D:Mitral Valve Stenosis

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Disease Term
Synonyms Mitral Stenoses, MITRAL STENOSIS, Mitral Valve Stenoses, Stenoses Mitral, Stenoses Mitral Valve, Stenosis Mitral, Stenosis Mitral Valve, Valve Stenoses Mitral, Valve Stenosis Mitral
Documents 229
Hot Single Events 32
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mitral Valve Stenosis. They are ordered first by their relevance to Mitral Valve Stenosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68482 Cga Regulation of Gh 1 0.00 1.89 0.31 72.64
2 INT68479 Gnrh1 Regulation of Lhb 1 0.00 1.58 0.25 70.44
3 INT68480 Negative_regulation of Gnrh1 Regulation of Lhb 1 0.00 0.67 0.15 34.76
4 INT269784 Crp Positive_regulation of Vcam1 1 0.00 1.6 0.11 5.00
5 INT269783 Crp Positive_regulation of Sele 1 0.00 1.69 0.11 5.00
6 INT269785 Crp Positive_regulation of ICAM1 1 0.00 1.68 0.11 5.00
7 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 5.00
8 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0 5.00
9 INT340504 Agtr1a Negative_regulation of Phosphorylation of Pik3cb 1 0.06 1.16 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mitral Valve Stenosis. They are ordered first by their pain relevance and then by number of times they were reported in Mitral Valve Stenosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT4047 Binding of F13A1 105 0.43 66.54 11.81 99.50
2 INT151743 Binding of Gusb 11 0.24 8.73 1.63 99.36
3 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 99.24
4 INT132702 Binding of ASD1 2 0.03 1.71 0.63 99.16
5 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19 97.88
6 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 97.80
7 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 96.84
8 INT47625 Negative_regulation of IFIH1 4 0.51 1.68 0.39 96.48
9 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 95.76
10 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 94.68
11 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 93.68
12 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 92.56
13 INT47010 Negative_regulation of Gusb 6 0.43 4.16 1.2 91.40
14 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 90.00
15 INT239083 Binding of PPY 9 0.32 7.59 2.9 90.00
16 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 89.84
17 INT50367 Negative_regulation of COX8A 10 0.57 5.13 2.38 85.08
18 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67 84.12
19 INT54886 Negative_regulation of ANGPT2 25 0.42 9.33 3.79 84.12
20 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 83.84
21 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 83.84
22 INT2105 Negative_regulation of Rhd 10 0.41 4.9 3.4 83.76
23 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 83.20
24 INT4931 Localization of IFNG 53 0.78 33.25 13.65 83.20
25 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 82.00
26 INT19511 Localization of Il6 212 0.81 118.17 67.67 82.00
27 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 81.36
28 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 81.28
29 INT64709 Gene_expression of VTN 11 0.67 11.01 1.97 80.80
30 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 80.64
31 INT6849 Localization of IL1B 229 0.81 112.56 69.63 80.64
32 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 80.48
33 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 77.24
34 INT309859 Positive_regulation of PPH2 1 0.01 1.75 0 76.08
35 INT1261 Localization of Adh1 63 0.81 19.36 16.09 74.16
36 INT36054 Transcription of IL1B 53 0.72 32.64 17.31 73.96
37 INT110768 Transcription of Mcpt1 12 0.52 7.66 4.71 73.44
38 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 72.64
39 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 71.84
40 INT5126 Positive_regulation of Positive_regulation of Lhb 16 0.48 2.12 5.23 71.84
41 INT7224 Positive_regulation of Gene_expression of Lhb 18 0.45 10.22 3.4 71.84
42 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 70.44
43 INT291341 Phosphorylation of Ifnar1 2 0.03 0.99 0.22 70.12
44 INT23367 Positive_regulation of Positive_regulation of Gnrh1 9 0.50 0.97 2.97 70.00
45 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 69.52
46 INT118538 Binding of ANG 5 0.47 3.02 0.92 69.12
47 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 67.20
48 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 67.20
49 INT240127 Binding of Nppb 19 0.37 22.42 3.3 66.80
50 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 64.80
51 INT291340 Phosphorylation of Mpeg1 1 0.51 0.36 0.08 60.40
52 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 52.24
53 INT21610 Positive_regulation of ANGPT2 23 0.41 13.28 3.03 50.36
54 INT131351 Positive_regulation of Gene_expression of Nppb 2 0.50 13.72 1.14 47.56
55 INT34811 Localization of Cpb1 3 0.65 0 0.84 45.68
56 INT1530 Regulation of Gh 382 0.61 115.96 112.47 44.64
57 INT99426 Negative_regulation of Gene_expression of Atp2a2 19 0.59 13.7 1.96 39.04
58 INT214006 Negative_regulation of Gene_expression of Dnahc8 2 0.03 1.28 0.24 39.04
59 INT30168 Gene_expression of Dnahc8 20 0.65 4.17 1.73 37.52
60 INT88182 Gene_expression of Atp2a2 40 0.78 22.91 4.26 36.80
61 INT29424 Negative_regulation of Positive_regulation of Lhb 21 0.56 4.58 4.03 34.76
62 INT9785 Negative_regulation of Positive_regulation of Gnrh1 18 0.43 1.88 7.35 34.64
63 INT398 Localization of AGT 45 0.78 16.97 11.54 28.72
64 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 28.24
65 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 25.52
66 INT73429 Negative_regulation of Atp2a2 20 0.20 9.05 0.74 25.08
67 INT131877 Negative_regulation of Nps 12 0.39 8.19 3.56 19.76
68 INT99427 Positive_regulation of Gene_expression of Atp2a2 5 0.64 4.13 1.14 14.00
69 INT332665 Negative_regulation of ALDH1B1 1 0.02 0.1 0.15 13.68
70 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 6.44
71 INT23921 Negative_regulation of NPPB 13 0.58 16.19 0.9 6.20
72 INT296884 Negative_regulation of Negative_regulation of NPPB 1 0.01 1.37 0 6.20
73 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
74 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 5.00
75 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
76 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
77 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
78 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 5.00
79 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
80 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 5.00
81 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
82 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 5.00
83 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
84 INT5617 Localization of Nppa 266 0.81 83.51 83.89 5.00
85 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
86 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 5.00
87 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
88 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
89 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
90 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
91 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
92 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
93 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
94 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
95 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
96 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
97 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
98 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
99 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
100 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
101 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 5.00
102 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
103 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
104 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45 5.00
105 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
106 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
107 INT1158 Regulation of Agt 106 0.61 29.4 30.29 5.00
108 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
109 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
110 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
111 INT7678 Localization of Alb 142 0.81 80.93 22.49 5.00
112 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 5.00
113 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
114 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
115 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
116 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 5.00
117 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
118 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 5.00
119 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 5.00
120 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
121 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 5.00
122 INT74545 Negative_regulation of Gene_expression of Prkcg 22 0.42 7.77 16.26 5.00
123 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 5.00
124 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 5.00
125 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15 5.00
126 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 5.00
127 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 5.00
128 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
129 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
130 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83 5.00
131 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 5.00
132 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 5.00
133 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83 5.00
134 INT17996 Binding of Crp 40 0.37 31.4 7.8 5.00
135 INT38971 Positive_regulation of Gene_expression of Gtf3a 27 0.60 18.25 7.77 5.00
136 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46 5.00
137 INT3098 Positive_regulation of Epo 46 0.70 28.27 7 5.00
138 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 5.00
139 INT31226 Localization of PPY 20 0.78 9.93 6.8 5.00
140 INT78182 Positive_regulation of ACCS 43 0.43 46.39 6.78 5.00
141 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75 5.00
142 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 5.00
143 INT934 Regulation of Gtf3a 25 0.35 11.35 6.34 5.00
144 INT8916 Regulation of Igf1 45 0.60 13.06 5.81 5.00
145 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 5.00
146 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53 5.00
147 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 5.00
148 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 5.00
149 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 5.00
150 INT5619 Positive_regulation of Gene_expression of Nppa 21 0.70 11.95 4.41 5.00
151 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15 5.00
152 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05 5.00
153 INT116643 Phosphorylation of Pik3cb 12 0.80 4.73 3.87 5.00
154 INT16408 Negative_regulation of Nppb 14 0.53 5.49 3.74 5.00
155 INT159472 Localization of NPPB 32 0.79 33.67 3.59 5.00
156 INT9085 Localization of Nppb 32 0.81 15.1 3.47 5.00
157 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75 5.00
158 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 5.00
159 INT45272 Regulation of Nps 15 0.39 8.08 2.69 5.00
160 INT155889 Binding of Nps 22 0.42 9.79 2.6 5.00
161 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 5.00
162 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47 5.00
163 INT3182 Negative_regulation of PPY 12 0.42 4.65 2.28 5.00
164 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26 5.00
165 INT45202 Regulation of Cys1 8 0.08 5.62 2.23 5.00
166 INT158016 Positive_regulation of VEGFC 7 0.49 6.58 2.18 5.00
167 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16 5.00
168 INT89240 Gene_expression of VEGFC 23 0.75 15.94 2.03 5.00
169 INT57923 Gene_expression of CYP3A 12 0.71 2.62 2 5.00
170 INT93789 Gene_expression of Tnnc1 28 0.76 17.3 1.99 5.00
171 INT14586 Gene_expression of Cpb1 23 0.58 6.18 1.99 5.00
172 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98 5.00
173 INT84264 Regulation of NPPB 22 0.61 21.18 1.94 5.00
174 INT143127 Positive_regulation of FLT1 44 0.66 21.7 1.92 5.00
175 INT52965 Negative_regulation of TNXA 18 0.43 8.38 1.9 5.00
176 INT61685 Positive_regulation of Gene_expression of Pah 6 0.43 4.05 1.79 5.00
177 INT237862 Positive_regulation of Gene_expression of Nps 8 0.43 3.82 1.52 5.00
178 INT24736 Positive_regulation of SERPINA5 17 0.49 9.55 1.47 5.00
179 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37 5.00
180 INT39468 Positive_regulation of hf 10 0.33 13.5 1.32 5.00
181 INT274750 Gene_expression of Mpeg1 4 0.55 6.1 1.3 5.00
182 INT199681 Gene_expression of SERPINA5 13 0.36 15.42 1.25 5.00
183 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21 5.00
184 INT127363 Binding of Cpb1 8 0.32 2.5 1.14 5.00
185 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13 5.00
186 INT127372 Gene_expression of Ager 9 0.57 14.44 0.98 5.00
187 INT174705 Phosphorylation of Gtf3a 7 0.02 4.11 0.97 5.00
188 INT77856 Binding of Cps1 6 0.30 2.32 0.95 5.00
189 INT65498 Positive_regulation of F7 4 0.11 8.51 0.79 5.00
190 INT19316 Positive_regulation of Localization of Nppb 2 0.50 3.15 0.73 5.00
191 INT170625 Binding of SERPINA5 8 0.32 8.42 0.69 5.00
192 INT237866 Positive_regulation of Positive_regulation of Nps 5 0.48 2.67 0.69 5.00
193 INT151157 Negative_regulation of SERPINA5 5 0.23 3.68 0.64 5.00
194 INT46134 Positive_regulation of Gene_expression of Cys1 4 0.50 11.52 0.61 5.00
195 INT274748 Positive_regulation of Gene_expression of Mpeg1 3 0.41 0.59 0.61 5.00
196 INT89239 Negative_regulation of Gene_expression of VEGFC 2 0.39 1.11 0.59 5.00
197 INT157226 Positive_regulation of Gene_expression of Tnnc1 11 0.49 6.21 0.57 5.00
198 INT144700 Gene_expression of Kras 21 0.41 12.28 0.57 5.00
199 INT279499 Negative_regulation of Tnni1 5 0.57 4.35 0.53 5.00
200 INT230238 Binding of Pik3cb 6 0.21 2.27 0.51 5.00
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