D:Microcephaly

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Disease Term
Synonyms Microcephalies
Documents 77
Hot Single Events 42
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Microcephaly. They are ordered first by their relevance to Microcephaly and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT317900 Binding of NCAPH2 and MCPH1 1 0.02 0.53 0 84.52
2 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15 72.48
3 INT35363 Binding of GH1 and GHRH 2 0.36 0.94 0.36 63.28
4 INT78445 Binding of GHRH and IGF1 1 0.20 0.72 0.06 63.28
5 INT234800 RAB27A Positive_regulation of INS 1 0.02 1.26 0 52.12
6 INT234793 RAB27A Positive_regulation of Localization of INS 1 0.03 1.26 0 52.12
7 INT35157 GH1 Regulation of GHRH 3 0.17 0.5 0.99 25.00
8 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 25.00
9 INT78446 Binding of GH1 and IGFBP3 1 0.11 0.48 0.1 25.00
10 INT234831 Binding of SPTLC1 and Abo 1 0.00 1.61 0.23 23.28
11 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07 17.12
12 INT234791 Binding of AVP and AVPR2 1 0.14 0.55 0 17.12
13 INT234796 Binding of AQP2 and AVP 1 0.15 1.1 0 17.12
14 INT302369 Binding of Arx and Dlx1 1 0.34 0 0.43 5.00
15 INT250531 Ghrh Regulation of Gh 1 0.22 0 0.41 5.00
16 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4 5.00
17 INT241614 CCNA2 Regulation of PRB3 1 0.06 0 0.37 5.00
18 INT302371 Dlx1 Regulation of Gene_expression of Arx 1 0.28 0 0.35 5.00
19 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24 5.00
20 INT302367 Dlx2 Regulation of Gene_expression of Arx 1 0.59 0.23 0.22 5.00
21 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2 5.00
22 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19 5.00
23 INT302372 Arx Negative_regulation of Gene_expression of Calb2 1 0.13 0.05 0.18 5.00
24 INT250533 Ghrh Regulation of Localization of Gh 1 0.13 0 0.15 5.00
25 INT250535 Ghrh Regulation of Gene_expression of Gh 1 0.31 0 0.15 5.00
26 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06 5.00
27 INT279889 Il6 Regulation of Socs3 1 0.21 0.17 0.05 5.00
28 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03 5.00
29 INT279885 Ctcf Regulation of H19 1 0.12 0 0 5.00
30 INT296163 Mcph1 Regulation of Tert 1 0.03 0.19 0 5.00
31 INT279891 Shbdp1 Negative_regulation of PCDHB@ 1 0.01 0.09 0 5.00
32 INT302364 Binding of Arx and Reln 1 0.32 1.25 0 5.00
33 INT279886 Shbdp1 Negative_regulation of Pcdhb1 1 0.10 0.09 0 5.00
34 INT302370 Binding of Arx and Dcx 1 0.35 1.25 0 5.00
35 INT279884 Nipbl Regulation of Transcription of Pcdhb1 1 0.25 0.05 0 5.00
36 INT279892 Shbdp1 Negative_regulation of Gene_expression of PCDHB@ 1 0.01 0.09 0 5.00
37 INT234790 B4GALNT1 Positive_regulation of AGFG1 1 0.00 0.08 0 5.00
38 INT296164 Mcph1 Regulation of Chek1 1 0.25 0.19 0 5.00
39 INT302373 Binding of Arx and Tuba1a 1 0.30 1.26 0 5.00
40 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
41 INT302368 Binding of Arx and Pafah1b1 1 0.27 1.25 0 5.00
42 INT234803 AVP Regulation of AQP2 1 0.11 1.3 0 5.00
43 INT296162 Mcph1 Regulation of Brca1 1 0.26 0.19 0 5.00
44 INT234794 Binding of GDI1 and AGFG1 1 0.01 0 0 5.00
45 INT279888 Binding of Rec8 and Nipbl 1 0.01 0.81 0 5.00
46 INT234797 AVP Regulation of GOPC 1 0.01 0.65 0 5.00
47 INT279890 Nipbl Regulation of Gene_expression of PCDHB@ 1 0.07 0.1 0 5.00
48 INT234795 Negative_regulation of CHM Negative_regulation of RAB27A 1 0.01 0.8 0 5.00
49 INT210285 Ccrs1 Regulation of RAI1 1 0.00 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Microcephaly. They are ordered first by their pain relevance and then by number of times they were reported in Microcephaly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 99.32
2 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 99.28
3 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 98.60
4 INT114499 Gene_expression of MCPH1 38 0.67 26.68 4.55 96.76
5 INT9683 Binding of GH1 57 0.47 21.14 5.99 96.28
6 INT135337 Gene_expression of PTPRN2 2 0.72 0.82 0 92.24
7 INT1597 Negative_regulation of Binding of Oprl1 11 0.59 1.38 6.62 92.16
8 INT114 Binding of Oprl1 139 0.48 23 103.35 91.84
9 INT59200 Negative_regulation of Ube2d3 3 0.13 2.37 1.23 91.24
10 INT96649 Gene_expression of ARSA 5 0.65 2.82 0.8 91.08
11 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 91.08
12 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 91.08
13 INT317913 Gene_expression of SHANK3 1 0.64 2.19 0.13 91.08
14 INT317918 Gene_expression of MAPK8IP2 2 0.59 1.43 0.09 91.08
15 INT317917 Gene_expression of RABL2B 1 0.61 0.68 0.03 91.08
16 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 90.92
17 INT164731 Regulation of MCPH1 4 0.45 0.5 0.25 90.48
18 INT317903 Gene_expression of NCAPG2 1 0.64 1.56 0 90.00
19 INT317909 Binding of MAPK8IP2 1 0.31 0.84 0.03 89.88
20 INT200132 Regulation of Ercc2 2 0.36 4.56 0.05 89.64
21 INT200135 Regulation of Ercc3 2 0.34 3.47 0.05 89.64
22 INT182293 Binding of MAPK8 11 0.34 4.6 0.77 89.48
23 INT249 Localization of GHRH 215 0.80 78.02 51.87 88.80
24 INT139281 Gene_expression of VIPR2 3 0.74 0.88 0.2 88.60
25 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2 88.56
26 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07 88.20
27 INT176180 Negative_regulation of Nr1h2 6 0.16 7.47 0.69 87.12
28 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 87.12
29 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 87.12
30 INT152045 Negative_regulation of Trav6-3 10 0.57 6.42 1.16 87.12
31 INT317905 Gene_expression of ESYT2 1 0.64 0.76 0 86.60
32 INT302341 Positive_regulation of Arx 1 0.44 0.4 0.11 86.32
33 INT57958 Positive_regulation of Myo5a 9 0.41 7.52 0.77 85.04
34 INT317906 Gene_expression of WDR60 1 0.71 0.74 0 84.68
35 INT210272 Binding of Ccrs1 1 0.01 1.13 0 84.68
36 INT172370 Binding of MCPH1 6 0.34 4.75 0.13 84.52
37 INT252 Localization of GH1 529 0.80 227.4 122.05 84.16
38 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 84.16
39 INT317916 Binding of NCAPH2 1 0.04 0.53 0 84.12
40 INT317912 Gene_expression of NCAPH2 1 0.06 0.74 0 81.92
41 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 81.20
42 INT317907 Gene_expression of DLGAP2 1 0.63 0.85 0 80.48
43 INT81155 Localization of CDCP1 5 0.08 4.49 1.4 78.36
44 INT63839 Binding of CRS 31 0.41 34.05 4.7 77.72
45 INT14572 Binding of INS 205 0.48 175.43 13.38 74.20
46 INT65606 Binding of TBX1 2 0.30 3.13 0.41 72.20
47 INT33170 Binding of Chrm1 11 0.48 1.58 2.1 71.96
48 INT921 Regulation of GH1 172 0.60 52.88 51.04 62.64
49 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 59.92
50 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 59.92
51 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 59.36
52 INT302338 Gene_expression of Arx 1 0.77 2.8 4.93 59.04
53 INT302345 Positive_regulation of Gene_expression of Arx 1 0.69 1.06 1.4 59.04
54 INT234828 Gene_expression of RAB3A 2 0.30 2.05 0.37 57.68
55 INT241625 Regulation of Gene_expression of Atf4 2 0.43 0.83 0.59 56.40
56 INT302339 Regulation of Arx 1 0.45 1.23 0.66 55.92
57 INT241623 Gene_expression of Atf4 12 0.74 8.67 2.85 55.84
58 INT200133 Negative_regulation of Xpa 5 0.58 9.85 0.09 53.36
59 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 52.36
60 INT812 Localization of INS 1026 0.81 515.6 145.31 51.16
61 INT206950 Positive_regulation of Atf4 14 0.45 7.02 5.71 50.72
62 INT90491 Binding of Igf1 25 0.44 9.75 1.36 48.84
63 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84 48.08
64 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 47.68
65 INT279846 Gene_expression of Nipbl 1 0.68 11.1 0.56 46.56
66 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 45.48
67 INT302342 Localization of Arx 1 0.80 0.94 0.83 45.48
68 INT47780 Gene_expression of CREM 17 0.74 5.37 2.13 44.64
69 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 44.32
70 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 44.16
71 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 43.96
72 INT188665 Gene_expression of St6galnac2 5 0.06 3.93 1.08 42.88
73 INT228295 Negative_regulation of Transcription of INS 2 0.43 1.1 0.07 41.64
74 INT183046 Transcription of INS 25 0.70 11.14 1.13 40.92
75 INT60388 Gene_expression of Helt 90 0.07 19.18 41.72 40.52
76 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 39.04
77 INT21794 Positive_regulation of Gene_expression of Npy 20 0.70 8.44 9.3 39.04
78 INT98686 Gene_expression of Calb2 28 0.51 12.07 2.84 39.04
79 INT302358 Positive_regulation of Gene_expression of Calb2 1 0.12 0.11 0.27 39.04
80 INT53212 Negative_regulation of RAB27A 4 0.57 2.46 0.26 38.64
81 INT234824 Negative_regulation of SYTL4 1 0.07 0.95 0 38.64
82 INT248207 Positive_regulation of Calb2 3 0.20 0.49 0.46 38.32
83 INT302362 Positive_regulation of Positive_regulation of Calb2 1 0.11 0.12 0.3 38.32
84 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 38.04
85 INT51897 Binding of OPCML 8 0.43 5.59 1.11 37.92
86 INT120165 Binding of NTM 2 0.47 2.23 0.29 37.92
87 INT317915 Binding of SNX19 1 0.36 2.04 0.2 37.92
88 INT317919 Binding of VPS26B 1 0.23 0.93 0.1 37.92
89 INT317908 Binding of NCAPD3 1 0.32 0.91 0.1 37.92
90 INT317904 Binding of THYN1 1 0.32 0.96 0.1 37.92
91 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 37.08
92 INT17417 Positive_regulation of Ighd 16 0.69 24.29 2.8 36.52
93 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 35.92
94 INT21646 Positive_regulation of Npy 40 0.70 31.31 13.57 35.76
95 INT122472 Positive_regulation of Positive_regulation of Npy 6 0.51 2.66 0.83 35.76
96 INT180497 Binding of MRI1 45 0.42 28.35 14.77 35.52
97 INT277258 Localization of Satb2 1 0.81 3.59 0.04 35.32
98 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 34.24
99 INT244343 Localization of NTM 16 0.73 14.26 0.26 32.56
100 INT250510 Gene_expression of Arsi 1 0.12 0.8 0 31.52
101 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 28.80
102 INT234810 Regulation of RAB5A 3 0.38 1.64 0.16 28.80
103 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 27.44
104 INT317914 Localization of NCAPD3 1 0.65 0.88 0.1 27.44
105 INT250515 Regulation of Gene_expression of Ucp2 3 0.39 1.88 0.22 25.96
106 INT104290 Gene_expression of Ucp2 21 0.78 12.81 2.34 25.60
107 INT227265 Negative_regulation of Gene_expression of Ucp2 4 0.57 3.5 0.25 25.60
108 INT78447 Protein_catabolism of GH1 2 0.36 1.2 0.36 25.00
109 INT240519 Regulation of Scn8a 3 0.06 0.9 0.71 24.84
110 INT277254 Negative_regulation of Satb2 1 0.43 3.26 0.04 24.76
111 INT296151 Gene_expression of Mcph1 1 0.78 1.33 0.19 24.40
112 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 22.92
113 INT317911 Localization of VPS26B 1 0.47 0.88 0.1 22.72
114 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 22.40
115 INT51895 Localization of OPCML 6 0.68 3.43 0.54 18.48
116 INT317920 Localization of SNX19 1 0.73 1.88 0.2 18.48
117 INT317910 Localization of THYN1 1 0.65 0.88 0.1 18.48
118 INT174155 Negative_regulation of Brca1 4 0.36 1.77 0.07 17.84
119 INT296140 Negative_regulation of Chek1 1 0.35 0.45 0 17.84
120 INT234812 Binding of AVPR2 1 0.17 0.55 0 17.12
121 INT277257 Binding of Satb2 1 0.37 2.51 0 16.32
122 INT167446 Regulation of CCNA2 2 0.39 2.01 3.49 16.24
123 INT302354 Gene_expression of Xic 1 0.02 0.08 0.08 9.20
124 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
125 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 5.00
126 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 5.00
127 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
128 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 5.00
129 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 5.00
130 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
131 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
132 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 5.00
133 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
134 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
135 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
136 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 5.00
137 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
138 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
139 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
140 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
141 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
142 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
143 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
144 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
145 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 5.00
146 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
147 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
148 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67 5.00
149 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
150 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
151 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
152 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
153 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
154 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
155 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 5.00
156 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
157 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54 5.00
158 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 5.00
159 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 5.00
160 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
161 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
162 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 5.00
163 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 5.00
164 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
165 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 5.00
166 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
167 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 5.00
168 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04 5.00
169 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
170 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
171 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
172 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
173 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
174 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
175 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89 5.00
176 INT123419 Binding of NAV1 37 0.48 7.09 26.43 5.00
177 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 5.00
178 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
179 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 5.00
180 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52 5.00
181 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
182 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 5.00
183 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
184 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 5.00
185 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 5.00
186 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
187 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44 5.00
188 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
189 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
190 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
191 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 5.00
192 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
193 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
194 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
195 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 5.00
196 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
197 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
198 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
199 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
200 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
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