D:Motor Neuron Diseases

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Disease Term
Synonyms Amyotrophic Lateral Sclerosis, ANTERIOR HORN CELL DISEASE, Familial Motor Neuron Disease, Lateral Scleroses, Lateral Scleroses Primary, Lateral Sclerosis, Lateral Sclerosis Primary, LOU GEHRIG S DISEASE, LOU GEHRIG S SYNDROME, Lou Gehrigs Disease, Lou Gehrigs Syndrome
Documents 719
Hot Single Events 200
Hot Interactions 87

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Motor Neuron Diseases. They are ordered first by their relevance to Motor Neuron Diseases and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08 100.00
2 INT162436 Binding of Igfals and Tardbp 1 0.16 2.68 0 100.00
3 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 100.00
4 INT264679 IGFALS Positive_regulation of CTSC 1 0.02 1.68 0 100.00
5 INT220724 Binding of IGFALS and SOD1 1 0.06 2.1 0.06 100.00
6 INT162435 Binding of Igfals and Rapsn 1 0.19 1.34 0 100.00
7 INT162437 Binding of Igf1 and Igfals 1 0.10 1.45 0 100.00
8 INT303335 Binding of Igfals and CHMP2B 1 0.05 1.3 0 100.00
9 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 100.00
10 INT305505 Negative_regulation of Binding of Igfals and Slc17a6 1 0.16 1.12 0.21 100.00
11 INT305510 Binding of Igfals and Slc17a6 1 0.14 1.11 0.21 100.00
12 INT303337 Binding of SOD1 and Igfals 1 0.06 1.27 0.08 100.00
13 INT303815 Binding of Igfals and Tdp1 1 0.11 1.68 0.1 100.00
14 INT215901 Ins1 Positive_regulation of Igfals 1 0.02 0.81 0.15 100.00
15 INT215902 Igfbp2 Positive_regulation of Igfals 1 0.15 0.8 0.15 100.00
16 INT234164 Binding of Sod1 and Dynll1 1 0.06 1.27 0 100.00
17 INT220725 Binding of IGFALS and IGHD1OR15-1A 1 0.01 1.05 0.03 100.00
18 INT283543 Binding of GARS and Setx 1 0.01 3.71 0 100.00
19 INT283542 Binding of SPG19 and Setx 1 0.06 3.69 0 100.00
20 INT327792 Binding of IGFALS and Alms1 1 0.00 1.15 0.11 100.00
21 INT254906 Binding of Igfals and Chmp2b 1 0.02 0.85 0 100.00
22 INT328982 Binding of Igfals and Cts 1 0.05 0.92 0.8 100.00
23 INT328978 Binding of Igfals and Muted 1 0.02 0.85 0.73 100.00
24 INT328980 Binding of Cst7 and Igfals 1 0.06 0.85 0.73 100.00
25 INT328975 Binding of Igfals and Mup1 1 0.11 0.85 0.73 100.00
26 INT342181 Binding of Igfals and Ros1 1 0.01 0.76 0.41 100.00
27 INT349355 CSF2 Negative_regulation of CSTA 1 0.01 1.43 0 99.84
28 INT279961 CSF2 Negative_regulation of TTR 1 0.04 1.07 0.23 99.84
29 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0 99.68
30 INT264678 Binding of SETX and KRT20 1 0.00 2.17 0 99.38
31 INT203407 Cap2 Negative_regulation of Nptn 1 0.06 0.59 0 99.32
32 INT203398 Enc1 Negative_regulation of Nptn 1 0.07 0.59 0 99.32
33 INT203411 Mllt11 Negative_regulation of Nptn 1 0.08 0.58 0 99.32
34 INT203392 Olfm1 Negative_regulation of Nptn 1 0.08 0.58 0 99.32
35 INT203414 Vsnl1 Negative_regulation of Nptn 1 0.16 0.58 0 99.32
36 INT264682 Binding of VAPB and SETX 1 0.28 1.09 0 99.16
37 INT203406 Cap2 Negative_regulation of Rtn4 1 0.07 0.59 0 99.08
38 INT203418 Enc1 Negative_regulation of Rtn4 1 0.08 0.58 0 99.08
39 INT203396 Mllt11 Negative_regulation of Rtn4 1 0.09 0.58 0 99.08
40 INT203399 Olfm1 Negative_regulation of Rtn4 1 0.09 0.58 0 99.08
41 INT203410 Vsnl1 Negative_regulation of Rtn4 1 0.18 0.58 0 99.08
42 INT283533 Binding of GARS and SPG19 1 0.00 1.72 0 98.98
43 INT203413 Cap2 Negative_regulation of Rtn1 1 0.06 0.59 0 98.84
44 INT203402 Enc1 Negative_regulation of Rtn1 1 0.07 0.58 0 98.84
45 INT203417 Mllt11 Negative_regulation of Rtn1 1 0.08 0.58 0 98.84
46 INT203391 Olfm1 Negative_regulation of Rtn1 1 0.08 0.58 0 98.84
47 INT203401 Vsnl1 Negative_regulation of Rtn1 1 0.17 0.58 0 98.84
48 INT305511 Negative_regulation of Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2 98.80
49 INT203404 Cap2 Negative_regulation of Chn1 1 0.06 0.58 0 98.60
50 INT203397 Enc1 Negative_regulation of Chn1 1 0.08 0.58 0 98.60
51 INT203416 Mllt11 Negative_regulation of Chn1 1 0.09 0.58 0 98.60
52 INT203415 Olfm1 Negative_regulation of Chn1 1 0.08 0.58 0 98.60
53 INT203394 Vsnl1 Negative_regulation of Chn1 1 0.17 0.58 0 98.60
54 INT305508 Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2 98.44
55 INT203409 Cap2 Negative_regulation of Bex1 1 0.07 0.58 0 98.36
56 INT203403 Enc1 Negative_regulation of Bex1 1 0.08 0.58 0 98.36
57 INT203393 Mllt11 Negative_regulation of Bex1 1 0.09 0.58 0 98.36
58 INT203400 Olfm1 Negative_regulation of Bex1 1 0.09 0.58 0 98.36
59 INT203405 Vsnl1 Negative_regulation of Bex1 1 0.19 0.58 0 98.36
60 INT302671 Zmat3 Positive_regulation of Gene_expression of Sod1 1 0.04 0.3 0 97.68
61 INT328976 Binding of Cst7 and Cts 1 0.08 0.92 0.79 97.00
62 INT328983 Binding of Cst7 and Muted 1 0.04 0.84 0.73 97.00
63 INT328977 Binding of Cst7 and Mup1 1 0.18 0.84 0.73 97.00
64 INT203408 Vsnl1 Negative_regulation of Cap2 1 0.15 0.58 0 95.92
65 INT303338 Binding of ULK1 and Atg13 1 0.07 0.73 0 94.80
66 INT352579 CNTF Negative_regulation of Gene_expression of NPY 1 0.17 0.89 0.07 92.84
67 INT273047 Binding of Aqp4 and Sct 1 0.04 1.41 0 92.24
68 INT191128 Positive_regulation of P2RX7 Positive_regulation of Localization of Il1b 1 0.02 0.71 0.34 91.00
69 INT328981 Binding of Mup1 and Cts 1 0.14 1.05 0.88 89.28
70 INT328974 Binding of Muted and Mup1 1 0.06 0.83 0.71 89.28
71 INT328979 Binding of Muted and Cts 1 0.03 0.9 0.78 88.60
72 INT297736 Cbr1 Positive_regulation of Ucp3 1 0.11 1.29 0.07 87.68
73 INT297735 Cbr1 Positive_regulation of Sod2 1 0.11 1.28 0.07 87.68
74 INT261579 Serpinc1 Negative_regulation of Gene_expression of CYBB 1 0.00 1.69 0.18 85.96
75 INT141281 ARTN Regulation of Gdnf 1 0.48 0.32 0.12 85.44
76 INT141279 Nrtn Regulation of Gdnf 1 0.14 0.32 0.12 85.44
77 INT141280 PSPN Regulation of Gdnf 1 0.48 0.32 0.12 85.44
78 INT251582 TNF Positive_regulation of Tnfrsf1b 1 0.29 2.11 0.32 84.80
79 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35 84.60
80 INT324692 Binding of Cd14 and Sod1m 1 0.01 1.07 0.03 83.96
81 INT63511 F2 Negative_regulation of SERPINE2 1 0.15 0.97 0.16 83.80
82 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 83.68
83 INT305504 Slc17a6 Positive_regulation of Ex 1 0.05 0.67 0.22 83.52
84 INT63512 Vip Positive_regulation of Localization of SERPINE2 1 0.63 1.84 0.5 83.12
85 INT288349 TNF Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.1 0.18 82.88
86 INT288351 Mcpt1 Positive_regulation of Gene_expression of TNF 1 0.02 1.1 0.18 82.88
87 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08 82.24
88 INT152111 IL1B Negative_regulation of Ltp 1 0.03 0.85 0.66 78.08
89 INT193454 Dbh Negative_regulation of Negative_regulation of Ndufaf1 1 0.02 1.22 0.05 76.52
90 INT239806 TFAM Positive_regulation of HSR 1 0.00 0.53 0.13 76.00
91 INT28816 Binding of TRPV4 and MND1 1 0.27 0.52 0.1 75.00
92 INT298858 Positive_regulation of Binding of VAPA and RILP 1 0.07 0.54 0 73.04
93 INT298847 Binding of VAPA and RILP 1 0.05 0.54 0 73.04
94 INT203419 Binding of EIF4A1 and Gtf3a 1 0.00 0.5 0.07 72.12
95 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6 70.88
96 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0 70.80
97 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13 69.88
98 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13 69.72
99 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59 66.12
100 INT351760 Adarb1 Regulation of Gria2 1 0.30 1.7 0.07 61.32
101 INT255809 Binding of SF1 and U2AF2 1 0.21 0.3 0 61.00
102 INT297738 Cbr1 Positive_regulation of Ifih1 1 0.01 1.83 0.39 57.84
103 INT255810 SLU7 Positive_regulation of Binding of SNRPA 1 0.01 0.23 0 55.80
104 INT346913 Binding of Kars and Positive_regulation of Gene_expression of Ros1 1 0.03 1.25 0.46 55.52
105 INT346914 Binding of Kars and Positive_regulation of Gene_expression of Car2 1 0.05 1.24 0.45 55.52
106 INT63510 SERPINE2 Positive_regulation of Localization of Vip 1 0.15 0.52 0.21 55.36
107 INT197499 Binding of Apoe and Tfrc 1 0.14 1.54 0.17 53.60
108 INT298845 VAPA Regulation of Negative_regulation of RAB7A 1 0.12 0.32 0 53.28
109 INT298864 VAPB Regulation of Negative_regulation of RAB7A 1 0.32 0.32 0 53.28
110 INT249600 IFNA1 Positive_regulation of Gene_expression of Cd40 1 0.49 1.13 0.52 50.16
111 INT303333 MAPK1 Positive_regulation of Mknk2 1 0.04 0.14 0 50.00
112 INT303331 Mtor Positive_regulation of Rps6kb1 1 0.07 0.07 0 50.00
113 INT303332 ras Positive_regulation of Raf1 1 0.02 0.07 0 50.00
114 INT303334 Binding of SOS1 and Grb2 1 0.00 0.11 0 50.00
115 INT303257 MAPK1 Positive_regulation of NEK4 1 0.05 0.14 0 50.00
116 INT303336 MAPKAPK2 Positive_regulation of Hspb2 1 0.04 0.24 0 50.00
117 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2 44.68
118 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19 40.64
119 INT190751 Adcyap1 Positive_regulation of Vipr2 2 0.16 1.02 0.36 39.88
120 INT273048 Adcyap1 Positive_regulation of Adcyap1r1 1 0.11 1.02 0.19 39.88
121 INT273046 Vip Negative_regulation of Gene_expression of Adcyap1 1 0.20 1.14 0.21 38.72
122 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 38.48
123 INT281880 Binding of Aco1 and Cish 1 0.00 0.16 0 38.48
124 INT283544 Binding of GARS and Bscl2 1 0.01 1.74 0 36.72
125 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37 35.80
126 INT266375 S100b Positive_regulation of Ager 1 0.02 1.8 0.31 35.52
127 INT266373 Itgam Positive_regulation of Ager 1 0.01 0.84 0.1 35.24
128 INT221953 UTS2R Positive_regulation of Gene_expression of CDK5R1 1 0.16 0.23 0.04 34.88
129 INT266385 S100a6 Positive_regulation of Ager 1 0.01 0.84 0.1 34.80
130 INT262515 Positive_regulation of Kcnj6 Positive_regulation of Binding of Bcl2 1 0.00 0.48 0 26.36
131 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62 25.00
132 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66 25.00
133 INT152112 Binding of NTSR1 and Bdnf 1 0.08 0.27 0.33 25.00
134 INT210225 Ptpn2 Positive_regulation of Gene_expression of Ifng 1 0.15 1.44 0.42 24.28
135 INT297739 Binding of Cbr1 and Ucp3 1 0.06 0.5 0 23.04
136 INT305883 Pcx Negative_regulation of Binding of Tjp1 1 0.04 0.11 0.04 21.36
137 INT305875 Pcx Negative_regulation of Binding of Ocln 1 0.03 0.11 0.04 21.36
138 INT265346 Binding of Ocln and Tjp1 7 0.05 1.11 0.09 19.64
139 INT244421 Binding of DST and Ctss 1 0.02 0.42 0.41 18.56
140 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11 17.76
141 INT311535 ROS1 Negative_regulation of CA2 1 0.19 0.61 0.04 17.16
142 INT261497 Binding of PTGDR and LMOD1 1 0.00 0.51 0.54 16.16
143 INT281881 Binding of Aco1 and Ros1 1 0.01 1.93 0.1 14.60
144 INT298876 RAB7A Positive_regulation of Protein_catabolism of NTRK1 1 0.14 0.44 0.22 12.16
145 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29 10.00
146 INT298862 Binding of MCC and VPS13C 1 0.00 0.36 0 8.64
147 INT298859 Positive_regulation of Binding of MCC and VPS13C 1 0.01 0.36 0 8.64
148 INT254909 ARSH Regulation of Sumf1 1 0.00 0.9 0.04 7.44
149 INT254908 ARSH Regulation of Eef1a1 1 0.00 0.89 0.04 7.44
150 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11 6.88
151 INT321181 Binding of Ntrk2 and Ntf5 1 0.09 0.08 0.14 6.88
152 INT223475 Binding of Ntrk1 and Ntrk2 2 0.22 0.25 0.14 6.88
153 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 6.24
154 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78 5.68
155 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 5.00
156 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
157 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4 5.00
158 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84 5.00
159 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72 5.00
160 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71 5.00
161 INT266391 Binding of Ager and S100a1 1 0.01 5.63 1.69 5.00
162 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57 5.00
163 INT334633 Binding of Cntnap1 and Nav1 1 0.10 1.36 1.48 5.00
164 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 5.00
165 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 5.00
166 INT281077 Binding of Gria2 and Gria3 2 0.24 0.35 1.19 5.00
167 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15 5.00
168 INT224728 Col7a1 Positive_regulation of Cia1 1 0.00 2.9 1.12 5.00
169 INT296458 Binding of Gria2 and Pick1 3 0.24 1.86 1.07 5.00
170 INT296460 Binding of Gria2 and Myo18a 1 0.01 1.49 1.06 5.00
171 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99 5.00
172 INT281085 Binding of Gria2 and Nsf 2 0.26 0.4 0.94 5.00
173 INT132610 Bdnf Positive_regulation of Ntrk2 4 0.46 1.09 0.93 5.00
174 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
175 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85 5.00
176 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84 5.00
177 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8 5.00
178 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79 5.00
179 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76 5.00
180 INT224725 Gm2458 Negative_regulation of Cia1 1 0.00 2.01 0.74 5.00
181 INT231349 Il10 Negative_regulation of Gene_expression of TNF 2 0.23 1.82 0.67 5.00
182 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67 5.00
183 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
184 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64 5.00
185 INT181084 Binding of S100a8 and S100a9 6 0.42 2.91 0.62 5.00
186 INT224726 Negative_regulation of Binding of Fgf2 and Cia1 1 0.01 0.92 0.62 5.00
187 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
188 INT224731 Binding of VEGFA and Cia1 1 0.01 0.91 0.61 5.00
189 INT224733 Negative_regulation of Binding of VEGFA and Cia1 1 0.01 0.91 0.61 5.00
190 INT224727 Binding of Fgf2 and Cia1 1 0.01 0.91 0.61 5.00
191 INT296463 Binding of Gria1 and Pick1 1 0.16 0.32 0.59 5.00
192 INT296486 Binding of Pick1 and GRIP1 1 0.03 0.32 0.59 5.00
193 INT296472 Camk2a Positive_regulation of Prkaca 1 0.09 0.32 0.57 5.00
194 INT296456 Gria1 Negative_regulation of Rbm39 1 0.00 0.45 0.57 5.00
195 INT296475 Binding of Pick1 and Myo18a 2 0.01 1.63 0.57 5.00
196 INT224724 Gm2458 Negative_regulation of Metap2 1 0.02 1.57 0.57 5.00
197 INT296446 Binding of Gria2 and Gria4 1 0.13 0.55 0.57 5.00
198 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55 5.00
199 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55 5.00
200 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Motor Neuron Diseases. They are ordered first by their pain relevance and then by number of times they were reported in Motor Neuron Diseases. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 100.00
2 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 100.00
3 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 100.00
4 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 100.00
5 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 100.00
6 INT243382 Positive_regulation of CSTA 4 0.05 14.65 0.12 100.00
7 INT200185 Regulation of Igfals 10 0.26 11.4 1.47 100.00
8 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 100.00
9 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 100.00
10 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 100.00
11 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 100.00
12 INT203372 Positive_regulation of Igfals 10 0.40 9.24 1.11 100.00
13 INT191125 Gene_expression of Igfals 12 0.25 12.96 2.89 100.00
14 INT163998 Gene_expression of CTSC 9 0.65 11.24 1.69 100.00
15 INT332592 Binding of MND1 1 0.08 9.21 0.16 100.00
16 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 100.00
17 INT203311 Positive_regulation of Gene_expression of Igfals 5 0.16 6.87 0.8 100.00
18 INT31989 Binding of SOD1 43 0.47 19.38 2.55 100.00
19 INT200186 Binding of Igfals 5 0.19 4.46 1.52 100.00
20 INT191123 Positive_regulation of Igfals 3 0.18 2.89 0.68 100.00
21 INT92288 Binding of Igfals 3 0.13 3.14 1 100.00
22 INT335980 Regulation of Igfals 1 0.17 2.26 0.12 100.00
23 INT139935 Gene_expression of Slc17a6 36 0.78 8.43 10.61 100.00
24 INT43907 Binding of CD79A 28 0.48 28.11 3.04 100.00
25 INT220730 Protein_catabolism of IGFALS 1 0.14 2.38 0 100.00
26 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 100.00
27 INT234160 Localization of Igfals 4 0.16 3.8 0.74 100.00
28 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 100.00
29 INT264686 Positive_regulation of Gene_expression of IGFALS 2 0.28 2.21 0.27 100.00
30 INT332589 Localization of MND1 1 0.12 2.01 0 100.00
31 INT335981 Regulation of Gene_expression of Igfals 1 0.17 0.83 0 100.00
32 INT332591 Positive_regulation of MND1 1 0.11 1.56 0 100.00
33 INT203373 Protein_catabolism of Igfals 1 0.07 1.07 0 100.00
34 INT349357 Negative_regulation of Transcription of CSTA 1 0.02 1.26 0 100.00
35 INT349360 Positive_regulation of Transcription of CSTA 1 0.02 1.25 0 100.00
36 INT200189 Negative_regulation of Igfals 7 0.24 4.19 1.39 100.00
37 INT305498 Positive_regulation of Gene_expression of Slc17a6 1 0.50 1.13 0.54 100.00
38 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 100.00
39 INT229301 Gene_expression of NR0B2 3 0.18 3.49 0.16 100.00
40 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 100.00
41 INT20205 Binding of IgG 108 0.46 66.68 8.57 100.00
42 INT283245 Gene_expression of MND1 2 0.11 1.94 0.07 100.00
43 INT191122 Localization of Igfals 2 0.20 2.16 0.5 100.00
44 INT303800 Negative_regulation of Igfals 1 0.11 1.05 0 100.00
45 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 100.00
46 INT327784 Regulation of Gene_expression of IGFALS 1 0.07 1.21 0.13 100.00
47 INT200206 Negative_regulation of Gene_expression of Igfals 4 0.21 3.83 0.5 100.00
48 INT283536 Binding of Setx 1 0.36 3.69 0 100.00
49 INT303797 Phosphorylation of Igfals 1 0.21 1.61 0 100.00
50 INT191124 Positive_regulation of Gene_expression of Igfals 1 0.03 1.8 0.29 100.00
51 INT349358 Regulation of Regulation of IGFALS 1 0.19 0.5 0 100.00
52 INT291630 Regulation of Gene_expression of CSTA 2 0.06 1.01 0.08 100.00
53 INT174128 Regulation of Gene_expression of Igfals 1 0.06 0.41 0 100.00
54 INT91899 Binding of Sod1 17 0.47 11.56 2.63 99.98
55 INT14500 Positive_regulation of Gene_expression of CST3 9 0.67 7.46 1.87 99.98
56 INT91900 Localization of Sod1 12 0.77 6.62 1.51 99.96
57 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 99.96
58 INT116432 Positive_regulation of Positive_regulation of SOD1 3 0.40 3.88 0.2 99.96
59 INT203359 Protein_catabolism of Cdh23 1 0.09 0.52 0 99.96
60 INT174131 Regulation of Negative_regulation of Sod1 1 0.43 0.52 0 99.96
61 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 99.94
62 INT203365 Gene_expression of Mllt11 1 0.52 0.46 0.04 99.92
63 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 99.92
64 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 99.88
65 INT226037 Binding of Epo 5 0.36 2.99 0.32 99.88
66 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 99.86
67 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.84
68 INT63036 Negative_regulation of CSTA 4 0.36 9.42 0.22 99.84
69 INT63035 Gene_expression of CSTA 10 0.56 11.56 0.57 99.84
70 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 99.84
71 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 99.84
72 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 99.84
73 INT349361 Negative_regulation of Gene_expression of CSTA 1 0.02 1.57 0 99.84
74 INT349362 Transcription of CSTA 1 0.02 1.38 0 99.84
75 INT307615 Negative_regulation of Positive_regulation of CSF2 4 0.36 3.55 0.48 99.84
76 INT169747 Localization of AQP4 17 0.75 16.64 2.79 99.84
77 INT349359 Regulation of Transcription of CSTA 1 0.01 0.15 0 99.84
78 INT175556 Regulation of Positive_regulation of PTH 3 0.39 2.34 0.12 99.82
79 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 99.80
80 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 99.80
81 INT144465 Gene_expression of DMPK 9 0.69 5.01 0.94 99.80
82 INT153997 Negative_regulation of Gene_expression of Slc17a6 2 0.59 3.01 2.42 99.80
83 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 99.78
84 INT303796 Gene_expression of Tdp1 1 0.77 70.15 2.55 99.76
85 INT265574 Positive_regulation of Gene_expression of Hgf 5 0.62 3.6 0.31 99.76
86 INT76813 Gene_expression of Hgf 20 0.75 10.96 2.08 99.76
87 INT14690 Localization of CSF2 124 0.80 85.17 27.26 99.76
88 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 99.74
89 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47 99.72
90 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 99.70
91 INT303326 Gene_expression of CHMP2B 25 0.75 10.08 0.76 99.68
92 INT303305 Negative_regulation of LMNB1 1 0.04 0.82 0.04 99.68
93 INT203378 Regulation of PVALB 3 0.24 0.68 0.3 99.68
94 INT203317 Negative_regulation of Gene_expression of Cycs 1 0.22 0.89 0 99.68
95 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 99.66
96 INT266786 Binding of ASAH1 2 0.11 3.87 0.44 99.66
97 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 99.66
98 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 99.62
99 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 99.62
100 INT33099 Negative_regulation of INSRR 32 0.40 13.82 9.85 99.62
101 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.60
102 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07 99.60
103 INT254885 Gene_expression of Chmp2b 1 0.24 0.84 0 99.60
104 INT8801 Gene_expression of Csf3 71 0.74 45.6 10.83 99.56
105 INT199343 Positive_regulation of Igfbp2 8 0.67 7.85 0.28 99.56
106 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76 99.52
107 INT250272 Positive_regulation of Gene_expression of AQP4 11 0.54 9.79 1.85 99.52
108 INT100185 Positive_regulation of LMNB1 3 0.25 1.83 0.4 99.52
109 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 99.52
110 INT63037 Regulation of CSTA 10 0.37 13.37 0.92 99.48
111 INT82950 Positive_regulation of Gdnf 36 0.51 11.72 10.5 99.44
112 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 99.44
113 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73 99.44
114 INT327779 Regulation of Gene_expression of AQP4 5 0.48 4.5 0.6 99.42
115 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 99.40
116 INT178029 Gene_expression of Epo 25 0.76 14.98 1.46 99.40
117 INT203340 Binding of Syt13 1 0.20 0.58 0.13 99.40
118 INT203306 Gene_expression of Cycs 1 0.40 0.89 0 99.36
119 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53 99.32
120 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.32
121 INT203330 Negative_regulation of Binding of Sod1 1 0.28 1.03 0.1 99.32
122 INT36893 Negative_regulation of Coq10a 36 0.55 22.24 5.47 99.28
123 INT203376 Negative_regulation of PVALB 3 0.23 0.61 0.43 99.28
124 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 99.28
125 INT50933 Transcription of Il6 38 0.72 24.31 11.58 99.28
126 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78 99.26
127 INT17961 Regulation of Pla2g4a 9 0.25 4.86 2.3 99.26
128 INT126174 Positive_regulation of Regulation of Pla2g4a 1 0.37 1.03 0.34 99.26
129 INT204330 Protein_catabolism of SOD1 8 0.84 4.75 0.1 99.24
130 INT240277 Negative_regulation of Protein_catabolism of SOD1 1 0.42 1.23 0.03 99.24
131 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 99.24
132 INT66202 Negative_regulation of Mgat4a 2 0.04 0.43 1.02 99.24
133 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 99.22
134 INT25237 Binding of NRSN1 4 0.29 2.58 0.53 99.22
135 INT25236 Binding of REG1A 6 0.47 3.69 0.91 99.22
136 INT203344 Gene_expression of Cebpd 1 0.53 3.11 0.4 99.20
137 INT63238 Gene_expression of Mt1 27 0.65 10.86 2.53 99.20
138 INT74867 Gene_expression of Mt2 13 0.53 5.22 1.76 99.20
139 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16 99.20
140 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68 99.20
141 INT96520 Gene_expression of PRPH 5 0.75 2.55 0.39 99.20
142 INT288630 Gene_expression of Cntf 6 0.75 3.99 1.89 99.18
143 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 99.16
144 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 99.16
145 INT180459 Gene_expression of Cdh23 4 0.14 5.11 0.52 99.16
146 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 99.16
147 INT292763 Localization of Tardbp 6 0.80 12.51 0.91 99.16
148 INT230495 Regulation of Gene_expression of Alms1 4 0.04 4.53 0.53 99.16
149 INT140414 Positive_regulation of AQP4 25 0.64 23.43 2.47 99.12
150 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 99.12
151 INT327783 Regulation of Transcription of AQP4 1 0.35 1.03 0 99.12
152 INT327785 Transcription of AQP4 3 0.56 2.19 0.23 99.12
153 INT28817 Binding of TRPV4 6 0.39 3.92 2.59 99.12
154 INT111741 Negative_regulation of Gene_expression of Vip 3 0.33 3.38 2.26 99.10
155 INT265198 Negative_regulation of Gene_expression of Vipr2 3 0.59 1.5 0.31 99.10
156 INT242856 Binding of Cst7 2 0.18 3.04 1.93 99.00
157 INT19768 Negative_regulation of LAMC2 11 0.57 10.54 5.32 99.00
158 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69 99.00
159 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 98.94
160 INT162429 Negative_regulation of Gene_expression of Sod1 6 0.48 2.46 0.53 98.92
161 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 98.92
162 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 98.84
163 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 98.84
164 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 98.84
165 INT72747 Localization of IgG 55 0.53 30.88 4.19 98.84
166 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 98.80
167 INT88007 Regulation of GDNF 2 0.34 0.82 0.16 98.80
168 INT335733 Positive_regulation of Tardbp 8 0.69 28.41 0.41 98.76
169 INT203343 Positive_regulation of Fcgbp 1 0.33 1.52 0.32 98.76
170 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 98.72
171 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.72
172 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 98.72
173 INT214 Localization of AVP 370 0.81 208.51 91.09 98.72
174 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 98.72
175 INT89661 Gene_expression of Hrec 102 0.21 69.91 39.57 98.70
176 INT120898 Transcription of Hrec 1 0.07 0.5 0.64 98.70
177 INT303284 Regulation of Gene_expression of Tardbp 2 0.45 6.82 0 98.64
178 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 98.64
179 INT187472 Regulation of Gene_expression of Sod1 5 0.53 2.68 0.37 98.64
180 INT303276 Regulation of Gene_expression of Ang 1 0.24 0.89 0 98.64
181 INT81188 Gene_expression of Vipr2 16 0.78 4.38 3.7 98.64
182 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 98.60
183 INT24926 Regulation of Csf3 17 0.52 10.41 3.04 98.60
184 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 98.60
185 INT87361 Negative_regulation of TTR 25 0.57 5.74 1.51 98.60
186 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 98.58
187 INT267203 Negative_regulation of Cryab 2 0.29 3.98 0 98.56
188 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69 98.56
189 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 98.52
190 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87 98.52
191 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14 98.50
192 INT38672 Binding of KRT20 69 0.39 48.01 6.31 98.48
193 INT95924 Negative_regulation of Bczr1 1 0.00 1.5 0.47 98.48
194 INT41728 Gene_expression of CHAT 65 0.75 42.19 12.73 98.48
195 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99 98.40
196 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 98.40
197 INT303799 Phosphorylation of Tdp1 1 0.82 22.84 0.71 98.36
198 INT103882 Gene_expression of MECP2 17 0.76 10.47 0.96 98.36
199 INT49324 Binding of Hgf 9 0.36 5.5 0.88 98.36
200 INT62711 Binding of HGF 27 0.31 15.23 2.08 98.36
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