding of MMP9 and MOCS1 1 0.01 1.71 0.94 38.48
87 INT301632 Binding of Dbi and Fabp1 1 0.13 0.49 0.07 36.44
88 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0 35.04
89 INT136141 Hsd11b1 Positive_regulation of Gene_expression of Agrp 1 0.64 0.2 0.47 34.12
90 INT337884 Ins1 Negative_regulation of Gene_expression of Nr2f2 1 0.11 0.08 0.27 32.04
91 INT238825 LTF Regulation of Localization of RBP4 1 0.05 1.08 0.16 30.44
92 INT184131 Binding of Socs6 and Irs2 1 0.11 0.2 0.03 29.84
93 INT184081 Binding of Irs4 and Socs6 1 0.11 0.2 0.03 29.84
94 INT184136 Binding of Socs7 and Irs2 1 0.13 0.15 0.03 29.44
95 INT184118 Binding of Irs4 and Socs7 1 0.13 0.15 0.03 29.44
96 INT334541 Binding of HIVEP1 and TNF 1 0.01 1.32 0.13 29.28
97 INT184101 Binding of Irs2 and Sh2 1 0.05 0.15 0.03 29.20
98 INT184127 Binding of Irs4 and Sh2 1 0.05 0.15 0.03 29.20
99 INT326997 HSD11B1 Negative_regulation of Hdl2 1 0.12 2.06 0 28.72
100 INT326996 HLN2 Negative_regulation of Hdl2 1 0.06 2.05 0 28.72
101 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38 28.52
102 INT303446 Timp1 Negative_regulation of Mmp2 1 0.19 0.33 0.31 27.96
103 INT326979 HLN2 Negative_regulation of JPH3 1 0.02 2.05 0 27.84
104 INT326980 HSD11B1 Negative_regulation of JPH3 1 0.03 2.05 0 27.84
105 INT340292 Ea1 Positive_regulation of Ins1 1 0.04 0.6 0.43 23.56
106 INT229711 Positive_regulation of Nr4a3 Regulation of Ins1 1 0.01 0.29 0.05 23.28
107 INT229712 Nr4a3 Regulation of Ins1 1 0.01 0.29 0.05 23.28
108 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 20.80
109 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 20.80
110 INT236146 Binding of Ppara and Pprc1 1 0.01 0 0.03 20.20
111 INT355687 Art2b Positive_regulation of Gene_expression of Mc3r 1 0.02 1.01 0.48 18.24
112 INT316112 Binding of S100B and SAE1 1 0.05 1.5 0.08 14.24
113 INT340291 Ea1 Regulation of Gene_expression of Ins1 1 0.03 0.62 0.46 14.00
114 INT302712 Binding of Hprt and Hrh1 1 0.25 1.07 0.2 12.64
115 INT302711 Binding of Hrh1 and Spnb4 1 0.18 1.07 0.2 12.64
116 INT236149 Binding of Ncoa1 and Ppara 1 0.07 0 0.03 11.40
117 INT314624 Ex Regulation of GCG 1 0.01 0.67 0 10.72
118 INT314621 Ex Regulation of INS 1 0.06 0.67 0 10.00
119 INT184108 Csf3 Positive_regulation of Mapk1 1 0.09 0.64 0.08 5.92
120 INT329897 PPARA Regulation of Cpt2 1 0.09 0.05 0.07 5.76
121 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
122 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
123 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
124 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
125 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 5.00
126 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78 5.00
127 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 5.00
128 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
129 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49 5.00
130 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4 5.00
131 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18 5.00
132 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11 5.00
133 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1 5.00
134 INT203178 IL18 Positive_regulation of Gene_expression of Lts1 1 0.01 1.98 1.02 5.00
135 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99 5.00
136 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
137 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 1.47 0.94 5.00
138 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89 5.00
139 INT337899 Positive_regulation of MC3R Positive_regulation of Gene_expression of Bdnf 1 0.31 0 0.87 5.00
140 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86 5.00
141 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83 5.00
142 INT309001 Ins1 Positive_regulation of Mmp9 1 0.20 1.96 0.83 5.00
143 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83 5.00
144 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82 5.00
145 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82 5.00
146 INT78348 Binding of GALR1 and GAL 4 0.41 1.47 0.8 5.00
147 INT203164 PTGER2 Regulation of ALOX5 1 0.00 0.9 0.78 5.00
148 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77 5.00
149 INT203171 PTGER2 Negative_regulation of ALOX5 1 0.01 0.89 0.77 5.00
150 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77 5.00
151 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71 5.00
152 INT184125 Il12a Positive_regulation of Stat4 2 0.11 1.04 0.7 5.00
153 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7 5.00
154 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69 5.00
155 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69 5.00
156 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
157 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69 5.00
158 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67 5.00
159 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
160 INT340298 Ea1 Positive_regulation of Ppargc1a 1 0.05 1.03 0.64 5.00
161 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64 5.00
162 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64 5.00
163 INT172825 Binding of Crp and T2dm2 1 0.00 4.5 0.62 5.00
164 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61 5.00
165 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 5.00
166 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6 5.00
167 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59 5.00
168 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58 5.00
169 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57 5.00
170 INT294708 CRP Positive_regulation of Gene_expression of VCAM1 2 0.31 1.92 0.56 5.00
171 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 5.00
172 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53 5.00
173 INT184111 Epo Positive_regulation of Il7 1 0.06 0.26 0.52 5.00
174 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52 5.00
175 INT184088 Epo Positive_regulation of Il2 1 0.07 0.26 0.52 5.00
176 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51 5.00
177 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51 5.00
178 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
179 INT184099 Il4 Positive_regulation of Stat4 1 0.13 0.28 0.49 5.00
180 INT184105 Il6 Positive_regulation of Socs3 2 0.42 1.34 0.48 5.00
181 INT184094 Gene_expression of Socs3 Negative_regulation of Positive_regulation of Il6 1 0.12 1.49 0.48 5.00
182 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 5.00
183 INT184117 Il12a Positive_regulation of Stat6 1 0.07 0.28 0.48 5.00
184 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47 5.00
185 INT303445 Mmp3 Positive_regulation of Mmp9 1 0.01 1.19 0.47 5.00
186 INT203177 Negative_regulation of CPOX Positive_regulation of Gene_expression of Lts1 1 0.00 0.72 0.46 5.00
187 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
188 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46 5.00
189 INT184124 Socs3 Regulation of Il6 1 0.13 1.4 0.43 5.00
190 INT184138 Ik Positive_regulation of Stat3 1 0.01 0.29 0.43 5.00
191 INT198536 Cox11 Negative_regulation of HK1 1 0.22 0.08 0.41 5.00
192 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41 5.00
193 INT203163 LTB4R Regulation of Gene_expression of ALOX5 1 0.00 0.98 0.41 5.00
194 INT340301 Ea1 Positive_regulation of Gene_expression of ACOX1 1 0.01 0.72 0.4 5.00
195 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4 5.00
196 INT184135 Il11ra1 Positive_regulation of Stat3 1 0.20 0.3 0.4 5.00
197 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4 5.00
198 INT238382 Il13 Positive_regulation of Gene_expression of Ppara 1 0.18 0.79 0.4 5.00
199 INT236110 Binding of Ppara and Olfm4 1 0.00 1.22 0.4 5.00
200 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Metabolic Disorder. They are ordered first by their pain relevance and then by number of times they were reported in Metabolic Disorder. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 100.00
2 INT326991 Negative_regulation of Localization of HSD11B1 1 0.29 3.92 0 100.00
3 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85 100.00
4 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 100.00
5 INT165620 Negative_regulation of Gene_expression of HSD11B1 10 0.41 14.52 0.45 100.00
6 INT114081 Positive_regulation of Hpt 4 0.18 1.41 0.09 100.00
7 INT187665 Negative_regulation of Negative_regulation of HSD11B1 2 0.42 2.82 0 100.00
8 INT238041 Binding of OPLL 7 0.27 2.95 0.54 99.98
9 INT122041 Binding of Ppara 308 0.48 189.17 51.48 99.92
10 INT236140 Negative_regulation of Fto 1 0.03 2.42 0.11 99.92
11 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 99.90
12 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 99.90
13 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 99.86
14 INT334998 Positive_regulation of Fgf21 1 0.66 4.8 0.14 99.84
15 INT334987 Positive_regulation of Fgf15 1 0.66 2.32 0.31 99.84
16 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 99.82
17 INT35359 Negative_regulation of LCT 23 0.59 9.13 2.29 99.82
18 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 99.80
19 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 99.80
20 INT181817 Negative_regulation of Gene_expression of Ppara 58 0.58 43.24 7.67 99.80
21 INT317357 Binding of Prkag1 2 0.25 3.23 0.3 99.80
22 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 99.78
23 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.78
24 INT15509 Negative_regulation of HMBS 14 0.58 13.13 2.78 99.78
25 INT110165 Negative_regulation of Arg1 8 0.38 3.21 0.48 99.78
26 INT27527 Negative_regulation of Hal 2 0.42 0.66 0.42 99.78
27 INT28739 Binding of Ins1 35 0.37 22.43 2.14 99.76
28 INT39997 Negative_regulation of Gla 8 0.59 6.38 1.51 99.74
29 INT100202 Negative_regulation of Ggta1 2 0.41 0.9 0.21 99.74
30 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.72
31 INT53343 Positive_regulation of NAMPT 13 0.60 10.94 1.58 99.72
32 INT306951 Positive_regulation of Gene_expression of NAMPT 1 0.60 6.08 0.72 99.72
33 INT138798 Negative_regulation of Pcca 1 0.59 0.67 0.1 99.70
34 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46 99.66
35 INT205607 Regulation of Fgf1 4 0.24 3.34 0.04 99.64
36 INT110299 Negative_regulation of Bpgm 1 0.03 0.33 0.14 99.60
37 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42 99.58
38 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 99.52
39 INT24800 Negative_regulation of AMPD1 44 0.59 21.19 6.76 99.52
40 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 99.46
41 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 99.42
42 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 99.40
43 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 99.38
44 INT36327 Negative_regulation of Acads 4 0.57 1.72 0.52 99.32
45 INT306954 Binding of NAMPT 8 0.36 7.98 0.74 99.32
46 INT306949 Gene_expression of NAMPT 27 0.67 24.47 2.86 99.32
47 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 99.30
48 INT56494 Localization of Ide 73 0.68 22.9 11.26 99.30
49 INT17481 Positive_regulation of Arid4b 2 0.27 0.79 0.22 99.28
50 INT3040 Gene_expression of MIA3 81 0.24 53.61 12.62 99.24
51 INT82918 Binding of AMBP 23 0.39 23.31 1.71 99.10
52 INT73340 Negative_regulation of Faah 134 0.59 38.67 85.03 99.08
53 INT235754 Positive_regulation of Casp4 2 0.42 2.47 0.22 99.04
54 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 98.96
55 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 98.92
56 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04 98.84
57 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 98.80
58 INT812 Localization of INS 1026 0.81 515.6 145.31 98.78
59 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 98.76
60 INT122860 Negative_regulation of HGD 3 0.57 2.03 0.42 98.64
61 INT71003 Regulation of CHRM3 4 0.07 2.03 1.06 98.56
62 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 98.48
63 INT1114 Localization of Ins1 748 0.80 192.95 165.48 98.48
64 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 98.36
65 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 98.28
66 INT110166 Negative_regulation of Negative_regulation of DNAH8 1 0.36 0.36 0.18 98.24
67 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 98.16
68 INT122745 Negative_regulation of TPH1 6 0.59 2.94 1.2 98.16
69 INT111345 Negative_regulation of Cbs 2 0.30 2.82 0.36 98.04
70 INT85297 Positive_regulation of Gene_expression of TNNI3 29 0.50 29.77 1.68 98.04
71 INT115039 Positive_regulation of FMR1 4 0.49 2.26 0.46 98.00
72 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53 97.96
73 INT49377 Negative_regulation of Scd1 11 0.49 9.84 1.88 97.92
74 INT75907 Binding of LEP 53 0.46 46.65 8.44 97.92
75 INT238050 Negative_regulation of OPLL 1 0.21 0.99 0.21 97.92
76 INT217636 Regulation of fa 3 0.05 1.2 0.08 97.86
77 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 97.84
78 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2 97.80
79 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 97.76
80 INT141382 Negative_regulation of ASS1 2 0.57 1.07 0 97.74
81 INT250581 Gene_expression of SELS 4 0.78 47.37 3.27 97.52
82 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 97.40
83 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.36
84 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 97.36
85 INT57360 Gene_expression of STAR 31 0.66 12.72 2.24 97.36
86 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86 97.28
87 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5 97.28
88 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05 97.24
89 INT86437 Binding of IL6 154 0.48 121.22 29.3 97.12
90 INT85947 Regulation of Cckar 2 0.36 2.4 2.86 97.12
91 INT36354 Localization of CTs 26 0.64 20.84 9.31 97.08
92 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 96.96
93 INT8691 Localization of Insr 85 0.80 9.27 30.32 96.92
94 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 96.88
95 INT236152 Negative_regulation of SPAG8 2 0.41 2.24 0.05 96.88
96 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 96.84
97 INT228296 Protein_catabolism of RRAD 1 0.01 0.81 0 96.68
98 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 96.54
99 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68 96.44
100 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5 96.44
101 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 96.40
102 INT207035 Gene_expression of CFB 4 0.63 18.4 1.72 96.40
103 INT96338 Gene_expression of HPSE 17 0.75 18.71 2.73 96.36
104 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 96.32
105 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 96.32
106 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 96.28
107 INT141272 Binding of FAAH 7 0.48 8.27 1.46 96.24
108 INT425 Localization of PRL 455 0.81 189.64 144.8 96.20
109 INT28151 Positive_regulation of CTs 55 0.61 35.09 20.14 96.12
110 INT149485 Regulation of Gene_expression of C3 5 0.60 3.39 0.75 96.04
111 INT207088 Localization of Ptpn1 2 0.35 1.48 0.36 96.00
112 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 95.96
113 INT176173 Positive_regulation of Nr1h2 19 0.52 10.95 1.88 95.92
114 INT23191 Gene_expression of HDLCQ1 13 0.60 14.39 1.58 95.92
115 INT130998 Regulation of PRKAB1 11 0.45 5.7 1.33 95.92
116 INT151583 Regulation of Prkag1 11 0.21 3.68 0.85 95.92
117 INT229277 Positive_regulation of Positive_regulation of Nr1h2 1 0.12 0.54 0.03 95.92
118 INT181185 Localization of Iba1 12 0.49 7.44 1.01 95.76
119 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 95.76
120 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 95.72
121 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 95.68
122 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 95.68
123 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 95.68
124 INT133118 Negative_regulation of FAAH 25 0.59 13.05 9.37 95.64
125 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 95.56
126 INT106745 Localization of CRP 65 0.81 66.44 15.21 95.56
127 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 95.52
128 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 95.48
129 INT136137 Positive_regulation of Gene_expression of Hsd11b1 1 0.60 0.56 0.03 95.24
130 INT136133 Gene_expression of Hsd11b1 1 0.67 0.56 0.03 95.24
131 INT198495 Gene_expression of Ranbp2 1 0.78 3.31 3.14 95.22
132 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14 95.20
133 INT335007 Protein_catabolism of Fgf23 1 0.59 1.28 0.03 95.20
134 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 95.12
135 INT236136 Regulation of Cd5 1 0.00 0.8 0.17 95.08
136 INT73626 Positive_regulation of Gene_expression of PPARG 22 0.70 18.82 4.4 95.00
137 INT188760 Regulation of ZC3H12A 4 0.04 4.02 0.27 95.00
138 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14 94.92
139 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 94.84
140 INT50535 Gene_expression of CA3 25 0.51 9.25 2.89 94.84
141 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 94.80
142 INT110208 Binding of ABR 2 0.35 10.49 0.81 94.72
143 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 94.68
144 INT236130 Regulation of Gm11605 1 0.01 1.58 0.33 94.64
145 INT118372 Regulation of Fgf23 4 0.55 3.31 0.15 94.56
146 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 94.48
147 INT108405 Gene_expression of FAAH 48 0.78 28.22 9.97 94.48
148 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 94.48
149 INT66318 Gene_expression of NR3C1 26 0.76 20 7.55 94.48
150 INT103565 Negative_regulation of Cps1 1 0.13 1.17 0.07 94.44
151 INT219648 Gene_expression of Hd 16 0.27 8.78 0.68 94.40
152 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85 94.36
153 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 94.36
154 INT135880 Positive_regulation of Gene_expression of Fgf23 4 0.46 7.52 0.29 94.36
155 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 94.36
156 INT130082 Regulation of Rxra 6 0.42 3.78 1.96 94.36
157 INT116542 Positive_regulation of Localization of CTS 3 0.43 0.54 0 94.36
158 INT1893 Localization of Gh 1041 0.79 340.23 256.58 94.04
159 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 94.04
160 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 94.00
161 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 93.92
162 INT756 Gene_expression of C3 138 0.75 100.6 19.2 93.76
163 INT222959 Positive_regulation of Gene_expression of PLIN2 2 0.09 0.67 0.08 93.76
164 INT184019 Gene_expression of Socs5 6 0.53 4.94 0.72 93.68
165 INT112003 Localization of ROS1 94 0.73 66.32 12.16 93.64
166 INT171989 Gene_expression of Ank 8 0.78 11.76 4.36 93.60
167 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 93.56
168 INT225758 Localization of Ppi-rs 1 0.08 3.18 0.45 93.48
169 INT225752 Positive_regulation of Localization of Ppi-rs 1 0.05 1.02 0.15 93.48
170 INT95321 Localization of Hcrtr1 4 0.79 14.81 1.66 93.40
171 INT291459 Positive_regulation of Localization of Hcrtr1 1 0.49 1.06 0 93.40
172 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 93.36
173 INT222962 Gene_expression of PLIN2 2 0.10 0.67 0.08 93.36
174 INT152166 Regulation of GALR3 1 0.27 0.94 0.23 93.28
175 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 93.20
176 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 93.20
177 INT163442 Gene_expression of Fgb 1 0.04 2.66 1.2 93.20
178 INT163440 Gene_expression of Fgg 1 0.03 2.65 1.19 93.20
179 INT163438 Gene_expression of Apoa4 1 0.07 1.36 0.59 93.20
180 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 93.12
181 INT57767 Gene_expression of HK1 17 0.30 9.72 3.22 92.92
182 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45 92.92
183 INT198514 Positive_regulation of Gene_expression of HK1 1 0.19 0.33 0.12 92.92
184 INT198515 Regulation of Gene_expression of HK1 1 0.18 0.33 0.12 92.92
185 INT152167 Regulation of GALR2 2 0.44 2.23 1.33 92.88
186 INT171998 Binding of DMD 58 0.47 38.13 3.35 92.76
187 INT174877 Localization of Hras1 4 0.04 0.97 0.2 92.72
188 INT77502 Regulation of GALR1 2 0.27 1.03 0.6 92.60
189 INT198505 Positive_regulation of Gene_expression of Ranbp2 1 0.50 0.49 0.42 92.60
190 INT19394 Negative_regulation of ZMYND10 4 0.42 3.16 0.17 92.60
191 INT198489 Regulation of Gene_expression of Ranbp2 1 0.45 0.33 0.12 92.60
192 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08 92.48
193 INT313838 Gene_expression of Fstl3 1 0.61 1.21 0.06 92.44
194 INT126577 Gene_expression of Ppi-rs 25 0.14 19.1 2.74 92.32
195 INT225757 Positive_regulation of Gene_expression of Ank 1 0.64 4.71 0.75 92.32
196 INT225754 Positive_regulation of Gene_expression of Ppi-rs 1 0.07 3.96 0.66 92.32
197 INT99176 Positive_regulation of Fap 4 0.13 7.5 0.22 92.32
198 INT2442 Localization of Mb 38 0.80 24.74 6.33 92.28
199 INT173703 Positive_regulation of PCOS1 3 0.01 3.76 1.05 92.28
200 INT334997 Localization of Fgf23 1 0.72 3.56 0 92.24
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