D:Microscopic Polyangiitis

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Disease Term
Synonyms MICROSCOPIC POLYANGIITIDES, Polyangiitides Microscopic, POLYANGIITIS MICROSCOPIC
Documents 44
Hot Single Events 25
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Microscopic Polyangiitis. They are ordered first by their relevance to Microscopic Polyangiitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT214380 Binding of IL1A and PRTN3 1 0.00 0.94 0.18 66.72
2 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 56.08
3 INT173977 Binding of TNF and Ighg1 1 0.03 0.28 0.39 45.52
4 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42 10.52
5 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42 10.52
6 INT181862 Binding of MPO and PRTN3 2 0.16 1.18 0.38 7.48
7 INT318299 Binding of F2 and PRTN3 1 0.01 1.92 0.33 7.48
8 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
9 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
10 INT254355 PF4 Positive_regulation of IFNA1 1 0.04 1.23 1.26 5.00
11 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66 5.00
12 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51 5.00
13 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51 5.00
14 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 5.00
15 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48 5.00
16 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
17 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28 5.00
18 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26 5.00
19 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23 5.00
20 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22 5.00
21 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21 5.00
22 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18 5.00
23 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
24 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
25 INT180345 Binding of HLA-DMA and HLA-DRB4 1 0.00 1.51 0.12 5.00
26 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
27 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
28 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
29 INT180344 CYP2A6 Regulation of AMELX 1 0.01 2.01 0.05 5.00
30 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05 5.00
31 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05 5.00
32 INT180348 CYP2A6 Regulation of AIRE 1 0.01 2.01 0.05 5.00
33 INT180351 Binding of TNFRSF25 and ENAM 1 0.01 1.85 0 5.00
34 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
35 INT180349 Binding of AMELX and BTG3 1 0.00 0.56 0 5.00
36 INT180346 Binding of PRTN3 and SMN1 1 0.00 3.22 0 5.00
37 INT180347 Binding of PRTN3 and BTG3 1 0.00 1.9 0 5.00
38 INT180350 Binding of HLA-DMA and ENAM 1 0.00 1.85 0 5.00
39 INT346971 Binding of IL4 and IL10 1 0.12 0.16 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Microscopic Polyangiitis. They are ordered first by their pain relevance and then by number of times they were reported in Microscopic Polyangiitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
2 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 99.12
3 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 98.96
4 INT64468 Positive_regulation of Gene_expression of Prtn3 1 0.00 2.33 0.29 98.92
5 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 98.80
6 INT56221 Regulation of MPO 8 0.61 8.44 1.84 98.80
7 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 98.28
8 INT37122 Gene_expression of Prtn3 3 0.60 3.65 1.04 97.78
9 INT24983 Binding of MPO 18 0.42 17.56 3.29 97.48
10 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 97.28
11 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 96.68
12 INT251082 Gene_expression of Serpina3c 2 0.65 2.3 0.07 96.56
13 INT114031 Gene_expression of ORM1 3 0.41 6.31 1.18 95.56
14 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75 94.80
15 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 94.32
16 INT12563 Localization of Mpo 33 0.81 20.99 9.58 93.60
17 INT251079 Gene_expression of G0s2 32 0.77 36.32 2.01 87.72
18 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95 87.72
19 INT220585 Gene_expression of Il1r2 17 0.72 17.42 1.51 87.72
20 INT159175 Gene_expression of HBD 11 0.54 15.66 1.37 87.72
21 INT251080 Gene_expression of Areg 5 0.60 8.16 0.42 87.72
22 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 87.68
23 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 87.24
24 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23 80.16
25 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 80.16
26 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 78.64
27 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03 76.00
28 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 75.24
29 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 75.00
30 INT144885 Gene_expression of AMELX 4 0.11 2.89 0.29 73.32
31 INT111155 Positive_regulation of G0s2 9 0.46 9.54 1.53 72.92
32 INT25634 Binding of Mpo 21 0.48 14.78 4.39 71.16
33 INT251085 Gene_expression of Sle4 1 0.34 1.06 0.1 69.72
34 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 67.80
35 INT50580 Binding of PPIG 39 0.36 11.17 12.34 66.56
36 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 65.76
37 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 65.76
38 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 65.76
39 INT6484 Binding of IL1B 122 0.47 75.84 35.07 64.80
40 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 62.72
41 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 62.32
42 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 61.96
43 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05 61.64
44 INT254369 Negative_regulation of COL18A1 2 0.16 1.61 0.61 61.00
45 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87 59.92
46 INT281008 Negative_regulation of Gene_expression of Capns1 1 0.03 1.79 0.04 59.84
47 INT90792 Localization of Il10 144 0.80 87.88 30.03 59.40
48 INT142761 Positive_regulation of TAs 6 0.40 2.28 2.61 58.44
49 INT168373 Gene_expression of Capns1 4 0.58 4.55 1.34 57.96
50 INT51158 Positive_regulation of Tacr1 33 0.70 15.22 13.91 57.56
51 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41 56.24
52 INT254370 Gene_expression of THBS2 1 0.06 2.24 1 55.16
53 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 54.00
54 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 54.00
55 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 54.00
56 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 53.56
57 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 51.12
58 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 50.52
59 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 50.16
60 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 46.32
61 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 46.32
62 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 41.04
63 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 40.32
64 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 39.28
65 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 32.40
66 INT214529 Negative_regulation of DEFB4A 2 0.39 0.76 0.05 29.12
67 INT142006 Positive_regulation of COL18A1 2 0.41 3.01 0.53 22.40
68 INT173971 Positive_regulation of Ppia-ps 1 0.04 0.99 0 21.36
69 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 12.08
70 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 11.44
71 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 10.56
72 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 9.84
73 INT173973 Binding of Ppia-ps 1 0.03 0.97 0 6.24
74 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
75 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
76 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
77 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
78 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
79 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
80 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
81 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
82 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
83 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
84 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
85 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
86 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
87 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
88 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
89 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
90 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
91 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
92 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
93 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
94 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
95 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
96 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
97 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
98 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
99 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
100 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
101 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
102 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
103 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
104 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
105 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
106 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
107 INT23222 Binding of Phax 52 0.31 7.61 30.4 5.00
108 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
109 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
110 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
111 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
112 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
113 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
114 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
115 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 5.00
116 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
117 INT6230 Localization of Ddc 40 0.79 13.11 20.88 5.00
118 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
119 INT157463 Gene_expression of CX3CL1 55 0.62 69.05 19.75 5.00
120 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
121 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
122 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
123 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 5.00
124 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 5.00
125 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
126 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
127 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
128 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
129 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 5.00
130 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
131 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 5.00
132 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 5.00
133 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
134 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
135 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
136 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
137 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
138 INT108485 Gene_expression of CXCL12 61 0.75 49.34 13.79 5.00
139 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 5.00
140 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 5.00
141 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 5.00
142 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
143 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 5.00
144 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
145 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
146 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
147 INT92574 Gene_expression of CXCL5 51 0.78 24.87 11.89 5.00
148 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36 5.00
149 INT176607 Gene_expression of Cx3cl1 27 0.75 19.51 11.32 5.00
150 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 5.00
151 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91 5.00
152 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88 5.00
153 INT157466 Gene_expression of CX3CR1 14 0.76 20.6 10.76 5.00
154 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
155 INT44602 Gene_expression of TNFSF13B 37 0.75 30.98 9.96 5.00
156 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
157 INT137400 Regulation of Mtx1 16 0.52 9.19 9.45 5.00
158 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
159 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
160 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
161 INT56223 Positive_regulation of MPO 35 0.70 43 8.2 5.00
162 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 5.00
163 INT47811 Positive_regulation of Localization of Ddc 11 0.69 4 7.6 5.00
164 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15 5.00
165 INT127691 Gene_expression of CXCL1 23 0.66 18.11 7.04 5.00
166 INT170381 Transcription of Gopc 59 0.60 15.96 6.82 5.00
167 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
168 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 5.00
169 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 5.00
170 INT117189 Binding of CXCR4 34 0.37 24.27 5.81 5.00
171 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 5.00
172 INT77146 Binding of IL4 23 0.36 13.69 5.39 5.00
173 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31 5.00
174 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
175 INT5303 Gene_expression of TAC3 19 0.75 5.25 5.2 5.00
176 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
177 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09 5.00
178 INT114311 Negative_regulation of Gene_expression of Gpt 33 0.38 17.83 4.94 5.00
179 INT211133 Negative_regulation of MTX1 8 0.19 3.86 4.87 5.00
180 INT142162 Binding of IL10 30 0.37 21.9 4.84 5.00
181 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
182 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6 5.00
183 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 5.00
184 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
185 INT67279 Localization of PRTN3 11 0.50 14.18 4.3 5.00
186 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 5.00
187 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
188 INT112340 Gene_expression of Cyp11a1 11 0.77 5.19 3.7 5.00
189 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
190 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 5.00
191 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 5.00
192 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
193 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 5.00
194 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09 5.00
195 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77 5.00
196 INT208588 Binding of CXCR2 11 0.48 6.43 2.68 5.00
197 INT72165 Gene_expression of CXCL6 8 0.52 4.76 2.6 5.00
198 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 5.00
199 INT8512 Gene_expression of PREP 17 0.65 7.98 2.5 5.00
200 INT150222 Positive_regulation of Gene_expression of TNFSF13B 12 0.11 7.49 2.43 5.00
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