D:Mitochondrial Disorders

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Deficiencies Oxidative Phosphorylation, DEFICIENCIES RESPIRATORY CHAIN, Deficiency Oxidative Phosphorylation, Deficiency Respiratory Chain, Disease Mitochondrial, Disorder Mitochondrial, Disorders Mitochondrial, Electron Transport Chain Deficiencies Mitochondrial, Mitochondrial Disease, Mitochondrial Diseases, Mitochondrial Disorder
Documents 144
Hot Single Events 39
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mitochondrial Disorders. They are ordered first by their relevance to Mitochondrial Disorders and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 5.00
2 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 5.00
3 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
4 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 5.00
5 INT183322 Binding of CNNM4 and RBM4B 1 0.12 0.59 0.46 5.00
6 INT182126 IRF6 Positive_regulation of Gene_expression of SELE 1 0.03 0.86 0.34 5.00
7 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21 5.00
8 INT212921 Positive_regulation of Binding of Car2 and Tg(CAG-EGFP)D4Nagy 1 0.12 0.22 0.19 5.00
9 INT212920 Binding of Car2 and Tg(CAG-EGFP)D4Nagy 1 0.09 0.22 0.19 5.00
10 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14 5.00
11 INT262618 Binding of SOAT1 and Kras 1 0.00 0.81 0.12 5.00
12 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1 5.00
13 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
14 INT187671 CGA Negative_regulation of Gene_expression of GNRH1 1 0.01 0 0.06 5.00
15 INT212922 Binding of Car2 and Gfm1 1 0.02 0.19 0.06 5.00
16 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
17 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04 5.00
18 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03 5.00
19 INT262617 Ager Positive_regulation of Rpe 1 0.00 0.81 0 5.00
20 INT187672 Binding of DBT and SCN5A 1 0.00 0.2 0 5.00
21 INT187677 Negative_regulation of FSHR Positive_regulation of DBT 1 0.03 0 0 5.00
22 INT187675 DBT Positive_regulation of Gene_expression of LEP 1 0.04 0.27 0 5.00
23 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
24 INT262619 Gopc Regulation of Gene_expression of ROS1 1 0.01 0.51 0 5.00
25 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0 5.00
26 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 5.00
27 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00
28 INT187667 DBT Positive_regulation of Localization of LEP 1 0.05 0.55 0 5.00
29 INT302675 Binding of OPA1 and PLAA 1 0.15 0.73 0 5.00
30 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
31 INT187669 FSHR Positive_regulation of DBT 1 0.03 0 0 5.00
32 INT187673 GNRH1 Regulation of Localization of PLOD1 1 0.06 0.09 0 5.00
33 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
34 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0 5.00
35 INT187668 Negative_regulation of GNRH1 Positive_regulation of PLOD1 1 0.06 0.07 0 5.00
36 INT251822 Binding of POLG and C10orf2 1 0.42 0.29 0 5.00
37 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00
38 INT262620 Renbp Positive_regulation of Ager Positive_regulation of Rpe 1 0.00 0.81 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mitochondrial Disorders. They are ordered first by their pain relevance and then by number of times they were reported in Mitochondrial Disorders. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT139008 Positive_regulation of Gfm1 21 0.35 7.79 2.34 100.00
2 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 100.00
3 INT79723 Positive_regulation of Sod2 34 0.70 24.61 3.92 99.92
4 INT33053 Positive_regulation of Cox6c 9 0.69 3.74 2.23 98.56
5 INT26364 Positive_regulation of CS 12 0.30 4.99 1.89 98.56
6 INT328570 Binding of MTERF 1 0.45 0.99 0 97.40
7 INT334157 Binding of DTNA 1 0.10 9.81 0.86 97.16
8 INT251827 Regulation of POLG 3 0.59 2.94 0.04 96.92
9 INT158837 Binding of POLG 4 0.37 4.69 0.44 96.52
10 INT46605 Positive_regulation of NAA50 17 0.49 6.33 1.76 95.84
11 INT68865 Gene_expression of ACOX1 13 0.52 5.49 2.09 95.68
12 INT116655 Binding of NAA50 3 0.36 1.93 0.78 95.56
13 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 95.32
14 INT69867 Gene_expression of Mip 36 0.75 24.54 10.38 94.76
15 INT210590 Positive_regulation of Gene_expression of Mip 10 0.67 8.09 1.68 94.76
16 INT102696 Binding of MRP63 4 0.46 3.68 0.27 94.16
17 INT158833 Regulation of Gene_expression of Gfm1 3 0.32 1.34 1.04 93.26
18 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 93.02
19 INT328566 Regulation of MTERF 1 0.37 1.05 0 92.68
20 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 92.52
21 INT266161 Regulation of Negative_regulation of POLG 1 0.38 0.56 0 92.52
22 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68 92.40
23 INT49191 Gene_expression of IFNAR1 14 0.41 9.96 3.84 90.20
24 INT157959 Binding of AQP4 32 0.48 43.44 7.44 89.72
25 INT256399 Positive_regulation of ND4 1 0.01 1.36 0 88.64
26 INT234577 Positive_regulation of Gene_expression of MRP63 1 0.10 0.58 0 88.44
27 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 88.40
28 INT234575 Gene_expression of MRP63 1 0.16 0.62 0 87.84
29 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 87.68
30 INT301935 Gene_expression of UCK2 5 0.13 4.4 0.27 85.44
31 INT317580 Gene_expression of Mrs2 2 0.67 10.17 3.08 85.12
32 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 85.04
33 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 84.64
34 INT17962 Regulation of Car2 124 0.41 33.98 22.71 83.60
35 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 82.72
36 INT69282 Binding of PHEX 4 0.15 1.43 0.41 82.72
37 INT261017 Regulation of Gclc 2 0.22 0.88 0.06 82.56
38 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 82.12
39 INT261026 Localization of Gclc 3 0.36 0.88 0.06 82.12
40 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 76.36
41 INT312972 Regulation of HLA-V 1 0.01 0.14 0 75.84
42 INT328574 Negative_regulation of MTERF 1 0.40 1.22 0.04 75.08
43 INT328565 Negative_regulation of Gene_expression of MTERF 1 0.54 1 0.04 75.08
44 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 75.00
45 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 75.00
46 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 75.00
47 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 74.76
48 INT328567 Gene_expression of MTERF 1 0.72 1 0.04 74.76
49 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 74.48
50 INT251830 Binding of TYMP 2 0.13 4.36 0.37 73.92
51 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 71.60
52 INT211239 Positive_regulation of KIAA0182 1 0.18 0.3 0 71.08
53 INT298759 Regulation of ATP5A1 4 0.60 0.25 0 70.92
54 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 66.64
55 INT328572 Localization of AKAP9 1 0.62 1.14 0.05 65.96
56 INT124300 Negative_regulation of Sod2 17 0.45 12.54 0.9 65.88
57 INT114519 Gene_expression of Hcm 10 0.57 13.01 0.57 64.84
58 INT156639 Localization of Hcm 5 0.64 7.65 0.16 64.72
59 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 63.20
60 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 63.20
61 INT159409 Gene_expression of PLAA 2 0.54 6.14 0.89 62.88
62 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 62.80
63 INT38252 Positive_regulation of Hcm 7 0.40 9.96 0.59 62.60
64 INT108156 Positive_regulation of MAPKAP1 4 0.08 1.91 1.14 61.88
65 INT312969 Negative_regulation of HLA-V 2 0.02 1.01 0 58.68
66 INT312977 Positive_regulation of Negative_regulation of HLA-V 1 0.02 0.17 0 58.68
67 INT298758 Negative_regulation of ATP5A1 2 0.57 0.12 0 58.68
68 INT302684 Negative_regulation of RRM2B 1 0.17 0.73 0.08 57.28
69 INT302686 Negative_regulation of Localization of RRM2B 1 0.38 0.73 0.08 57.28
70 INT302694 Localization of RRM2B 1 0.66 0.73 0.07 57.28
71 INT354341 Transcription of RGD1307443 1 0.09 0.12 0 56.88
72 INT302698 Negative_regulation of MPV17 1 0.16 0.67 0.08 56.48
73 INT302690 Negative_regulation of Localization of MPV17 1 0.37 0.67 0.08 56.48
74 INT302685 Localization of MPV17 1 0.65 0.67 0.07 56.48
75 INT302705 Localization of SUCLG1 1 0.65 0.66 0.07 55.92
76 INT302702 Negative_regulation of SUCLG1 1 0.16 0.66 0.07 55.92
77 INT302691 Negative_regulation of Localization of SUCLG1 1 0.37 0.66 0.07 55.92
78 INT354332 Transcription of Aldh5a1 1 0.67 0.12 0 55.76
79 INT74550 Negative_regulation of SUCLA2 5 0.41 3.6 1.24 55.28
80 INT52460 Localization of SUCLA2 5 0.67 2.5 0.86 55.28
81 INT155170 Negative_regulation of Localization of SUCLA2 2 0.38 1.26 0.28 55.28
82 INT354334 Transcription of Gpld1 1 0.62 0.11 0 55.04
83 INT302696 Negative_regulation of Localization of TK2 1 0.37 0.65 0.07 54.64
84 INT302700 Localization of TK2 1 0.65 0.65 0.07 54.64
85 INT302689 Negative_regulation of TK2 1 0.16 0.65 0.07 54.64
86 INT354339 Transcription of Dcdc2 1 0.48 0.11 0 54.48
87 INT302697 Negative_regulation of DGUOK 1 0.38 0.65 0.07 54.24
88 INT302681 Negative_regulation of Localization of DGUOK 1 0.38 0.65 0.07 54.24
89 INT302680 Localization of DGUOK 1 0.66 0.65 0.07 54.24
90 INT354333 Transcription of Nrsn1 1 0.48 0.11 0 53.92
91 INT224340 Localization of TYMP 3 0.62 2.86 0.3 53.68
92 INT302704 Negative_regulation of Localization of TYMP 1 0.35 0.64 0.07 53.68
93 INT211378 Negative_regulation of TYMP 2 0.56 1.45 0.07 53.68
94 INT248274 Positive_regulation of Capn1 2 0.67 0.55 0 53.28
95 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52 53.20
96 INT19047 Localization of SLC25A4 5 0.73 2.73 0.57 53.20
97 INT302699 Negative_regulation of Localization of SLC25A4 1 0.38 1.01 0.11 53.20
98 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 52.64
99 INT245157 Negative_regulation of Gene_expression of DMD 8 0.57 4.79 0.09 52.64
100 INT251828 Negative_regulation of C10orf2 3 0.37 2.87 0.41 52.48
101 INT302693 Localization of C10orf2 1 0.59 1 0.11 52.48
102 INT302695 Negative_regulation of Localization of C10orf2 1 0.33 1 0.11 52.48
103 INT284528 Negative_regulation of POLG2 2 0.17 2.19 0.33 52.00
104 INT302682 Localization of POLG2 1 0.67 1 0.11 52.00
105 INT302706 Negative_regulation of Localization of POLG2 1 0.38 1 0.11 52.00
106 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11 51.44
107 INT302692 Localization of POLG 1 0.69 0.99 0.1 51.44
108 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 50.24
109 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 50.20
110 INT306112 Regulation of NDUFV1 1 0.02 1 0 50.08
111 INT93916 Positive_regulation of IFNAR1 7 0.25 5.58 1.09 50.00
112 INT258134 Gene_expression of NPTX2 2 0.40 0.65 0 48.32
113 INT354336 Binding of Mrs2 1 0.36 0.59 0.2 46.56
114 INT117197 Gene_expression of Zmat3 19 0.05 8.3 2.05 45.80
115 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 44.28
116 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 39.60
117 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 39.60
118 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92 39.60
119 INT57232 Binding of Casp3 22 0.36 9.42 6.2 39.60
120 INT328568 Transcription of UIMC1 1 0.05 0.28 0 38.72
121 INT91550 Gene_expression of PPM1D 7 0.10 0.68 1.81 38.32
122 INT94784 Binding of ROS1 113 0.40 71.57 10.26 38.08
123 INT10100 Binding of ELANE 22 0.47 15.32 5.19 37.36
124 INT105021 Binding of GOPC 187 0.40 60.39 20.38 37.16
125 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 35.92
126 INT328573 Transcription of ANKIB1 1 0.67 0.28 0 35.68
127 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 34.32
128 INT103463 Localization of CPP 16 0.66 9.63 4.08 33.44
129 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 33.20
130 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 29.44
131 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 28.88
132 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 28.88
133 INT308322 Regulation of ATP6 1 0.25 1.84 0 28.60
134 INT308323 Regulation of APOBR 1 0.01 1.91 0 28.60
135 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 26.72
136 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 26.72
137 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 26.32
138 INT211240 Negative_regulation of Gene_expression of KIAA0182 1 0.15 0.18 0.07 26.08
139 INT211237 Gene_expression of KIAA0182 1 0.24 0.25 0.07 26.08
140 INT2910 Regulation of Abat 169 0.62 36.95 153.53 25.44
141 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 19.88
142 INT116625 Phosphorylation of Nefh 13 0.79 5.94 1.4 18.96
143 INT334158 Positive_regulation of DTNA 1 0.10 1.85 0.12 14.88
144 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 14.04
145 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62 13.20
146 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48 10.44
147 INT187725 Positive_regulation of Localization of CYP19A1 1 0.39 0.23 0 10.44
148 INT187719 Negative_regulation of Localization of CYP19A1 1 0.33 0.78 0 10.44
149 INT115707 Negative_regulation of CYP51A1 2 0.40 0.67 0.15 10.00
150 INT230 Positive_regulation of GGTLC1 14 0.68 11.78 1.55 9.60
151 INT328569 Negative_regulation of AKAP9 1 0.18 0.22 0 9.28
152 INT1129 Binding of Car2 69 0.35 14.01 9.2 8.96
153 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 6.04
154 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
155 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
156 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
157 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
158 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
159 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
160 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
161 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
162 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
163 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
164 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
165 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
166 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
167 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 5.00
168 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
169 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
170 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
171 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
172 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 5.00
173 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
174 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
175 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
176 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
177 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
178 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
179 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.00
180 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
181 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
182 INT6761 Binding of CALCA 100 0.48 26.71 62.05 5.00
183 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
184 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
185 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 5.00
186 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
187 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
188 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
189 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05 5.00
190 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
191 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
192 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
193 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 5.00
194 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
195 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
196 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 5.00
197 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
198 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
199 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
200 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox