D:Morphine Dependence

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Disease Term
Synonyms Abuse Morphine, Addiction Morphine, Dependence Morphine, Morphine Abuse, Morphine Addiction, MORPHINE USER, Morphine Users, User Morphine, Users Morphine
Documents 610
Hot Single Events 200
Hot Interactions 22

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Morphine Dependence. They are ordered first by their relevance to Morphine Dependence and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58 100.00
2 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57 100.00
3 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57 100.00
4 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22 99.76
5 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08 99.76
6 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19 99.52
7 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05 99.52
8 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42 98.82
9 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19 98.72
10 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42 95.92
11 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 0.02 0.18 1.24 95.36
12 INT136257 Tff3 Regulation of SGCG 1 0.00 0.18 1.24 95.36
13 INT136255 Tff3 Regulation of GRIA1 1 0.00 0.18 1.24 95.36
14 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23 95.36
15 INT93234 Negative_regulation of Pde4b Negative_regulation of Gene_expression of Fos 1 0.41 0.1 0.96 95.36
16 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88 94.64
17 INT136256 Creb1 Regulation of SGCG 1 0.26 0.18 1.23 94.64
18 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23 94.64
19 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62 93.76
20 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61 93.76
21 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85 92.52
22 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25 92.52
23 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18 75.28
24 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65 75.28
25 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64 75.28
26 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18 75.00
27 INT102863 Prkaca Regulation of Srgn 1 0.50 0.05 0.64 50.60
28 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58 50.28
29 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42 5.00
30 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16 5.00
31 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09 5.00
32 INT157541 Binding of YY1 and Regulation of Gene_expression of OPRM1 1 0.31 1.21 0.72 5.00
33 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72 5.00
34 INT233669 gr Positive_regulation of Transcription of Nfkbia 1 0.26 0.33 0.64 5.00
35 INT233671 gr Positive_regulation of Transcription of Tsc22d3 1 0.44 0.33 0.64 5.00
36 INT256296 Efnb1 Positive_regulation of Ephb1 1 0.03 0.66 0.54 5.00
37 INT233668 Cebpd Negative_regulation of Cebpg 1 0.43 0.66 0.46 5.00
38 INT227953 Chrm2 Regulation of Chrm5 1 0.21 0.33 0.13 5.00
39 INT227956 Drd2 Regulation of Chrm2 1 0.07 0.38 0.13 5.00
40 INT227957 Chrm4 Regulation of Localization of Drd2 1 0.19 0.38 0.13 5.00
41 INT227960 Drd2 Regulation of Chrm5 1 0.26 0.38 0.13 5.00
42 INT227958 Chrm2 Regulation of Localization of Drd2 1 0.17 0.38 0.13 5.00
43 INT227959 Drd2 Regulation of Chrm4 1 0.08 0.38 0.13 5.00
44 INT227954 Chrm4 Regulation of Chrm5 1 0.24 0.33 0.13 5.00
45 INT69909 Binding of MYC and PURA 1 0.24 0 0.1 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Morphine Dependence. They are ordered first by their pain relevance and then by number of times they were reported in Morphine Dependence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 100.00
2 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 100.00
3 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 100.00
4 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
5 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 100.00
6 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97 100.00
7 INT7884 Regulation of Localization of Oxt 102 0.62 7.95 61.71 100.00
8 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26 100.00
9 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 100.00
10 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 99.96
11 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76 99.92
12 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 99.92
13 INT92734 Binding of Ephb1 5 0.37 3.86 7.02 99.88
14 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.84
15 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.84
16 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 99.84
17 INT112211 Gene_expression of Slc6a1 8 0.78 4.48 6.86 99.84
18 INT112209 Positive_regulation of Gene_expression of Slc6a1 8 0.69 3.92 6.44 99.84
19 INT2366 Binding of Cck 192 0.48 30.64 163.46 99.84
20 INT114200 Negative_regulation of Gene_expression of Slc6a1 1 0.38 0.41 1.18 99.84
21 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 99.82
22 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 99.82
23 INT64164 Regulation of Prkca 34 0.62 10.44 30.99 99.80
24 INT5533 Binding of Oxt 43 0.48 8.69 18.35 99.80
25 INT89309 Negative_regulation of Pde4b 21 0.53 12.81 7.32 99.80
26 INT102019 Regulation of Gene_expression of Creb1 14 0.61 5.27 5.08 99.72
27 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 99.68
28 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72 99.68
29 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.68
30 INT47876 Binding of Pnoc 20 0.47 4.99 20.01 99.68
31 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.62
32 INT35992 Regulation of Sds 7 0.52 1.14 4.04 99.60
33 INT147898 Binding of Camk2a 16 0.37 4.01 4.87 99.56
34 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19 99.56
35 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38 99.52
36 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32 99.48
37 INT53385 Positive_regulation of Gene_expression of FosB 26 0.70 9.18 26.33 99.48
38 INT53384 Positive_regulation of FosB 41 0.69 8.43 28.91 99.48
39 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23 99.48
40 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89 99.48
41 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 99.48
42 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 99.48
43 INT16714 Regulation of Creb1 64 0.62 22.23 33.56 99.40
44 INT35993 Regulation of Aldh5a1 3 0.60 0.75 2.64 99.40
45 INT95495 Phosphorylation of Nefh 13 0.82 7.36 12.1 99.36
46 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 99.28
47 INT63351 Negative_regulation of Gene_expression of PECAM1 19 0.52 16.06 5.73 99.28
48 INT124655 Negative_regulation of PECAM1 13 0.23 10.32 3.78 99.28
49 INT113924 Binding of Mapk1 27 0.38 8.64 3.84 99.28
50 INT7827 Binding of Cck 32 0.48 4.66 23.73 99.28
51 INT3579 Localization of Oxt 555 0.81 43.35 292.44 99.26
52 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 99.26
53 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 99.26
54 INT1562 Localization of Crh 499 0.81 126.74 236.68 99.26
55 INT13145 Positive_regulation of Car1 60 0.70 16.32 23.23 99.26
56 INT21527 Gene_expression of FosB 47 0.78 11.2 34.39 99.24
57 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 99.24
58 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 99.22
59 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.16
60 INT69919 Regulation of PURA 1 0.37 0.1 0.26 99.16
61 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 99.12
62 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 99.12
63 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 99.08
64 INT102866 Regulation of Negative_regulation of Prkca 2 0.43 1.27 1.95 99.08
65 INT1316 Positive_regulation of Acot1 129 0.60 18.86 56.13 99.06
66 INT151872 Regulation of Negative_regulation of Nkrf 1 0.35 0.49 0.95 99.04
67 INT151873 Negative_regulation of Nkrf 1 0.33 0.49 0.95 99.04
68 INT116213 Regulation of Transcription of Slc1a2 1 0.61 0.41 1.12 99.00
69 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 98.96
70 INT109279 Regulation of Phosphorylation of Creb1 14 0.62 4.06 8.96 98.96
71 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 98.94
72 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 98.94
73 INT876 Localization of Gh1 843 0.80 67.75 340.82 98.90
74 INT112210 Regulation of Slc6a1 8 0.62 6.75 4.96 98.90
75 INT88789 Gene_expression of Dlg4 26 0.78 4.41 12.74 98.84
76 INT153321 Positive_regulation of Gene_expression of Dlg4 3 0.49 0.31 0.53 98.84
77 INT2578 Binding of Ins1 74 0.48 33.57 12.92 98.84
78 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72 98.84
79 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 98.84
80 INT2581 Regulation of Binding of Ins1 7 0.61 2.05 2.08 98.84
81 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81 98.82
82 INT7327 Regulation of Th 164 0.62 29.67 110.14 98.76
83 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17 98.76
84 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51 98.76
85 INT69915 Regulation of ATF2 2 0.34 0.81 0.42 98.76
86 INT74826 Gene_expression of Slc1a2 131 0.78 61.83 100.84 98.68
87 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 98.68
88 INT111056 Negative_regulation of Gene_expression of Flvcr2 9 0.13 4.15 7.18 98.68
89 INT123061 Negative_regulation of Transcription of Flvcr2 1 0.13 0.34 1.49 98.68
90 INT79136 Transcription of Flvcr2 4 0.39 0.66 3.35 98.68
91 INT12398 Regulation of Flvcr2 11 0.39 1.8 9.47 98.68
92 INT102510 Negative_regulation of Gene_expression of B3galt6 1 0.29 0.58 2.11 98.66
93 INT78568 Negative_regulation of Gene_expression of Glb1 4 0.30 0.78 2.84 98.66
94 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 98.64
95 INT128324 Regulation of Gene_expression of Per1 11 0.61 1.95 5.22 98.64
96 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77 98.64
97 INT12471 Regulation of Insrr 52 0.35 17.8 48.31 98.64
98 INT102858 Phosphorylation of Gucy1a3 1 0.31 0.1 0.41 98.64
99 INT3948 Regulation of Cck 291 0.62 58.07 255.88 98.58
100 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 98.56
101 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 98.56
102 INT5338 Regulation of Npy 92 0.62 25.54 51.24 98.56
103 INT7824 Regulation of Cck 39 0.62 5.31 39.28 98.52
104 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 98.50
105 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 98.44
106 INT4153 Binding of Insrr 109 0.40 17.99 72.15 98.44
107 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46 98.44
108 INT9779 Gene_expression of Glb1 23 0.58 8.01 6.04 98.44
109 INT64671 Gene_expression of NISCH 10 0.69 2.19 6.9 98.40
110 INT81608 Gene_expression of Col11a1 13 0.15 1.58 6.87 98.40
111 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 98.40
112 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 98.40
113 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87 98.36
114 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 98.32
115 INT6983 Negative_regulation of Positive_regulation of Ca2 18 0.41 4.29 5.03 98.32
116 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 98.28
117 INT164437 Regulation of Rabep2 1 0.24 2.12 4.87 98.20
118 INT52272 Localization of Igk 3 0.78 0.18 2.67 98.20
119 INT99535 Transcription of Slc1a2 6 0.72 1.31 3.46 98.20
120 INT149818 Gene_expression of Clock 81 0.70 14.15 10.04 98.16
121 INT102857 Phosphorylation of Srgn 1 0.72 0.26 1.71 98.10
122 INT74827 Positive_regulation of Gene_expression of Slc1a2 52 0.70 26.54 50.63 98.04
123 INT102512 Gene_expression of B3galt6 10 0.52 3.01 8.25 98.04
124 INT123554 Transcription of Dbi 5 0.72 1.13 1.13 98.00
125 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36 97.98
126 INT47846 Negative_regulation of Localization of Pdpk1 2 0.33 1.12 2.75 97.98
127 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 97.92
128 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 97.92
129 INT109150 Negative_regulation of Tubgcp2 4 0.38 2.04 5.12 97.86
130 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 97.80
131 INT23128 Binding of PTGER1 4 0.27 1.82 2.45 97.80
132 INT39782 Regulation of Akr7a5 1 0.19 0.27 1.08 97.80
133 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 97.78
134 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36 97.78
135 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 97.74
136 INT164441 Phosphorylation of Rabep2 1 0.44 2.37 4.75 97.64
137 INT55036 Regulation of Adcy8 3 0.44 0.85 2.56 97.64
138 INT5040 Regulation of Gal 42 0.60 12.72 21.18 97.56
139 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 97.52
140 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 97.52
141 INT605 Regulation of Acot1 61 0.62 10.7 26.34 97.52
142 INT61159 Regulation of Gene_expression of Creb1 46 0.62 24.07 20.52 97.52
143 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 97.44
144 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 97.44
145 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62 97.44
146 INT88008 Positive_regulation of Gene_expression of GDNF 14 0.70 8.9 3.61 97.44
147 INT110445 Phosphorylation of Gtf3a 15 0.09 5.58 3.07 97.36
148 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83 97.16
149 INT158665 Regulation of Sgpl1 1 0.04 0.3 1.02 97.16
150 INT99076 Regulation of Gene_expression of FosB 7 0.62 1.34 7.32 97.16
151 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 97.12
152 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 97.12
153 INT4822 Localization of Ca2 417 0.80 99.57 96.45 97.08
154 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61 97.08
155 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 96.96
156 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99 96.84
157 INT92971 Binding of Creb1 31 0.47 11.3 6.22 96.72
158 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 96.72
159 INT147143 Binding of IV 3 0.07 3.33 1.47 96.68
160 INT117394 Positive_regulation of Gene_expression of NISCH 3 0.45 0.41 1.35 96.64
161 INT102854 Regulation of Gucy1a3 2 0.23 0.19 1.15 96.64
162 INT164438 Gene_expression of Rabep2 1 0.32 1.21 2 96.60
163 INT164440 Gene_expression of Nacc1 1 0.05 1.2 2 96.60
164 INT69922 Positive_regulation of ATF2 3 0.05 1.28 0.74 96.60
165 INT69910 Positive_regulation of PURA 1 0.25 0.1 0.34 96.60
166 INT69921 Positive_regulation of Binding of PURA 1 0.26 0.1 0.34 96.60
167 INT96532 Negative_regulation of Gene_expression of Slc1a2 24 0.59 14.22 17.91 96.56
168 INT8346 Gene_expression of Qrfp 136 0.70 19.49 70.21 96.40
169 INT102023 Regulation of Creb1 51 0.62 16.29 16.71 96.40
170 INT158666 Regulation of Transcription of Creb1 6 0.45 2.41 2.44 96.40
171 INT158667 Regulation of Transcription of Gtf3a 5 0.03 4.9 1.56 96.40
172 INT22825 Regulation of Gtf3a 36 0.25 19.93 5.03 96.40
173 INT4207 Regulation of Avp 267 0.62 63.72 115.33 96.32
174 INT88909 Positive_regulation of Gene_expression of Dnm1 6 0.70 3.43 4.59 96.28
175 INT16735 Localization of Drd1a 11 0.61 0.35 8.42 96.16
176 INT451 Regulation of Oxt 142 0.62 22.07 69.42 96.16
177 INT28544 Regulation of Gene_expression of Pigm 6 0.24 1.04 3.96 96.12
178 INT69914 Binding of PURA 1 0.29 0.1 0.73 96.08
179 INT101189 Transcription of Gtf3a 49 0.17 24.39 7.93 96.00
180 INT88906 Gene_expression of Dnm1 5 0.78 10.48 3.7 95.84
181 INT109478 Positive_regulation of Nlrp5 1 0.10 0.26 1.44 95.80
182 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 95.76
183 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 95.76
184 INT62576 Transcription of Creb1 34 0.69 16.97 10.6 95.72
185 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 95.68
186 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23 95.68
187 INT50056 Positive_regulation of Dll1 13 0.67 3.16 13.7 95.56
188 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 95.50
189 INT1898 Regulation of Crh 220 0.62 61.33 102.64 95.48
190 INT48747 Positive_regulation of Dbp 7 0.24 1.28 4.69 95.48
191 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 95.36
192 INT136253 Phosphorylation of Tff3 1 0.03 0.18 1.23 95.36
193 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 95.32
194 INT159871 Regulation of Gene_expression of Slc23a2 1 0.45 0.35 1.21 95.32
195 INT159870 Regulation of Gene_expression of Slc23a1 1 0.58 0.35 1.2 95.32
196 INT12751 Gene_expression of Pigm 91 0.58 22.42 29.2 95.16
197 INT98110 Regulation of Gene_expression of Slc1a2 16 0.62 11.76 17.31 95.08
198 INT122500 Protein_catabolism of Slco1c1 17 0.52 16.7 1.7 95.00
199 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 94.76
200 INT55037 Positive_regulation of Adcy8 7 0.61 5.92 5.36 94.72
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