D:Mitral Valve Prolapse

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Disease Term
Synonyms Asynchronous Valve Closure Syndrome, BARLOW S SYNDROME, Click Murmur Syndrome, Click Murmur Syndrome Mitral, CLICK MURMUR SYNDROME SYSTOLIC, Click Murmur Syndromes Mitral, CLICK MURMUR SYNDROMES SYSTOLIC, CLICK SYNDROME, FLOPPY MITRAL VALVE, Floppy Mitral Valves, Floppy Valve Syndrome
Documents 165
Hot Single Events 39
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mitral Valve Prolapse. They are ordered first by their relevance to Mitral Valve Prolapse and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT180200 Binding of BCAR1 and MMVP1 1 0.11 8.57 0.08 100.00
2 INT267778 Binding of Mvp and Gopc 1 0.12 0.83 0 100.00
3 INT267777 Positive_regulation of Binding of Mvp and IgG 1 0.12 0.89 0 100.00
4 INT267783 Binding of Mvp and IgG 1 0.09 0.89 0 100.00
5 INT146131 Binding of Gnrh1 and Hspd1 1 0.02 0.88 0 100.00
6 INT146132 Binding of Gnrh1 and Tmem65 1 0.02 0.88 0 100.00
7 INT267781 Mvp Positive_regulation of Gopc 1 0.18 0.19 0.06 87.84
8 INT267780 Binding of Mvp and Positive_regulation of Hand1 1 0.16 0.48 0.05 36.56
9 INT187361 Binding of Gabrg1 and Kcnn3 1 0.36 0.13 0.3 5.00
10 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
11 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 5.00
12 INT267776 Binding of Vdac3 and IgG 1 0.01 0.69 0.08 5.00
13 INT209454 Binding of PSMD1 and PSMD2 1 0.15 0 0 5.00
14 INT209452 Binding of PSMD2 and PSMD3 1 0.07 0.2 0 5.00
15 INT209453 Binding of PSMD1 and PSMD3 1 0.08 0.2 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mitral Valve Prolapse. They are ordered first by their pain relevance and then by number of times they were reported in Mitral Valve Prolapse. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9973 Binding of MMVP1 14 0.48 22.66 1.79 100.00
2 INT267746 Gene_expression of Mvp 1 0.64 4.25 0.22 100.00
3 INT27753 Positive_regulation of MMVP1 5 0.43 7.1 0.74 100.00
4 INT968 Gene_expression of MMVP1 2 0.52 2.3 0.27 100.00
5 INT267744 Binding of Mvp 1 0.27 2.57 0.24 100.00
6 INT236457 Localization of MVP 1 0.31 2.55 0.35 100.00
7 INT170444 Binding of Gopc 172 0.39 45.05 20.71 100.00
8 INT236456 Gene_expression of MVP 1 0.28 1.46 0.29 100.00
9 INT180202 Localization of MMVP1 1 0.25 1.69 0 100.00
10 INT267756 Positive_regulation of Gene_expression of Mvp 1 0.36 1.1 0.07 100.00
11 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 100.00
12 INT47029 Protein_catabolism of MMVP1 1 0.17 1.34 0.09 100.00
13 INT180201 Regulation of MMVP1 1 0.08 1.57 0.11 100.00
14 INT967 Regulation of Gene_expression of MMVP1 1 0.23 1.05 0.19 100.00
15 INT187359 Negative_regulation of Mvp 1 0.06 1.12 0.12 100.00
16 INT267751 Positive_regulation of Mvp 1 0.34 0.55 0.05 100.00
17 INT59165 Binding of fc 67 0.36 37.51 8.68 99.82
18 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 99.80
19 INT20205 Binding of IgG 108 0.46 66.68 8.57 99.72
20 INT212916 Positive_regulation of Binding of 5 0.24 1.74 0.04 99.72
21 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 99.64
22 INT10783 Negative_regulation of Gnrh1 24 0.59 7.9 6.2 99.60
23 INT191017 Localization of Cd79a 28 0.56 13.94 2.55 98.18
24 INT72747 Localization of IgG 55 0.53 30.88 4.19 98.18
25 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 97.84
26 INT38595 Localization of BCAR1 8 0.73 2.9 6.25 97.68
27 INT68247 Gene_expression of Ighg3 6 0.65 1.76 0.79 97.60
28 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 97.36
29 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 97.36
30 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 96.84
31 INT114143 Negative_regulation of Vdac3 2 0.39 0.85 0.47 95.52
32 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 94.88
33 INT236455 Binding of MVP 1 0.18 0.32 0 92.56
34 INT22383 Binding of IL2 59 0.48 39.06 8.56 92.28
35 INT15796 Regulation of IL2 66 0.61 25.43 20.62 92.28
36 INT10787 Gene_expression of Gnrh1 64 0.78 23.06 6.76 90.08
37 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 89.16
38 INT146130 Binding of Gnrh1 6 0.47 2.21 0.03 87.92
39 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27 81.60
40 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26 76.00
41 INT96073 Localization of Casp1 11 0.78 4.91 1.29 75.28
42 INT277801 Positive_regulation of Ms4a1 2 0.44 1.95 0.06 74.52
43 INT267753 Negative_regulation of Apba1 1 0.01 0.43 0.05 70.56
44 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 66.00
45 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 66.00
46 INT182339 Gene_expression of Ms4a1 18 0.68 16.6 0.42 65.48
47 INT279379 Regulation of Gene_expression of Ms4a1 1 0.15 0.86 0.03 65.48
48 INT277800 Positive_regulation of Gene_expression of Ms4a1 2 0.44 2.02 0.03 65.48
49 INT127927 Positive_regulation of ADCY4 2 0.15 0.67 0.07 62.80
50 INT269103 Gene_expression of AOX1 2 0.26 1.97 0.46 60.84
51 INT269105 Localization of AOX1 1 0.31 2.16 0.5 58.40
52 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 58.20
53 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 47.56
54 INT267745 Positive_regulation of Aars 1 0.06 0.85 0 40.40
55 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 38.56
56 INT104394 Positive_regulation of Gene_expression of Cxcl10 28 0.65 25.64 8.79 38.56
57 INT237054 Negative_regulation of Gene_expression of Cxcl10 11 0.56 10.26 3.4 38.56
58 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 36.88
59 INT267757 Gene_expression of Aars 1 0.05 0.84 0 35.56
60 INT20378 Localization of Hand1 53 0.71 41.96 13.31 29.48
61 INT233357 Localization of Il12b 7 0.16 3.4 1.12 29.48
62 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68 28.08
63 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 27.80
64 INT172078 Localization of Cd3e 22 0.37 9.88 2.27 23.80
65 INT160562 Localization of Cd4 49 0.71 27.58 6.78 23.64
66 INT133169 Positive_regulation of Il12b 25 0.49 13 3.64 23.24
67 INT200874 Positive_regulation of Localization of Gopc 27 0.38 5.69 7.5 21.36
68 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87 21.36
69 INT90792 Localization of Il10 144 0.80 87.88 30.03 20.84
70 INT173693 Localization of Gopc 249 0.65 70.49 38.81 20.60
71 INT187360 Gene_expression of Kcnn2 17 0.55 2.51 3.91 19.60
72 INT187355 Gene_expression of Kcnn1 2 0.28 1.47 0.86 19.60
73 INT56594 Positive_regulation of Localization of Il4 17 0.48 10.17 4.15 10.80
74 INT99777 Positive_regulation of Localization of Cxcl10 4 0.50 3.71 1.24 9.44
75 INT20379 Localization of Il4 85 0.73 51.22 20.55 9.12
76 INT99778 Localization of Cxcl10 12 0.75 14.24 3.91 9.12
77 INT39877 Positive_regulation of EPX 13 0.69 6.01 1.21 8.68
78 INT153861 Binding of EPX 9 0.46 0.49 0.41 8.68
79 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 6.48
80 INT205692 Positive_regulation of Positive_regulation of Casp1 5 0.46 3 2.44 6.48
81 INT157605 Localization of COL3A1 3 0.80 0.55 0.29 6.28
82 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
83 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
84 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
85 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
86 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
87 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
88 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
89 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
90 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
91 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
92 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
93 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 5.00
94 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
95 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
96 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
97 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
98 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
99 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
100 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
101 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
102 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
103 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
104 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
105 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
106 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
107 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 5.00
108 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
109 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
110 INT133156 Binding of Cd40 77 0.48 45.92 13.77 5.00
111 INT99780 Positive_regulation of Cxcl10 43 0.69 39.67 13.27 5.00
112 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
113 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
114 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81 5.00
115 INT35707 Gene_expression of Nlrp1a 20 0.75 9.61 9.32 5.00
116 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
117 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76 5.00
118 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
119 INT78320 Gene_expression of EPCAM 57 0.75 50.34 7.53 5.00
120 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52 5.00
121 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27 5.00
122 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 5.00
123 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 5.00
124 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
125 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1 5.00
126 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47 5.00
127 INT63957 Positive_regulation of Tnnt2 33 0.69 18.56 5.41 5.00
128 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
129 INT37227 Regulation of EGF 19 0.45 11.16 5.17 5.00
130 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 5.00
131 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 5.00
132 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6 5.00
133 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
134 INT99020 Gene_expression of Nlrp3 23 0.75 18.86 4.4 5.00
135 INT145532 Localization of Dlg4 25 0.79 1.97 4.36 5.00
136 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32 5.00
137 INT150144 Gene_expression of Kcnn3 31 0.78 7.67 4.24 5.00
138 INT54886 Negative_regulation of ANGPT2 25 0.42 9.33 3.79 5.00
139 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 5.00
140 INT187168 Binding of Cd74 13 0.27 11.2 3.44 5.00
141 INT279383 Negative_regulation of Ttpa 2 0.06 16.02 3.37 5.00
142 INT142084 Positive_regulation of Kdm5d 22 0.29 5.88 3.17 5.00
143 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08 5.00
144 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 5.00
145 INT8103 Binding of TP53 46 0.44 40.2 2.96 5.00
146 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77 5.00
147 INT155889 Binding of Nps 22 0.42 9.79 2.6 5.00
148 INT70273 Gene_expression of CALB2 9 0.75 7.85 2.54 5.00
149 INT213681 Gene_expression of TYMS 9 0.33 8.96 2.45 5.00
150 INT3590 Positive_regulation of AVL9 7 0.40 7.94 2.36 5.00
151 INT227772 Binding of Cd80 11 0.29 7.85 2.2 5.00
152 INT92260 Binding of Nlrp3 14 0.46 8.94 2.13 5.00
153 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 5.00
154 INT98788 Negative_regulation of EPHB1 11 0.37 3.65 1.64 5.00
155 INT150141 Positive_regulation of Gene_expression of Kcnn3 14 0.66 3.54 1.64 5.00
156 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51 5.00
157 INT134092 Binding of Cxcl2 5 0.21 2.57 1.45 5.00
158 INT9784 Binding of B2M 9 0.47 6.18 1.44 5.00
159 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41 5.00
160 INT29986 Binding of Fcer2a 9 0.27 4.34 1.38 5.00
161 INT47434 Gene_expression of Tnnt2 14 0.60 10.4 1.37 5.00
162 INT146759 Positive_regulation of LCN2 18 0.69 18.44 1.08 5.00
163 INT224722 Binding of Mcpt1 6 0.10 4.82 1.03 5.00
164 INT267750 Binding of Casp1 4 0.35 1.53 1.02 5.00
165 INT13696 Regulation of COL3A1 2 0.45 2.97 0.95 5.00
166 INT150137 Transcription of Kcnn3 4 0.53 0.46 0.87 5.00
167 INT58765 Positive_regulation of Gene_expression of ANGPT2 11 0.38 8.2 0.81 5.00
168 INT191952 Negative_regulation of Positive_regulation of NFKB2 4 0.11 3.31 0.76 5.00
169 INT2108 Localization of Mif 5 0.77 2.7 0.73 5.00
170 INT63958 Regulation of Tnnt2 7 0.45 5.36 0.7 5.00
171 INT20208 Gene_expression of Slc3a2 7 0.40 0.71 0.63 5.00
172 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63 5.00
173 INT164595 Binding of LCN2 8 0.37 6.03 0.6 5.00
174 INT150142 Negative_regulation of Kcnn3 5 0.59 2.82 0.58 5.00
175 INT129164 Binding of Cd22 6 0.19 4.46 0.57 5.00
176 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 5.00
177 INT241243 Gene_expression of Pkd2 30 0.77 9.05 0.53 5.00
178 INT62868 Gene_expression of Ifna 15 0.67 5.37 0.51 5.00
179 INT187358 Localization of Kcnn3 2 0.72 1.65 0.51 5.00
180 INT13717 Positive_regulation of TYMS 3 0.40 1.64 0.49 5.00
181 INT189446 Gene_expression of MSLN 24 0.42 13.37 0.47 5.00
182 INT209914 Gene_expression of Nlrp2 2 0.31 0.88 0.46 5.00
183 INT11118 Gene_expression of RAPGEF5 13 0.65 9.35 0.43 5.00
184 INT202762 Gene_expression of PSMD3 8 0.47 1.44 0.42 5.00
185 INT269104 Positive_regulation of AOX1 1 0.19 4.25 0.4 5.00
186 INT241236 Negative_regulation of Pkd2 11 0.43 1.82 0.39 5.00
187 INT150826 Positive_regulation of Pkd1 9 0.37 3.65 0.35 5.00
188 INT269102 Binding of AOX1 1 0.21 1.99 0.35 5.00
189 INT76065 Localization of MSLN 6 0.68 5.93 0.34 5.00
190 INT279380 Positive_regulation of Ttpa 2 0.07 2.66 0.33 5.00
191 INT189445 Positive_regulation of MSLN 20 0.37 3.5 0.3 5.00
192 INT236270 Binding of Hhex 2 0.07 1.55 0.29 5.00
193 INT241240 Gene_expression of Pkd1 18 0.54 12.2 0.27 5.00
194 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 5.00
195 INT132459 Binding of FABP3 4 0.35 2.19 0.2 5.00
196 INT187356 Binding of Kcnn3 1 0.25 1.17 0.19 5.00
197 INT202591 Regulation of AVL9 2 0.02 1.58 0.19 5.00
198 INT235725 Regulation of SRC 7 0.44 4.71 0.19 5.00
199 INT208476 Binding of Pkd1 13 0.39 7.23 0.17 5.00
200 INT354535 Regulation of Negative_regulation of Pkd2 1 0.15 1.03 0.14 5.00
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