D:Microphthalmia

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Disease Term
Synonyms Congenital Microphthalmos, Microphthalmos, Nanophthalmos, SMALL EYEBALL, Small Globe Of The Eye
Documents 53
Hot Single Events 98
Hot Interactions 21

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Microphthalmia. They are ordered first by their relevance to Microphthalmia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71 100.00
2 INT213816 Binding of Tcf12 and Tfeb 1 0.01 1.91 0.27 100.00
3 INT213800 Kit Positive_regulation of Mitf 1 0.30 1.24 0.15 100.00
4 INT213817 Phosphorylation of Tfe3 Positive_regulation of Mitf 1 0.22 1.22 0.15 100.00
5 INT213811 Tfe3 Positive_regulation of Spg21 1 0.05 1.21 0.15 100.00
6 INT213807 Mitf Positive_regulation of Spg21 1 0.05 1.2 0.15 100.00
7 INT104975 MITF Regulation of Transcription of PRSS1 1 0.68 0.35 1.46 100.00
8 INT104972 MITF Regulation of Transcription of TYR 1 0.20 0.35 1.45 100.00
9 INT213804 Binding of Mitf and Tfeb 1 0.24 0.81 0.24 100.00
10 INT213813 Binding of Tcf4 and Tfeb 1 0.14 0.81 0.24 100.00
11 INT213805 Binding of Tcf12 and Tcf4 1 0.00 0.79 0.23 99.96
12 INT213797 Kit Positive_regulation of Tfe3 1 0.28 1.24 0.14 99.80
13 INT245722 Binding of Vsx2 and Mfrp 1 0.24 1.2 0 98.44
14 INT213801 Binding of Tcf12 and Tfe3 1 0.01 1.11 0.03 98.16
15 INT104973 SGCG Regulation of Gene_expression of MC1R 1 0.67 0.17 0.63 97.84
16 INT213803 Binding of Foxm1 and Tfe3 1 0.00 1.09 0.03 96.24
17 INT213810 Binding of Foxm1 and Tfeb 1 0.00 1.09 0.03 96.24
18 INT213814 F3 Positive_regulation of Pars2 1 0.01 0.58 0.21 95.64
19 INT213422 MITF Negative_regulation of PROC 1 0.00 0.52 0.03 93.00
20 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15 80.32
21 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74 80.28
22 INT225620 Gene_expression of IGHD6-13 Negative_regulation of Binding of Asc2 1 0.12 0.87 0 77.28
23 INT107726 BIRC2 Regulation of ASIP 1 0.03 0.24 0.35 76.88
24 INT213802 Il4 Regulation of Gene_expression of Insrr 1 0.00 0.76 0.29 71.60
25 INT213808 Il12a Regulation of Gene_expression of Insrr 1 0.00 0.76 0.28 71.60
26 INT225542 Binding of D0Nrs1 and Asc2 1 0.01 0.63 0 71.44
27 INT225601 Binding of D0Nrs1 and Ncoa6 1 0.04 0.84 0 71.44
28 INT107722 ASIP Negative_regulation of EIF4E1B 1 0.02 0.43 0.07 61.48
29 INT107727 ASIP Negative_regulation of RRM2 1 0.29 0.43 0.07 61.16
30 INT107724 ASIP Negative_regulation of NR4A3 1 0.15 0.43 0.06 60.92
31 INT107725 ASIP Negative_regulation of EVI2B 1 0.41 0.43 0.06 60.52
32 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82 58.72
33 INT213809 F2 Positive_regulation of F2rl3 2 0.12 0.61 0.5 58.68
34 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16 58.68
35 INT225545 Negative_regulation of Binding of nr and Asc2 1 0.03 0.79 0 58.68
36 INT225509 Negative_regulation of Binding of nr and Ncoa6 1 0.11 0.79 0 58.68
37 INT225609 Negative_regulation of Binding of Ncoa6 and Asc2 1 0.14 0.79 0 58.68
38 INT225600 Binding of Ncoa6 and Asc2 1 0.12 0.78 0 58.12
39 INT225552 Binding of nr and Ncoa6 1 0.09 1.04 0 58.12
40 INT225519 Binding of nr and Asc2 1 0.04 0.78 0 57.88
41 INT234800 RAB27A Positive_regulation of INS 1 0.02 1.26 0 48.28
42 INT234793 RAB27A Positive_regulation of Localization of INS 1 0.03 1.26 0 48.28
43 INT288370 a Positive_regulation of Mc1r 1 0.39 0 0.44 44.92
44 INT234831 Binding of SPTLC1 and Abo 1 0.00 1.61 0.23 31.12
45 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3 30.72
46 INT155702 MC1R Positive_regulation of CAMP 1 0.48 0 0.2 25.00
47 INT155703 POMC Positive_regulation of CAMP 1 0.49 0 0.2 25.00
48 INT288371 Binding of Atrn and a 1 0.39 0 0.74 22.24
49 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07 13.28
50 INT234791 Binding of AVP and AVPR2 1 0.14 0.55 0 13.28
51 INT234796 Binding of AQP2 and AVP 1 0.15 1.1 0 13.28
52 INT213812 Sh2b2 Positive_regulation of Tfeb 1 0.44 0.45 0.2 10.16
53 INT125568 Binding of Casr and Ncoa6 3 0.50 1.13 0.46 5.00
54 INT213798 Sh2b2 Regulation of tf 1 0.12 0.53 0.27 5.00
55 INT213799 Sh2b2 Regulation of Tfeb 1 0.26 0.54 0.27 5.00
56 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 5.00
57 INT288372 Atrn Positive_regulation of a 1 0.52 0 0.19 5.00
58 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
59 INT288368 Atrn Positive_regulation of Binding of a 1 0.48 0 0.19 5.00
60 INT225607 Ncoa6 Regulation of Gene_expression of Casr 1 0.15 0.68 0.17 5.00
61 INT225501 Plcl1 Regulation of Gene_expression of Casr 1 0.04 0.67 0.16 5.00
62 INT225608 Ppara Regulation of Ncoa6 1 0.27 0.44 0.14 5.00
63 INT213421 Binding of CXCL2 and SET 1 0.11 0.17 0.1 5.00
64 INT213417 Binding of CCL7 and SET 1 0.11 0.17 0.1 5.00
65 INT213414 Binding of CXCL1 and SET 1 0.10 0.17 0.1 5.00
66 INT213415 Binding of CCL8 and SET 1 0.11 0.17 0.1 5.00
67 INT213420 Binding of IL6 and SET 1 0.10 0.17 0.1 5.00
68 INT213416 Binding of CCL2 and SET 1 0.11 0.17 0.1 5.00
69 INT213418 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of VCAM1 1 0.29 0.15 0.08 5.00
70 INT262939 PAX6 Regulation of CDH4 1 0.02 0.97 0.08 5.00
71 INT262937 PAX6 Regulation of CDH8 1 0.03 0.98 0.08 5.00
72 INT288374 Binding of MLANA and Msx1 1 0.09 0 0.08 5.00
73 INT262944 PAX6 Regulation of CDH6 1 0.03 0.97 0.08 5.00
74 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08 5.00
75 INT225494 Binding of Casr and Asc2 1 0.03 0.63 0.07 5.00
76 INT225490 Med1 Positive_regulation of Ppara 1 0.12 0.26 0.06 5.00
77 INT225556 Binding of Ncoa6 and Cytip 1 0.12 1.7 0.04 5.00
78 INT225493 Binding of Esr1 and Pprc1 2 0.01 0.17 0.04 5.00
79 INT213815 Binding of Tfeb and Stub1 1 0.13 0.09 0.04 5.00
80 INT225569 Binding of Ncoa6 and Ep300 1 0.18 0.63 0.04 5.00
81 INT288369 Binding of Laptm5 and Mgrn1 1 0.05 0 0.04 5.00
82 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0 5.00
83 INT225485 Binding of Acsl1 and Ncoa6 1 0.01 0 0 5.00
84 INT225479 Binding of Parp1 and Acsl1 1 0.00 0 0 5.00
85 INT225610 Ncoa6 Regulation of Rb1 1 0.03 0.21 0 5.00
86 INT225535 Binding of Pprc1 and Zfp335 1 0.00 0 0 5.00
87 INT225583 Binding of Ncoa1 and Tpr 1 0.00 0.07 0 5.00
88 INT225562 Binding of Srcs4 and Ep300 1 0.02 0 0 5.00
89 INT225496 Binding of Prh1 and Zfp335 1 0.00 0 0 5.00
90 INT225559 Binding of Esr1 and Ncoa6 1 0.18 0 0 5.00
91 INT225565 Ncoa6 Regulation of Creb1 1 0.06 0.21 0 5.00
92 INT225592 Binding of Tfrc and Pprc1 1 0.00 0 0 5.00
93 INT225548 Asc2 Positive_regulation of Positive_regulation of Rars 1 0.08 0 0 5.00
94 INT225484 Binding of Acp5 and Tpr 1 0.01 0 0 5.00
95 INT262938 Binding of PAX6 and SIX3 1 0.13 0.9 0 5.00
96 INT225616 Binding of D0Nrs1 and IGHD6-13 1 0.02 0.42 0 5.00
97 INT225550 Binding of Mybbp1a and Carm1 1 0.06 0 0 5.00
98 INT225520 Binding of Ncoa2 and Ncoa6 1 0.05 0.11 0 5.00
99 INT225606 Ncoa6 Regulation of Atf2 1 0.05 0.21 0 5.00
100 INT225560 Ncoa6 Positive_regulation of nr 1 0.09 0 0 5.00
101 INT225589 Ncoa6 Positive_regulation of Binding of nr 1 0.10 0 0 5.00
102 INT225617 Binding of ITGB3BP and D0Nrs1 1 0.00 0.15 0 5.00
103 INT225505 Ncoa6 Positive_regulation of Positive_regulation of Tfrc 1 0.10 0 0 5.00
104 INT225630 MED23 Positive_regulation of Localization of D0Nrs1 1 0.03 0.17 0 5.00
105 INT225513 Binding of D0Nrs1 and Wtmq2 1 0.00 0 0 5.00
106 INT225584 Ncoa6 Negative_regulation of Gfer 1 0.04 0.2 0 5.00
107 INT225591 Asc2 Positive_regulation of Positive_regulation of Tfrc 1 0.03 0 0 5.00
108 INT225645 Binding of TAF1 and Acp5 1 0.01 0 0 5.00
109 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0 5.00
110 INT225593 Ncoa6 Positive_regulation of Prkdc 1 0.02 0 0 5.00
111 INT225539 D0Nrs1 Positive_regulation of Ncoa6 1 0.03 0.37 0 5.00
112 INT225581 Binding of Emr1 and Ncoa6 1 0.01 0 0 5.00
113 INT225555 Asc2 Positive_regulation of Positive_regulation of D0Nrs1 1 0.01 0 0 5.00
114 INT225586 Rbm39 Positive_regulation of Rars 1 0.08 0 0 5.00
115 INT225517 Binding of nr and Cytip 1 0.02 0 0 5.00
116 INT225644 Binding of TARBP2 and Acp5 1 0.04 0.15 0 5.00
117 INT225641 Binding of MED23 and Acp5 1 0.39 0.14 0 5.00
118 INT225480 Binding of Prkdc and Acsl1 1 0.00 0 0 5.00
119 INT225500 Negative_regulation of Ncoa6 Positive_regulation of gr 1 0.09 0 0 5.00
120 INT225561 Binding of Tfrc and Ncoa6 1 0.07 0 0 5.00
121 INT225533 Binding of Emr1 and Esr1 1 0.01 0 0 5.00
122 INT332136 POGLUT1 Negative_regulation of HJURP 1 0.00 0.06 0 5.00
123 INT225575 Ncoa6 Positive_regulation of gr 1 0.10 0 0 5.00
124 INT225613 TARBP2 Positive_regulation of Prkdc 1 0.00 0 0 5.00
125 INT225486 Rbm39 Positive_regulation of Acsl1 1 0.00 0 0 5.00
126 INT225572 Binding of Asc2 and Rbm39 1 0.04 0 0 5.00
127 INT225564 Ncoa6 Regulation of Trp53 1 0.04 0.93 0 5.00
128 INT225642 Binding of XRCC5 and Acsl1 1 0.01 0 0 5.00
129 INT225621 Positive_regulation of Binding of TARBP2 and Esr1 1 0.03 0 0 5.00
130 INT225531 R3hcc1 Positive_regulation of Positive_regulation of Esr1 1 0.00 0 0 5.00
131 INT225566 Ncoa6 Regulation of Stat2 1 0.14 0.21 0 5.00
132 INT332135 POGLUT1 Negative_regulation of NLRP5 1 0.00 0.06 0 5.00
133 INT225626 Binding of TARBP2 and Esr1 1 0.02 0 0 5.00
134 INT225623 Negative_regulation of Binding of nr and IGHD6-13 1 0.15 0.05 0 5.00
135 INT225611 Binding of Esr1 and Asc2 1 0.05 0 0 5.00
136 INT225483 Binding of Acsl1 and D0Nrs1 1 0.00 0 0 5.00
137 INT225536 Ncoa6 Positive_regulation of Localization of Ide 1 0.02 0.41 0 5.00
138 INT225615 Binding of nr and IGHD6-13 1 0.12 0.05 0 5.00
139 INT225521 Binding of Prmt1 and Mybbp1a 1 0.05 0 0 5.00
140 INT225516 Ncoa6 Positive_regulation of D0Nrs1 1 0.04 0.3 0 5.00
141 INT225643 Binding of TARBP2 and Acsl1 1 0.00 0 0 5.00
142 INT225573 Rbm39 Positive_regulation of Positive_regulation of Esr1 1 0.08 0 0 5.00
143 INT225590 Ncoa6 Regulation of Srf 1 0.08 0.21 0 5.00
144 INT225532 Ncoa6 Regulation of Jun 1 0.03 0.21 0 5.00
145 INT225597 Binding of Gfer and Paxip1 1 0.02 0 0 5.00
146 INT225487 Acsl1 Positive_regulation of D0Nrs1 1 0.00 0 0 5.00
147 INT332069 POGLUT1 Negative_regulation of fd 1 0.00 0.06 0 5.00
148 INT225594 Ncoa6 Positive_regulation of Positive_regulation of Rars 1 0.28 0 0 5.00
149 INT225612 Gene_expression of Sae1 Negative_regulation of Ncoa6 Positive_regulation of D0Nrs1 1 0.00 0 0 5.00
150 INT225523 Rbm39 Positive_regulation of Positive_regulation of Tfrc 1 0.03 0 0 5.00
151 INT225619 Binding of TARBP2 and Ep300 1 0.02 0 0 5.00
152 INT225481 Binding of Med1 and Acp5 1 0.16 0 0 5.00
153 INT225595 Ncoa6 Regulation of Nfkb1 1 0.04 0.21 0 5.00
154 INT306339 Binding of CRX and PAX6 1 0.53 0.27 0 5.00
155 INT225495 Zfp335 Positive_regulation of Transcription of Jun 1 0.01 0 0 5.00
156 INT225482 Binding of Mybbp1a and Acp5 1 0.09 0.06 0 5.00
157 INT225624 Binding of STL and Cytip 1 0.00 0 0 5.00
158 INT225506 Binding of Jun and Rbm39 1 0.04 0 0 5.00
159 INT225551 Binding of Paxip1 and Ncoa6 1 0.26 0.47 0 5.00
160 INT225491 Binding of D0Nrs1 and Pprc1 1 0.00 0 0 5.00
161 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00
162 INT225508 Ncoa6 Positive_regulation of Jun 1 0.13 0 0 5.00
163 INT225554 Binding of Pprc1 and Cytip 1 0.00 0 0 5.00
164 INT225571 Binding of Ncoa1 and Tfrc 1 0.01 0 0 5.00
165 INT225530 Binding of Gfer and Ncoa6 1 0.04 0.46 0 5.00
166 INT225614 Binding of XRCC5 and Parp1 1 0.09 0 0 5.00
167 INT225502 Binding of Emr1 and D0Nrs1 1 0.00 0 0 5.00
168 INT225633 Binding of STL and MED23 1 0.02 0 0 5.00
169 INT225579 Binding of Ncoa1 and D0Nrs1 1 0.00 0 0 5.00
170 INT225557 Ncoa6 Positive_regulation of Pprc1 1 0.01 0.3 0 5.00
171 INT234790 B4GALNT1 Positive_regulation of AGFG1 1 0.00 0.08 0 5.00
172 INT225604 Ncoa6 Positive_regulation of Positive_regulation of gr 1 0.12 0 0 5.00
173 INT225528 Ncoa6 Positive_regulation of Nfkb1 1 0.08 0 0 5.00
174 INT225578 Binding of Vdr and Pprc1 1 0.00 0 0 5.00
175 INT225515 Binding of Ncoa6 and Rbm39 1 0.14 0.26 0 5.00
176 INT225603 Rbm39 Positive_regulation of gr 1 0.04 0 0 5.00
177 INT225512 Binding of D0Nrs1 and Cytip 1 0.01 0.21 0 5.00
178 INT225510 D0Nrs1 Positive_regulation of Transcription of Jun 1 0.01 0 0 5.00
179 INT225558 Binding of Ncoa6 and Pprc1 1 0.01 0.47 0 5.00
180 INT225498 Binding of Srcs4 and Cytip 1 0.01 0 0 5.00
181 INT225629 APP Positive_regulation of Positive_regulation of nr 1 0.01 0.08 0 5.00
182 INT225574 Rbm39 Positive_regulation of Tfrc 1 0.03 0 0 5.00
183 INT225507 Zfp335 Positive_regulation of Positive_regulation of D0Nrs1 1 0.00 0 0 5.00
184 INT225522 Rbm39 Positive_regulation of D0Nrs1 1 0.01 0 0 5.00
185 INT225526 Binding of Ncoa6 and Zfp335 1 0.04 0.26 0 5.00
186 INT225568 Binding of Mybbp1a and Pprc1 1 0.00 0 0 5.00
187 INT225599 Ncoa6 Negative_regulation of Paxip1 1 0.26 0.2 0 5.00
188 INT225541 Binding of Med1 and Tpr 1 0.00 0.07 0 5.00
189 INT234803 AVP Regulation of AQP2 1 0.11 1.3 0 5.00
190 INT262940 Regulation of Binding of PAX6 and SIX3 1 0.16 0.91 0 5.00
191 INT225547 Binding of Tpr and Cytip 1 0.00 0 0 5.00
192 INT225537 Binding of Paxip1 and Mll2 1 0.12 0 0 5.00
193 INT225634 Binding of TARBP2 and MED23 1 0.04 0.15 0 5.00
194 INT225543 Binding of D0Nrs1 and Ep300 1 0.01 0 0 5.00
195 INT262942 Binding of PAX6 and SOX2 1 0.18 0.9 0 5.00
196 INT225582 Asc2 Positive_regulation of Localization of Ide 1 0.01 0.41 0 5.00
197 INT225602 Positive_regulation of Binding of Ncoa6 and Cytip 1 0.17 0 0 5.00
198 INT225628 MED23 Positive_regulation of D0Nrs1 1 0.03 0.16 0 5.00
199 INT262943 Regulation of Binding of PAX6 and SOX2 1 0.17 0.91 0 5.00
200 INT234794 Binding of GDI1 and AGFG1 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Microphthalmia. They are ordered first by their pain relevance and then by number of times they were reported in Microphthalmia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT153757 Positive_regulation of Mitf 10 0.46 8.38 1.22 100.00
2 INT213794 Phosphorylation of Mitf 2 0.42 2.56 0.15 100.00
3 INT97449 Transcription of Mitf 4 0.69 4.28 0.09 100.00
4 INT213767 Positive_regulation of Transcription of Mitf 1 0.31 2.64 0 100.00
5 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17 100.00
6 INT32648 Gene_expression of Tyrp1 80 0.66 17.9 16.59 100.00
7 INT97450 Gene_expression of Mitf 36 0.75 17.22 0.39 100.00
8 INT153758 Binding of Mitf 5 0.47 2.5 0.46 100.00
9 INT62421 Gene_expression of Trpc2 8 0.68 5.48 0.67 100.00
10 INT131612 Negative_regulation of Mitf 3 0.56 3.91 0.23 100.00
11 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 100.00
12 INT213771 Positive_regulation of Gene_expression of Mitf 4 0.48 2.01 0.12 100.00
13 INT213766 Regulation of Mitf 6 0.44 3.18 0.1 100.00
14 INT213774 Positive_regulation of Positive_regulation of Mitf 1 0.31 1.53 0.58 100.00
15 INT64208 Gene_expression of Rtl1 18 0.75 7.51 6.16 100.00
16 INT49807 Regulation of tryptase 3 0.05 1.99 0.19 100.00
17 INT100005 Binding of MITF 7 0.47 6.93 0.44 100.00
18 INT193440 Positive_regulation of MCO 4 0.45 1.22 0 100.00
19 INT49454 Negative_regulation of Gene_expression of Gtf3a 13 0.08 9.99 2.43 100.00
20 INT97451 Negative_regulation of Gene_expression of Mitf 3 0.41 0.88 0.17 100.00
21 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22 100.00
22 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 100.00
23 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84 100.00
24 INT49020 Negative_regulation of TYR 11 0.58 1.97 2.68 100.00
25 INT155704 Positive_regulation of MITF 10 0.45 7.51 0.7 100.00
26 INT107729 Negative_regulation of DCT 1 0.27 0.48 0.35 100.00
27 INT213772 Positive_regulation of Tfeb 1 0.39 3.5 1.35 99.96
28 INT239757 Gene_expression of VSX2 1 0.61 3 0 99.96
29 INT239753 Gene_expression of MFRP 1 0.64 3 0 99.96
30 INT239760 Binding of VSX2 1 0.29 1.47 0 99.96
31 INT239759 Binding of MFRP 1 0.31 2.04 0 99.96
32 INT7376 Positive_regulation of CAMP 17 0.67 6.39 6.6 99.96
33 INT245715 Binding of Mfrp 1 0.48 3.46 0 99.80
34 INT213773 Phosphorylation of Tfe3 1 0.39 1.22 0.14 99.80
35 INT62423 Regulation of Gene_expression of Trpc2 1 0.45 0.33 0.08 99.76
36 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.76
37 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 99.70
38 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 99.68
39 INT62425 Regulation of Gene_expression of Tyrp1 7 0.29 1.44 1.41 99.48
40 INT172558 Positive_regulation of Cdh1 11 0.49 8.92 0.42 99.36
41 INT213793 Gene_expression of Tpsb2 1 0.02 1.03 0.45 99.34
42 INT62427 Regulation of Gene_expression of Tyr 1 0.32 0.33 0.07 99.20
43 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 99.16
44 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 99.14
45 INT49488 Gene_expression of mMCP-7 37 0.75 26.11 7.68 99.12
46 INT57243 Transcription of SGCG 10 0.69 3.43 3.04 98.96
47 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 98.84
48 INT245717 Binding of Vsx2 2 0.27 1.2 0 98.44
49 INT213789 Phosphorylation of Kit 7 0.69 5.32 0.43 98.28
50 INT207134 Positive_regulation of tryptase 11 0.47 11.16 1.21 97.88
51 INT104980 Transcription of PRSS1 5 0.69 3.54 2.12 97.56
52 INT49021 Transcription of TYR 2 0.68 0.58 0.99 97.56
53 INT49808 Localization of tryptase 11 0.78 8.74 2.67 97.48
54 INT131308 Gene_expression of Pitx3 11 0.74 3.69 3.5 97.24
55 INT181489 Localization of Spg21 16 0.12 10.89 6.84 97.12
56 INT207082 Positive_regulation of Pars2 10 0.14 5.45 2.22 96.96
57 INT88415 Gene_expression of DYM 3 0.58 5.26 0.43 96.32
58 INT84730 Positive_regulation of Rtl1 5 0.49 2.06 0.48 96.08
59 INT245716 Gene_expression of Mfrp 1 0.78 2.35 0 95.80
60 INT55566 Gene_expression of Dct 5 0.36 1.13 0.94 95.70
61 INT81776 Positive_regulation of F3 8 0.07 3.77 1.21 95.64
62 INT239755 Regulation of Gene_expression of MFRP 1 0.43 1.53 0 95.56
63 INT239758 Regulation of Gene_expression of VSX2 1 0.41 1.53 0 95.56
64 INT332059 Negative_regulation of NLRP5 1 0.00 0.57 0 94.04
65 INT245713 Negative_regulation of Mfrp 1 0.43 0.85 0 93.48
66 INT300329 Regulation of Binding of Mitf 1 0.24 0.27 0 92.72
67 INT71644 Gene_expression of MLANA 16 0.75 11.55 1.82 92.64
68 INT213769 Binding of Spg21 18 0.03 7.96 6.77 90.88
69 INT213788 Gene_expression of Tfeb 18 0.66 7.9 2.07 90.56
70 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12 90.40
71 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 90.40
72 INT22836 Regulation of F2 9 0.59 2.3 1.49 89.96
73 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34 89.64
74 INT82653 Regulation of F2r 8 0.36 3.78 2.62 89.44
75 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54 89.16
76 INT88195 Gene_expression of ZAK 15 0.74 4.79 1.55 89.00
77 INT93507 Gene_expression of ASIP 14 0.60 3.98 7.55 88.32
78 INT213759 Transcription of Tfeb 1 0.58 1.29 0 88.20
79 INT213760 Transcription of Tfe3 1 0.42 1.28 0 88.20
80 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91 88.00
81 INT27144 Negative_regulation of Dct 4 0.16 1.48 0.46 88.00
82 INT225450 Negative_regulation of Gene_expression of Ncoa1 1 0.06 0.97 0 87.88
83 INT225322 Negative_regulation of Gene_expression of nr 1 0.10 0.96 0 87.88
84 INT225358 Negative_regulation of Gene_expression of Med1 2 0.30 1.16 0 87.88
85 INT213762 Gene_expression of Tfe3 1 0.47 1.34 0 87.60
86 INT262953 Binding of PAX6 13 0.48 5.28 0.06 87.52
87 INT225369 Gene_expression of nr 7 0.17 1.97 0.07 87.12
88 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 86.72
89 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 86.72
90 INT91608 Negative_regulation of ASIP 3 0.40 0.51 2.04 85.96
91 INT30040 Negative_regulation of TYRP1 11 0.51 2.72 2.54 85.76
92 INT332064 Gene_expression of NLRP5 1 0.01 0.54 0 84.88
93 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93 81.76
94 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39 81.60
95 INT124588 Gene_expression of Ncoa1 9 0.49 2.38 0.27 81.60
96 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01 81.20
97 INT155833 Gene_expression of Cma1 9 0.58 15.28 2.04 80.92
98 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 80.28
99 INT59447 Negative_regulation of Tyr 12 0.56 4.57 3.32 79.92
100 INT46369 Positive_regulation of AK1 3 0.09 1.24 0.94 79.52
101 INT213779 Positive_regulation of Localization of Tfeb 1 0.43 0.59 0.15 79.44
102 INT213790 Localization of Tfeb 1 0.64 0.58 0.15 78.80
103 INT213434 Gene_expression of HNMT 4 0.64 4.33 0.46 78.20
104 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 77.80
105 INT225464 Gene_expression of IGHD6-13 1 0.65 1.26 0 77.28
106 INT63365 Gene_expression of Spg21 21 0.65 12.9 7.37 77.04
107 INT262962 Localization of PITX2 1 0.42 0.64 0.06 76.60
108 INT125565 Gene_expression of Ncoa6 3 0.75 10.15 0.59 76.36
109 INT225445 Gene_expression of Asc2 10 0.32 4.34 0.42 76.36
110 INT108793 Gene_expression of PITX2 12 0.75 3.91 2.89 76.24
111 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18 75.84
112 INT225441 Binding of Asc2 1 0.14 2.16 0 75.28
113 INT125566 Binding of Ncoa6 2 0.47 5.64 0.43 75.28
114 INT195993 Localization of STARD13 1 0.01 2.58 0 75.20
115 INT195992 Localization of FRA12E 1 0.01 1.11 0 75.04
116 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 75.00
117 INT21737 Binding of MC1R 129 0.48 45.45 56.54 75.00
118 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 75.00
119 INT245721 Localization of FRZB 6 0.78 4.3 0.6 74.28
120 INT178255 Localization of a 4 0.65 0.72 1.1 74.20
121 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 71.60
122 INT347288 Positive_regulation of JPH1 1 0.13 0.74 0 71.52
123 INT225327 Phosphorylation of D0Nrs1 1 0.05 0.63 0 71.44
124 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 71.16
125 INT14572 Binding of INS 205 0.48 175.43 13.38 70.36
126 INT213785 Positive_regulation of Gene_expression of Tfeb 1 0.59 1.04 0.37 69.56
127 INT245718 Positive_regulation of Mfrp 1 0.44 0.5 0 66.76
128 INT234828 Gene_expression of RAB3A 2 0.30 2.05 0.37 65.52
129 INT245719 Binding of Epyc 1 0.10 0.83 0 65.16
130 INT300324 Regulation of Transcription of Myh1 1 0.24 0.36 0 64.12
131 INT141083 Transcription of Myh1 32 0.64 1.23 0.06 63.52
132 INT174442 Positive_regulation of Gene_expression of tryptase 3 0.17 1.63 0.87 63.12
133 INT213782 Regulation of Spg21 2 0.03 1.41 0.66 60.88
134 INT108260 Positive_regulation of Par2 20 0.54 10.77 5.94 60.40
135 INT231950 Gene_expression of Myh1 31 0.69 3.7 0.51 60.00
136 INT102741 Gene_expression of Atp9b 20 0.75 8.01 3.34 60.00
137 INT290461 Regulation of Gene_expression of Mitf 3 0.59 3.13 0 58.92
138 INT225342 Negative_regulation of Ncoa6 1 0.49 1.75 0.1 58.68
139 INT225338 Negative_regulation of Asc2 1 0.12 0.79 0 58.68
140 INT213764 Binding of F2rl3 2 0.21 0.37 0.11 58.12
141 INT156231 Binding of F2r 9 0.23 3.78 1.57 58.12
142 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 54.68
143 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 52.48
144 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77 52.48
145 INT120693 Positive_regulation of MEPE 7 0.50 8.22 0.79 52.48
146 INT83033 Negative_regulation of MEPE 2 0.41 2.55 0.21 52.48
147 INT206869 Gene_expression of ALDH1A2 3 0.38 2.51 0.16 51.84
148 INT347286 Regulation of ALDH1A2 1 0.11 0.1 0.04 50.04
149 INT225425 Transcription of Ncoa6 1 0.69 1.34 0 49.96
150 INT812 Localization of INS 1026 0.81 515.6 145.31 47.32
151 INT235781 Positive_regulation of PAX6 2 0.50 0.36 0.08 46.88
152 INT55251 Gene_expression of a 142 0.67 81.21 23.03 44.92
153 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 43.84
154 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09 43.84
155 INT262963 Negative_regulation of PAX6 4 0.59 4.92 0.04 42.16
156 INT5789 Gene_expression of PMEL 23 0.75 13.18 2.67 41.36
157 INT47780 Gene_expression of CREM 17 0.74 5.37 2.13 40.80
158 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 40.12
159 INT213445 Regulation of Gene_expression of APOLD1 1 0.03 1.12 0.05 38.00
160 INT228295 Negative_regulation of Transcription of INS 2 0.43 1.1 0.07 37.80
161 INT183046 Transcription of INS 25 0.70 11.14 1.13 37.08
162 INT127145 Gene_expression of SET 46 0.65 10.39 1.7 36.56
163 INT54137 Positive_regulation of Positive_regulation of Serpine1 4 0.70 0.79 1.06 36.40
164 INT213447 Gene_expression of APOLD1 1 0.09 2.98 0.22 36.24
165 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 36.00
166 INT171848 Positive_regulation of Ctsa 8 0.27 5.24 1.13 36.00
167 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 36.00
168 INT114703 Positive_regulation of Wt1 5 0.46 4.25 0.24 36.00
169 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2 36.00
170 INT213768 Positive_regulation of Gene_expression of Pars2 1 0.10 0.55 0.19 35.44
171 INT53212 Negative_regulation of RAB27A 4 0.57 2.46 0.26 34.80
172 INT234824 Negative_regulation of SYTL4 1 0.07 0.95 0 34.80
173 INT213776 Positive_regulation of Gene_expression of Spg21 1 0.05 0.95 0.45 34.16
174 INT117495 Gene_expression of Pars2 13 0.38 7.93 4.24 33.84
175 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 29.76
176 INT695 Binding of POMC 304 0.48 56.66 126.85 29.60
177 INT107468 Gene_expression of Atrn 4 0.76 0.47 1.02 28.80
178 INT288354 Gene_expression of Mgrn1 1 0.60 0 0.58 27.24
179 INT332058 Positive_regulation of NLRP5 1 0.01 0 0 26.00
180 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22 25.00
181 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 24.96
182 INT234810 Regulation of RAB5A 3 0.38 1.64 0.16 24.96
183 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 23.92
184 INT262959 Localization of PAX6 2 0.75 1.65 0 20.64
185 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26 19.84
186 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13 19.84
187 INT159819 Gene_expression of F2rl3 5 0.45 5.53 5.24 19.12
188 INT158311 Positive_regulation of F2rl3 7 0.51 1.77 1.44 19.12
189 INT213783 Positive_regulation of Positive_regulation of tryptase 1 0.03 1.41 0.51 18.88
190 INT213778 Positive_regulation of Positive_regulation of Pars2 1 0.10 1.4 0.5 18.52
191 INT288355 Localization of Mgrn1 1 0.67 0 0.52 17.92
192 INT181488 Positive_regulation of Spg21 13 0.12 15.52 10.03 17.84
193 INT288361 Localization of Laptm5 2 0.09 0.32 0.61 17.44
194 INT213763 Positive_regulation of Positive_regulation of Tfeb 1 0.39 0.7 0.23 17.24
195 INT111770 Regulation of PMEL 2 0.44 0.4 0.12 15.44
196 INT234812 Binding of AVPR2 1 0.17 0.55 0 13.28
197 INT213777 Positive_regulation of Phosphorylation of Kit 2 0.58 1.36 0.26 6.40
198 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 6.00
199 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
200 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
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