D:Mevalonate Kinase Deficiency

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Disease Term
Synonyms Aciduria Mevalonic, Hyper Igd Syndrome, Hyper Igd Syndromes, Hyperimmunoglobulinemia D, KINASE DEFICIENCIES MEVALONATE, Kinase Deficiency Mevalonate, MEVALONATE KINASE DEFICIENCIES, MEVALONIC ACIDURIA, Periodic Fever Dutch Type, Syndrome Hyper Igd, SYNDROMES HYPER IGD
Documents 14
Hot Single Events 65
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mevalonate Kinase Deficiency. They are ordered first by their relevance to Mevalonate Kinase Deficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT326383 Binding of Rhoa and Gopc 2 0.04 0.89 0 100.00
2 INT334472 Gopc Regulation of Positive_regulation of Rhoa 1 0.02 0.3 0 95.72
3 INT334469 Gopc Regulation of Localization of Rhoa 1 0.02 0.3 0 95.72
4 INT334474 PGGT1B Regulation of Localization of Rac1 1 0.03 0.47 0 95.32
5 INT334473 PGGT1B Regulation of Localization of Rhoa 1 0.04 0.47 0 95.32
6 INT334468 Rhoa Regulation of Localization of Rac1 1 0.25 0.18 0 95.32
7 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0 92.56
8 INT334471 Arhgdia Negative_regulation of Cdc42ep3 1 0.00 0 0 47.44
9 INT333476 IL12B Positive_regulation of Localization of AFP 1 0.03 0.26 0.57 5.00
10 INT333477 CXCL10 Positive_regulation of TH1L 1 0.14 0.32 0.56 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mevalonate Kinase Deficiency. They are ordered first by their pain relevance and then by number of times they were reported in Mevalonate Kinase Deficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 100.00
2 INT57958 Positive_regulation of Myo5a 9 0.41 7.52 0.77 100.00
3 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 100.00
4 INT90213 Negative_regulation of Mvk 3 0.05 6.28 0.59 100.00
5 INT192784 Positive_regulation of Gene_expression of Myo5a 2 0.45 3.39 0.04 100.00
6 INT334446 Regulation of Mvk 1 0.29 1.37 0.18 100.00
7 INT160258 Negative_regulation of Myo5a 3 0.35 3.96 0.09 100.00
8 INT192785 Regulation of Myo5a 4 0.05 9.05 0.93 100.00
9 INT192783 Phosphorylation of Myo5a 1 0.04 2.01 0.12 100.00
10 INT170444 Binding of Gopc 172 0.39 45.05 20.71 100.00
11 INT114993 Binding of Myo5a 15 0.30 11.46 5.48 100.00
12 INT264629 Localization of Rac1 8 0.72 5.7 0.79 99.92
13 INT228103 Positive_regulation of Rac1 25 0.67 18.92 0.57 99.84
14 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92 99.84
15 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22 99.84
16 INT67174 Negative_regulation of Rac1 22 0.56 10.72 0.99 99.84
17 INT284357 Gene_expression of Mvk 2 0.38 1.78 0 99.84
18 INT334443 Positive_regulation of Positive_regulation of Rac1 1 0.33 1.1 0.08 99.84
19 INT334464 Positive_regulation of PGGT1B 1 0.03 0.37 0 99.84
20 INT180419 Regulation of Positive_regulation of Rhoa 2 0.39 0.9 0.04 99.80
21 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02 99.48
22 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17 99.48
23 INT284359 Negative_regulation of Mvk 4 0.37 6.62 0.99 99.48
24 INT116903 Negative_regulation of Hmgcr 32 0.43 10.71 1.3 99.44
25 INT317823 Positive_regulation of Negative_regulation of Mvk 2 0.30 3.33 0.62 99.24
26 INT284362 Positive_regulation of Mvk 3 0.44 3.32 0.46 99.22
27 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 99.18
28 INT180418 Binding of Rhoa 16 0.32 7.05 0.2 99.16
29 INT16012 Binding of Rac1 17 0.37 6.9 0.53 99.16
30 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98 99.16
31 INT180420 Negative_regulation of Gene_expression of Rhoa 3 0.37 1.65 0.55 99.16
32 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 99.04
33 INT334440 Negative_regulation of Transcription of Mvk 1 0.27 2.18 0.33 98.98
34 INT192791 Negative_regulation of MVK 3 0.16 5.64 0.25 98.84
35 INT184484 Positive_regulation of Cdc42ep3 5 0.02 5.16 0.77 98.80
36 INT334449 Transcription of Mvk 1 0.44 2.18 0.33 98.78
37 INT334438 Positive_regulation of Localization of Rac1 1 0.33 2.37 0 98.48
38 INT334445 Regulation of Positive_regulation of Rac1 1 0.40 1.73 0.04 98.48
39 INT334450 Regulation of Localization of Rac1 1 0.30 0.65 0 98.48
40 INT334441 Regulation of Localization of Rhoa 1 0.33 0.88 0 98.42
41 INT146196 Localization of Rhoa 6 0.78 4.68 2.3 98.22
42 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84 98.22
43 INT200874 Positive_regulation of Localization of Gopc 27 0.38 5.69 7.5 97.96
44 INT173693 Localization of Gopc 249 0.65 70.49 38.81 97.96
45 INT182749 Binding of Hmgcr 3 0.32 0.55 0.22 97.42
46 INT334452 Localization of Cdc42ep3 1 0.01 1.2 0.12 97.40
47 INT250545 Regulation of Hmgcr 5 0.11 4.94 0.23 97.00
48 INT17417 Positive_regulation of Ighd 16 0.69 24.29 2.8 95.72
49 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 95.72
50 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 95.72
51 INT192786 Positive_regulation of Gene_expression of Ighd 2 0.11 2.26 0.05 95.72
52 INT334467 Positive_regulation of Gene_expression of PGGT1B 1 0.04 0.3 0 95.52
53 INT334465 Gene_expression of PGGT1B 1 0.06 0.3 0 95.52
54 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48 95.32
55 INT302613 Positive_regulation of Gene_expression of Rac1 14 0.67 3.7 0.08 95.28
56 INT203688 Positive_regulation of Hmgcr 10 0.17 6.08 0.52 93.08
57 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5 90.36
58 INT6849 Localization of IL1B 229 0.81 112.56 69.63 84.24
59 INT78480 Localization of Nfkb1 39 0.80 23.14 13.64 84.24
60 INT116552 Positive_regulation of Localization of Nfkb1 16 0.61 12.7 7.74 84.24
61 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12 84.24
62 INT156269 Regulation of Localization of Nfkb1 1 0.00 1.53 0.1 84.24
63 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 81.04
64 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35 81.04
65 INT65538 Regulation of Positive_regulation of Nfkb1 17 0.51 8.31 6.5 81.04
66 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 78.56
67 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 75.00
68 INT57545 Positive_regulation of Positive_regulation of Ighd 1 0.15 1.78 0.24 75.00
69 INT117980 Regulation of Rac1 10 0.45 3.72 1.88 73.48
70 INT180415 Regulation of Rhoa 7 0.53 3.92 0.22 73.48
71 INT334466 Binding of PGGT1B 1 0.03 0.18 0 63.52
72 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 59.24
73 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68 51.20
74 INT117735 Positive_regulation of Regulation of Nfkb1 3 0.44 2.93 0.91 51.20
75 INT52529 Regulation of Nfkb1 48 0.61 26.2 20.89 50.72
76 INT95286 Regulation of Localization of Nfkb1 6 0.60 3.82 0.71 50.72
77 INT117736 Regulation of Localization of Il1b 1 0.02 1.33 0.18 50.72
78 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 50.16
79 INT48081 Localization of Il1b 46 0.80 21.59 22.4 47.44
80 INT334457 Binding of Arhgdia 1 0.03 0 0 41.20
81 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
82 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
83 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
84 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
85 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
86 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
87 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
88 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
89 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
90 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
91 INT52722 Localization of RETNLB 54 0.38 48.63 27.98 5.00
92 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
93 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
94 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 5.00
95 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
96 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
97 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
98 INT137181 Gene_expression of CXCL9 25 0.65 13.09 9.56 5.00
99 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 5.00
100 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 5.00
101 INT92234 Regulation of CXCL10 15 0.42 8.37 5.09 5.00
102 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 5.00
103 INT25464 Binding of SAA1 11 0.42 6.89 3.72 5.00
104 INT174477 Negative_regulation of IL7 11 0.47 10.35 3.69 5.00
105 INT155011 Negative_regulation of IL17A 8 0.54 6.43 3.64 5.00
106 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54 5.00
107 INT176386 Positive_regulation of Gene_expression of TH1L 14 0.32 9.17 3.4 5.00
108 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1 5.00
109 INT92648 Positive_regulation of IL12B 7 0.20 4.55 2.19 5.00
110 INT226492 Negative_regulation of IL13 11 0.28 7.17 2.04 5.00
111 INT24453 Binding of NLRP3 18 0.48 13.7 1.93 5.00
112 INT322198 Positive_regulation of AMCN 13 0.43 7.79 1.73 5.00
113 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56 5.00
114 INT43019 Regulation of PHGDH 4 0.26 2.46 1.53 5.00
115 INT160606 Localization of AFP 6 0.74 3.39 1.29 5.00
116 INT226444 Negative_regulation of CCL11 3 0.41 2.32 1.12 5.00
117 INT192761 Positive_regulation of Gene_expression of SAA1 5 0.40 7.45 0.82 5.00
118 INT24029 Regulation of AFP 7 0.44 6.45 0.51 5.00
119 INT333486 Negative_regulation of SPAG17 1 0.00 0.65 0.47 5.00
120 INT333489 Negative_regulation of PRSS21 1 0.01 2.7 0.36 5.00
121 INT61611 Positive_regulation of ANC 17 0.41 4.43 0.31 5.00
122 INT194049 Positive_regulation of Binding of CRP 3 0.48 4.48 0.24 5.00
123 INT333490 Localization of PRSS21 1 0.02 4.07 0.16 5.00
124 INT191794 Positive_regulation of ALLC 3 0.11 2.16 0.16 5.00
125 INT333485 Transcription of PRSS21 1 0.01 3.57 0.15 5.00
126 INT333484 Negative_regulation of ALLC 1 0.11 0.71 0.15 5.00
127 INT333488 Positive_regulation of Positive_regulation of AMCN 1 0.25 1.14 0.04 5.00
128 INT333492 Positive_regulation of Positive_regulation of ANC 1 0.19 1.14 0.04 5.00
129 INT333491 Positive_regulation of Binding of SAA1 1 0.29 1.05 0.04 5.00
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