D:Mitral Valve Insufficiency

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms INCOMPETENCE MITRAL, Incompetence Mitral Valve, Insufficiency Mitral, Insufficiency Mitral Valve, Mitral Incompetence, MITRAL INSUFFICIENCY, Mitral Regurgitation, Mitral Valve Incompetence, MITRAL VALVE REGURGITATION, Regurgitation Mitral, Regurgitation Mitral Valve
Documents 516
Hot Single Events 51
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mitral Valve Insufficiency. They are ordered first by their relevance to Mitral Valve Insufficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT180200 Binding of BCAR1 and MMVP1 1 0.11 8.57 0.08 76.56
2 INT68482 Cga Regulation of Gh 1 0.00 1.89 0.31 69.44
3 INT68479 Gnrh1 Regulation of Lhb 1 0.00 1.58 0.25 67.24
4 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83 34.24
5 INT68480 Negative_regulation of Gnrh1 Regulation of Lhb 1 0.00 0.67 0.15 31.56
6 INT11684 Binding of CSF2 and IL3 6 0.36 3.3 0.72 5.00
7 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
8 INT269784 Crp Positive_regulation of Vcam1 1 0.00 1.6 0.11 5.00
9 INT269783 Crp Positive_regulation of Sele 1 0.00 1.69 0.11 5.00
10 INT269785 Crp Positive_regulation of ICAM1 1 0.00 1.68 0.11 5.00
11 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1 5.00
12 INT291837 Binding of Pecam1 and Vegfa 1 0.09 1.1 0.07 5.00
13 INT356379 DMD Positive_regulation of Negative_regulation of Utrn 1 0.54 0.84 0.07 5.00
14 INT325769 Binding of EPOR and Positive_regulation of Phosphorylation of JAK2 1 0.66 0 0.06 5.00
15 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 5.00
16 INT325770 Binding of EPOR and PIK3R2 1 0.01 0.18 0 5.00
17 INT325771 EPOR Positive_regulation of MAPK1 1 0.16 0.29 0 5.00
18 INT334894 Binding of CALCR and ARMC9 1 0.01 0.41 0 5.00
19 INT356377 Dmd Positive_regulation of Negative_regulation of Mib2 1 0.03 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mitral Valve Insufficiency. They are ordered first by their pain relevance and then by number of times they were reported in Mitral Valve Insufficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 100.00
2 INT17879 Positive_regulation of Ppap2a 17 0.53 9.72 3.8 100.00
3 INT178834 Localization of MR1 8 0.21 6.52 0.48 100.00
4 INT178833 Positive_regulation of Localization of MR1 3 0.14 2.62 0.1 100.00
5 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71 100.00
6 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 100.00
7 INT178831 Positive_regulation of Positive_regulation of MR1 2 0.38 1.37 0.05 100.00
8 INT141132 Regulation of ACCS 14 0.29 13.92 1.89 100.00
9 INT176892 Binding of MR1 36 0.32 15.55 2.58 100.00
10 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48 100.00
11 INT177593 Positive_regulation of Gene_expression of MR1 17 0.43 9.36 1.13 100.00
12 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43 100.00
13 INT334907 Protein_catabolism of Nppb 2 0.56 8.28 0.22 99.98
14 INT129534 Gene_expression of Nppb 19 0.58 23.68 1.6 99.98
15 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 99.98
16 INT110039 Positive_regulation of Nppb 38 0.53 34.54 2.88 99.96
17 INT110040 Binding of Nppb 9 0.18 8.91 0.19 99.78
18 INT65673 Positive_regulation of DSE 4 0.41 2.86 0.33 99.74
19 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19 99.44
20 INT180201 Regulation of MMVP1 1 0.08 1.57 0.11 99.36
21 INT318839 Binding of NUCKS1 2 0.13 0.84 0.18 98.84
22 INT242986 Positive_regulation of Gene_expression of Nppb 3 0.26 2.77 0.5 98.58
23 INT123464 Binding of ATP5G3 3 0.18 1.92 0.79 98.56
24 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 98.40
25 INT68189 Gene_expression of TNNT1 27 0.75 14.87 4.03 98.24
26 INT191706 Positive_regulation of Gene_expression of TNNT1 5 0.49 3.61 0.64 98.24
27 INT39468 Positive_regulation of hf 10 0.33 13.5 1.32 98.20
28 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 98.00
29 INT64806 Binding of asa 10 0.30 4.11 3.14 97.96
30 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75 97.20
31 INT93877 Binding of Clta 2 0.18 1.29 0.23 96.72
32 INT293079 Negative_regulation of Gene_expression of SERPINA5 1 0.21 1.36 0.16 96.64
33 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 96.44
34 INT72947 Binding of CHM 9 0.42 5.86 0.06 95.20
35 INT57424 Positive_regulation of TNNT1 42 0.67 31.84 9.7 94.88
36 INT170625 Binding of SERPINA5 8 0.32 8.42 0.69 94.24
37 INT199681 Gene_expression of SERPINA5 13 0.36 15.42 1.25 94.16
38 INT22882 Negative_regulation of IMPA1 10 0.57 5.19 0.31 92.64
39 INT239247 Positive_regulation of APOA5 7 0.37 3.68 0.51 91.76
40 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 91.28
41 INT59859 Localization of ARSD 11 0.65 9.67 1.88 89.60
42 INT78809 Negative_regulation of ADK 3 0.34 1.89 1.85 88.84
43 INT16184 Negative_regulation of CHKB 20 0.53 10.61 1.42 88.84
44 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56 87.20
45 INT34141 Positive_regulation of IMPA1 8 0.50 2.38 1.12 86.48
46 INT171772 Binding of CPB1 13 0.32 9.92 0.75 84.80
47 INT182890 Gene_expression of Atp2c1 1 0.58 1.19 0.15 83.68
48 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71 82.52
49 INT166819 Gene_expression of IMPA1 12 0.65 3.85 1.77 82.04
50 INT166818 Positive_regulation of Gene_expression of IMPA1 3 0.36 0.99 1.06 82.04
51 INT35500 Regulation of Emb 1 0.23 1.25 0.27 80.08
52 INT114519 Gene_expression of Hcm 10 0.57 13.01 0.57 79.36
53 INT34143 Regulation of IMPA1 14 0.44 4.83 0.58 79.00
54 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87 78.88
55 INT2105 Negative_regulation of Rhd 10 0.41 4.9 3.4 77.88
56 INT9973 Binding of MMVP1 14 0.48 22.66 1.79 77.88
57 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 76.40
58 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16 76.40
59 INT173086 Negative_regulation of VHL 14 0.59 12.54 0.29 76.40
60 INT325800 Negative_regulation of EGLN3 1 0.32 0.6 0.13 76.40
61 INT325793 Negative_regulation of EPOR 1 0.58 0.6 0.13 76.40
62 INT182891 Positive_regulation of Atp2c1 1 0.43 1.49 0.38 76.16
63 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 75.20
64 INT240127 Binding of Nppb 19 0.37 22.42 3.3 73.60
65 INT47029 Protein_catabolism of MMVP1 1 0.17 1.34 0.09 73.12
66 INT199209 Regulation of Ict1 4 0.05 2.53 0.03 72.68
67 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 72.16
68 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 72.16
69 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81 72.16
70 INT189614 Gene_expression of EGLN1 6 0.49 4.3 0.12 72.16
71 INT325784 Gene_expression of EGLN3 1 0.37 0.46 0.12 72.16
72 INT325777 Gene_expression of EGLN2 1 0.31 0.46 0.12 72.16
73 INT100861 Binding of CRP 179 0.48 175.2 26.45 71.76
74 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 70.48
75 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 70.00
76 INT22391 Positive_regulation of WASF1 2 0.45 1.52 0.63 69.76
77 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 69.44
78 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 68.64
79 INT5126 Positive_regulation of Positive_regulation of Lhb 16 0.48 2.12 5.23 68.64
80 INT7224 Positive_regulation of Gene_expression of Lhb 18 0.45 10.22 3.4 68.64
81 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 67.24
82 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59 66.92
83 INT23367 Positive_regulation of Positive_regulation of Gnrh1 9 0.50 0.97 2.97 66.80
84 INT182889 Binding of Atp2c1 1 0.32 0.22 0 66.72
85 INT199208 Gene_expression of Ict1 7 0.08 3.92 0.08 66.68
86 INT199207 Regulation of Gene_expression of Ict1 1 0.00 0.61 0 66.68
87 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 66.32
88 INT180388 Positive_regulation of Gene_expression of ACCS 9 0.21 9.43 1.34 64.80
89 INT268100 Regulation of Gene_expression of ACCS 2 0.06 1.81 0.23 64.80
90 INT291341 Phosphorylation of Ifnar1 2 0.03 0.99 0.22 64.80
91 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 60.44
92 INT84264 Regulation of NPPB 22 0.61 21.18 1.94 60.32
93 INT63959 Regulation of Tnni3 11 0.21 4.69 1.57 60.32
94 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 59.04
95 INT310741 Gene_expression of POLG2 1 0.36 0.87 0.03 58.68
96 INT199206 Negative_regulation of Ict1 9 0.05 3.67 0.21 57.44
97 INT37865 Positive_regulation of Alad 5 0.27 3.13 0.6 56.48
98 INT81972 Positive_regulation of Dse 20 0.57 16.5 2.99 56.40
99 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 56.32
100 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 55.52
101 INT65324 Gene_expression of Tnni3 12 0.66 7.97 1.25 55.16
102 INT16923 Positive_regulation of Tnni3 32 0.50 25.01 5.44 55.16
103 INT156130 Binding of SERPING1 29 0.42 26.16 2.52 53.84
104 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 53.80
105 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 53.48
106 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89 52.16
107 INT291340 Phosphorylation of Mpeg1 1 0.51 0.36 0.08 49.76
108 INT17685 Negative_regulation of Cog1 23 0.42 15.65 3.56 46.40
109 INT131351 Positive_regulation of Gene_expression of Nppb 2 0.50 13.72 1.14 46.20
110 INT171070 Positive_regulation of Hey2 8 0.05 10.12 1.96 44.32
111 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84 44.16
112 INT1530 Regulation of Gh 382 0.61 115.96 112.47 41.44
113 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 39.52
114 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 38.32
115 INT293077 Regulation of SERPINA5 2 0.24 1.42 0.29 37.04
116 INT29424 Negative_regulation of Positive_regulation of Lhb 21 0.56 4.58 4.03 31.56
117 INT9785 Negative_regulation of Positive_regulation of Gnrh1 18 0.43 1.88 7.35 31.44
118 INT121335 Localization of SCD 10 0.68 6.81 1.51 31.20
119 INT94713 Regulation of CD34 11 0.45 8.02 0.58 30.88
120 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 30.80
121 INT291342 Negative_regulation of Mpeg1 3 0.40 5.76 0.2 27.92
122 INT15610 Localization of GOPC 223 0.65 68.26 28.7 27.68
123 INT77290 Gene_expression of asa 15 0.33 10.17 4.97 24.24
124 INT325780 Positive_regulation of EPOR 1 0.69 2.86 0.36 23.68
125 INT17056 Gene_expression of DLD 37 0.57 13.15 5.47 22.56
126 INT259033 Gene_expression of LCA5L 1 0.01 2.71 0.16 17.68
127 INT303530 Gene_expression of Gspt1 2 0.07 1.23 0.1 14.80
128 INT350311 Positive_regulation of Gene_expression of Gspt1 1 0.05 1.09 0 14.80
129 INT134748 Positive_regulation of SV2A 7 0.46 2.89 0.82 14.48
130 INT302888 Positive_regulation of HIST1H4PS1 3 0.05 1.52 0.32 13.20
131 INT268212 Negative_regulation of Gene_expression of Pol 3 0.25 2.13 0.04 7.12
132 INT108559 Gene_expression of Pol 46 0.45 30.07 1.14 6.24
133 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 5.08
134 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
135 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
136 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
137 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
138 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
139 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
140 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
141 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
142 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
143 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
144 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
145 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
146 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
147 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
148 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
149 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
150 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
151 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
152 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
153 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
154 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 5.00
155 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
156 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
157 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
158 INT5617 Localization of Nppa 266 0.81 83.51 83.89 5.00
159 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
160 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
161 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
162 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
163 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
164 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
165 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 5.00
166 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
167 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
168 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
169 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
170 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
171 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 5.00
172 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
173 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 5.00
174 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
175 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
176 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
177 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
178 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
179 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
180 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
181 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
182 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
183 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
184 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45 5.00
185 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
186 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
187 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
188 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
189 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
190 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
191 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
192 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
193 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
194 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4 5.00
195 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
196 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
197 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
198 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
199 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
200 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox