D:Methemoglobinemia

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Disease Term
Synonyms Blue Baby Syndrome, Methemoglobinaemia, Methemoglobinemias
Documents 218
Hot Single Events 23
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Methemoglobinemia. They are ordered first by their relevance to Methemoglobinemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT168010 Asap1 Positive_regulation of HBG2 1 0.01 3.03 1.82 96.04
2 INT49398 Positive_regulation of Binding of SHB and MHB 1 0.36 0.15 0.6 75.00
3 INT49397 Binding of SHB and MHB 1 0.27 0.15 0.6 75.00
4 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38 5.00
5 INT273616 PVR Positive_regulation of Pah 1 0.10 0.86 0.07 5.00
6 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0 5.00
7 INT256209 AVP Regulation of PVR 1 0.06 0.99 0 5.00
8 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Methemoglobinemia. They are ordered first by their pain relevance and then by number of times they were reported in Methemoglobinemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 99.90
2 INT28521 Gene_expression of HBG2 56 0.77 16.62 8.64 99.84
3 INT22431 Negative_regulation of HBG2 20 0.58 6.6 3.33 99.60
4 INT4046 Positive_regulation of HBG2 42 0.69 13.66 8.51 99.60
5 INT63043 Positive_regulation of Gene_expression of HBG2 6 0.48 1.75 0.26 99.40
6 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 99.38
7 INT39699 Negative_regulation of Positive_regulation of RYBP 11 0.41 3.73 10.42 99.10
8 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 98.84
9 INT22967 Positive_regulation of RYBP 94 0.56 37.04 85.92 98.48
10 INT30644 Positive_regulation of Localization of RYBP 6 0.58 0.93 5.43 98.48
11 INT2021 Binding of HBG2 13 0.36 4.2 2.65 98.44
12 INT4656 Localization of RYBP 49 0.77 5.28 46.21 98.12
13 INT3703 Negative_regulation of Grhpr 38 0.50 11.43 9.2 97.64
14 INT37863 Regulation of HBG2 11 0.61 3.95 4.34 96.44
15 INT298578 Negative_regulation of CYB5R3 1 0.25 0.47 0.1 94.00
16 INT50453 Regulation of Gene_expression of HBG2 6 0.45 1.6 0.86 92.00
17 INT194298 Gene_expression of DHPS 1 0.62 8.84 0.37 90.72
18 INT36779 Localization of HBG2 3 0.59 1.57 2 88.88
19 INT194530 Gene_expression of UOX 17 0.65 11.78 0.17 88.80
20 INT36451 Gene_expression of G6PD 26 0.75 7.2 1.09 86.96
21 INT131820 Binding of Gpr75 1 0.02 0.49 0.09 86.88
22 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 84.28
23 INT34767 Gene_expression of PTGIR 36 0.42 14.79 6.69 82.80
24 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 79.68
25 INT194299 Binding of DHPS 1 0.39 2.22 0.17 76.80
26 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64 76.68
27 INT11837 Positive_regulation of MHB 8 0.69 1.07 5.55 75.00
28 INT11838 Gene_expression of MHB 3 0.52 0.38 1.2 75.00
29 INT75279 Binding of Cyb5 2 0.33 0.26 0.05 75.00
30 INT11836 Regulation of MHB 2 0.23 0.07 1.67 75.00
31 INT11834 Negative_regulation of MHB 1 0.42 0.07 0.58 75.00
32 INT49400 Gene_expression of SHB 2 0.63 0.38 0.56 75.00
33 INT11835 Binding of MHB 1 0.35 0.07 0.4 75.00
34 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 74.24
35 INT68589 Gene_expression of Cacna1c 14 0.58 6.36 0.69 71.64
36 INT14502 Gene_expression of BCHE 40 0.67 18.52 4.6 71.48
37 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 69.60
38 INT546 Binding of ALB 311 0.48 85.98 60.14 67.88
39 INT103095 Binding of ISYNA1 10 0.28 6.17 2.03 63.68
40 INT194533 Binding of UOX 2 0.47 3.86 0.2 60.16
41 INT341394 Negative_regulation of Gene_expression of HBG2 1 0.41 0.14 0 58.56
42 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 47.76
43 INT216262 Gene_expression of CYGB 2 0.43 2.18 0.03 47.32
44 INT9660 Regulation of TNF 363 0.62 312.94 139.99 43.60
45 INT273613 Negative_regulation of PVR 7 0.17 5.06 1.26 41.44
46 INT7207 Regulation of HBG1 27 0.60 22.1 1.12 35.96
47 INT205651 Localization of FUS 4 0.36 4.15 0.31 34.80
48 INT18025 Binding of Pah 32 0.45 30.72 7.93 32.12
49 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 31.56
50 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 25.04
51 INT19286 Negative_regulation of Cacna1c 11 0.46 5.12 2.22 25.04
52 INT95576 Gene_expression of GUCY2C 4 0.42 1.78 0.21 25.04
53 INT273620 Positive_regulation of Gene_expression of GUCY2C 1 0.01 1.48 0 25.04
54 INT273619 Negative_regulation of Gene_expression of GUCY2C 1 0.01 0.79 0 25.04
55 INT183450 Positive_regulation of GUCY2C 6 0.04 4.45 1.88 22.56
56 INT216261 Regulation of Gene_expression of Cacna1c 3 0.25 1.12 0.15 20.64
57 INT216263 Regulation of Gene_expression of BCHE 1 0.44 0.6 0.04 20.64
58 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 13.20
59 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25 8.88
60 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
61 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 5.00
62 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
63 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
64 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
65 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
66 INT7894 Negative_regulation of Vip 59 0.59 11.76 27.36 5.00
67 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9 5.00
68 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 5.00
69 INT79349 Gene_expression of Sert1 58 0.77 12.7 20.65 5.00
70 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
71 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
72 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
73 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38 5.00
74 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
75 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
76 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 5.00
77 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 5.00
78 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 5.00
79 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
80 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68 5.00
81 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 5.00
82 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71 5.00
83 INT13435 Positive_regulation of RTCA 31 0.60 7.19 8.5 5.00
84 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 5.00
85 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17 5.00
86 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 5.00
87 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 5.00
88 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37 5.00
89 INT19541 Gene_expression of Ptgir 22 0.65 15.42 5.39 5.00
90 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
91 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76 5.00
92 INT3530 Regulation of BCHE 18 0.60 5.47 4.12 5.00
93 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 5.00
94 INT72798 Binding of ADA 12 0.47 7.84 3.39 5.00
95 INT79345 Positive_regulation of Gene_expression of Sert1 8 0.58 2.98 3.26 5.00
96 INT127455 Positive_regulation of Gene_expression of Slc6a4 9 0.59 5.62 3.2 5.00
97 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06 5.00
98 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 5.00
99 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86 5.00
100 INT29651 Regulation of Pah 11 0.37 9.95 2.79 5.00
101 INT56376 Negative_regulation of AMBP 29 0.35 21.49 2.59 5.00
102 INT257299 Binding of Pde5a 14 0.27 4.31 2.45 5.00
103 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22 5.00
104 INT9254 Negative_regulation of LDHA 23 0.43 13.3 2.2 5.00
105 INT78177 Negative_regulation of Gene_expression of Ednrb 4 0.41 1.04 2.16 5.00
106 INT10976 Negative_regulation of ENPP3 13 0.42 5.11 1.92 5.00
107 INT47885 Gene_expression of Max 5 0.65 0.54 1.84 5.00
108 INT82918 Binding of AMBP 23 0.39 23.31 1.71 5.00
109 INT119346 Positive_regulation of PTGIR 9 0.58 6.2 1.61 5.00
110 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58 5.00
111 INT35132 Gene_expression of PDAP1 18 0.52 9.05 1.5 5.00
112 INT31403 Positive_regulation of AFM 3 0.29 5.57 1.38 5.00
113 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 5.00
114 INT7991 Gene_expression of SPANXA1 8 0.67 3.41 1.2 5.00
115 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17 5.00
116 INT15746 Negative_regulation of PDAP1 13 0.52 6.45 1.12 5.00
117 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 5.00
118 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 5.00
119 INT129971 Regulation of PVR 5 0.60 3.96 0.97 5.00
120 INT213722 Positive_regulation of PVR 3 0.25 2.4 0.94 5.00
121 INT36978 Localization of Pah 9 0.73 7.43 0.82 5.00
122 INT128889 Regulation of Gene_expression of Ptgir 3 0.51 2.38 0.81 5.00
123 INT30314 Negative_regulation of Ptgir 3 0.34 1.08 0.76 5.00
124 INT225056 Positive_regulation of Gene_expression of AMBP 4 0.37 5.45 0.75 5.00
125 INT22385 Positive_regulation of Ptgir 8 0.41 5.16 0.71 5.00
126 INT168502 Positive_regulation of FUS 3 0.39 9.22 0.59 5.00
127 INT179373 Localization of XDH 3 0.20 1.97 0.54 5.00
128 INT126442 Negative_regulation of Gene_expression of Ednra 3 0.33 1.94 0.51 5.00
129 INT179214 Binding of AMIGO2 4 0.32 3.9 0.35 5.00
130 INT162847 Negative_regulation of SPANXA1 2 0.30 1.3 0.34 5.00
131 INT449 Localization of PDAP1 4 0.66 2.29 0.33 5.00
132 INT261239 Binding of XDH 10 0.34 3.16 0.31 5.00
133 INT45342 Binding of AVSD1 6 0.31 7.23 0.27 5.00
134 INT241467 Negative_regulation of Impdh1 1 0.01 1.45 0.27 5.00
135 INT273611 Positive_regulation of Localization of Pah 1 0.40 0.75 0.24 5.00
136 INT273610 Positive_regulation of Positive_regulation of PVR 1 0.14 1.15 0.23 5.00
137 INT101742 Regulation of Cacna1c 3 0.22 1.35 0.23 5.00
138 INT241468 Binding of Dhfr 2 0.13 1.41 0.17 5.00
139 INT205654 Gene_expression of FUS 9 0.32 11.53 0.16 5.00
140 INT286439 Regulation of Myl3 3 0.26 1.43 0.16 5.00
141 INT223026 Regulation of XDH 2 0.32 2.38 0.15 5.00
142 INT242346 Negative_regulation of Positive_regulation of PDAP1 2 0.45 2.43 0.15 5.00
143 INT205657 Negative_regulation of FUS 3 0.21 6.61 0.14 5.00
144 INT273614 Regulation of PVR 1 0.17 0.84 0.14 5.00
145 INT273612 Negative_regulation of Gene_expression of Ptgir 1 0.05 0.65 0.13 5.00
146 INT132392 Negative_regulation of UOX 3 0.43 1.37 0.13 5.00
147 INT205653 Negative_regulation of Localization of FUS 1 0.10 1.23 0.12 5.00
148 INT168503 Binding of FUS 5 0.29 5.12 0.12 5.00
149 INT184790 Positive_regulation of Gene_expression of Ptgir 3 0.04 2.57 0.12 5.00
150 INT205652 Localization of UOX 1 0.50 1.74 0.06 5.00
151 INT205656 Regulation of UOX 2 0.44 1.3 0.04 5.00
152 INT205998 Binding of PDAP1 3 0.33 2.66 0.03 5.00
153 INT194532 Positive_regulation of UOX 3 0.35 0.78 0.03 5.00
154 INT211830 Binding of PVR 3 0.32 2.26 0.03 5.00
155 INT279226 Regulation of FUS 1 0.21 0.83 0.03 5.00
156 INT205655 Negative_regulation of Binding of UOX 1 0.41 0.06 0 5.00
157 INT279225 Positive_regulation of Gene_expression of UOX 1 0.02 0.52 0 5.00
158 INT162846 Negative_regulation of Gene_expression of SPANXA1 1 0.30 0 0 5.00
159 INT205650 Phosphorylation of UOX 2 0.54 1.11 0 5.00
160 INT341395 Regulation of Negative_regulation of HBG2 1 0.26 0 0 5.00
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