D:Monosomy

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pChart

Disease Term
Synonyms Monosomies
Documents 32
Hot Single Events 42
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Monosomy. They are ordered first by their relevance to Monosomy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0 78.92
2 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0 78.92
3 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04 50.40
4 INT248765 Binding of RUNX1 and CSF2 1 0.02 1.36 0 50.00
5 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0 35.44
6 INT320712 Binding of NRAS and PIK3CD 1 0.21 1.66 0 28.08
7 INT320713 NRAS Positive_regulation of AKT1 1 0.37 0.84 0 28.08
8 INT320715 NRAS Positive_regulation of PIK3CD 1 0.27 1.66 0 28.08
9 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
10 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
11 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
12 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00
13 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
14 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
15 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
16 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 5.00
17 INT190137 Binding of S100A12 and Gfap 1 0.00 0.65 0 5.00
18 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00
19 INT210285 Ccrs1 Regulation of RAI1 1 0.00 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Monosomy. They are ordered first by their pain relevance and then by number of times they were reported in Monosomy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT248772 Negative_regulation of Binding of CSF2 4 0.39 5.16 0.19 100.00
2 INT248769 Negative_regulation of Binding of CSF3 1 0.28 1.56 0 100.00
3 INT142797 Negative_regulation of Gene_expression of SMARCB1 4 0.54 3.3 0.47 99.84
4 INT171095 Gene_expression of OR1P1 1 0.04 1.82 0.36 99.80
5 INT123705 Gene_expression of SMARCB1 40 0.73 19.47 2.2 99.68
6 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 99.64
7 INT115475 Negative_regulation of RUNX1 4 0.37 5 0.22 99.60
8 INT248768 Localization of SET 3 0.44 2.38 0.17 99.58
9 INT188755 Positive_regulation of Binding of CSF2 6 0.44 8.79 0.35 99.26
10 INT248767 Positive_regulation of Binding of CSF3 1 0.33 3.11 0 99.26
11 INT248771 Localization of IGKV6-21 1 0.01 2.24 0.08 99.18
12 INT14301 Binding of CSF2 82 0.48 67.95 8.98 98.90
13 INT14302 Binding of CSF3 6 0.33 3.09 0.09 98.90
14 INT179032 Negative_regulation of Cdcs1 1 0.04 1.39 0.06 98.04
15 INT225225 Negative_regulation of Gene_expression of Cyp2b10 2 0.29 2.43 0.27 97.72
16 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 97.68
17 INT183399 Gene_expression of Cyp2b10 17 0.39 18.39 0.71 97.56
18 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 96.04
19 INT320728 Gene_expression of APITD1 1 0.60 1.44 0 95.36
20 INT171091 Positive_regulation of SLC10A4 8 0.16 6.27 0.99 95.28
21 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75 94.56
22 INT271963 Phosphorylation of TSC1 2 0.31 2.02 0 94.56
23 INT164328 Negative_regulation of SMARCB1 8 0.24 4.04 0.4 94.08
24 INT171097 Positive_regulation of OR1P1 1 0.03 0.6 0.11 93.60
25 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32 91.84
26 INT225223 Localization of Cdkn2b 2 0.62 1.29 0.37 91.84
27 INT248770 Positive_regulation of Gene_expression of FLI1 1 0.02 0.67 0 91.20
28 INT134224 Gene_expression of FLI1 3 0.53 1.79 0.14 90.40
29 INT320720 Gene_expression of TBX3 1 0.29 3.53 0 89.44
30 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 87.20
31 INT320727 Positive_regulation of TBX3 1 0.19 0.84 0 86.68
32 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 86.28
33 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 86.28
34 INT26585 Gene_expression of Vim 117 0.77 39.97 6 85.20
35 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 84.84
36 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68 84.84
37 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 83.56
38 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 82.64
39 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 82.08
40 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 82.08
41 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 81.28
42 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 81.28
43 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 79.12
44 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 78.00
45 INT227416 Positive_regulation of DLAT 4 0.45 17.02 1.11 77.72
46 INT129934 Gene_expression of G6PC 3 0.57 5.3 0.35 76.20
47 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 75.32
48 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 75.32
49 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9 75.32
50 INT123733 Gene_expression of Fhit 5 0.78 12.34 0.26 75.32
51 INT179036 Gene_expression of Fez1 1 0.70 13.28 0.11 75.32
52 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 75.00
53 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 75.00
54 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 73.48
55 INT171093 Regulation of Gene_expression of OR1P1 1 0.02 1.12 0.28 73.48
56 INT171098 Regulation of OR1P1 1 0.02 1.12 0.28 73.48
57 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 73.20
58 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 71.64
59 INT174156 Localization of Trp53 16 0.72 13.52 1.18 68.24
60 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 64.52
61 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 63.28
62 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 63.28
63 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83 60.88
64 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49 58.28
65 INT61626 Transcription of IL6 73 0.72 42.04 17.86 57.92
66 INT171096 Transcription of PDGFA 5 0.47 4.42 0.79 57.92
67 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 55.68
68 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 50.64
69 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 50.00
70 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 50.00
71 INT79748 Positive_regulation of RUNX1 3 0.03 1.28 1.08 50.00
72 INT1267 Regulation of G6PC 3 0.44 1.39 0.98 50.00
73 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36 49.44
74 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 46.48
75 INT171094 Binding of PPM1J 1 0.03 0.61 0.24 45.36
76 INT118291 Binding of TXK 19 0.10 11.77 1.94 43.72
77 INT244657 Regulation of Lch 3 0.40 6.63 0.13 43.20
78 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 43.12
79 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 42.72
80 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 42.72
81 INT225224 Positive_regulation of Nf2 1 0.59 3.4 0.12 40.08
82 INT206135 Positive_regulation of NRAS 2 0.62 2.23 0.03 39.44
83 INT320721 Protein_catabolism of NRAS 1 0.59 0.89 0 39.44
84 INT115039 Positive_regulation of FMR1 4 0.49 2.26 0.46 37.60
85 INT60585 Regulation of TP53 59 0.59 54.55 5.21 36.64
86 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 33.44
87 INT8775 Binding of IGHE 167 0.48 102.61 23.54 30.76
88 INT115784 Gene_expression of GNAQ 5 0.65 4.48 0.7 30.76
89 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 29.48
90 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 28.84
91 INT320736 Binding of NRAS 1 0.32 0.82 0 28.08
92 INT320732 Binding of PIK3CD 3 0.20 1.66 0 27.88
93 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22 25.80
94 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 25.44
95 INT200671 Gene_expression of AKT3 4 0.69 1.88 0.13 18.80
96 INT320734 Positive_regulation of Gene_expression of AKT3 1 0.62 0.65 0 18.80
97 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 18.60
98 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 18.60
99 INT154828 Binding of Lch 2 0.31 3.51 0.06 17.52
100 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16 14.16
101 INT320730 Positive_regulation of Gene_expression of NBN 1 0.60 1.84 0 14.16
102 INT182667 Binding of DLAT 11 0.31 40.75 2.8 14.04
103 INT320718 Positive_regulation of Positive_regulation of CD2AP 1 0.08 0.55 0 14.00
104 INT203636 Positive_regulation of CD2AP 4 0.13 1.27 0.28 13.12
105 INT262953 Binding of PAX6 13 0.48 5.28 0.06 12.36
106 INT186460 Transcription of ASAP1 5 0.56 3.02 0.03 8.84
107 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 6.72
108 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
109 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
110 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
111 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
112 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
113 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
114 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
115 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
116 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
117 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
118 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
119 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
120 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
121 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
122 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
123 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
124 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
125 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
126 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67 5.00
127 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 5.00
128 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
129 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
130 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 5.00
131 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
132 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
133 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
134 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
135 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
136 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
137 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 5.00
138 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 5.00
139 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 5.00
140 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 5.00
141 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 5.00
142 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
143 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
144 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
145 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
146 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
147 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
148 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 5.00
149 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 5.00
150 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36 5.00
151 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
152 INT93110 Regulation of CDCP1 16 0.03 7.98 3.83 5.00
153 INT78203 Gene_expression of PMP22 12 0.63 7.49 3.58 5.00
154 INT9999 Regulation of Gene_expression of IGHE 32 0.60 15.75 3.53 5.00
155 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 5.00
156 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38 5.00
157 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 5.00
158 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
159 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 5.00
160 INT120529 Positive_regulation of ABCC2 7 0.49 2.32 2.94 5.00
161 INT104182 Gene_expression of ABCC2 19 0.76 5.92 2.88 5.00
162 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74 5.00
163 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
164 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
165 INT70242 Localization of HCC 18 0.66 23.95 2.35 5.00
166 INT9995 Localization of C6orf25 13 0.69 6.48 2.29 5.00
167 INT96762 Gene_expression of RAI1 9 0.56 5.77 2.17 5.00
168 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 5.00
169 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
170 INT65855 Localization of TP53 18 0.76 17.08 1.89 5.00
171 INT102839 Gene_expression of Pdc 15 0.52 6.3 1.87 5.00
172 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 5.00
173 INT23148 Gene_expression of RUNX1 10 0.10 6.58 1.71 5.00
174 INT167692 Binding of NCAM1 11 0.36 6.73 1.59 5.00
175 INT101859 Gene_expression of MCF2 34 0.49 19.45 1.51 5.00
176 INT90377 Gene_expression of HBA1 26 0.75 7.34 1.51 5.00
177 INT12035 Regulation of F2 21 0.45 12.66 1.47 5.00
178 INT283506 Gene_expression of SLC4A2 7 0.47 4 1.4 5.00
179 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39 5.00
180 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 5.00
181 INT21756 Regulation of Alb 15 0.43 8.21 1.19 5.00
182 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
183 INT209961 Binding of GAGE4 3 0.03 1.8 1.16 5.00
184 INT182666 Negative_regulation of DLAT 2 0.38 9.01 1.16 5.00
185 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15 5.00
186 INT3046 Gene_expression of LGALS1 20 0.75 12.48 1.11 5.00
187 INT204170 Binding of Mri1 5 0.22 4.45 1.11 5.00
188 INT158542 Gene_expression of HTN1 10 0.75 10.69 1.07 5.00
189 INT90240 Gene_expression of MYOG 19 0.75 10 1.06 5.00
190 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 5.00
191 INT21660 Regulation of CHM 14 0.61 8.51 0.93 5.00
192 INT210276 Positive_regulation of Gene_expression of PMP22 3 0.46 1.58 0.88 5.00
193 INT283494 Positive_regulation of ABCB11 1 0.13 0.81 0.87 5.00
194 INT283514 Localization of NR1I2 2 0.74 3.15 0.87 5.00
195 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86 5.00
196 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 5.00
197 INT38558 Positive_regulation of DBT 9 0.31 1.59 0.86 5.00
198 INT137082 Regulation of ABCC2 2 0.16 1.11 0.85 5.00
199 INT130582 Gene_expression of ABCB4 3 0.67 1.05 0.82 5.00
200 INT145986 Positive_regulation of CTLA4 8 0.56 2.66 0.82 5.00
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