D:Mitochondrial Myopathies

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Disease Term
Synonyms Disease Luft, DISEASE LUFT S, LUFT DISEASE, LUFT S DISEASE, Lufts Disease, Megaconial Myopathies, Megaconial Myopathy, Mitochondrial Myopathy, Myopathies Mitochondrial, Myopathies Pleoconial, Myopathy Megaconial
Documents 123
Hot Single Events 16
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mitochondrial Myopathies. They are ordered first by their relevance to Mitochondrial Myopathies and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT297738 Cbr1 Positive_regulation of Ifih1 1 0.01 1.83 0.39 59.56
2 INT297736 Cbr1 Positive_regulation of Ucp3 1 0.11 1.29 0.07 5.00
3 INT297735 Cbr1 Positive_regulation of Sod2 1 0.11 1.28 0.07 5.00
4 INT297733 Cbr1 Regulation of Gene_expression of Bcl2 1 0.05 0.94 0.07 5.00
5 INT269273 Regulation of Mt1 Regulation of Gene_expression of Mecr 1 0.12 0.34 0.04 5.00
6 INT297737 Cbr1 Positive_regulation of Bax 1 0.06 0.53 0.03 5.00
7 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
8 INT297739 Binding of Cbr1 and Ucp3 1 0.06 0.5 0 5.00
9 INT269275 Binding of CNOT1 and Mecr 1 0.36 0.06 0 5.00
10 INT297740 Cbr1 Negative_regulation of Positive_regulation of PROC 1 0.00 0.42 0 5.00
11 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
12 INT297741 Cbr1 Negative_regulation of PROC 1 0.00 0.4 0 5.00
13 INT297734 Cbr1 Regulation of Positive_regulation of Ifih1 1 0.00 0.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mitochondrial Myopathies. They are ordered first by their pain relevance and then by number of times they were reported in Mitochondrial Myopathies. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT28320 Negative_regulation of Abo 16 0.58 5.69 4.7 99.92
2 INT102696 Binding of MRP63 4 0.46 3.68 0.27 98.96
3 INT249052 Protein_catabolism of SMN1 1 0.02 1.98 0.1 97.44
4 INT328570 Binding of MTERF 1 0.45 0.99 0 95.84
5 INT334157 Binding of DTNA 1 0.10 9.81 0.86 95.28
6 INT328566 Regulation of MTERF 1 0.37 1.05 0 94.28
7 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 88.96
8 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 87.12
9 INT245157 Negative_regulation of Gene_expression of DMD 8 0.57 4.79 0.09 85.72
10 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 85.40
11 INT334158 Positive_regulation of DTNA 1 0.10 1.85 0.12 83.44
12 INT269267 Gene_expression of Celf3 1 0.08 1.4 0.03 83.24
13 INT269261 Positive_regulation of Gene_expression of Celf3 1 0.06 0.99 0 83.24
14 INT116655 Binding of NAA50 3 0.36 1.93 0.78 81.40
15 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 81.20
16 INT139008 Positive_regulation of Gfm1 21 0.35 7.79 2.34 80.16
17 INT25070 Negative_regulation of Ndufs2 3 0.21 0.99 1.13 78.32
18 INT328574 Negative_regulation of MTERF 1 0.40 1.22 0.04 76.68
19 INT328565 Negative_regulation of Gene_expression of MTERF 1 0.54 1 0.04 76.68
20 INT328567 Gene_expression of MTERF 1 0.72 1 0.04 76.36
21 INT59073 Gene_expression of Nae1 1 0.01 1.22 0.08 76.08
22 INT266894 Positive_regulation of Positive_regulation of Sod2 5 0.41 3.26 0.67 75.04
23 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11 75.00
24 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 75.00
25 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 74.44
26 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 69.56
27 INT79723 Positive_regulation of Sod2 34 0.70 24.61 3.92 69.56
28 INT328572 Localization of AKAP9 1 0.62 1.14 0.05 67.56
29 INT288331 Gene_expression of Sod1m 5 0.09 6.99 0.77 63.08
30 INT288330 Positive_regulation of Gene_expression of Sod1m 4 0.08 5.88 0.67 63.08
31 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 58.04
32 INT197172 Negative_regulation of Gene_expression of Gfm1 2 0.02 1.68 0.04 55.88
33 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 55.36
34 INT297715 Positive_regulation of Cbr1 1 0.08 2.59 0.39 53.80
35 INT328568 Transcription of UIMC1 1 0.05 0.28 0 35.60
36 INT308322 Regulation of ATP6 1 0.25 1.84 0 33.28
37 INT308323 Regulation of APOBR 1 0.01 1.91 0 33.28
38 INT328573 Transcription of ANKIB1 1 0.67 0.28 0 32.56
39 INT269259 Regulation of Mecr 1 0.62 1.97 0 30.00
40 INT269254 Gene_expression of Mecr 1 0.78 10.69 0.14 26.48
41 INT269253 Positive_regulation of Gene_expression of Mecr 1 0.70 6.95 0.06 26.48
42 INT297712 Positive_regulation of Gtf2e1 1 0.01 0.14 0 25.64
43 INT269256 Gene_expression of Aurka 2 0.65 0.62 0 12.40
44 INT269263 Positive_regulation of Gene_expression of Aurka 1 0.49 0.3 0 12.40
45 INT115707 Negative_regulation of CYP51A1 2 0.40 0.67 0.15 6.88
46 INT328569 Negative_regulation of AKAP9 1 0.18 0.22 0 6.16
47 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
48 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
49 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 5.00
50 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
51 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
52 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
53 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2 5.00
54 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
55 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07 5.00
56 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 5.00
57 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
58 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
59 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
60 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 5.00
61 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77 5.00
62 INT78695 Regulation of Casp3 24 0.44 9.43 10.48 5.00
63 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 5.00
64 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83 5.00
65 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
66 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
67 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 5.00
68 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64 5.00
69 INT111377 Positive_regulation of Ifih1 16 0.60 11.22 6.99 5.00
70 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 5.00
71 INT124605 Gene_expression of Ifih1 16 0.57 7.36 5.33 5.00
72 INT9863 Negative_regulation of Ifih1 17 0.20 10.58 5.07 5.00
73 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06 5.00
74 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 5.00
75 INT1983 Negative_regulation of Cbr1 4 0.58 4.44 4.52 5.00
76 INT112692 Localization of Bax 31 0.80 20.97 3.98 5.00
77 INT105975 Gene_expression of ACACA 16 0.75 5.73 3.86 5.00
78 INT2936 Gene_expression of AGL 36 0.49 9.55 3.63 5.00
79 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 5.00
80 INT116143 Positive_regulation of Casp9 32 0.67 30.34 3.04 5.00
81 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 5.00
82 INT79722 Regulation of Cat 14 0.62 5.88 2.86 5.00
83 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 5.00
84 INT16964 Binding of IFNG 27 0.48 14.31 2.45 5.00
85 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 5.00
86 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13 5.00
87 INT127777 Positive_regulation of Mthfr 4 0.38 3.8 2.09 5.00
88 INT35745 Negative_regulation of AGL 29 0.50 9.16 2.03 5.00
89 INT26364 Positive_regulation of CS 12 0.30 4.99 1.89 5.00
90 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89 5.00
91 INT48218 Gene_expression of KRIT1 16 0.75 7.59 1.8 5.00
92 INT46605 Positive_regulation of NAA50 17 0.49 6.33 1.76 5.00
93 INT70322 Gene_expression of MAPKAP1 10 0.65 6.06 1.7 5.00
94 INT297726 Gene_expression of Cbr1 27 0.20 7.68 1.64 5.00
95 INT297709 Positive_regulation of Gene_expression of Ucp3 5 0.56 4.67 1.28 5.00
96 INT33520 Negative_regulation of CYC1 11 0.57 5.36 1.26 5.00
97 INT124603 Positive_regulation of Gene_expression of Ifih1 3 0.16 1.17 1.22 5.00
98 INT141184 Negative_regulation of Casp9 5 0.42 5.48 1.15 5.00
99 INT108156 Positive_regulation of MAPKAP1 4 0.08 1.91 1.14 5.00
100 INT146030 Negative_regulation of Positive_regulation of Ifih1 2 0.29 1.16 1.13 5.00
101 INT203372 Positive_regulation of Igfals 10 0.40 9.24 1.11 5.00
102 INT107653 Gene_expression of ACAT1 9 0.60 4.74 1.03 5.00
103 INT60122 Negative_regulation of MADD 3 0.11 2.23 0.93 5.00
104 INT37950 Regulation of PDSS1 3 0.44 1.24 0.91 5.00
105 INT124300 Negative_regulation of Sod2 17 0.45 12.54 0.9 5.00
106 INT122652 Regulation of B4GALNT1 5 0.11 1.76 0.88 5.00
107 INT137276 Binding of Acads 3 0.32 1.82 0.84 5.00
108 INT297724 Gene_expression of Ucp3 13 0.63 10.67 0.79 5.00
109 INT173422 Gene_expression of ETFDH 11 0.45 5.78 0.78 5.00
110 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 5.00
111 INT186523 Binding of ETFDH 10 0.25 5.63 0.72 5.00
112 INT156875 Positive_regulation of Gene_expression of Casp8 2 0.49 2.49 0.7 5.00
113 INT232841 Gene_expression of Scap 11 0.02 8.68 0.7 5.00
114 INT76902 Binding of AGL 3 0.02 2.23 0.64 5.00
115 INT3491 Negative_regulation of CPT2 8 0.57 4.32 0.62 5.00
116 INT5261 Localization of AGL 10 0.36 3.17 0.61 5.00
117 INT98609 Negative_regulation of PYGM 11 0.43 6.21 0.6 5.00
118 INT120591 Positive_regulation of Acads 2 0.40 1.25 0.56 5.00
119 INT79725 Regulation of Sod2 8 0.61 4.95 0.54 5.00
120 INT74630 Negative_regulation of ACADVL 8 0.58 2.49 0.53 5.00
121 INT198903 Binding of Pilra 5 0.04 2.18 0.5 5.00
122 INT69947 Negative_regulation of MTAP 5 0.40 2.63 0.48 5.00
123 INT142598 Negative_regulation of KRIT1 3 0.57 0.57 0.4 5.00
124 INT274203 Positive_regulation of PABPN1 1 0.16 2.41 0.37 5.00
125 INT163803 Regulation of Gene_expression of Cat 3 0.61 1.51 0.33 5.00
126 INT297719 Positive_regulation of Ucp3 12 0.56 11.39 0.23 5.00
127 INT124714 Localization of PFKM 2 0.37 1.45 0.21 5.00
128 INT297728 Binding of Sod1m 2 0.04 3.45 0.21 5.00
129 INT269264 Regulation of Mt1 6 0.21 2.71 0.2 5.00
130 INT199843 Protein_catabolism of Casp9 6 0.26 4.5 0.18 5.00
131 INT312973 Binding of ACADVL 1 0.23 2.35 0.17 5.00
132 INT218167 Positive_regulation of Gene_expression of ETFDH 1 0.33 1.19 0.15 5.00
133 INT167957 Gene_expression of Grxcr1 8 0.10 3.43 0.14 5.00
134 INT297711 Negative_regulation of Gene_expression of Cbr1 1 0.07 1.02 0.12 5.00
135 INT240786 Binding of Bcl2a1c 10 0.18 9.47 0.12 5.00
136 INT206938 Regulation of Casp9 5 0.44 3.99 0.12 5.00
137 INT297707 Positive_regulation of Gene_expression of Cbr1 4 0.13 1.76 0.11 5.00
138 INT297723 Negative_regulation of Binding of Casp9 1 0.17 1.18 0.11 5.00
139 INT297716 Binding of Casp9 1 0.15 1.18 0.11 5.00
140 INT161127 Localization of SLC22A16 2 0.73 1.34 0.1 5.00
141 INT112328 Negative_regulation of PHKG1 2 0.46 0.83 0.1 5.00
142 INT297710 Regulation of Cbr1 1 0.08 1.12 0.09 5.00
143 INT297706 Negative_regulation of Mwq1 1 0.04 1.24 0.09 5.00
144 INT3492 Negative_regulation of CPT1A 2 0.39 0.24 0.08 5.00
145 INT214921 Localization of MAPKAP1 3 0.09 2.5 0.08 5.00
146 INT297708 Regulation of Cox4i1 1 0.07 0.98 0.07 5.00
147 INT80667 Gene_expression of PFKM 4 0.57 2.13 0.07 5.00
148 INT153679 Regulation of AGL 4 0.04 1.49 0.07 5.00
149 INT240787 Positive_regulation of Bcl2a1c 12 0.22 9.79 0.06 5.00
150 INT297725 Negative_regulation of Ucp3 2 0.35 4.03 0.05 5.00
151 INT269274 Regulation of MTNR1A 3 0.60 1.47 0.05 5.00
152 INT269260 Regulation of Gene_expression of Mecr 1 0.62 2.19 0.04 5.00
153 INT269266 Regulation of Regulation of Mt1 1 0.13 0.17 0.04 5.00
154 INT269262 Positive_regulation of Regulation of Mt1 1 0.23 0.62 0.04 5.00
155 INT297729 Regulation of Regulation of Sod2 1 0.37 0.05 0.03 5.00
156 INT269265 Positive_regulation of Mecr 1 0.70 3.7 0.03 5.00
157 INT269252 Positive_regulation of Celf3 1 0.07 0.96 0.03 5.00
158 INT266823 Regulation of Grxcr1 3 0.06 1.4 0.03 5.00
159 INT269257 Localization of Mecr 1 0.75 0.13 0.03 5.00
160 INT312971 Negative_regulation of MLYCD 1 0.05 0 0 5.00
161 INT234572 Regulation of MRP63 1 0.09 0.08 0 5.00
162 INT312967 Positive_regulation of Binding of AGL 1 0.03 0.55 0 5.00
163 INT297727 Positive_regulation of Positive_regulation of Ifih1 1 0.02 0.27 0 5.00
164 INT312966 Regulation of Gene_expression of AGL 1 0.03 0.27 0 5.00
165 INT312969 Negative_regulation of HLA-V 2 0.02 1.01 0 5.00
166 INT234577 Positive_regulation of Gene_expression of MRP63 1 0.10 0.58 0 5.00
167 INT297718 Localization of Cbr1 1 0.13 0.4 0 5.00
168 INT269255 Transcription of Mecr 1 0.72 0.84 0 5.00
169 INT238840 Gene_expression of Pygm 2 0.65 1.9 0 5.00
170 INT298759 Regulation of ATP5A1 4 0.60 0.25 0 5.00
171 INT234574 Negative_regulation of POLRMT 1 0.21 0 0 5.00
172 INT312970 Negative_regulation of ACSL1 1 0.01 0.56 0 5.00
173 INT312977 Positive_regulation of Negative_regulation of HLA-V 1 0.02 0.17 0 5.00
174 INT234573 Gene_expression of TRNL1 1 0.03 0 0 5.00
175 INT269268 Binding of Mecr 1 0.33 0.06 0 5.00
176 INT269270 Negative_regulation of Mecr 1 0.37 1.13 0 5.00
177 INT312974 Gene_expression of CPT2 1 0.47 0.94 0 5.00
178 INT234575 Gene_expression of MRP63 1 0.16 0.62 0 5.00
179 INT312972 Regulation of HLA-V 1 0.01 0.14 0 5.00
180 INT298758 Negative_regulation of ATP5A1 2 0.57 0.12 0 5.00
181 INT312976 Protein_catabolism of ACAT1 1 0.02 0.46 0 5.00
182 INT269258 Transcription of Celf3 1 0.07 0.26 0 5.00
183 INT312975 Negative_regulation of MSMO1 1 0.01 0 0 5.00
184 INT234576 Negative_regulation of MRP63 1 0.09 0 0 5.00
185 INT297717 Positive_regulation of Positive_regulation of Ucp3 1 0.56 1.11 0 5.00
186 INT297713 Regulation of Ucp3 1 0.22 0.69 0 5.00
187 INT312968 Gene_expression of ACADVL 1 0.36 0.45 0 5.00
188 INT297714 Binding of Cbr1 1 0.06 0.57 0 5.00
189 INT312978 Negative_regulation of Pygm 1 0.42 0.95 0 5.00
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