D:Metabolic Syndrome

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Disease Term
Synonyms Abdominal Obesity, Addison S Disease, Cushing S Disease, Cushing S Syndrome, Insulin Resistance Syndrome, OBESITY, Syndrome Of Insulin Resistance, SYNDROME X
Documents 944
Hot Single Events 200
Hot Interactions 99

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Metabolic Syndrome. They are ordered first by their relevance to Metabolic Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4 100.00
2 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22 100.00
3 INT351001 Binding of Adh7 and Ins1 1 0.00 1.62 0.05 100.00
4 INT172824 Positive_regulation of Binding of Tnfsf4 and T2dm2 1 0.00 2.97 0.12 100.00
5 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37 100.00
6 INT323019 Binding of PTX3 and Crp 1 0.06 1.17 0.13 100.00
7 INT175909 Binding of ROS1 and CNBP 1 0.01 1.78 0.19 100.00
8 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19 100.00
9 INT172818 Binding of T2dm2 and Hypism 1 0.00 3.62 0.1 100.00
10 INT172835 Binding of AGT and T2dm2 1 0.00 1.73 0 100.00
11 INT172839 Binding of ANGPT2 and T2dm2 1 0.00 1.72 0 100.00
12 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4 100.00
13 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09 100.00
14 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09 100.00
15 INT172833 Binding of FFAR1 and T2dm2 1 0.00 1.55 0 100.00
16 INT240620 Binding of INS and SHBG 4 0.12 3.35 0.15 100.00
17 INT172836 Binding of INS and T2dm2 1 0.00 1.65 0.08 100.00
18 INT157265 PPARG Positive_regulation of PPARA 1 0.22 1.15 0.09 99.96
19 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09 99.96
20 INT172831 Binding of INS and Tnfsf4 1 0.02 1.07 0 99.96
21 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0 99.84
22 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22 99.80
23 INT157274 Adipoq Positive_regulation of ADIPOR1 1 0.00 1.2 0.09 99.44
24 INT157266 PPARA Positive_regulation of ADIPOR1 1 0.00 1.19 0.09 99.12
25 INT332896 Binding of Hdac3 and Ncor1 1 0.31 1.38 0 99.00
26 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09 98.60
27 INT157268 Adipor1 Positive_regulation of Adipor2 1 0.01 0.89 0.08 98.56
28 INT157271 Adipor1 Positive_regulation of PRKAA1 1 0.01 0.89 0.08 98.56
29 INT157272 Adipor1 Positive_regulation of APRT 1 0.12 0.88 0.07 98.56
30 INT300486 LEP Positive_regulation of ROS1 1 0.15 0.91 0.09 98.50
31 INT157264 PPARA Positive_regulation of PRKAA1 1 0.03 0.92 0.08 98.40
32 INT157263 PPARA Positive_regulation of APRT 1 0.54 0.92 0.08 98.40
33 INT157270 PPARA Positive_regulation of Adipor2 1 0.05 0.92 0.08 98.40
34 INT224410 Binding of CRP and CIMT 3 0.42 10.46 1.2 98.08
35 INT258084 Binding of IL6 and Regulation of Gene_expression of INS 1 0.11 0.62 0.05 97.80
36 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22 97.64
37 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2 97.30
38 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2 97.30
39 INT288853 Binding of HSD11B1 and LDLR 1 0.26 1.52 0.04 97.00
40 INT305335 Olfr927-ps1 Negative_regulation of Akr1b3 1 0.02 1.6 0.17 96.96
41 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78 96.04
42 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38 96.04
43 INT240624 Binding of ADIPOQ and Hdl1 1 0.02 0.85 0.1 96.04
44 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14 95.76
45 INT344722 Binding of Lig3 and Chdh 1 0.00 1.48 0 95.04
46 INT344716 Binding of Hdl1 and Chdh 1 0.03 3.24 0 95.04
47 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08 94.28
48 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15 93.86
49 INT305271 Binding of Lep and Obsty1 1 0.06 4.86 0 93.84
50 INT290026 Binding of PPARG and CHDH 1 0.10 6.61 0 93.00
51 INT242035 Binding of SNRNP70 and CHDH 1 0.02 3.41 0.06 93.00
52 INT327808 EPO Regulation of VEGFA 1 0.07 1.36 0.12 92.84
53 INT218615 Negative_regulation of INS Negative_regulation of Gene_expression of IGF1 1 0.33 0.89 0 92.28
54 INT301633 Binding of Ros1 and Cyb5 1 0.00 0.41 0 92.24
55 INT301634 Positive_regulation of Binding of Ros1 and Cyb5 1 0.00 0.41 0 92.24
56 INT332905 Binding of LPL and SNRNP70 1 0.01 1.34 0 92.12
57 INT332943 Binding of SNRNP70 and Adipoq 1 0.00 1.35 0 92.12
58 INT332904 Binding of LEP and SNRNP70 1 0.00 1.34 0 92.12
59 INT242025 Binding of CRP and CHDH 7 0.18 15.72 0.36 91.92
60 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28 90.80
61 INT301621 Ppara Positive_regulation of Gene_expression of Mttp 1 0.22 0.59 0 90.64
62 INT301635 Ppara Positive_regulation of Gene_expression of Fabp1 1 0.26 0.29 0 90.64
63 INT242023 Binding of CHDH and CIMT 1 0.09 1.01 0 90.24
64 INT301620 Positive_regulation of Binding of Ros1 and Scd1 1 0.03 0.41 0 90.08
65 INT301652 Binding of Ros1 and Scd1 1 0.02 0.41 0 90.08
66 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37 88.80
67 INT306794 Binding of LEP and COPD 1 0.15 3.94 0.09 88.00
68 INT332285 Binding of KLRD1 and CRLF1 1 0.00 1.71 0.14 87.64
69 INT253945 Adrm1 Negative_regulation of Hdl1 1 0.00 1.18 0 87.36
70 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28 87.28
71 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 87.28
72 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14 87.28
73 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14 87.28
74 INT253944 Positive_regulation of Prkca Positive_regulation of Gene_expression of Ins1 1 0.01 1.53 0.35 87.12
75 INT270759 Binding of HSD11B1 and TERT 1 0.07 1.67 0 87.08
76 INT332907 Binding of LPL and SUGT1 1 0.00 1.3 0 86.80
77 INT240625 Binding of CRP and Hdlcl1 1 0.01 2.56 0.19 86.68
78 INT172830 INS Positive_regulation of Agtrap 1 0.01 1.17 0 84.84
79 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14 84.52
80 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14 84.52
81 INT172825 Binding of Crp and T2dm2 1 0.00 4.5 0.62 84.28
82 INT305334 Jun Positive_regulation of Gene_expression of Tcstv1 1 0.00 1.04 0.27 84.16
83 INT172822 Binding of Fga and T2dm2 1 0.01 2.24 0.31 83.20
84 INT227339 Binding of TNF and Ins1 1 0.28 4.08 0.31 83.12
85 INT321405 AGT Positive_regulation of MAPK8 1 0.00 0.94 0.03 82.96
86 INT332885 Binding of Ppara and Ppargc1a 1 0.40 0.3 0 82.88
87 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36 82.68
88 INT213390 Positive_regulation of Binding of CHKB and SELPLG 1 0.01 0.46 0 82.52
89 INT213391 Positive_regulation of Binding of CHKB and XPO1 1 0.04 0.46 0 82.52
90 INT301637 Positive_regulation of Ros1 Positive_regulation of Phosphorylation of Ins1 1 0.00 0.91 0.1 82.48
91 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03 82.32
92 INT179492 Binding of Ins1 and Adipoq 1 0.16 1.16 0.23 82.24
93 INT213393 Binding of CHKB and SELPLG 1 0.01 0.46 0 82.00
94 INT213394 Binding of CHKB and XPO1 1 0.03 0.46 0 82.00
95 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03 81.92
96 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15 80.52
97 INT239317 Egfl7 Positive_regulation of Hdl1 2 0.01 2.3 0.14 80.48
98 INT344709 Niacr1 Positive_regulation of Hdl1 1 0.32 2.74 0.46 80.16
99 INT332286 PIK3CD Positive_regulation of MTOR 1 0.14 0.73 0.03 80.04
100 INT197727 Binding of RARA and Positive_regulation of PPARA 1 0.02 0.96 0.05 79.08
101 INT197741 Binding of Rdh5 and Positive_regulation of PPARA 1 0.27 0.95 0.05 79.08
102 INT301657 Binding of Dbi and Ppara 1 0.26 0.23 0 78.28
103 INT301650 Ins1 Positive_regulation of Dbi 1 0.02 0.23 0 78.28
104 INT298993 Il2 Positive_regulation of Gene_expression of Il13 1 0.01 0.73 0.24 78.24
105 INT299003 Il18 Positive_regulation of Gene_expression of Il13 1 0.11 0.73 0.24 78.24
106 INT242022 Negative_regulation of Binding of CRP and CIMT 1 0.33 1.01 0 77.32
107 INT240903 Mapk8 Positive_regulation of Ros1 2 0.09 1.01 0.1 76.96
108 INT235313 Cyp3a23/3a1 Positive_regulation of Ins1 1 0.14 0.82 0.05 76.96
109 INT307698 Binding of Crp and pad 1 0.04 3.71 0.12 76.96
110 INT230818 Ins1 Positive_regulation of Gene_expression of Agt 1 0.07 1.11 0.04 76.88
111 INT230820 Ins1 Positive_regulation of ras 1 0.12 1.1 0.04 76.88
112 INT230817 Ins1 Positive_regulation of Regulation of Agt 1 0.07 1.11 0.04 76.88
113 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 76.00
114 INT353062 HSD11B1 Regulation of Gene_expression of ADIPOQ 1 0.13 5.03 0 75.32
115 INT353061 HSD11B1 Regulation of Gene_expression of LEP 1 0.20 5.03 0 75.32
116 INT301632 Binding of Dbi and Fabp1 1 0.13 0.49 0.07 75.04
117 INT323071 Binding of RT1-DOa and Ppara 1 0.13 0.74 0.09 75.00
118 INT141623 OLR1 Positive_regulation of Gene_expression of TF 1 0.01 1.39 0.21 75.00
119 INT141625 Crp Positive_regulation of Gene_expression of TF 1 0.11 1.39 0.21 75.00
120 INT323056 LDLR Regulation of HSD11B1 1 0.01 1.2 0.05 74.96
121 INT186540 Binding of Cort and Hpse 1 0.05 0.92 0.08 74.40
122 INT250554 Binding of F5 and SELS 1 0.24 1.07 0 73.28
123 INT242024 CRP Regulation of CIMT 1 0.24 0.44 0 72.24
124 INT172829 Binding of Nfkb1 and ISYNA1 1 0.00 2.06 0.17 72.12
125 INT172820 Binding of Nfkb1 and T2dm2 1 0.00 2.14 0.17 72.12
126 INT301638 Ppara Regulation of Slc27a2 1 0.30 0.29 0.14 72.08
127 INT323494 Ghrl Regulation of Ins1 1 0.16 2.12 0.17 71.92
128 INT323486 Ghrl Regulation of Localization of Ins1 1 0.21 2.07 0.07 71.92
129 INT306238 Tead1 Regulation of Ins1 1 0.00 1.04 0.05 71.92
130 INT254747 Positive_regulation of Binding of Skil and Fig4 1 0.03 0.14 0 71.24
131 INT172832 Binding of ROS1 and Renbp 1 0.00 0.83 0.03 71.16
132 INT254746 Binding of Skil and Fig4 1 0.02 0.14 0 70.84
133 INT301496 PPA1 Negative_regulation of CYP4F3 1 0.01 0.69 0.05 70.00
134 INT301497 UBXN11 Negative_regulation of CYP4F3 1 0.37 0.69 0.05 70.00
135 INT348583 MECP2 Regulation of PPARG 1 0.46 0.73 0 69.88
136 INT348591 EZH2 Regulation of Negative_regulation of MECP2 1 0.15 0.73 0 69.88
137 INT348585 EZH2 Regulation of PPARG 1 0.41 0.73 0 69.48
138 INT260600 Binding of Ppargc1a and Siglec1 1 0.14 1.25 0 69.12
139 INT172759 INS Positive_regulation of Localization of REN 1 0.03 0.64 0 67.52
140 INT172828 Iapp Positive_regulation of Localization of REN 1 0.02 0.64 0 66.92
141 INT335607 Binding of INS and TGS1 1 0.04 0.95 0 66.80
142 INT172837 ROS1 Positive_regulation of Nfkb1 1 0.00 2.11 0.16 66.72
143 INT172827 ROS1 Positive_regulation of Tnf 1 0.01 2.1 0.16 66.16
144 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12 64.72
145 INT301177 Gene_expression of UCP2 Positive_regulation of Gene_expression of ROS1 1 0.32 0.98 0 64.48
146 INT151902 PLG Positive_regulation of Protein_catabolism of F13A1 1 0.00 0.16 0 64.48
147 INT355639 OLR1 Positive_regulation of VCAM1 1 0.02 0.57 0 64.40
148 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04 64.32
149 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15 63.04
150 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23 62.72
151 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08 62.16
152 INT301649 Irs1 Negative_regulation of Transcription of G6pc 1 0.05 0.65 0.08 62.16
153 INT319735 Positive_regulation of Binding of IL6 and IL8 1 0.01 1.35 0.11 61.88
154 INT301641 Irs2 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08 61.76
155 INT301628 Irs2 Negative_regulation of Transcription of G6pc 1 0.04 0.65 0.08 61.76
156 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11 61.48
157 INT229371 Positive_regulation of Pparg Negative_regulation of Gene_expression of Edn1 1 0.01 0.92 0.04 61.04
158 INT262619 Gopc Regulation of Gene_expression of ROS1 1 0.01 0.51 0 60.80
159 INT228169 Gm2733 Regulation of Adipoq 1 0.00 0.51 0.05 60.32
160 INT332970 Binding of Ppara and Tmed4 1 0.05 1.91 0.03 60.32
161 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 60.24
162 INT136143 Positive_regulation of Binding of Agrp and Hsd11b1 1 0.43 0.56 0.3 60.24
163 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29 60.24
164 INT136142 Binding of Agrp and Hsd11b1 1 0.33 0.56 0.3 59.32
165 INT355642 OLR1 Positive_regulation of Gene_expression of CCL2 1 0.03 2.85 0 58.64
166 INT355638 OLR1 Positive_regulation of Localization of CCL2 1 0.02 1.42 0 58.64
167 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 58.08
168 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 58.08
169 INT160520 Binding of HSD11B1 and Crp 1 0.02 0.29 0 58.08
170 INT323496 Binding of Rip and Ghsr 1 0.08 0.34 0 57.72
171 INT301619 Positive_regulation of Irs1 Positive_regulation of Gene_expression of Srebf1 1 0.10 0.67 0.08 57.08
172 INT239337 Abca1 Positive_regulation of RCT 1 0.07 3.11 0.24 57.04
173 INT239322 Hdl1 Positive_regulation of RCT 1 0.02 2.16 0.03 57.04
174 INT239333 Abcg1 Positive_regulation of RCT 1 0.06 1.29 0.03 57.04
175 INT239340 Cand1 Positive_regulation of RCT 1 0.11 1.26 0.03 57.04
176 INT252423 Binding of TCIRG1 and SLURP1 1 0.00 0.33 0.16 56.56
177 INT252428 Negative_regulation of Binding of TCIRG1 and SLURP1 1 0.00 0.33 0.16 56.56
178 INT301623 Ins1 Positive_regulation of Slc27a2 1 0.01 0.37 0.07 56.56
179 INT301658 Ins1 Positive_regulation of Slc27a4 1 0.01 0.37 0.07 56.16
180 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81 55.76
181 INT252454 Negative_regulation of Binding of Adora2b and SLURP1 1 0.02 0.33 0.16 55.76
182 INT301656 Ins1 Positive_regulation of Srebf1 1 0.02 0.73 0.07 55.56
183 INT291625 Binding of CSTA and RAPGEF5 1 0.03 4.81 0.37 55.52
184 INT301660 Ppara Regulation of Gene_expression of CYP4A11 1 0.24 0.65 0.09 55.12
185 INT301663 Ppara Regulation of CYP4A11 1 0.14 0.65 0.09 55.12
186 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07 55.08
187 INT239327 Positive_regulation of Binding of Lcat and Hdl1 1 0.06 1.52 0.06 55.04
188 INT239326 Binding of Lcat and Hdl1 1 0.05 1.52 0.06 55.04
189 INT301646 Srebf1 Negative_regulation of Gene_expression of Irs2 1 0.08 0.62 0.08 54.36
190 INT329225 Prkag1 Positive_regulation of Akt1 1 0.09 1.27 0.07 54.16
191 INT172816 Crp Positive_regulation of Transcription of Nos3 1 0.06 0.91 0.1 53.12
192 INT172819 Crp Positive_regulation of Gene_expression of Nos3 1 0.06 0.91 0.1 53.12
193 INT246478 Binding of SERPINE1 and ANGPTL5 1 0.01 1.32 0.1 53.08
194 INT301643 Binding of Dbi and fa 1 0.05 0.45 0.03 53.04
195 INT301622 Binding of Fabp4 and fa 1 0.01 0.45 0.03 53.04
196 INT306241 Ins1 Negative_regulation of Gene_expression of PCK1 1 0.00 0.91 0.08 53.00
197 INT99728 Binding of F13A1 and PLG 4 0.02 2.51 0.63 52.72
198 INT180958 Binding of F13A1 and PLAT 2 0.03 2.16 0.47 52.72
199 INT240769 Positive_regulation of Binding of F13A1 and PLG 1 0.02 0.9 0.04 52.72
200 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 51.60

Single Events

The table below shows the top 200 pain related interactions that have been reported for Metabolic Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Metabolic Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 100.00
2 INT154104 Binding of ARID1B 47 0.39 69.82 1.49 100.00
3 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 100.00
4 INT14572 Binding of INS 205 0.48 175.43 13.38 100.00
5 INT182787 Binding of ETV3 14 0.37 25.44 0.37 100.00
6 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 100.00
7 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
8 INT812 Localization of INS 1026 0.81 515.6 145.31 100.00
9 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 100.00
10 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 100.00
11 INT267698 Gene_expression of ARID1B 18 0.63 20.47 0.47 100.00
12 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 100.00
13 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 100.00
14 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59 100.00
15 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 100.00
16 INT1114 Localization of Ins1 748 0.80 192.95 165.48 100.00
17 INT182788 Gene_expression of ETV3 8 0.40 11.33 0.36 100.00
18 INT182800 Positive_regulation of ETV3 5 0.46 10.01 0.14 100.00
19 INT123466 Binding of T2dm2 21 0.37 34.87 2.91 100.00
20 INT32795 Positive_regulation of Hypism 17 0.15 20.16 1.73 100.00
21 INT167602 Binding of Mbsyd 2 0.14 3 0.31 100.00
22 INT240614 Gene_expression of Etv3 5 0.38 6.1 0.99 100.00
23 INT75907 Binding of LEP 53 0.46 46.65 8.44 100.00
24 INT253873 Positive_regulation of Mbsyd 3 0.14 4.1 0.19 100.00
25 INT45079 Binding of Ahr 21 0.44 10.07 1 100.00
26 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72 100.00
27 INT75908 Regulation of LEP 77 0.60 60.16 15.19 100.00
28 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 100.00
29 INT173208 Binding of CNBP 9 0.25 11.01 1.23 100.00
30 INT28539 Binding of Etv3 7 0.21 3.83 0.74 100.00
31 INT342577 Positive_regulation of Binding of Pth 1 0.34 1.36 0 100.00
32 INT39948 Binding of FLNA 45 0.42 58.05 4.27 100.00
33 INT97777 Positive_regulation of CNBP 7 0.37 9.85 1.09 100.00
34 INT167601 Negative_regulation of Mbsyd 1 0.02 1.2 0.27 100.00
35 INT310271 Localization of Etv3 1 0.43 1.63 0 100.00
36 INT232538 Gene_expression of FAM5C 1 0.77 12.35 0.25 100.00
37 INT174753 Gene_expression of Apoa2 15 0.75 13.82 0.41 100.00
38 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 100.00
39 INT162069 Negative_regulation of Binding of Pth 2 0.30 1.25 0 100.00
40 INT259032 Binding of PEX1 2 0.01 4.67 0.15 100.00
41 INT270747 Negative_regulation of ETV3 2 0.10 2.91 0.04 100.00
42 INT9650 Gene_expression of LPA 141 0.75 104.57 29 100.00
43 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75 100.00
44 INT99550 Regulation of FLNA 51 0.54 27.88 2.58 100.00
45 INT46646 Localization of FLNA 19 0.73 18.83 2.53 100.00
46 INT165621 Negative_regulation of TGS1 4 0.14 4.5 0.72 100.00
47 INT332296 Negative_regulation of Gene_expression of ETV3 1 0.25 0.65 0.04 100.00
48 INT8027 Regulation of Gene_expression of Ngf 34 0.62 26.32 31.16 100.00
49 INT64713 Regulation of Gene_expression of Ngfr 4 0.50 2.04 1.36 100.00
50 INT147098 Gene_expression of ECA1 4 0.15 2.83 0.48 100.00
51 INT258192 Gene_expression of Mbsyd 1 0.07 0.73 0 100.00
52 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 99.96
53 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 99.96
54 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.96
55 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 99.96
56 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 99.96
57 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 99.96
58 INT113149 Gene_expression of Tmprss11d 15 0.75 8.51 2.72 99.96
59 INT344695 Positive_regulation of Tgs1 1 0.02 1.86 0 99.96
60 INT301612 Negative_regulation of CYP4A11 1 0.36 1.15 0.07 99.96
61 INT1893 Localization of Gh 1041 0.79 340.23 256.58 99.92
62 INT24332 Regulation of Hdl1 28 0.45 45.45 4.26 99.92
63 INT61116 Positive_regulation of Ppara 119 0.69 58.62 21.6 99.92
64 INT65356 Localization of LEP 46 0.79 41.17 5.43 99.92
65 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 99.92
66 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 99.92
67 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 99.92
68 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 99.92
69 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 99.92
70 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 99.92
71 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 99.92
72 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46 99.88
73 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 99.88
74 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15 99.88
75 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 99.88
76 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 99.88
77 INT166021 Positive_regulation of MCL1 36 0.67 62.97 1.44 99.86
78 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.84
79 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81 99.84
80 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 99.84
81 INT227273 Localization of Adipoq 22 0.72 18.04 1.72 99.84
82 INT112626 Positive_regulation of Cts 5 0.59 8.03 4.59 99.84
83 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59 99.84
84 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 99.84
85 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 99.84
86 INT227337 Gene_expression of NAFLD2 7 0.05 10.98 0.83 99.84
87 INT332299 Negative_regulation of Gene_expression of IRS1 1 0.31 0.65 0.04 99.84
88 INT4146 Binding of SHBG 49 0.47 31 4.71 99.82
89 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 99.80
90 INT306954 Binding of NAMPT 8 0.36 7.98 0.74 99.80
91 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 99.78
92 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.78
93 INT62570 Binding of Pth 48 0.48 26.45 4.85 99.76
94 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 99.76
95 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03 99.76
96 INT334924 Binding of MEHMO 1 0.01 9.69 0.26 99.76
97 INT187411 Gene_expression of Cd320 23 0.75 12.1 1.39 99.76
98 INT139804 Binding of PTX3 6 0.48 7.42 1.21 99.76
99 INT239215 Binding of Agt 9 0.38 6.75 1.35 99.76
100 INT172785 Positive_regulation of Binding of Tnfsf4 1 0.05 2.89 0.12 99.76
101 INT172800 Binding of Tnfsf4 2 0.04 4.58 0.45 99.76
102 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 99.76
103 INT130700 Gene_expression of HSPA5 16 0.75 11.55 2.81 99.76
104 INT27077 Binding of CD36 4 0.37 2.14 0.72 99.76
105 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 99.74
106 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 99.74
107 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 99.74
108 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 99.72
109 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 99.72
110 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96 99.72
111 INT213154 Positive_regulation of Binding of TIMP1 2 0.41 1.33 0.55 99.72
112 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53 99.70
113 INT100861 Binding of CRP 179 0.48 175.2 26.45 99.68
114 INT170385 Regulation of Clock 29 0.49 4.95 6.39 99.68
115 INT172783 Regulation of Localization of Serpine1 3 0.30 3.83 0.32 99.68
116 INT309804 Gene_expression of Olr1603-ps 1 0.06 10.52 0 99.68
117 INT309812 Positive_regulation of Gene_expression of Olr1603-ps 1 0.05 3.72 0 99.68
118 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15 99.68
119 INT15772 Negative_regulation of Hdlcl1 17 0.41 15.77 1.45 99.68
120 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 99.64
121 INT1530 Regulation of Gh 382 0.61 115.96 112.47 99.64
122 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 99.64
123 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62 99.64
124 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 99.62
125 INT156201 Negative_regulation of Gene_expression of MTOR 6 0.58 7.7 0.36 99.62
126 INT214 Localization of AVP 370 0.81 208.51 91.09 99.62
127 INT228294 Binding of RRAD 2 0.00 2.55 0 99.62
128 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.60
129 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 99.60
130 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 99.60
131 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 99.60
132 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16 99.60
133 INT66646 Regulation of Chdh 13 0.44 16.24 8.84 99.60
134 INT61540 Negative_regulation of Gene_expression of Ngfr 11 0.59 6.36 3.43 99.58
135 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39 99.56
136 INT1631 Binding of Hdl1 42 0.36 49.22 2.92 99.56
137 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 99.56
138 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85 99.56
139 INT317357 Binding of Prkag1 2 0.25 3.23 0.3 99.54
140 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 99.54
141 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07 99.52
142 INT28739 Binding of Ins1 35 0.37 22.43 2.14 99.52
143 INT16608 Positive_regulation of FFAR1 40 0.37 18.48 3.59 99.52
144 INT91338 Binding of Lep 31 0.48 26.86 5.39 99.52
145 INT251 Regulation of INS 398 0.62 232.47 55.04 99.48
146 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 99.48
147 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 99.48
148 INT136488 Regulation of LMNA 13 0.60 3.53 0.2 99.48
149 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 99.46
150 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42 99.44
151 INT309810 Gene_expression of Tmem150a 1 0.07 10.26 0 99.40
152 INT309813 Positive_regulation of Gene_expression of Tmem150a 1 0.05 3.71 0 99.40
153 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 99.38
154 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 99.38
155 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47 99.36
156 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 99.36
157 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 99.32
158 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 99.32
159 INT250645 Gene_expression of Samsn1 6 0.33 9.95 0.86 99.32
160 INT74614 Positive_regulation of Apoa1 16 0.68 23.95 5.04 99.32
161 INT94285 Negative_regulation of CD36 10 0.43 6.61 1.98 99.32
162 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.30
163 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 99.30
164 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.30
165 INT198052 Positive_regulation of Gene_expression of MCL1 19 0.48 24.19 0.47 99.28
166 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 99.28
167 INT31582 Gene_expression of Hdl1 103 0.66 118.95 6.42 99.28
168 INT197173 Positive_regulation of Cyp4a10 29 0.62 15.68 1.61 99.28
169 INT239303 Positive_regulation of Gene_expression of Hdl1 8 0.36 12.46 0.53 99.28
170 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 99.24
171 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84 99.24
172 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 99.20
173 INT37544 Binding of ANGPT2 9 0.19 6.51 0.69 99.20
174 INT31778 Negative_regulation of Adrb2 2 0.07 1.34 0.72 99.20
175 INT23188 Localization of Serpine1 22 0.79 16.06 1.96 99.16
176 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 99.16
177 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43 99.12
178 INT227944 Binding of EDAR 5 0.25 2.88 0.07 99.12
179 INT227457 Positive_regulation of Gene_expression of CIMT 9 0.15 3.19 0.54 99.10
180 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8 99.06
181 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 99.04
182 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 99.04
183 INT179481 Positive_regulation of Wdtc1 8 0.67 7.11 0.71 99.04
184 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75 99.04
185 INT102377 Binding of GHS 4 0.22 2.62 0.7 99.04
186 INT249049 Positive_regulation of ARID1B 14 0.56 24.77 0.71 99.00
187 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 99.00
188 INT3214 Localization of Ins1 527 0.80 196.9 79.26 99.00
189 INT265371 Binding of Hdac3 2 0.27 0.94 0 99.00
190 INT332842 Binding of Ncor1 1 0.36 0.91 0 99.00
191 INT139803 Gene_expression of PTX3 22 0.75 26.21 5.07 98.98
192 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 98.96
193 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 98.90
194 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 98.90
195 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67 98.88
196 INT129425 Negative_regulation of Ldlr 22 0.42 17.15 0.97 98.88
197 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 98.88
198 INT232235 Negative_regulation of Gene_expression of Ldlr 3 0.42 3.13 0.34 98.88
199 INT235635 Negative_regulation of Phosphorylation of IRS1 7 0.37 3.78 0.42 98.86
200 INT332297 Negative_regulation of Binding of MTOR 2 0.40 1.6 0.18 98.86
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